RU2139052C1 - Комбинация ингибитора вич-протеазы с другими антивирусными соединениями, фармацевтическая композиция на их основе и способ получения фармацевтической композиции - Google Patents

Комбинация ингибитора вич-протеазы с другими антивирусными соединениями, фармацевтическая композиция на их основе и способ получения фармацевтической композиции Download PDF

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Publication number
RU2139052C1
RU2139052C1 RU95122135/14A RU95122135A RU2139052C1 RU 2139052 C1 RU2139052 C1 RU 2139052C1 RU 95122135/14 A RU95122135/14 A RU 95122135/14A RU 95122135 A RU95122135 A RU 95122135A RU 2139052 C1 RU2139052 C1 RU 2139052C1
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RU
Russia
Prior art keywords
hydroxy
tert
phenylmethyl
pentanamide
indanyl
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Application number
RU95122135/14A
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English (en)
Russian (ru)
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RU95122135A (ru
Inventor
П.Вакка Джозеф (US)
П.Вакка Джозеф
П.Гар Джеймс (US)
П.Гар Джеймс
Д.Дорси Брюс (US)
Д.Дорси Брюс
Холлоуэй М.Катарин (US)
Холлоуэй М.Катарин
В.Хангейт Рэндалл (US)
В.Хангейт Рэндалл
Original Assignee
Мерк Энд Ко., Инк.
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Publication of RU95122135A publication Critical patent/RU95122135A/ru
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Publication of RU2139052C1 publication Critical patent/RU2139052C1/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
RU95122135/14A 1993-03-31 1994-03-24 Комбинация ингибитора вич-протеазы с другими антивирусными соединениями, фармацевтическая композиция на их основе и способ получения фармацевтической композиции RU2139052C1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4072993A 1993-03-31 1993-03-31
US040729 1993-03-31
PCT/US1994/003209 WO1994022480A1 (fr) 1993-03-31 1994-03-24 Inhibiteurs de la protease du vih entrant dans des preparations pharmaceutiques pour le traitement du sida

Publications (2)

Publication Number Publication Date
RU95122135A RU95122135A (ru) 1998-02-10
RU2139052C1 true RU2139052C1 (ru) 1999-10-10

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Family Applications (1)

Application Number Title Priority Date Filing Date
RU95122135/14A RU2139052C1 (ru) 1993-03-31 1994-03-24 Комбинация ингибитора вич-протеазы с другими антивирусными соединениями, фармацевтическая композиция на их основе и способ получения фармацевтической композиции

Country Status (35)

Country Link
EP (1) EP0617968B1 (fr)
JP (1) JPH08508496A (fr)
KR (1) KR100311551B1 (fr)
CN (1) CN1090186C (fr)
AT (1) ATE230610T1 (fr)
AU (1) AU685772B2 (fr)
BG (1) BG62083B1 (fr)
BR (1) BR9406503A (fr)
CA (1) CA2120192A1 (fr)
CY (1) CY2326B1 (fr)
CZ (1) CZ286412B6 (fr)
DE (1) DE69431972T2 (fr)
DK (1) DK0617968T3 (fr)
DZ (1) DZ1766A1 (fr)
ES (1) ES2188604T3 (fr)
FI (1) FI954580A0 (fr)
HK (1) HK1009248A1 (fr)
HR (1) HRP940209B1 (fr)
HU (1) HUT74006A (fr)
IL (1) IL109166A (fr)
LV (1) LV13141B (fr)
NO (1) NO953876L (fr)
NZ (1) NZ265164A (fr)
PL (1) PL310895A1 (fr)
PT (1) PT617968E (fr)
RO (1) RO118000B1 (fr)
RU (1) RU2139052C1 (fr)
SA (1) SA94140745B1 (fr)
SG (1) SG64366A1 (fr)
SI (1) SI9420017B (fr)
SK (1) SK279471B6 (fr)
TW (1) TW307684B (fr)
WO (1) WO1994022480A1 (fr)
YU (1) YU49275B (fr)
ZA (1) ZA942255B (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2520967C1 (ru) * 2013-02-08 2014-06-27 Федеральное государственное бюджетное учреждение науки Новосибирский институт органической химии им. Н.Н. Ворожцова Сибирского отделения Российской академии наук (НИОХ СО РАН) СИММЕТРИЧНЫЕ ДИИМИНЫ НА ОСНОВЕ КАМФОРЫ - ИНГИБИТОРЫ РЕПРОДУКЦИИ ВИРУСА ГРИППА (ШТАММ A/California/07/09 (H1N1)pdm09)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ288312B6 (en) * 1993-12-15 2001-05-16 Merck & Co Inc HIV-protease inhibitors and pharmaceutical preparations in which they are comprised
UA49803C2 (uk) * 1994-06-03 2002-10-15 Дж.Д. Сьорль Енд Ко Спосіб лікування ретровірусних інфекцій
US5476874A (en) * 1994-06-22 1995-12-19 Merck & Co., Inc. New HIV protease inhibitors
JPH10507917A (ja) * 1994-10-25 1998-08-04 メルク エンド カンパニー インコーポレーテッド Ｈｉｖプロテアーゼ阻害剤の微生物合成
US6689761B1 (en) 1995-02-01 2004-02-10 Merck & Co., Inc. Combination therapy for HIV infection
US6479526B1 (en) 1995-04-12 2002-11-12 The Procter & Gamble Company Pharmaceutical composition for inhibiting the growth of viruses and cancers
US6262093B1 (en) 1995-04-12 2001-07-17 The Proctor & Gamble Company Methods of treating cancer with benzimidazoles
US6265427B1 (en) 1995-06-07 2001-07-24 The Proctor & Gamble Company Pharmaceutical composition for the method of treating leukemia
US5900429A (en) 1997-01-28 1999-05-04 The Procter & Gamble Company Method for inhibiting the growth of cancers
PE11499A1 (es) * 1997-05-16 1999-03-01 Procter & Gamble Tratamiento del hiv y cancer
US6506783B1 (en) 1997-05-16 2003-01-14 The Procter & Gamble Company Cancer treatments and pharmaceutical compositions therefor
HU9701081D0 (en) * 1997-06-23 1997-08-28 Gene Research Lab Inc N Pharmaceutical composition of antitumoral activity
US6245789B1 (en) 1998-05-19 2001-06-12 The Procter & Gamble Company HIV and viral treatment
WO2000002862A1 (fr) 1998-07-08 2000-01-20 G.D. Searle & Co. Inhibiteurs de la protease retrovirale
AU6508899A (en) 1998-10-13 2000-05-01 Du Pont Pharmaceuticals Company Selective eradication of virally-infected cells by combined use of a cytotoxic agent and an antiviral agent
US6423734B1 (en) 1999-08-13 2002-07-23 The Procter & Gamble Company Method of preventing cancer
US6462062B1 (en) 2000-09-26 2002-10-08 The Procter & Gamble Company Compounds and methods for use thereof in the treatment of cancer or viral infections
US6608096B1 (en) 2000-09-26 2003-08-19 University Of Arizona Foundation Compounds and methods for use thereof in the treatment of cancer or viral infections
US6407105B1 (en) 2000-09-26 2002-06-18 The Procter & Gamble Company Compounds and methods for use thereof in the treatment of cancer or viral infections
US6380232B1 (en) 2000-09-26 2002-04-30 The Procter & Gamble Company Benzimidazole urea derivatives, and pharmaceutical compositions and unit dosages thereof
US7781478B2 (en) 2004-07-14 2010-08-24 Ptc Therapeutics, Inc. Methods for treating hepatitis C
US7772271B2 (en) 2004-07-14 2010-08-10 Ptc Therapeutics, Inc. Methods for treating hepatitis C
US8013006B2 (en) 2004-07-14 2011-09-06 Ptc Therapeutics, Inc. Methods for treating hepatitis C
US7868037B2 (en) 2004-07-14 2011-01-11 Ptc Therapeutics, Inc. Methods for treating hepatitis C
MX2007000762A (es) 2004-07-22 2007-04-02 Ptc Therapeutics Inc Tienopiridinas para tratamientode hepatitis c.
CN109528747A (zh) * 2018-12-13 2019-03-29 中国人民解放军总医院 扎西他滨在制备抗菌消炎药物中的应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06508146A (ja) * 1991-06-04 1994-09-14 スミスクライン・ビーチャム・コーポレイション 炭素環および複素環式ｈｉｖプロテアーゼ抑制剤

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2520967C1 (ru) * 2013-02-08 2014-06-27 Федеральное государственное бюджетное учреждение науки Новосибирский институт органической химии им. Н.Н. Ворожцова Сибирского отделения Российской академии наук (НИОХ СО РАН) СИММЕТРИЧНЫЕ ДИИМИНЫ НА ОСНОВЕ КАМФОРЫ - ИНГИБИТОРЫ РЕПРОДУКЦИИ ВИРУСА ГРИППА (ШТАММ A/California/07/09 (H1N1)pdm09)

Also Published As

Publication number Publication date
JPH08508496A (ja) 1996-09-10
CZ286412B6 (en) 2000-04-12
HU9502860D0 (en) 1995-11-28
SI9420017B (sl) 2003-12-31
KR960701661A (ko) 1996-03-28
FI954580A (fi) 1995-09-27
LV13141B (en) 2004-08-20
DZ1766A1 (fr) 2002-02-17
IL109166A0 (en) 1994-06-24
CN1090186C (zh) 2002-09-04
HRP940209B1 (en) 2004-04-30
RO118000B1 (ro) 2002-12-30
SI9420017A (en) 1996-10-31
BG100016A (en) 1996-04-30
DE69431972D1 (de) 2003-02-13
CN1120316A (zh) 1996-04-10
TW307684B (fr) 1997-06-11
NO953876L (no) 1995-11-30
AU5921394A (en) 1994-10-06
HUT74006A (en) 1996-10-28
ATE230610T1 (de) 2003-01-15
NO953876D0 (no) 1995-09-29
PT617968E (pt) 2003-03-31
YU49275B (sh) 2005-03-15
CZ252895A3 (en) 1996-07-17
EP0617968A1 (fr) 1994-10-05
AU685772B2 (en) 1998-01-29
SA94140745B1 (ar) 2006-07-11
HRP940209A2 (en) 1998-02-28
EP0617968B1 (fr) 2003-01-08
ZA942255B (en) 1994-11-01
SK122595A3 (en) 1997-03-05
DK0617968T3 (da) 2003-02-24
KR100311551B1 (ko) 2001-12-28
DE69431972T2 (de) 2003-08-28
BR9406503A (pt) 1996-01-02
IL109166A (en) 1999-08-17
SK279471B6 (sk) 1998-11-04
SG64366A1 (en) 1999-04-27
ES2188604T3 (es) 2003-07-01
NZ265164A (en) 1997-09-22
PL310895A1 (en) 1996-01-08
BG62083B1 (bg) 1999-02-26
FI954580A0 (fi) 1995-09-27
CA2120192A1 (fr) 1994-10-01
WO1994022480A1 (fr) 1994-10-13
CY2326B1 (en) 2003-11-14
HK1009248A1 (en) 1999-05-28
YU15994A (sh) 1999-06-15

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Effective date: 20040325