RU2020113246A - Комбинация ингибитора parp и антагониста, связывающегося с осью pd-1 - Google Patents

Комбинация ингибитора parp и антагониста, связывающегося с осью pd-1 Download PDF

Info

Publication number
RU2020113246A
RU2020113246A RU2020113246A RU2020113246A RU2020113246A RU 2020113246 A RU2020113246 A RU 2020113246A RU 2020113246 A RU2020113246 A RU 2020113246A RU 2020113246 A RU2020113246 A RU 2020113246A RU 2020113246 A RU2020113246 A RU 2020113246A
Authority
RU
Russia
Prior art keywords
cancer
amount
parp inhibitor
thalazoparib
patient
Prior art date
Application number
RU2020113246A
Other languages
English (en)
Russian (ru)
Other versions
RU2020113246A3 (enExample
Inventor
Джон Эндрю БЛЕЙК-ХАСКИНС
Кристоффель Хендрик БОСХОФФ
Россано ЧЕЗАРИ
Димитри Серж Антуан НУЙТЕН
Росс Энтони СТЮАРТ
Фабиан ЗОРЕН
Original Assignee
Мерк Патент Гмбх
Пфайзер Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Мерк Патент Гмбх, Пфайзер Инк. filed Critical Мерк Патент Гмбх
Publication of RU2020113246A publication Critical patent/RU2020113246A/ru
Publication of RU2020113246A3 publication Critical patent/RU2020113246A3/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
RU2020113246A 2017-10-13 2018-10-10 Комбинация ингибитора parp и антагониста, связывающегося с осью pd-1 RU2020113246A (ru)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762572024P 2017-10-13 2017-10-13
US62/572,024 2017-10-13
US201862697587P 2018-07-13 2018-07-13
US62/697,587 2018-07-13
PCT/US2018/055174 WO2019075032A1 (en) 2017-10-13 2018-10-10 COMBINATION OF A PARP INHIBITOR AND A PD-1 AXIS BINDING ANTAGONIST

Publications (2)

Publication Number Publication Date
RU2020113246A true RU2020113246A (ru) 2021-11-15
RU2020113246A3 RU2020113246A3 (enExample) 2021-11-15

Family

ID=64049735

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2020113246A RU2020113246A (ru) 2017-10-13 2018-10-10 Комбинация ингибитора parp и антагониста, связывающегося с осью pd-1

Country Status (13)

Country Link
US (1) US20200254091A1 (enExample)
EP (1) EP3694551A1 (enExample)
JP (1) JP2020536887A (enExample)
KR (1) KR20200071097A (enExample)
CN (1) CN111225685A (enExample)
AU (1) AU2018347331A1 (enExample)
BR (1) BR112020006371A2 (enExample)
CA (1) CA3078806A1 (enExample)
IL (1) IL273994A (enExample)
MX (1) MX2020003361A (enExample)
RU (1) RU2020113246A (enExample)
TW (1) TW201922288A (enExample)
WO (1) WO2019075032A1 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20190062515A (ko) * 2016-10-06 2019-06-05 화이자 인코포레이티드 암의 치료를 위한 아벨루맙의 투약 용법
WO2018119142A1 (en) 2016-12-21 2018-06-28 Amgen Inc. Anti-tnf alpha antibody formulations
TWI852940B (zh) * 2018-09-04 2024-08-21 美商泰沙羅公司 治療癌症之方法
CN113116881B (zh) * 2019-12-31 2025-03-07 甫康（上海）健康科技有限责任公司 一种用于治疗肿瘤的药物组合及其应用
JP2023524270A (ja) * 2020-05-04 2023-06-09 メルク・シャープ・アンド・ドーム・エルエルシー Ｐｄ－１アンタゴニスト、化学放射線療法およびｐａｒｐ阻害剤の組み合わせを用いた癌の治療方法
WO2022200982A1 (en) * 2021-03-24 2022-09-29 Pfizer Inc. Combination of talazoparib and an anti-androgen for the treatment of ddr gene mutated metastatic castration-sensitive prostate cancer
TWI883565B (zh) 2022-10-02 2025-05-11 美商輝瑞大藥廠 用於治療轉移性去勢抵抗性前列腺癌之他拉唑帕尼及恩雜魯胺之組合
TW202425976A (zh) 2022-12-17 2024-07-01 美商輝瑞大藥廠 用於治療轉移性去勢抵抗性前列腺癌之他拉唑帕尼及恩雜魯胺之組合
TW202600137A (zh) 2024-04-04 2026-01-01 美商輝瑞股份有限公司 於使用ｐａｒｐ抑制劑的治療作為預測性生物標記之ｔｍｐｒｓｓ２－ｅｒｇ和ｒｂｉ及使用ｐａｒｐ抑制劑之治療方法
WO2026078615A1 (en) 2024-10-09 2026-04-16 Pfizer Inc. Combination of talazoparib and enzalutamide in the treatment of metastatic castration-resistant prostate cancer
WO2026078619A1 (en) 2024-10-09 2026-04-16 Pfizer Inc. Combination of talazoparib and enzalutamide in the treatment of metastatic castration-resistant prostate cancer

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
CN104478875B (zh) 2008-08-06 2017-04-12 麦迪韦逊科技有限公司 聚(adp‑核糖)聚合酶(parp)的二氢吡啶并酞嗪酮抑制剂
EP2531033A4 (en) 2010-02-03 2013-07-31 Biomarin Pharm Inc POLY (ADP-RIBOSE) POLYMERASE (PARP) DIHYDROPYRIDOPHTHALAZINE HEMMER FOR USE IN THE TREATMENT OF PTEN-LACK ASSOCIATED DISEASES
KR101826652B1 (ko) 2010-02-08 2018-02-07 메디베이션 테크놀로지즈, 인크. 디히드로피리도프탈라지논 유도체의 합성 방법
KR20190120458A (ko) 2010-10-21 2019-10-23 메디베이션 테크놀로지즈 엘엘씨 결정질의 (8s,9r)-5-플루오로-8-(4-플루오로페닐)-9-(1-메틸-1h-1,2,4-트리아졸-5-일)-8,9-디하이드로-2h-피리도[4,3,2-de]프탈라진-3(7h)-온 토실레이트 염
KR101764096B1 (ko) 2011-11-28 2017-08-02 메르크 파텐트 게엠베하 항-ｐｄ-ｌ1 항체 및 그의 용도
CN105916846A (zh) 2013-11-07 2016-08-31 麦迪韦逊科技有限公司 用于合成经保护的n-烷基三唑甲醛的三唑中间体
PL3102605T3 (pl) * 2014-02-04 2019-06-28 Pfizer Inc. Połączenie antagonisty pd-1 i inhibitora vegfr do leczenia nowotworu
EP3563870A1 (en) * 2014-07-15 2019-11-06 F. Hoffmann-La Roche AG Methods of treating cancer using pd-1 axis binding antagonists and mek inhibitors
EA201790290A1 (ru) 2014-07-31 2017-07-31 Медивэйшн Текнолоджиз, Инк. Формерные соли (2s,3s)-метил 7-фтор-2-(4-фторфенил)-3-(1-метил-1h-1,2,4-триазол-5-ил)-4-оксо-1,2,3,4-тетрагидрохинолин-5-карбоксилата и способы их получения
CN107206088A (zh) * 2014-12-05 2017-09-26 豪夫迈·罗氏有限公司 使用pd‑1轴拮抗剂和hpk1拮抗剂用于治疗癌症的方法和组合物
TWI595006B (zh) 2014-12-09 2017-08-11 禮納特神經系統科學公司 抗ｐｄ－１抗體類和使用彼等之方法
RU2714233C2 (ru) * 2015-02-26 2020-02-13 Мерк Патент Гмбх Ингибиторы pd-1 / pd-l1 для лечения рака
MX2017015937A (es) * 2015-06-08 2018-12-11 Genentech Inc Métodos de tratamiento del cáncer con anticuerpos anti-ox40 y antagonistas de unión al eje de pd-1.
SG11201803462PA (en) 2015-10-26 2018-05-30 Medivation Tech Llc Treatment of small cell lung cancer with a parp inhibitor

Also Published As

Publication number Publication date
AU2018347331A1 (en) 2020-04-09
BR112020006371A2 (pt) 2020-09-29
WO2019075032A1 (en) 2019-04-18
EP3694551A1 (en) 2020-08-19
JP2020536887A (ja) 2020-12-17
RU2020113246A3 (enExample) 2021-11-15
MX2020003361A (es) 2020-07-29
KR20200071097A (ko) 2020-06-18
US20200254091A1 (en) 2020-08-13
CA3078806A1 (en) 2019-04-18
IL273994A (en) 2020-05-31
TW201922288A (zh) 2019-06-16
CN111225685A (zh) 2020-06-02

Similar Documents

Publication Publication Date Title
RU2020113246A (ru) Комбинация ингибитора parp и антагониста, связывающегося с осью pd-1
Wang et al. MicroRNA-125 in immunity and cancer
Polivka Jr et al. Advances in experimental targeted therapy and immunotherapy for patients with glioblastoma multiforme
Wang et al. Astragaloside IV inhibits pathological functions of gastric cancer-associated fibroblasts
JP2016514689A5 (enExample)
JP2013531038A (ja) 癌の治療のための低酸素活性化プロドラッグおよび血管新生阻害剤の投与方法
JP2020536887A5 (enExample)
WO2020146521A3 (en) Rnai agents for inhibiting expression of hif-2 alpha (epas1), compositions thereof, and methods of use
CN105349486A (zh) 黄芪多糖在骨髓间充质干细胞中的应用
US20210236492A1 (en) Method for treating pancreatic cancer
Tehrani et al. PANC-1 cancer stem-like cell death with silybin encapsulated in polymersomes and deregulation of stemness-related miRNAs and their potential targets
JP2014500871A5 (enExample)
Su et al. Utilizing chemotherapy-induced tumor RNA nanoparticles to improve cancer chemoimmunotherapy
Gao et al. Genomic analyses identify gene candidates for acquired irinotecan resistance in melanoma cells
WO2023272831A1 (zh) 水苏糖在制备用于治疗去势抵抗性前列腺癌药物中的应用
JP2016123339A (ja) 多能性幹細胞の品質診断方法及び診断キット、抗がん剤並びに疾患モデル動物
JP2019501959A (ja) 腫瘍の診断および治療におけるＡｋｔ２の使用
JP5546064B2 (ja) 肺がん予後および薬物調製における２つのマイクロＲＮＡｓの使用
RU2014110271A (ru) Восприимчивость к ингибиторам ангиогенеза
Gao et al. Tetrahedral framework nucleic acids loaded with chrysophanol for the treatment of chronic kidney disease
Kim et al. Preliminary efficacy of pembrolizumab plus lenvatinib in recurrent clear cell gynecological cancer: Phase II LARA trial (GCGS-OV4/APGOT-OV3).
EP4154909A1 (en) Diagnosis and treatment of cancers showing high expression of piwi and/or nmd complex protein
CN114126621A (zh) 用于癌症治疗的组合疗法
Zhang et al. Inhibitory effects of phenolic alkaloids of Menispermum dauricum on gastric cancer in vivo
CN109248318B (zh) Shank2基因的功能与用途