RU2151770C1 - Производные пиридонкарбоновой кислоты, способы их получения, противоопухолевое средство и фармацевтическая композиция - Google Patents
Производные пиридонкарбоновой кислоты, способы их получения, противоопухолевое средство и фармацевтическая композиция Download PDFInfo
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- RU2151770C1 RU2151770C1 RU97100718/04A RU97100718A RU2151770C1 RU 2151770 C1 RU2151770 C1 RU 2151770C1 RU 97100718/04 A RU97100718/04 A RU 97100718/04A RU 97100718 A RU97100718 A RU 97100718A RU 2151770 C1 RU2151770 C1 RU 2151770C1
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- carboxylic acid
- hydrogen atom
- halogen atom
- lower alkyl
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- SUKJFIGYRHOWBL-UHFFFAOYSA-N sodium hypochlorite Chemical compound [Na+].Cl[O-] SUKJFIGYRHOWBL-UHFFFAOYSA-N 0.000 description 1
- 235000010288 sodium nitrite Nutrition 0.000 description 1
- AKHNMLFCWUSKQB-UHFFFAOYSA-L sodium thiosulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=S AKHNMLFCWUSKQB-UHFFFAOYSA-L 0.000 description 1
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Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (10)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP6/156578 | 1994-06-14 | ||
| JP15657894 | 1994-06-14 | ||
| JP19792194 | 1994-07-28 | ||
| JP6/197921 | 1994-07-28 | ||
| JP30691494 | 1994-11-15 | ||
| JP6/306914 | 1994-11-15 | ||
| JP6/339956 | 1994-12-28 | ||
| JP33995694 | 1994-12-28 | ||
| JP8170595 | 1995-03-13 | ||
| JP7/81705 | 1995-03-13 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU97100718A RU97100718A (ru) | 1999-02-10 |
| RU2151770C1 true RU2151770C1 (ru) | 2000-06-27 |
Family
ID=27524935
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU97100718/04A RU2151770C1 (ru) | 1994-06-14 | 1995-06-06 | Производные пиридонкарбоновой кислоты, способы их получения, противоопухолевое средство и фармацевтическая композиция |
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| EP (1) | EP0787726B1 (enExample) |
| JP (1) | JP3391796B2 (enExample) |
| KR (1) | KR100350921B1 (enExample) |
| CN (1) | CN1053668C (enExample) |
| AT (1) | ATE209645T1 (enExample) |
| AU (1) | AU679859B2 (enExample) |
| BR (1) | BR9508037A (enExample) |
| CA (1) | CA2192824C (enExample) |
| CZ (1) | CZ292631B6 (enExample) |
| DE (1) | DE69524251T2 (enExample) |
| DK (1) | DK0787726T3 (enExample) |
| ES (1) | ES2163512T3 (enExample) |
| FI (1) | FI112485B (enExample) |
| HK (1) | HK1000495A1 (enExample) |
| HU (1) | HU220072B (enExample) |
| MX (1) | MX9606331A (enExample) |
| NO (1) | NO307255B1 (enExample) |
| NZ (1) | NZ287139A (enExample) |
| PL (1) | PL181867B1 (enExample) |
| PT (1) | PT787726E (enExample) |
| RO (1) | RO117793B1 (enExample) |
| RU (1) | RU2151770C1 (enExample) |
| SI (1) | SI0787726T1 (enExample) |
| SK (1) | SK281341B6 (enExample) |
| TW (1) | TW319769B (enExample) |
| WO (1) | WO1995034559A1 (enExample) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2405782C2 (ru) * | 2004-10-14 | 2010-12-10 | Ф.Хоффманн-Ля Рош Аг | Хиназолинилметилентиазолиноны в качестве cdk-1 ингибиторов |
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| JP5374153B2 (ja) * | 2005-09-02 | 2013-12-25 | サネシス ファーマシューティカルズ， インコーポレイテッド | 癌の治療のための（＋）−１，４−ジヒドロ−７−［（３ｓ，４ｓ）−３−メトキシ−４−（メチルアミノ）−１−ピロリジニル］−４−オキソ−１−（２−チアゾリル）−１，８−ナフチリジン−３−カルボン酸を使用する方法 |
| AU2006287149B2 (en) * | 2005-09-02 | 2013-05-23 | Sunesis Pharmaceuticals, Inc. | Methods of using (+)-1,4-dihydro-7-[(3S,4S)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid for treatment of cancer |
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| RU2428983C2 (ru) * | 2005-09-02 | 2011-09-20 | Санесис Фармасьютикалз, Инк. | Способы применения (+)-1,4-дигидро-7-[(3s,4s)-3-метокси-4-(метиламино)-1-пирролидинил]-4-оксо-1-(2-тиазолил)-1,8-нафтиридин-3-карбоновой кислоты для лечения рака |
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| CN101305000A (zh) * | 2005-09-14 | 2008-11-12 | 詹森药业有限公司 | 作为c-fms激酶抑制剂的5-氧代-5,8-二氢-吡啶并-嘧啶类 |
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| CA2708264C (en) * | 2007-12-10 | 2018-07-03 | Sunesis Pharmaceuticals, Inc. | Methods of using (+)-1,4-dihydro-7-[(3s,4s)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid for treatment of antecedent hematologic disorders |
| JP5936862B2 (ja) | 2009-02-27 | 2016-06-22 | サネシス ファーマシューティカルズ， インコーポレイテッド | Ｂｒｃａ２活性が低下した癌対象の治療のためのｓｎｓ−５９５の使用方法 |
| UA110465C2 (en) * | 2009-09-04 | 2016-01-12 | Sunesis Pharmaceutecals Inc | Stable sns-595 composition |
| TW201120037A (en) * | 2009-10-26 | 2011-06-16 | Sunesis Pharmaceuticals Inc | Compounds and methods for treatment of cancer |
| NZ618795A (en) | 2011-05-13 | 2015-07-31 | Array Biopharma Inc | Pyrrolidinyl urea, pyrrolidinyl thiourea and pyrrolidinyl guanidine compounds as trka kinase inhibitors |
| CN103497186B (zh) * | 2013-09-24 | 2015-02-25 | 浙江司太立制药股份有限公司 | 含有烷氧亚氨基取代的萘啶酮羧酸衍生物及其制备方法 |
| EP3604305B1 (en) * | 2017-03-24 | 2024-08-28 | Wakunaga Pharmaceutical Co., Ltd. | Novel pyridone carboxylic acid derivative or salt thereof |
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- 1995-06-06 DE DE69524251T patent/DE69524251T2/de not_active Expired - Lifetime
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2405782C2 (ru) * | 2004-10-14 | 2010-12-10 | Ф.Хоффманн-Ля Рош Аг | Хиназолинилметилентиазолиноны в качестве cdk-1 ингибиторов |
| RU2405781C2 (ru) * | 2004-10-14 | 2010-12-10 | Ф.Хоффманн-Ля Рош Аг | 1, 5-нафтиридиназолидиноны, обладающие cdk1 антипролиферативной активностью |
| RU2548031C2 (ru) * | 2008-12-31 | 2015-04-10 | Санесис Фармасьютикалз, Инк. | Способ получения (+)-1,4-дигидро-7-[(3s,4s)-3-метокси-4-(метиламино)-1-пирролидинил]-4-оксо-1-(2-тиазолил)-1,8-нафтиридин-3-карбоновой кислоты |
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