RU2128655C1 - Бензопирановые и бензоконденсированные соединения, промежуточные соединения, фармацевтическая композиция и способ ингибирования - Google Patents

Бензопирановые и бензоконденсированные соединения, промежуточные соединения, фармацевтическая композиция и способ ингибирования Download PDF

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RU2128655C1
RU2128655C1 RU97105834A RU97105834A RU2128655C1 RU 2128655 C1 RU2128655 C1 RU 2128655C1 RU 97105834 A RU97105834 A RU 97105834A RU 97105834 A RU97105834 A RU 97105834A RU 2128655 C1 RU2128655 C1 RU 2128655C1
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group
compound
substituted
compounds
hydroxy
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RU97105834A
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RU97105834A (ru
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А.Домброски Марк
Кох Кевин
Даниэль Пископьо Энтони
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Пфайзер Инк.
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/42—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4
    • C07D311/56—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4 without hydrogen atoms in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/12—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings
    • C07C39/14—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings with at least one hydroxy group on a condensed ring system containing two rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyrane Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
RU97105834A 1994-10-13 1995-05-26 Бензопирановые и бензоконденсированные соединения, промежуточные соединения, фармацевтическая композиция и способ ингибирования RU2128655C1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US32287694A 1994-10-13 1994-10-13
US08/322876 1994-10-13
US08/322,876 1994-10-13
PCT/IB1995/000401 WO1996011920A1 (en) 1994-10-13 1995-05-26 Benzopyran and benzo-fused compounds, their preparation and their use as leukotriene b4 (ltb4) antagonists

Publications (2)

Publication Number Publication Date
RU2128655C1 true RU2128655C1 (ru) 1999-04-10
RU97105834A RU97105834A (ru) 1999-04-27

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JP (1) JP2983295B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
KR (1) KR100232341B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CN (1) CN1160399A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
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BR (1) BR9504385A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA2201742A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
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NO (1) NO971672L (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
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RU (1) RU2128655C1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
TR (1) TR199501270A2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
TW (1) TW304941B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
WO (1) WO1996011920A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ZA (1) ZA958597B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

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CN1108298C (zh) * 1996-09-16 2003-05-14 辉瑞大药厂 制备取代的苯并二氢吡喃醇衍生物的方法
CA2274908A1 (en) * 1996-12-13 1998-06-18 Eli Lilly And Company Leukotriene antagonists for cerebral focal stroke
IL128731A0 (en) * 1998-03-12 2000-01-31 Pfizer Prod Inc Method of preventing allograft rejection
EP0963755A3 (en) * 1998-04-16 2001-03-14 Pfizer Products Inc. Use of benzopyranes for preventing allograft rejection
SE0004245D0 (sv) 2000-11-20 2000-11-20 Pharmacia Ab Novel compounds and their use
JP2004518685A (ja) * 2001-01-30 2004-06-24 ファイザー・プロダクツ・インク クロマニル安息香酸の調製方法
AU4239302A (en) * 2001-06-28 2003-01-02 Pfizer Products Inc. Benzoic acid substituted benzopyrans for the treatment of atherosclerosis
DE60330864D1 (de) 2002-06-19 2010-02-25 Biovitrum Ab Publ Neue verbindungen, deren verwendung und herstellung
CN101014369A (zh) * 2004-07-22 2007-08-08 法玛西亚公司 利用cox—2选择性抑制剂和ltb4受体拮抗剂的组合用于治疗炎症和疼痛的组合物
US7674822B2 (en) 2004-11-24 2010-03-09 Wyeth PTP1b inhibitors
WO2006065686A2 (en) 2004-12-13 2006-06-22 Galileo Pharmaceuticals, Inc. Spiro derivatives as lipoxygenase inhibitors
EP1856079A4 (en) 2005-02-25 2008-12-31 Galileo Pharmaceuticals Inc CHROMANS, THIOCHROMANS AND HETEROCYCLIC DIHYDROQUINOLINES
US7842713B2 (en) * 2006-04-20 2010-11-30 Pfizer Inc Fused phenyl amido heterocyclic compounds
JP2009536953A (ja) 2006-05-11 2009-10-22 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ Ｃｅｔｐ阻害剤としての１，２，３，４−テトラヒドロ−キノリン誘導体
CA2651817A1 (en) 2006-05-11 2007-11-22 Janssen Pharmaceutica N.V. 3,4-dihydro-2h-benzo[1,4]oxazine and thiazine derivatives as cetp inhibitors
NZ591366A (en) 2008-09-11 2012-05-25 Pfizer Heteroaryls amide derivatives and their use as glucokinase activators
MY151246A (en) 2009-03-11 2014-04-30 Pfizer Benzofuranyl derivatives
WO2013123081A2 (en) * 2012-02-14 2013-08-22 Children's Hospital Medical Center Use of small molecule inhibitors targeting the interaction between rac gtpase and p67 (phox)
CN102920692A (zh) * 2012-10-25 2013-02-13 中国人民解放军第二军医大学 (e)-2-(1-羟基-4-环己酮)乙基咖啡酸酯在制备防治类风湿关节炎的药物中的应用
EP3268358A1 (en) 2015-03-13 2018-01-17 Forma Therapeutics, Inc. Alpha-cinnamide compounds and compositions as hdac8 inhibitors
TW201711999A (zh) 2015-09-03 2017-04-01 佛瑪治療公司 ﹝６，６﹞稠合雙環組蛋白脫乙醯基酶８（ｈｄａｃ８）抑制劑
US20190382363A1 (en) 2015-11-30 2019-12-19 Merck Sharp & Dohme Corp. Aryl sulfonamides as blt1 antagonists
US10370368B2 (en) 2015-11-30 2019-08-06 Merck Sharp & Dohme Corp. Aryl acylsulfonamides as BLT1 antagonists
EP3383869B1 (en) 2015-11-30 2023-06-28 Merck Sharp & Dohme LLC Aryl sulfonamides as blt1 antagonists
WO2017095722A1 (en) 2015-11-30 2017-06-08 Merck Sharp & Dohme Corp. Aryl acylsulfonamides as blt1 antagonists
WO2018071687A1 (en) * 2016-10-13 2018-04-19 The Regents Of The University Of California Methods of treating pruritis
CN119700747B (zh) * 2025-02-26 2025-05-06 云南农业大学 苦杏碱醇a在制备防治骨质疏松症产品中的应用

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SU469247A3 (ru) * 1972-01-14 1975-04-30 Майлз Лабораториз Инк (Фирма) Способ получени производных хромона
WO1993015066A1 (en) * 1992-01-23 1993-08-05 Pfizer Inc. Benzopyran and related ltb4 antagonists
WO1993015067A1 (en) * 1992-01-23 1993-08-05 Pfizer Inc. Benzopyran and related ltb4 antagonists

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SU469247A3 (ru) * 1972-01-14 1975-04-30 Майлз Лабораториз Инк (Фирма) Способ получени производных хромона
WO1993015066A1 (en) * 1992-01-23 1993-08-05 Pfizer Inc. Benzopyran and related ltb4 antagonists
WO1993015067A1 (en) * 1992-01-23 1993-08-05 Pfizer Inc. Benzopyran and related ltb4 antagonists

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HUT77515A (hu) 1998-05-28
CZ111797A3 (cs) 1998-07-15
PE10897A1 (es) 1997-04-21
IL115529A0 (en) 1996-01-19
AU2416795A (en) 1996-05-06
FI971524A0 (fi) 1997-04-11
TW304941B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1997-05-11
US6133286A (en) 2000-10-17
BR9504385A (pt) 1997-05-27
AU696890B2 (en) 1998-09-24
NZ285156A (en) 1999-01-28
US6051601A (en) 2000-04-18
JPH09512035A (ja) 1997-12-02
CO4480024A1 (es) 1997-07-09
ZA958597B (en) 1997-04-14
EP0785930A1 (en) 1997-07-30
WO1996011920A1 (en) 1996-04-25
FI971524A7 (fi) 1997-04-11
KR970706270A (ko) 1997-11-03
MX9702731A (es) 1997-06-28
CN1160399A (zh) 1997-09-24
CA2201742A1 (en) 1996-04-25
NO971672D0 (no) 1997-04-11
PL319688A1 (en) 1997-08-18
NO971672L (no) 1997-06-11
TR199501270A2 (tr) 1996-06-21
KR100232341B1 (ko) 2000-07-01
JP2983295B2 (ja) 1999-11-29

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