RU2017120358A - Анти-il-1-бета антитела и способы их применения - Google Patents

Анти-il-1-бета антитела и способы их применения Download PDF

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Publication number
RU2017120358A
RU2017120358A RU2017120358A RU2017120358A RU2017120358A RU 2017120358 A RU2017120358 A RU 2017120358A RU 2017120358 A RU2017120358 A RU 2017120358A RU 2017120358 A RU2017120358 A RU 2017120358A RU 2017120358 A RU2017120358 A RU 2017120358A
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RU
Russia
Prior art keywords
amino acid
seq
humanized antibody
sequence
acid sequence
Prior art date
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RU2017120358A
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English (en)
Russian (ru)
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RU2017120358A3 (enExample
Inventor
Штефан ДЕНГЛЬ
Петер Михаэль ХЮЛЬСМАНН
Кристиан ГАССНЕР
Зебастиан БРОЙЕР
Олаф МУНДИГЛЬ
Ги ЖОРЖ
Ральф Шумахер
Гуидо ХАРТМАНН
Забине ГРЮНЕР
Original Assignee
Ф.Хоффманн-Ля Рош Аг
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Publication of RU2017120358A publication Critical patent/RU2017120358A/ru
Publication of RU2017120358A3 publication Critical patent/RU2017120358A3/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C07K16/245—IL-1
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
RU2017120358A 2014-11-10 2015-11-06 Анти-il-1-бета антитела и способы их применения RU2017120358A (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14192523 2014-11-10
EP14192523.0 2014-11-10
PCT/EP2015/075875 WO2016075034A1 (en) 2014-11-10 2015-11-06 ANTI-IL-1beta ANTIBODIES AND METHODS OF USE

Publications (2)

Publication Number Publication Date
RU2017120358A true RU2017120358A (ru) 2018-12-13
RU2017120358A3 RU2017120358A3 (enExample) 2019-05-29

Family

ID=51868114

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2017120358A RU2017120358A (ru) 2014-11-10 2015-11-06 Анти-il-1-бета антитела и способы их применения

Country Status (15)

Country Link
US (1) US10344085B2 (enExample)
EP (1) EP3218402A1 (enExample)
JP (1) JP6787888B2 (enExample)
KR (1) KR20170081253A (enExample)
CN (1) CN107074942A (enExample)
AR (1) AR102594A1 (enExample)
AU (1) AU2015345320A1 (enExample)
BR (1) BR112017009817A2 (enExample)
CA (1) CA2963719A1 (enExample)
IL (1) IL251165A0 (enExample)
MX (1) MX2017005987A (enExample)
RU (1) RU2017120358A (enExample)
SG (1) SG11201702550WA (enExample)
TW (1) TW201632552A (enExample)
WO (1) WO2016075034A1 (enExample)

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EP3218400A1 (en) 2014-11-10 2017-09-20 F. Hoffmann-La Roche AG Anti-pdgf-b antibodies and methods of use
JP2017537896A (ja) 2014-11-10 2017-12-21 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 二重特異性抗体及び眼科に使用する方法
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CN114466663B (zh) 2019-07-25 2026-01-02 建新公司 以FcRn拮抗剂治疗抗体介导的障碍的方法
CN114524875B (zh) * 2021-11-11 2023-07-25 江苏莱森生物科技研究院有限公司 偶联IL-1β单克隆抗体的纳米硅球及应用
CN117126278B (zh) * 2023-10-26 2024-01-05 中国科学院苏州纳米技术与纳米仿生研究所 一种单克隆抗体及其应用

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JP2017537896A (ja) 2014-11-10 2017-12-21 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 二重特異性抗体及び眼科に使用する方法
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Also Published As

Publication number Publication date
CA2963719A1 (en) 2016-05-19
JP6787888B2 (ja) 2020-11-18
US20170247447A1 (en) 2017-08-31
SG11201702550WA (en) 2017-04-27
WO2016075034A1 (en) 2016-05-19
IL251165A0 (en) 2017-04-30
AU2015345320A1 (en) 2017-04-06
AR102594A1 (es) 2017-03-08
MX2017005987A (es) 2017-06-29
RU2017120358A3 (enExample) 2019-05-29
CN107074942A (zh) 2017-08-18
TW201632552A (zh) 2016-09-16
JP2017534646A (ja) 2017-11-24
BR112017009817A2 (pt) 2018-02-14
KR20170081253A (ko) 2017-07-11
US10344085B2 (en) 2019-07-09
EP3218402A1 (en) 2017-09-20

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