RU2017115808A - Способ модуляции активности car-индуцированных иммунных клеток - Google Patents
Способ модуляции активности car-индуцированных иммунных клеток Download PDFInfo
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- RU2017115808A RU2017115808A RU2017115808A RU2017115808A RU2017115808A RU 2017115808 A RU2017115808 A RU 2017115808A RU 2017115808 A RU2017115808 A RU 2017115808A RU 2017115808 A RU2017115808 A RU 2017115808A RU 2017115808 A RU2017115808 A RU 2017115808A
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- car
- immune cell
- domain
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- dimerization
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- 210000002865 immune cell Anatomy 0.000 title claims 30
- 238000000034 method Methods 0.000 title claims 22
- 238000006471 dimerization reaction Methods 0.000 claims 26
- 230000002401 inhibitory effect Effects 0.000 claims 20
- 150000001875 compounds Chemical class 0.000 claims 8
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA201470623 | 2014-10-07 | ||
| DKPA201470623 | 2014-10-07 | ||
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| EP3240805B1 (en) | 2014-12-15 | 2024-11-27 | The Regents of the University of California | Bispecific or-gate chimeric antigen receptor responsive to cd19 and cd20 |
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| PH12013501201A1 (en) * | 2010-12-09 | 2013-07-29 | Univ Pennsylvania | Use of chimeric antigen receptor-modified t cells to treat cancer |
| KR102064230B1 (ko) * | 2013-02-15 | 2020-01-13 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | 키메라 항원 수용체 및 이의 이용 방법 |
| ES2671004T3 (es) * | 2013-03-07 | 2018-06-04 | Baylor College Of Medicine | Dirección a CD138 en cáncer |
| HK1220205A1 (zh) | 2013-03-15 | 2017-04-28 | Celgene Corporation | 修饰的t淋巴细胞 |
| US9745368B2 (en) * | 2013-03-15 | 2017-08-29 | The Trustees Of The University Of Pennsylvania | Targeting cytotoxic cells with chimeric receptors for adoptive immunotherapy |
| TWI654206B (zh) * | 2013-03-16 | 2019-03-21 | 諾華公司 | 使用人類化抗－ｃｄ１９嵌合抗原受體治療癌症 |
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| US10472613B2 (en) | 2019-11-12 |
| CN107109368A (zh) | 2017-08-29 |
| EP3204491A1 (en) | 2017-08-16 |
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