RU2017140674A3 - - Google Patents

Download PDF

Info

Publication number
RU2017140674A3
RU2017140674A3 RU2017140674A RU2017140674A RU2017140674A3 RU 2017140674 A3 RU2017140674 A3 RU 2017140674A3 RU 2017140674 A RU2017140674 A RU 2017140674A RU 2017140674 A RU2017140674 A RU 2017140674A RU 2017140674 A3 RU2017140674 A3 RU 2017140674A3
Authority
RU
Russia
Application number
RU2017140674A
Other languages
Russian (ru)
Other versions
RU2017140674A (ru
RU2737496C2 (ru
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=57198783&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=RU2017140674(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed filed Critical
Publication of RU2017140674A publication Critical patent/RU2017140674A/ru
Publication of RU2017140674A3 publication Critical patent/RU2017140674A3/ru
Application granted granted Critical
Publication of RU2737496C2 publication Critical patent/RU2737496C2/ru

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
    • A61K31/5685Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone having an oxo group in position 17, e.g. androsterone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/66Phosphorus compounds
    • A61K31/675Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/66Phosphorus compounds
    • A61K31/683Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/685Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
RU2017140674A 2015-04-29 2016-04-29 Способы лечения рака RU2737496C2 (ru)

Applications Claiming Priority (27)

Application Number Priority Date Filing Date Title
US201562154699P 2015-04-29 2015-04-29
US62/154,699 2015-04-29
US201562155451P 2015-04-30 2015-04-30
US62/155,451 2015-04-30
US201562158469P 2015-05-07 2015-05-07
US62/158,469 2015-05-07
US201562192944P 2015-07-15 2015-07-15
US201562192940P 2015-07-15 2015-07-15
US62/192,940 2015-07-15
US62/192,944 2015-07-15
US201562252085P 2015-11-06 2015-11-06
US62/252,085 2015-11-06
US201562252916P 2015-11-09 2015-11-09
US62/252,916 2015-11-09
US201562265774P 2015-12-10 2015-12-10
US201562265696P 2015-12-10 2015-12-10
US201562265658P 2015-12-10 2015-12-10
US201562265663P 2015-12-10 2015-12-10
US62/265,658 2015-12-10
US62/265,774 2015-12-10
US62/265,696 2015-12-10
US62/265,663 2015-12-10
US201662323576P 2016-04-15 2016-04-15
US201662323572P 2016-04-15 2016-04-15
US62/323,576 2016-04-15
US62/323,572 2016-04-15
PCT/US2016/030317 WO2016176665A1 (en) 2015-04-29 2016-04-29 Methods of treating cancer

Publications (3)

Publication Number Publication Date
RU2017140674A RU2017140674A (ru) 2019-05-29
RU2017140674A3 true RU2017140674A3 (cg-RX-API-DMAC7.html) 2019-09-27
RU2737496C2 RU2737496C2 (ru) 2020-12-01

Family

ID=57198783

Family Applications (3)

Application Number Title Priority Date Filing Date
RU2017140675A RU2747228C2 (ru) 2015-04-29 2016-04-29 Способы лечения рака
RU2017140674A RU2737496C2 (ru) 2015-04-29 2016-04-29 Способы лечения рака
RU2017140676A RU2745678C2 (ru) 2015-04-29 2016-04-29 Способы лечения рака

Family Applications Before (1)

Application Number Title Priority Date Filing Date
RU2017140675A RU2747228C2 (ru) 2015-04-29 2016-04-29 Способы лечения рака

Family Applications After (1)

Application Number Title Priority Date Filing Date
RU2017140676A RU2745678C2 (ru) 2015-04-29 2016-04-29 Способы лечения рака

Country Status (14)

Country Link
US (12) US20180153828A1 (cg-RX-API-DMAC7.html)
EP (4) EP3288382A4 (cg-RX-API-DMAC7.html)
JP (9) JP6926066B2 (cg-RX-API-DMAC7.html)
KR (9) KR102682763B1 (cg-RX-API-DMAC7.html)
CN (5) CN113750091B (cg-RX-API-DMAC7.html)
AU (3) AU2016256470B2 (cg-RX-API-DMAC7.html)
BR (3) BR112017023228A2 (cg-RX-API-DMAC7.html)
CA (3) CA2984200C (cg-RX-API-DMAC7.html)
HK (3) HK1251409A1 (cg-RX-API-DMAC7.html)
IL (10) IL255189B2 (cg-RX-API-DMAC7.html)
MX (6) MX393599B (cg-RX-API-DMAC7.html)
RU (3) RU2747228C2 (cg-RX-API-DMAC7.html)
SG (4) SG11201708860SA (cg-RX-API-DMAC7.html)
WO (3) WO2016176666A1 (cg-RX-API-DMAC7.html)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9421264B2 (en) 2014-03-28 2016-08-23 Duke University Method of treating cancer using selective estrogen receptor modulators
PL3122426T3 (pl) 2014-03-28 2023-05-15 Duke University Leczenie raka sutka z zastosowaniem selektywnych modulatorów receptora estrogenowego
BR112017023228A2 (en) * 2015-04-29 2018-11-06 Radius Pharmaceuticals, Inc. methods for cancer treatment
AR107616A1 (es) 2016-02-15 2018-05-16 Sanofi Sa Compuestos de 6,7-dihidro-5h-benzo[7]anuleno sustituidos, procesos para su preparación y usos terapéuticos de los mismos
TWI794171B (zh) 2016-05-11 2023-03-01 美商滬亞生物國際有限公司 Hdac抑制劑與pd-l1抑制劑之組合治療
TWI808055B (zh) 2016-05-11 2023-07-11 美商滬亞生物國際有限公司 Hdac 抑制劑與 pd-1 抑制劑之組合治療
CA3036568A1 (en) * 2016-09-27 2018-04-05 Radius Health, Inc. Methods for treating ovarian cancer
NZ752443A (en) 2016-10-11 2022-11-25 Univ Duke Lasofoxifene treatment of er+ breast cancer
SG11201903908PA (en) 2016-11-17 2019-05-30 Sanofi Sa Novel substituted n-(3-fluoropropyl)-pyrrolidine compounds, processes for their preparation and therapeutic uses thereof
EP3565542B1 (en) 2017-01-05 2024-04-10 Radius Pharmaceuticals, Inc. Polymorphic forms of rad1901-2hcl
EP3595725B1 (en) * 2017-03-16 2023-05-03 Eisai R&D Management Co., Ltd. Combination therapies for the treatment of breast cancer
US12012421B2 (en) 2017-07-07 2024-06-18 Hoffmann-La Roche Inc. Solid forms of [(1S)-1-[(2S,4R,5R)-5-(5-amino-2-oxo-thiazolo[4,5-d]pyrimidin-3-yl)-4-hydroxy-tetrahydrofuran-2-yl]propyl] acetate
EP3434272A1 (en) * 2017-07-25 2019-01-30 Sanofi Combination comprising palbociclib and 6-(2,4-dichlorophenyl)-5-[4-[(3s)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7h-benzo[7]annulene-2-carboxylic acid
US11179365B2 (en) 2017-11-16 2021-11-23 Novartis Ag Pharmaceutical combination comprising LSZ102 and ribociclib
US12012420B2 (en) 2017-11-21 2024-06-18 Hoffmann-La Roche, Inc. Solid forms of [(1S)-1-[(2S,4R,5R)-5-(5-amino-2-oxo-thiazolo[4,5-d]pyrimidin-3-yl)-4-hydroxy-tetrahydrofuran-2-yl]propyl] acetate
US10695333B2 (en) 2017-12-01 2020-06-30 Novartis Ag Pharmaceutical combination comprising LSZ102 and alpelisib
CN117771239A (zh) 2018-04-10 2024-03-29 杜克大学 乳腺癌的拉索昔芬治疗
CN110585429B (zh) * 2018-06-12 2022-10-21 江苏恒瑞医药股份有限公司 酪氨酸激酶抑制剂联合单克隆抗体以及紫杉醇类药物治疗肿瘤疾病的用途
SG11202013177WA (en) * 2018-07-04 2021-01-28 Radius Pharmaceuticals Inc Polymorphic forms of rad 1901-2hcl
CN112638869B (zh) 2018-09-07 2025-04-25 赛诺菲 6-(2,4-二氯苯基)-5-[4-[(3s)-1-(3-氟丙基)吡咯烷-3-基]氧基苯基]-8,9-二氢-7h-苯并[7]轮烯-2-甲酸甲酯的盐及其制备方法
MA54293A (fr) * 2018-11-30 2021-10-06 Radius Pharmaceuticals Inc Élacestrant en combinaison avec de l'abemaciclib chez des femmes atteintes d'un cancer du sein
WO2020118213A1 (en) * 2018-12-06 2020-06-11 Radius Pharmaceuticals, Inc. Methods for treating cancer resistant to cdk4/6 inhibitors
JP7497353B2 (ja) * 2018-12-06 2024-06-10 ラジウス ファーマシューティカルズ,インコーポレイテッド Esr1変異を含むモデルにおいて癌を治療するための方法
BR112021011222A2 (pt) * 2018-12-12 2021-08-24 Chemocentryx, Inc. Inibidores de cxcr7 para o tratamento de câncer
MA54946A (fr) 2019-02-12 2021-12-22 Radius Pharmaceuticals Inc Procédés et composés
JP2022531898A (ja) * 2019-05-09 2022-07-12 サノフイ 転移性または進行性乳房がん患者において使用するための6-(2,4-ジクロロフェニル)-5-[4-[(3s)-1-(3-フルオロプロピル)ピロリジン-3-イル]オキシフェニル]-8,9-ジヒドロ-7h-ベンゾ[7]アヌレン-2-カルボン酸
AU2020311337A1 (en) 2019-07-07 2022-01-20 Olema Pharmaceuticals, Inc. Regimens of estrogen receptor antagonists
KR102341347B1 (ko) * 2019-11-28 2021-12-20 의료법인 성광의료재단 암 치료제에 대한 내성 암의 진단을 위한 조성물, 키트 및 방법
TW202146007A (zh) 2020-02-27 2021-12-16 法商賽諾菲公司 包含阿培利司(alpelisib)與6-(2,4-二氯苯基)-5-[4-[(3s)-1-(3-氟丙基)吡咯啶-3-基]氧苯基]-8,9-二氫-7h-苯并[7]輪烯-2-羧酸之組合
JP7708772B2 (ja) * 2020-03-06 2025-07-15 オレマ ファーマシューティカルズ インク. エストロゲン受容体関連疾患の治療方法
CA3179907A1 (en) * 2020-04-24 2021-10-28 Astrazeneca Ab Dosage regimen for the treatment of cancer
JP2023500558A (ja) 2020-05-12 2023-01-10 ジェネンテック, インコーポレイテッド Gdc-9545及びcdk4/6阻害剤を含む併用療法を使用した乳がん治療
MX2023001572A (es) * 2020-08-05 2023-05-08 Aizant Drug Res Solutions Private Limited Formas farmaceuticas sólidas de palbociclib.
US20220193072A1 (en) * 2020-12-14 2022-06-23 Arvinas Operations, Inc. Methods of treating breast cancer with tetrahydronaphthalene derivatives as estrogen receptor degrader
JP2024506348A (ja) * 2021-02-16 2024-02-13 ジェネンテック, インコーポレイテッド Gdc-9545とアベマシクリブ又はリボシクリブとを含む併用療法を使用する乳がんの治療
CN113662942B (zh) * 2021-08-19 2023-02-07 中国人民解放军陆军军医大学第一附属医院 药物组合物及其在smo突变性髓母细胞瘤中的应用
WO2023064519A1 (en) 2021-10-14 2023-04-20 Teva Pharmaceuticals International Gmbh Solid state forms of elacestrant and processes for preparation thereof
DE102021130035A1 (de) 2021-11-17 2023-05-17 USound GmbH MEMS-Schallwandler mit einer gekrümmten Kontur eines Kragarmelements
GB202116903D0 (en) 2021-11-18 2022-01-05 Sermonix Pharmaceuticals Inc Lasofoxifene treatment of aromatase-resistant er+ cancer
WO2024104268A1 (zh) * 2022-11-15 2024-05-23 苏州科睿思制药有限公司 艾拉司群二盐酸盐的共晶及其制备方法和用途
KR20240105964A (ko) * 2022-12-29 2024-07-08 주식회사 삼양홀딩스 약동학적 특성이 우수한 풀베스트란트의 약학 조성물 및 그 제조 방법
EP4574811A1 (en) 2023-12-22 2025-06-25 Sandoz Ag Crystalline forms of elacestrant dihydrochloride
WO2025158416A1 (en) 2024-01-25 2025-07-31 Assia Chemical Industries Ltd. Solid state forms of elacestrant and processes for preparation thereof

Family Cites Families (160)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3939346A1 (de) 1989-11-29 1991-06-06 Behringwerke Ag Arzneimitel zur subkutanen oder intramuskulaeren applikation enthaltend polypeptide
US5589452A (en) 1992-07-14 1996-12-31 Syntex (U.S.A.) Inc. Analogs of parathyroid hormone and parathyroid hormone related peptide: synthesis and use for the treatment of osteoporosis
US5977070A (en) 1992-07-14 1999-11-02 Piazza; Christin Teresa Pharmaceutical compositions for the nasal delivery of compounds useful for the treatment of osteoporosis
US5821225A (en) 1992-07-14 1998-10-13 Syntex (U.S.A.) Inc. Method for the treatment of corticosteroid induced osteopenia comprising administration of modified PTH or PTHrp
DE19517430A1 (de) 1995-05-12 1996-11-14 Boehringer Mannheim Gmbh Pharmazeutische Darreichungsform von Parathormon mit einer zwei- bis sechsstündigen Wirkstoff-Freisetzungsperiode
IT1285405B1 (it) 1995-06-06 1998-06-03 Alza Corp Modificazione di farmaci polipeptidici per accrescere il flusso per elettrotrasporto.
US5955574A (en) 1995-07-13 1999-09-21 Societe De Conseils De Recherches Et D'applications Scientifiques, S.A. Analogs of parathyroid hormone
US5723577A (en) 1995-07-13 1998-03-03 Biomeasure Inc. Analogs of parathyroid hormone
US7410948B2 (en) 1995-07-13 2008-08-12 Societe De Conseils De Recherches Et D'applications Scientifiques, Sas Analogs of parathyroid hormone
US6544949B1 (en) 1995-07-13 2003-04-08 Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S. Analogs of parathyroid hormone
US5969095A (en) 1995-07-13 1999-10-19 Biomeasure, Inc. Analogs of parathyroid hormone
DE19538687A1 (de) 1995-10-17 1997-04-24 Boehringer Mannheim Gmbh Stabile pharmazeutische Darreichungsformen enthaltend Parathormon
DE19539574A1 (de) 1995-10-25 1997-04-30 Boehringer Mannheim Gmbh Zubereitungen und Verfahren zur Stabilisierung biologischer Materialien mittels Trocknungsverfahren ohne Einfrieren
TW518219B (en) 1996-04-26 2003-01-21 Chugai Pharmaceutical Co Ltd Erythropoietin solution preparation
TW505654B (en) 1996-07-30 2002-10-11 Hoffmann La Roche Synthesis of analogs of PTH and PTHrP
US6017729A (en) 1996-12-23 2000-01-25 Immunex Corporation Receptor activator of NF-κB
US6136784A (en) 1997-01-08 2000-10-24 Amylin Pharmaceuticals, Inc. Amylin agonist pharmaceutical compositions containing insulin
US6316408B1 (en) 1997-04-16 2001-11-13 Amgen Inc. Methods of use for osetoprotegerin binding protein receptors
WO1999012561A2 (en) 1997-09-09 1999-03-18 F. Hoffman-La Roche Ag FRACTURE HEALING USING PTHrP ANALOGS
ZA9811127B (en) 1997-12-09 2000-07-11 Lilly Co Eli Stabilized teriparatide solutions.
US6770623B1 (en) 1997-12-09 2004-08-03 Eli Lilly And Company Stabilized teriparatide solutions
AU757192B2 (en) 1997-12-11 2003-02-06 Alza Corporation Device for enhancing transdermal agent flux
AU739616B2 (en) 1997-12-11 2001-10-18 Alza Corporation Device for enhancing transdermal agent flux
EP0922467A3 (en) 1997-12-12 2000-05-24 Takeda Chemical Industries, Ltd. Iontophoretic drug delivery
JP4154017B2 (ja) 1997-12-30 2008-09-24 久光製薬株式会社 イオントフォレーシス装置および薬物ユニット
US6091975A (en) 1998-04-01 2000-07-18 Alza Corporation Minimally invasive detecting device
SE9801495D0 (sv) 1998-04-28 1998-04-28 Astra Ab Protein formulationa
US6316410B1 (en) 1999-09-22 2001-11-13 National Research Council Of Canada Parathyroid hormone analogues for the treatment of osteoporosis
WO2001036039A2 (en) 1999-11-17 2001-05-25 Novartis Ag Iontophoretic transdermal delivery of peptides
GB9930882D0 (en) 1999-12-30 2000-02-23 Nps Allelix Corp GLP-2 formulations
US20010044431A1 (en) 2000-03-21 2001-11-22 Rodriguez Gustavo C. Prevention of ovarian cancer by administration of products that induce biologic effects in the ovarian epithelium
US6756480B2 (en) 2000-04-27 2004-06-29 Amgen Inc. Modulators of receptors for parathyroid hormone and parathyroid hormone-related protein
US20050124537A1 (en) 2000-04-27 2005-06-09 Amgen Inc. Modulators of receptors for parathyroid hormone and parathyroid hormone-related protein
EP1307232B1 (en) 2000-08-03 2007-03-07 Antares Pharma IPL AG Novel composition for transdermal and/or transmucosal administration of active compounds that ensures adequate therapeutic levels
EP1313700B1 (en) 2000-08-23 2005-11-09 Akzo Nobel N.V. 10-aryl-11h-benzo[b]fluorene derivatives and analogs as estrogenic compounds
US7186683B2 (en) 2000-09-18 2007-03-06 Sanos Bioscience A/S Use of GLP for the treatment, prevention, diagnosis, and prognosis of bone-related and nutrition-related disorders
US7371721B2 (en) 2000-09-18 2008-05-13 Sanos Bioscience A/S Use of GLP-2 and related compounds for the treatment, prevention, diagnosis, and prognosis of bone-related disorders and calcium homeostasis related syndromes
WO2002094368A1 (en) 2000-10-26 2002-11-28 Alza Corporation Transdermal drug delivery devices having coated microprotrusions
MXPA03009603A (es) 2001-04-20 2004-12-06 Johnson & Johnson Arreglo de microproyeccion que tiene un agente benefico que contiene un recubrimiento.
NO345566B1 (no) 2001-06-26 2021-04-19 Amgen Inc OPGL bindende antistoff, farmasøytisk sammensetning samt anvendelse derav
US6881203B2 (en) 2001-09-05 2005-04-19 3M Innovative Properties Company Microneedle arrays and methods of manufacturing the same
US8853266B2 (en) 2001-12-06 2014-10-07 University Of Tennessee Research Foundation Selective androgen receptor modulators for treating diabetes
ES2297056T3 (es) 2001-12-20 2008-05-01 Alza Corporation Micro-proyecciones para perforacion de la piel que tienen control de la profundidad de perforacion.
JP2005524630A (ja) 2002-01-14 2005-08-18 ノルディック・ビオサイエンス・エー/エス エストロゲン受容体を介する軟骨破壊の抑制
AU2003219787A1 (en) 2002-02-14 2003-09-04 Bayer Pharmaceuticals Corporation Formulation strategies in stabilizing peptides in organic solvents and in dried states
EP1513547A4 (en) 2002-05-23 2009-11-04 Michael F Holick USE OF PEPTIDE ANALOGUES OF PARATHYROID HORMONE FOR THE TREATMENT OF VAGINAL ATROPHY
TW200307553A (en) 2002-05-24 2003-12-16 Akzo Nobel Nv Treatment of post-menopausal complaints in breast cancer patients
WO2003105772A2 (en) 2002-06-13 2003-12-24 Beth Israel Deaconess Medical Center, Inc. Analogs of parathyroid hormone and pth-related protein as bone anabolic agents
WO2004007520A2 (en) 2002-07-12 2004-01-22 Medarex, Inc. Methods and compositions for preventing oxidative degradation of proteins
MXPA05000597A (es) 2002-07-19 2005-04-28 3M Innovative Properties Co Dispositivos de microaguja y aparatos de administracion por microaguja.
WO2004035624A2 (en) 2002-10-14 2004-04-29 Novo Nordisk A/S Glucagon - like peptide - 2 variants
JP2006517389A (ja) 2002-10-14 2006-07-27 ノボ ノルディスク アクティーゼルスカブ Glp−2化合物、製剤、及びそれらの使用
US8133505B2 (en) 2002-10-31 2012-03-13 Transpharma Medical Ltd. Transdermal delivery system for dried particulate or lyophilized medications
US7662404B2 (en) 2002-10-31 2010-02-16 Transpharma Medical Ltd. Transdermal delivery system for dried particulate or lyophilized peptides and polypeptides
US7383084B2 (en) 2002-10-31 2008-06-03 Transpharma Medical Ltd. Transdermal delivery system for dried particulate or lyophilized medications
IL152574A (en) 2002-10-31 2009-09-22 Transpharma Medical Ltd A system for passing through the skin of dry items or dried medicines
CA2511966A1 (en) 2002-11-01 2004-07-22 Amgen Inc. Modulators of receptors for parathyroid hormone and parathyroid hormone-related protein
JP4500689B2 (ja) * 2002-12-26 2010-07-14 エーザイ・アール・アンド・ディー・マネジメント株式会社 選択的エストロゲン受容体モジュレーター
JP2007505164A (ja) 2003-06-10 2007-03-08 スミスクライン ビーチャム コーポレーション アンドロゲン、グルココルチコイド、ミネラルコルチコイドおよびプロゲステロン受容体のモジュレーターとしての1−アミノナフタレン類
WO2005000795A2 (en) 2003-06-10 2005-01-06 Smithkline Beecham Corporation Aniline derivatived androgen-, glucocorticoid-, mineralcorticoid- and progesterone- receptor modulators
WO2005000309A2 (en) 2003-06-27 2005-01-06 Ionix Pharmaceuticals Limited Chemical compounds
TW200518771A (en) 2003-06-30 2005-06-16 Alza Corp Formulations for coated microprojections containing non-volatile counterions
EP1638468B1 (en) 2003-06-30 2007-08-15 Alza Corporation Method for coating skin piercing microprojections
WO2005014034A1 (en) 2003-07-14 2005-02-17 Nps Allelix Corp. Stabilized formulation of parathyroid hormone
US7141544B2 (en) 2003-10-10 2006-11-28 Baxter International, Inc. Stabilization of pharmaceutical protein formulations with small peptides
US20050124625A1 (en) 2003-10-21 2005-06-09 Salvati Mark E. Piperazine derivatives and their use as modulators of nuclear hormone receptor function
GB0324551D0 (en) 2003-10-21 2003-11-26 Karobio Ab Novel compounds
CA2543280A1 (en) 2003-10-28 2005-05-19 Alza Corporation Delivery of polymer conjugates of therapeutic peptides and proteins via coated microporjections
WO2005044333A2 (en) 2003-10-31 2005-05-19 Alza Corporation Self-actuating applicator for microprojection array
CN100548228C (zh) 2003-11-13 2009-10-14 阿尔扎公司 用于透皮递送的组合物和装置
EP1687274A1 (en) 2003-11-20 2006-08-09 Warner-Lambert Company LLC Androgen receptor modulators
BRPI0416822A (pt) 2003-11-21 2007-03-06 Alza Corp método e sistema de liberação de vacina transdérmica com ultra-som
IL159273A0 (en) 2003-12-09 2004-06-01 Transpharma Medical Ltd Transdermal delivery system for sustained release of polypeptides
US20070196395A1 (en) 2003-12-12 2007-08-23 Mackerell Alexander Immunomodulatory compounds that target and inhibit the py'binding site of tyrosene kinase p56 lck sh2 domain
RU2397176C2 (ru) 2004-01-07 2010-08-20 Эндорешерш, Инк. Стероидные фармацевтические продукты, направленные на спираль 12
IL160033A0 (en) 2004-01-25 2004-06-20 Transpharma Medical Ltd Transdermal delivery system for polynucleotides
TWI359026B (en) 2004-02-12 2012-03-01 Sankyo Co Pharmaceutical composition for the osteoclast rela
GB0405033D0 (en) 2004-03-05 2004-04-07 Karobio Ab Novel pharmaceutical compositions
US20080125399A1 (en) 2004-04-08 2008-05-29 Jiabing Wang 17 Beta-Acetamide-4-Azasteroids As Androgen Receptor Modulators
WO2005115441A2 (en) 2004-05-10 2005-12-08 Nastech Pharmaceutical Company Inc. Compositions and methods for enhanced mucosal delivery of parathyroid hormone
EP1747193A1 (en) 2004-05-11 2007-01-31 Pfizer Products Incorporated Benzonitrile derivatives to treat musculoskeletal frailty
CA2566032A1 (en) 2004-05-13 2005-12-01 Alza Corporation Apparatus and method for transdermal delivery of parathyroid hormone agents
WO2005113008A1 (en) 2004-05-21 2005-12-01 Mediplex Corp. Delivery agents for enhancing mucosal absorption of therapeutic agents
US7906137B2 (en) 2004-05-21 2011-03-15 Mediplex Corporation, Korea Delivery agents for enhancing mucosal absorption of therapeutic agents
US20090069226A1 (en) 2004-05-28 2009-03-12 Amylin Pharmaceuticals, Inc. Transmucosal delivery of peptides and proteins
TW200621282A (en) 2004-08-13 2006-07-01 Wyeth Corp Stabilizing formulations
AU2005310238A1 (en) 2004-10-29 2006-06-08 Merck Sharp & Dohme Corp. N-(pyridin-3-yl)-2-phenylbutanamides as androgen receptor modulators
CA2588080C (en) 2004-11-18 2013-01-08 3M Innovative Properties Company Masking method for coating a microneedle array
US8057842B2 (en) 2004-11-18 2011-11-15 3M Innovative Properties Company Method of contact coating a microneedle array
WO2006054299A2 (en) 2004-11-18 2006-05-26 Transpharma Medical Ltd. Combined micro-channel generation and iontophoresis for transdermal delivery of pharmaceutical agents
CA2593112A1 (en) 2005-01-21 2006-07-27 Alza Corporation Therapeutic peptide formulations for coating microneedles with improved stability containing at least one counterion
WO2006113552A2 (en) 2005-04-15 2006-10-26 Smithkline Beecham Corporation Cyanoarylamines
KR100700869B1 (ko) 2005-06-03 2007-03-29 재단법인 목암생명공학연구소 Pth, 완충제 및 안정제를 포함하는 안정한 pth조성물
JP2008546643A (ja) 2005-06-06 2008-12-25 スミスクライン ビーチャム コーポレーション 4−置換アリールアミン誘導体および医薬組成物におけるその使用
WO2007005887A2 (en) 2005-07-01 2007-01-11 Ligand Pharmaceuticals Incorporated Androgen receptor modulator compounds, compositions and uses thereof
US20070021216A1 (en) 2005-07-19 2007-01-25 Sony Ericsson Mobile Communications Ab Seamless gaming method and apparatus
JP2008303145A (ja) 2005-09-22 2008-12-18 Takeda Chem Ind Ltd Grk阻害剤からなる強心薬
CA2629193C (en) 2005-11-18 2016-03-29 3M Innovative Properties Company Coatable compositions, coatings derived therefrom and microarrays having such coatings
JP2009522288A (ja) 2005-12-28 2009-06-11 アルザ コーポレイション 安定な治療剤形
WO2007106597A2 (en) 2006-03-15 2007-09-20 Alza Corporation Method for the transdermal delivery of parathyroid hormone agents for treating osteopenia
WO2007124409A2 (en) 2006-04-20 2007-11-01 Velocys, Inc. Process for treating and/or forming a non-newtonian fluid using microchannel process technology
WO2007124411A1 (en) 2006-04-20 2007-11-01 3M Innovative Properties Company Device for applying a microneedle array
US8779004B2 (en) 2006-04-20 2014-07-15 Amgen, Inc. Stable emulsion formulations
CN101085743B (zh) 2006-06-06 2012-02-15 浙江大德药业集团有限公司 含氟烷氧基康普立停衍生物及制法和用途
US8933130B2 (en) 2006-06-23 2015-01-13 Radius Health, Inc. Treatment of vasomotor symptoms with selective estrogen receptor modulators
MX2009000385A (es) 2006-07-12 2009-04-06 Univ Tennessee Res Foundation Acil-anilidas sustituidas y metodos de uso de las mismas.
KR101202240B1 (ko) 2006-08-24 2012-11-16 유니버시티 오브 테네시 리서치 파운데이션 치환된 아실아닐리드 및 그의 사용 방법
EA015644B1 (ru) 2006-08-25 2011-10-31 Арес Трейдинг С.А. Способ лечения заболеваний хряща
CN1927815A (zh) 2006-09-25 2007-03-14 天津理工大学 邻苄胺基苯基醚化合物、化合物的衍生物及其制备方法与用途
ES2739459T3 (es) 2006-10-03 2020-01-31 Radius Health Inc Una composición estable que comprende una proteína anabólica ósea, es decir un análogo de PTHrP y usos de la misma
US7803770B2 (en) 2006-10-03 2010-09-28 Radius Health, Inc. Method of treating osteoporosis comprising administration of PTHrP analog
WO2008044033A1 (en) 2006-10-11 2008-04-17 Astrazeneca Ab Amide derivatives
US20100030100A1 (en) 2007-02-06 2010-02-04 Hisamitsu Pharmaceutical Co., Inc. Microneedle Device For Diagnosis Of Allergy
WO2008121602A1 (en) 2007-03-29 2008-10-09 Smithkline Beecham Corporation Chemical compounds
WO2008124000A2 (en) 2007-04-02 2008-10-16 Ligand Pharmaceuticals Incorporated Thiazole derivatives as androgen receptor modulator compounds
AU2008241470B2 (en) 2007-04-16 2013-11-07 Corium Pharma Solutions, Inc. Solvent-cast microneedle arrays containing active
GB0707938D0 (en) 2007-04-25 2007-05-30 Univ Strathclyde Precipitation stabilising compositions
JP5350369B2 (ja) 2007-05-31 2013-11-27 ダコ デンマーク アクティーゼルスカブ 乳癌治療および予後におけるesrコピー数変化の利用方法
CA2690556A1 (en) 2007-06-12 2008-12-24 Schering Corporation Histone h2ax (hh2ax) biomarker for fti sensitivity
EP2155226A4 (en) 2007-06-14 2010-07-28 Univ California COMPOUNDS FOR INHIBITING THE PROTEIN AGGREGATION AND METHOD FOR THE PRODUCTION AND USE THEREOF
US20120150023A1 (en) 2007-08-06 2012-06-14 Kaspar Roger L Microneedle arrays for active agent delivery
DK2205169T3 (da) 2007-09-28 2017-02-20 The Queen's Univ Of Belfast Anordning og fremgangsmåde til fremføring
WO2009054988A1 (en) 2007-10-23 2009-04-30 Alza Corporation Transdermal sustained release drug delivery
EP2052736A1 (en) 2007-10-26 2009-04-29 Nycomed Danmark ApS Parathyroid hormone formulations und uses thereof
US8642532B2 (en) 2007-11-16 2014-02-04 Guohan Yang Excipients for protein stabilization
WO2009133861A1 (ja) 2008-04-28 2009-11-05 武田薬品工業株式会社 環状アミン化合物
WO2009137104A1 (en) * 2008-05-09 2009-11-12 Radius Health, Inc. Combination therapy for breastcancer comprising an antiestrogenic agent
WO2010022176A1 (en) 2008-08-19 2010-02-25 Ferring International Center S.A. Methods of treatment for skeletal conditons
EP2349200A1 (en) 2008-10-15 2011-08-03 Intarcia Therapeutics, Inc Highly concentrated drug particles, formulations, suspensions and uses thereof
BRPI0920973B8 (pt) 2008-11-04 2021-05-25 Aska Pharm Co Ltd composição aquosa contendo hormônio estimulanete de folículos
EP2355887B1 (en) 2008-11-18 2017-08-02 3M Innovative Properties Company Hollow microneedle array
KR101634836B1 (ko) 2008-12-26 2016-06-29 히사미쓰 세이야꾸 가부시키가이샤 마이크로 니들 디바이스
US20100203014A1 (en) 2009-02-04 2010-08-12 Aegis Therapeutics Llc Zwitterionic buffered acidic peptide and protein formulations
US20100226966A1 (en) 2009-03-03 2010-09-09 Daddona Peter E Method for transdermal controlled release drug delivery
WO2010118287A1 (en) 2009-04-10 2010-10-14 Radius Health, Inc. Selective androgen receptor modulators
JP5820805B2 (ja) 2009-04-24 2015-11-24 コリウム インターナショナル, インコーポレイテッド マイクロプロジェクションのアレイの製造のためのプロセス
CN102497909B (zh) 2009-07-31 2014-10-29 3M创新有限公司 中空微针阵列
US20120219538A1 (en) 2009-11-02 2012-08-30 Therapeomic Ag Stabilized protein formulations and use thereof
US20110172609A1 (en) 2010-01-08 2011-07-14 Ratio, Inc. Microneedle component assembly for drug delivery device
CN101912600B (zh) 2010-01-11 2014-01-29 杨国汉 改善胰岛素在溶液中稳定性的方法
IE20100174A1 (en) 2010-03-25 2012-02-29 Trinity College Dublin Transdermal administration of peptides
ES2719595T3 (es) 2010-05-04 2019-07-11 Corium Int Inc Método y dispositivo para la administración transdérmica de la hormona paratiroidea usando una matriz de microproyección
US9693950B2 (en) 2010-05-28 2017-07-04 3M Innovative Properties Company Aqueous formulations for coating microneedle arrays
EP2582371B1 (en) * 2010-06-16 2019-10-16 Endorecherche, Inc. Methods of treating or preventing estrogen-related diseases
WO2012075375A1 (en) 2010-12-02 2012-06-07 Lanco Biosciences, Inc. Delivery of parathyroid hormones by microinjection systems
JP2014508765A (ja) 2011-03-01 2014-04-10 スローン − ケタリング・インスティテュート・フォー・キャンサー・リサーチ 副甲状腺ホルモン類似体、組成物およびその使用
CA2833571A1 (en) 2011-04-22 2012-10-26 Radius Health, Inc. Method of drug delivery for pth, pthrp and related peptides
CA2857502C (en) 2011-11-30 2019-08-13 3M Innovative Properties Company Microneedle device including a peptide therapeutic agent and an amino acid and methods of making and using the same
GB201217439D0 (en) 2012-09-28 2012-11-14 Topotarget As Combination therapy
CN105451735B (zh) 2013-06-19 2019-01-11 西拉根制药公司 氮杂环丁烷雌激素受体调节剂和其用途
WO2014203129A1 (en) 2013-06-19 2014-12-24 Olema Pharmaceuticals, Inc. Combinations of benzopyran compounds, compositions and uses thereof
CN104436194B (zh) 2013-09-18 2018-03-30 北京大学 具有协同增效作用的抗癌组合物
EP3099305B1 (en) * 2014-01-27 2025-11-19 Dna Seq 2, Inc. Methods and systems for determination of an effective therapeutic regimen and drug discovery
WO2015136016A2 (en) 2014-03-13 2015-09-17 F. Hoffmann-La Roche Ag Therapeutic combinations with estrogen receptor modulators
US9421264B2 (en) 2014-03-28 2016-08-23 Duke University Method of treating cancer using selective estrogen receptor modulators
PL3122426T3 (pl) * 2014-03-28 2023-05-15 Duke University Leczenie raka sutka z zastosowaniem selektywnych modulatorów receptora estrogenowego
WO2015160986A2 (en) 2014-04-16 2015-10-22 Infinity Pharmaceuticals, Inc. Combination therapies
WO2016097071A1 (en) 2014-12-18 2016-06-23 F. Hoffmann-La Roche Ag Estrogen receptor modulators and uses thereof
AR104068A1 (es) * 2015-03-26 2017-06-21 Hoffmann La Roche Combinaciones de un compuesto inhibidor de fosfoinosítido 3-cinasa y un compuesto inhibidor de cdk4/6 para el tratamiento del cáncer
BR112017023228A2 (en) 2015-04-29 2018-11-06 Radius Pharmaceuticals, Inc. methods for cancer treatment

Also Published As

Publication number Publication date
IL297369B2 (en) 2024-06-01
CA2984200C (en) 2024-03-19
KR20180042155A (ko) 2018-04-25
KR20240097966A (ko) 2024-06-27
KR20250152678A (ko) 2025-10-23
KR20240110098A (ko) 2024-07-12
US20180169101A1 (en) 2018-06-21
JP7146992B2 (ja) 2022-10-04
CN113750091B (zh) 2025-03-11
CN108024541A (zh) 2018-05-11
JP2018518529A (ja) 2018-07-12
IL297369A (en) 2022-12-01
CN108024540A (zh) 2018-05-11
JP7696378B2 (ja) 2025-06-20
EP3288383A1 (en) 2018-03-07
KR20250152679A (ko) 2025-10-23
WO2016176666A1 (en) 2016-11-03
AU2016256471A1 (en) 2017-12-21
EP3294065A1 (en) 2018-03-21
JP7262508B2 (ja) 2023-04-21
EP3288382A4 (en) 2019-01-30
IL319266A (en) 2025-04-01
JP6926065B2 (ja) 2021-08-25
US20200368183A1 (en) 2020-11-26
US20180153828A1 (en) 2018-06-07
MX394676B (es) 2025-03-24
IL255148A0 (en) 2017-12-31
BR112017023233A2 (en) 2018-11-06
US11819480B2 (en) 2023-11-21
IL255261B1 (en) 2023-11-01
BR112017023228A2 (en) 2018-11-06
CN113750091A (zh) 2021-12-07
US20250367141A1 (en) 2025-12-04
WO2016176665A1 (en) 2016-11-03
RU2017140675A3 (cg-RX-API-DMAC7.html) 2019-09-27
CN108024541B (zh) 2021-07-20
US20220110890A1 (en) 2022-04-14
CA2984195A1 (en) 2016-11-03
CN108024540B (zh) 2021-09-17
KR20240095372A (ko) 2024-06-25
KR102871408B1 (ko) 2025-10-14
EP3288383A4 (en) 2019-01-23
SG11201708860SA (en) 2017-11-29
IL310069B2 (en) 2025-08-01
RU2017140674A (ru) 2019-05-29
IL323924A (en) 2025-12-01
JP7019422B2 (ja) 2022-02-15
US20240099996A1 (en) 2024-03-28
IL310069A (en) 2024-03-01
KR102682763B1 (ko) 2024-07-05
JP2022172039A (ja) 2022-11-14
JP6926066B2 (ja) 2021-08-25
IL255261B2 (en) 2024-03-01
MX2021005561A (es) 2022-07-01
IL255189B2 (en) 2024-04-01
WO2016176664A1 (en) 2016-11-03
CN108135177B (zh) 2021-06-01
IL255148B2 (en) 2023-04-01
MX2021003389A (es) 2021-05-28
SG11201708858WA (en) 2017-11-29
MX2017013794A (es) 2018-08-15
MX2021004881A (es) 2021-07-21
IL307983B1 (en) 2025-11-01
NZ737822A (en) 2024-10-25
CN108135177A (zh) 2018-06-08
HK1251409A1 (zh) 2019-02-01
JP7516472B2 (ja) 2024-07-16
US20220339126A1 (en) 2022-10-27
JP2024120996A (ja) 2024-09-05
JP2021102640A (ja) 2021-07-15
US20180214393A1 (en) 2018-08-02
CA2984195C (en) 2023-10-24
IL310069B1 (en) 2025-04-01
HK1251408A1 (zh) 2019-02-01
JP2023052631A (ja) 2023-04-11
JP2025170141A (ja) 2025-11-14
SG11201708861VA (en) 2017-11-29
CN113288887A (zh) 2021-08-24
IL307983A (en) 2023-12-01
MX2017013801A (es) 2018-08-15
AU2016256469B2 (en) 2020-12-10
KR102676705B1 (ko) 2024-06-18
BR112017023269A2 (en) 2018-11-06
IL255189A0 (en) 2017-12-31
US20250367140A1 (en) 2025-12-04
RU2745678C2 (ru) 2021-03-30
MX384908B (es) 2025-03-14
AU2016256471B2 (en) 2020-09-10
US12263141B2 (en) 2025-04-01
RU2737496C2 (ru) 2020-12-01
IL255148B (en) 2022-12-01
KR20180011780A (ko) 2018-02-02
AU2016256469A1 (en) 2017-12-14
IL307981B1 (en) 2025-11-01
IL307981A (en) 2023-12-01
JP2021105064A (ja) 2021-07-26
US20240091177A1 (en) 2024-03-21
MX2017013802A (es) 2018-08-15
EP3288382A1 (en) 2018-03-07
EP4039253A1 (en) 2022-08-10
AU2016256470B2 (en) 2020-10-15
JP2018514593A (ja) 2018-06-07
IL255261A0 (en) 2017-12-31
US11413258B2 (en) 2022-08-16
KR102676629B1 (ko) 2024-06-18
RU2017140676A (ru) 2019-05-29
MX384605B (es) 2025-03-14
RU2017140676A3 (cg-RX-API-DMAC7.html) 2019-09-27
US20200046655A1 (en) 2020-02-13
RU2747228C2 (ru) 2021-04-29
JP7745708B2 (ja) 2025-09-29
MX393599B (es) 2025-03-19
KR102871380B1 (ko) 2025-10-14
EP3294065A4 (en) 2019-03-20
IL323926A (en) 2025-12-01
JP2018514549A (ja) 2018-06-07
IL255189B1 (en) 2023-12-01
KR20250153309A (ko) 2025-10-24
SG10202104177VA (en) 2021-05-28
AU2016256469A8 (en) 2017-12-21
US20200038343A1 (en) 2020-02-06
NZ737825A (en) 2024-10-25
RU2017140675A (ru) 2019-05-29
NZ737819A (en) 2024-10-25
CA2984200A1 (en) 2016-11-03
CA2984357A1 (en) 2016-11-03
IL297369B1 (en) 2024-02-01
AU2016256470A1 (en) 2017-12-14
KR102871388B1 (ko) 2025-10-14
KR20180043202A (ko) 2018-04-27
HK1251407A1 (zh) 2019-02-01

Similar Documents

Publication Publication Date Title
BR112018005120A2 (cg-RX-API-DMAC7.html)
BR112017026609A2 (cg-RX-API-DMAC7.html)
BR112018002836A2 (cg-RX-API-DMAC7.html)
BR112018005697A2 (cg-RX-API-DMAC7.html)
BR112018004396A2 (cg-RX-API-DMAC7.html)
AU2022228198B1 (cg-RX-API-DMAC7.html)
BE2015C047I2 (cg-RX-API-DMAC7.html)
BE2015C044I2 (cg-RX-API-DMAC7.html)
BR0000695B1 (cg-RX-API-DMAC7.html)
BR0009717B1 (cg-RX-API-DMAC7.html)
CN303063343S (cg-RX-API-DMAC7.html)
BR0316652B1 (cg-RX-API-DMAC7.html)
BR0315725B1 (cg-RX-API-DMAC7.html)
BR0002874B1 (cg-RX-API-DMAC7.html)
BR0308527B1 (cg-RX-API-DMAC7.html)
BR0302598B1 (cg-RX-API-DMAC7.html)
BR0215049B1 (cg-RX-API-DMAC7.html)
BR0206635B1 (cg-RX-API-DMAC7.html)
BR0109862B1 (cg-RX-API-DMAC7.html)
BR0009994B1 (cg-RX-API-DMAC7.html)
BR0009942B1 (cg-RX-API-DMAC7.html)
BR0001684B1 (cg-RX-API-DMAC7.html)
BR0001536B1 (cg-RX-API-DMAC7.html)
BR0000763F1 (cg-RX-API-DMAC7.html)
CN303067691S (cg-RX-API-DMAC7.html)

Legal Events

Date Code Title Description
PD4A Correction of name of patent owner