RU2126797C1 - Производные 2,4-оксазолидиндиона или их фармацевтически приемлемая соль, способы их получения, лекарственная композиция, оказывающая гипогликемическое и гиполипидемическое действие, способ снижения содержания сахара и липидов в крови при лечении млекопитающих, страдающих диабетом или гиперлипидимией - Google Patents

Производные 2,4-оксазолидиндиона или их фармацевтически приемлемая соль, способы их получения, лекарственная композиция, оказывающая гипогликемическое и гиполипидемическое действие, способ снижения содержания сахара и липидов в крови при лечении млекопитающих, страдающих диабетом или гиперлипидимией Download PDF

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RU2126797C1
RU2126797C1 RU94006013A RU94006013A RU2126797C1 RU 2126797 C1 RU2126797 C1 RU 2126797C1 RU 94006013 A RU94006013 A RU 94006013A RU 94006013 A RU94006013 A RU 94006013A RU 2126797 C1 RU2126797 C1 RU 2126797C1
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carbon atoms
phenyl
substituted
oxazolidinedione
group
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RU94006013A
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Russian (ru)
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RU94006013A (ru
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Сохда Такаси
Икеда Хитоси
Момосе Ю
Имаи Сатико
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Такеда Кемикал Индастриз, Лтд.
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/44—Two oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Saccharide Compounds (AREA)
RU94006013A 1993-02-26 1994-02-25 Производные 2,4-оксазолидиндиона или их фармацевтически приемлемая соль, способы их получения, лекарственная композиция, оказывающая гипогликемическое и гиполипидемическое действие, способ снижения содержания сахара и липидов в крови при лечении млекопитающих, страдающих диабетом или гиперлипидимией RU2126797C1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP3823693 1993-02-26
JP05-038236 1993-02-26
JP19730493 1993-08-09
JP05-197304 1993-08-09

Publications (2)

Publication Number Publication Date
RU94006013A RU94006013A (ru) 1995-09-27
RU2126797C1 true RU2126797C1 (ru) 1999-02-27

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
RU94006013A RU2126797C1 (ru) 1993-02-26 1994-02-25 Производные 2,4-оксазолидиндиона или их фармацевтически приемлемая соль, способы их получения, лекарственная композиция, оказывающая гипогликемическое и гиполипидемическое действие, способ снижения содержания сахара и липидов в крови при лечении млекопитающих, страдающих диабетом или гиперлипидимией

Country Status (18)

Country Link
US (4) US5665748A (enExample)
EP (1) EP0612743B1 (enExample)
JP (2) JP3328720B2 (enExample)
KR (1) KR940019699A (enExample)
CN (1) CN1098411A (enExample)
AT (1) ATE157975T1 (enExample)
AU (1) AU673034B2 (enExample)
CA (1) CA2116387C (enExample)
DE (1) DE69405425T2 (enExample)
DK (1) DK0612743T3 (enExample)
ES (1) ES2108375T3 (enExample)
FI (1) FI940904A7 (enExample)
GR (1) GR3025342T3 (enExample)
HU (1) HUT70159A (enExample)
NO (1) NO305079B1 (enExample)
PH (1) PH31468A (enExample)
RU (1) RU2126797C1 (enExample)
TW (1) TW268952B (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
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RU2296760C2 (ru) * 2001-11-12 2007-04-10 Оно Фармасьютикал Ко., Лтд. Производные соединения карбоновой кислоты и средства, содержащие соединения в качестве активных ингредиентов
RU2355682C2 (ru) * 2004-01-20 2009-05-20 Мерк Энд Ко., Инк. Антидиабетические оксазолидиндионы

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US5641796A (en) * 1994-11-01 1997-06-24 Eli Lilly And Company Oral hypoglycemic agents
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CA2171702A1 (en) * 1995-03-14 1996-09-15 Takashi Sohda Benzofuran compounds and their use
JPH09136877A (ja) * 1995-06-16 1997-05-27 Takeda Chem Ind Ltd 複素環化合物、その製造法及び用途
PT891340E (pt) 1996-04-03 2003-03-31 Takeda Chemical Industries Ltd Derivados de oxazol sua preparacao e utilizacao
JPH09323930A (ja) 1996-04-04 1997-12-16 Takeda Chem Ind Ltd 悪液質の予防・治療剤
US5919782A (en) * 1996-05-06 1999-07-06 Dr. Reddy's Research Foundation Heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
US5889025A (en) * 1996-05-06 1999-03-30 Reddy's Research Foundation Antidiabetic compounds having hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
ZA973848B (en) * 1996-05-06 1997-12-02 Reddy Research Foundation Novel heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them.
FR2749583B1 (fr) 1996-06-07 1998-08-21 Lipha Nouveaux derives de thiazolidine -2,4- dione substitues, leurs procedes d'obtention et les compositions pharmaceutiques en renfermant
US6114526A (en) 1996-07-01 2000-09-05 Dr. Reddy's Research Foundation Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases
USRE39266E1 (en) * 1996-07-01 2006-09-05 Dr. Reddy's Laboratories, Limited Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases
CZ298812B6 (cs) 1996-07-01 2008-02-13 Dr. Reddy's Laboratories Limited Azolidindionové deriváty, způsob jejich přípravy, farmaceutické kompozice s jejich obsahem a jejich použití v léčbě diabetu a příbuzných nemocí
US6372750B2 (en) 1996-07-01 2002-04-16 Dr. Reddy's Research Foundation Heterocyclic compounds, process for their preparation and pharmaceutical compounds containing them and their use in the treatment of diabetes and related diseases
SK21099A3 (en) 1996-08-19 2000-05-16 Japan Tobacco Inc Propionic acid derivatives and applications thereof
US6011036A (en) * 1997-04-15 2000-01-04 Dr. Reddy's Research Foundation Heterocyclic compounds having antidiabetic hypolipidemic antihypertensive properties process for their preparation and pharmaceutical compositions containing them
US6011031A (en) * 1997-05-30 2000-01-04 Dr. Reddy's Research Foundation Azolidinediones useful for the treatment of diabetes, dyslipidemia and hypertension: process for their preparation and pharmaceutical compositions containing them
US7045519B2 (en) * 1998-06-19 2006-05-16 Chiron Corporation Inhibitors of glycogen synthase kinase 3
JP4533534B2 (ja) 1998-06-19 2010-09-01 ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド グリコーゲンシンターゼキナーゼ３のインヒビター
CN1053186C (zh) * 1998-07-09 2000-06-07 华东理工大学 喹啉噁唑啉化合物
JP2000044551A (ja) * 1998-07-27 2000-02-15 Konica Corp ３−置換−３−オキソ−２−（２，４−オキサゾリジンジオン−３−イル）プロピオン酸アミド化合物の製造方法
WO2000018745A1 (en) * 1998-09-30 2000-04-06 Roche Diagnostics Gmbh Oxazolidine derivatives for the treatment and prevention of metabolic bone disorders
US6121300A (en) 1998-11-10 2000-09-19 Wagle; Dilip R. Reversing advanced glycosylation cross-links using heterocyclic-substituted thiazolium salts
ATE316376T1 (de) * 1998-12-01 2006-02-15 Reddy Research Foundation Neue pharmazeutische zusammenstellung und deren herstellungsprozess
HK1039940B (en) 1999-04-07 2010-08-27 Sankyo Company, Limited Amine derivatives
AU770870B2 (en) 1999-06-18 2004-03-04 Merck & Co., Inc. Arylthiazolidinedione and aryloxazolidinedione derivatives
US6399640B1 (en) 1999-06-18 2002-06-04 Merck & Co., Inc. Arylthiazolidinedione and aryloxazolidinedione derivatives
GB9914977D0 (en) 1999-06-25 1999-08-25 Glaxo Group Ltd Chemical compounds
JP4316787B2 (ja) * 2000-01-11 2009-08-19 壽製薬株式会社 エーテル又はアミド誘導体、その製法並びにそれを含有する糖尿病治療剤、
US7105551B2 (en) 2000-12-20 2006-09-12 Smithkline Beecham Corporation Thiazole derivatives for treating PPAR related disorders
WO2002076959A1 (en) * 2001-03-23 2002-10-03 Takeda Chemical Industries, Ltd. Five-membered heterocyclic alkanoic acid derivative
WO2003059907A1 (en) * 2002-01-17 2003-07-24 Takeda Chemical Industries, Ltd. Nitrogenous heterocyclic compounds, process for preparation of the same and use thereof
TWI327462B (en) * 2002-01-18 2010-07-21 Sumitomo Chemical Co Condensed heterocyclic sulfonyl urea compound, a herbicide containing the same, and a method for weed control using the same
US7232828B2 (en) 2002-08-10 2007-06-19 Bethesda Pharmaceuticals, Inc. PPAR Ligands that do not cause fluid retention, edema or congestive heart failure
US7521465B2 (en) * 2003-01-17 2009-04-21 Bexel Pharmaceuticals, Inc. Diphenyl ether derivatives
US7781464B2 (en) * 2003-01-17 2010-08-24 Bexel Pharmaceuticals, Inc. Heterocyclic diphenyl ethers
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WO1992002520A1 (en) * 1990-08-06 1992-02-20 Beecham Group P.L.C. Oxazolidine dione derivatives

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WO1992002520A1 (en) * 1990-08-06 1992-02-20 Beecham Group P.L.C. Oxazolidine dione derivatives

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2296760C2 (ru) * 2001-11-12 2007-04-10 Оно Фармасьютикал Ко., Лтд. Производные соединения карбоновой кислоты и средства, содержащие соединения в качестве активных ингредиентов
RU2355682C2 (ru) * 2004-01-20 2009-05-20 Мерк Энд Ко., Инк. Антидиабетические оксазолидиндионы

Also Published As

Publication number Publication date
DE69405425D1 (de) 1997-10-16
AU673034B2 (en) 1996-10-24
ATE157975T1 (de) 1997-09-15
NO940610L (no) 1994-08-29
FI940904L (fi) 1994-11-29
NO940610D0 (no) 1994-02-23
US5972970A (en) 1999-10-26
HU9400578D0 (en) 1994-05-30
ES2108375T3 (es) 1997-12-16
DE69405425T2 (de) 1998-03-19
FI940904A0 (fi) 1994-02-25
US6552058B1 (en) 2003-04-22
CA2116387C (en) 2003-12-23
KR940019699A (ko) 1994-09-14
PH31468A (en) 1998-11-03
JP2000191651A (ja) 2000-07-11
EP0612743A1 (en) 1994-08-31
HUT70159A (en) 1995-09-28
AU5515894A (en) 1994-09-01
CN1098411A (zh) 1995-02-08
CA2116387A1 (en) 1994-08-27
US5665748A (en) 1997-09-09
US6147099A (en) 2000-11-14
DK0612743T3 (da) 1998-04-20
NO305079B1 (no) 1999-03-29
TW268952B (enExample) 1996-01-21
JP3328720B2 (ja) 2002-09-30
EP0612743B1 (en) 1997-09-10
GR3025342T3 (en) 1998-02-27
FI940904A7 (fi) 1994-11-29
JPH07165735A (ja) 1995-06-27

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