RU2020129180A - Терапевтический биопрепарат для лечения гепатоцеллюлярной карциномы - Google Patents
Терапевтический биопрепарат для лечения гепатоцеллюлярной карциномы Download PDFInfo
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- RU2020129180A RU2020129180A RU2020129180A RU2020129180A RU2020129180A RU 2020129180 A RU2020129180 A RU 2020129180A RU 2020129180 A RU2020129180 A RU 2020129180A RU 2020129180 A RU2020129180 A RU 2020129180A RU 2020129180 A RU2020129180 A RU 2020129180A
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- 206010073071 hepatocellular carcinoma Diseases 0.000 title 1
- 231100000844 hepatocellular carcinoma Toxicity 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
- 238000000034 method Methods 0.000 claims 15
- 206010028980 Neoplasm Diseases 0.000 claims 13
- 102000004169 proteins and genes Human genes 0.000 claims 12
- 108090000623 proteins and genes Proteins 0.000 claims 12
- 210000004027 cell Anatomy 0.000 claims 11
- 125000003275 alpha amino acid group Chemical group 0.000 claims 10
- 230000001112 coagulating effect Effects 0.000 claims 10
- 101000620348 Homo sapiens Plasmalemma vesicle-associated protein Proteins 0.000 claims 7
- 102100022427 Plasmalemma vesicle-associated protein Human genes 0.000 claims 6
- 239000000701 coagulant Substances 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 3
- 102000002262 Thromboplastin Human genes 0.000 claims 3
- 108010000499 Thromboplastin Proteins 0.000 claims 3
- 239000002246 antineoplastic agent Substances 0.000 claims 3
- 229940127089 cytotoxic agent Drugs 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims 3
- 230000002792 vascular Effects 0.000 claims 3
- 108060003951 Immunoglobulin Proteins 0.000 claims 2
- 208000007536 Thrombosis Diseases 0.000 claims 2
- 210000001367 artery Anatomy 0.000 claims 2
- 230000001580 bacterial effect Effects 0.000 claims 2
- 210000004899 c-terminal region Anatomy 0.000 claims 2
- 102000018358 immunoglobulin Human genes 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
- 238000006467 substitution reaction Methods 0.000 claims 2
- MLDQJTXFUGDVEO-UHFFFAOYSA-N BAY-43-9006 Chemical compound C1=NC(C(=O)NC)=CC(OC=2C=CC(NC(=O)NC=3C=C(C(Cl)=CC=3)C(F)(F)F)=CC=2)=C1 MLDQJTXFUGDVEO-UHFFFAOYSA-N 0.000 claims 1
- 241000588724 Escherichia coli Species 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- 241000233866 Fungi Species 0.000 claims 1
- 241000238631 Hexapoda Species 0.000 claims 1
- 239000005511 L01XE05 - Sorafenib Substances 0.000 claims 1
- 206010028851 Necrosis Diseases 0.000 claims 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims 1
- 241000235343 Saccharomycetales Species 0.000 claims 1
- 206010054094 Tumour necrosis Diseases 0.000 claims 1
- 239000004037 angiogenesis inhibitor Substances 0.000 claims 1
- 229960000397 bevacizumab Drugs 0.000 claims 1
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- 239000002552 dosage form Substances 0.000 claims 1
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- 210000003527 eukaryotic cell Anatomy 0.000 claims 1
- 208000005017 glioblastoma Diseases 0.000 claims 1
- 102000054625 human PLVAP Human genes 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
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- 210000004962 mammalian cell Anatomy 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000017074 necrotic cell death Effects 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 238000007674 radiofrequency ablation Methods 0.000 claims 1
- 238000001959 radiotherapy Methods 0.000 claims 1
- 229960003787 sorafenib Drugs 0.000 claims 1
- 238000001356 surgical procedure Methods 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
Classifications
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C07K2317/565—Complementarity determining region [CDR]
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/035—Fusion polypeptide containing a localisation/targetting motif containing a signal for targeting to the external surface of a cell, e.g. to the outer membrane of Gram negative bacteria, GPI- anchored eukaryote proteins
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Hematology (AREA)
- Mycology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Microbiology (AREA)
- Neurosurgery (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361904951P | 2013-11-15 | 2013-11-15 | |
| US61/904,951 | 2013-11-15 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2014145841A Division RU2739218C2 (ru) | 2013-11-15 | 2014-11-14 | Терапевтический биопрепарат для лечения гепатоцеллюлярной карциномы |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2020129180A true RU2020129180A (ru) | 2020-10-16 |
Family
ID=51951740
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2020129180A RU2020129180A (ru) | 2013-11-15 | 2014-11-14 | Терапевтический биопрепарат для лечения гепатоцеллюлярной карциномы |
| RU2014145841A RU2739218C2 (ru) | 2013-11-15 | 2014-11-14 | Терапевтический биопрепарат для лечения гепатоцеллюлярной карциномы |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2014145841A RU2739218C2 (ru) | 2013-11-15 | 2014-11-14 | Терапевтический биопрепарат для лечения гепатоцеллюлярной карциномы |
Country Status (12)
| Country | Link |
|---|---|
| US (6) | US9493552B2 (enExample) |
| EP (1) | EP2915545A1 (enExample) |
| JP (1) | JP6538331B2 (enExample) |
| KR (1) | KR102240342B1 (enExample) |
| CN (1) | CN104892767B (enExample) |
| AU (1) | AU2014262247C1 (enExample) |
| BR (1) | BR102014029197B1 (enExample) |
| CA (1) | CA2871114C (enExample) |
| IL (1) | IL235693B (enExample) |
| RU (2) | RU2020129180A (enExample) |
| SG (1) | SG10201407557VA (enExample) |
| TW (1) | TWI655212B (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ588587A (en) | 2008-03-19 | 2013-01-25 | China Synthetic Rubber Corp | Methods and agents for the diagnosis and treatment of hepatocellular carcinoma |
| US9493552B2 (en) | 2013-11-15 | 2016-11-15 | China Synthetic Rubber Corporation | Therapeutic biologic for treatment of hepatocellular carcinoma |
| CN109906088A (zh) | 2016-08-26 | 2019-06-18 | 奥野哲治 | 微血管血流减少剂及其应用 |
| CN108997497B (zh) | 2018-03-30 | 2022-02-25 | 华兰基因工程有限公司 | 特异结合人质膜膜泡关联蛋白pv-1的单克隆抗体及其制备方法与应用 |
| AU2019249427A1 (en) | 2018-04-02 | 2020-10-29 | Alamab Therapeutics, Inc. | Connexin 43 antibodies and use thereof |
| CN108913709A (zh) * | 2018-06-26 | 2018-11-30 | 山东兴瑞生物科技有限公司 | 用于治疗hcc的核酸、其制备方法、具有该核酸的car-t细胞及细胞的制备方法 |
| US12187794B2 (en) | 2019-02-04 | 2025-01-07 | Alamab Therapeutics, Inc. | Connexin 43 antibodies and use thereof |
| WO2022026914A1 (en) | 2020-07-31 | 2022-02-03 | Alamab Therapeutics, Inc. | Anti-connexin antibody formulations |
| CN116239694B (zh) * | 2022-05-09 | 2023-12-15 | 华兰基因工程(河南)有限公司 | 特异性结合pv-1蛋白的抗体或其抗原结合片段及其应用 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6749853B1 (en) * | 1992-03-05 | 2004-06-15 | Board Of Regents, The University Of Texas System | Combined methods and compositions for coagulation and tumor treatment |
| ES2153483T3 (es) * | 1994-07-11 | 2001-03-01 | Univ Texas | Metodos y composiciones para la coagulacion especifica en los vasos tumorales. |
| BR9806793A (pt) | 1997-01-22 | 2000-05-16 | Univ Texas | Processos e composições de fator tissular para coagulação e tratamento de tumores. |
| US20040067490A1 (en) | 2001-09-07 | 2004-04-08 | Mei Zhong | Therapeutic polypeptides, nucleic acids encoding same, and methods of use |
| AU1181802A (en) | 2000-09-27 | 2002-04-08 | Curagen Corp | Novel proteins and nucleic acids encoding same |
| DE10136273A1 (de) | 2001-07-25 | 2003-02-13 | Sabine Debuschewitz | Molekulare Marker beim hepatozellulären Karzinom |
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