JP2017531430A - Carによって誘導される免疫細胞の活性を調節するための方法 - Google Patents
Carによって誘導される免疫細胞の活性を調節するための方法 Download PDFInfo
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- JP2017531430A JP2017531430A JP2017518478A JP2017518478A JP2017531430A JP 2017531430 A JP2017531430 A JP 2017531430A JP 2017518478 A JP2017518478 A JP 2017518478A JP 2017518478 A JP2017518478 A JP 2017518478A JP 2017531430 A JP2017531430 A JP 2017531430A
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- A61K2239/10—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by the structure of the chimeric antigen receptor [CAR]
- A61K2239/23—On/off switch
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- C12N2740/10011—Retroviridae
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- C12N2740/10043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA201470623 | 2014-10-07 | ||
| DKPA201470623 | 2014-10-07 | ||
| PCT/EP2015/073197 WO2016055551A1 (en) | 2014-10-07 | 2015-10-07 | Method for modulating car-induced immune cells activity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017531430A true JP2017531430A (ja) | 2017-10-26 |
| JP2017531430A5 JP2017531430A5 (enExample) | 2018-11-08 |
Family
ID=51730284
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017518478A Pending JP2017531430A (ja) | 2014-10-07 | 2015-10-07 | Carによって誘導される免疫細胞の活性を調節するための方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US10472613B2 (enExample) |
| EP (1) | EP3204491A1 (enExample) |
| JP (1) | JP2017531430A (enExample) |
| KR (1) | KR20170068539A (enExample) |
| CN (1) | CN107109368A (enExample) |
| AU (1) | AU2015330017A1 (enExample) |
| BR (1) | BR112017007003A2 (enExample) |
| CA (1) | CA2963327A1 (enExample) |
| IL (1) | IL251429A0 (enExample) |
| MX (1) | MX2017004603A (enExample) |
| RU (1) | RU2017115808A (enExample) |
| WO (1) | WO2016055551A1 (enExample) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2021514677A (ja) * | 2018-03-02 | 2021-06-17 | アロジーン セラピューティクス,インコーポレイテッド | 誘導性キメラサイトカイン受容体 |
| JP2022535138A (ja) * | 2019-06-07 | 2022-08-04 | ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア | Cd28および4-1bbに個々に連結したデュアルcarを発現するt細胞 |
Families Citing this family (75)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102064230B1 (ko) | 2013-02-15 | 2020-01-13 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | 키메라 항원 수용체 및 이의 이용 방법 |
| EP3240805B1 (en) | 2014-12-15 | 2024-11-27 | The Regents of the University of California | Bispecific or-gate chimeric antigen receptor responsive to cd19 and cd20 |
| EP4134430A1 (en) | 2015-02-06 | 2023-02-15 | National University of Singapore | Methods for enhancing efficacy of therapeutic immune cells |
| US20170151281A1 (en) | 2015-02-19 | 2017-06-01 | Batu Biologics, Inc. | Chimeric antigen receptor dendritic cell (car-dc) for treatment of cancer |
| PT3298033T (pt) | 2015-05-18 | 2020-09-22 | Tcr2 Therapeutics Inc | Composições e utilizações médicas para reprogramação de tcr utilizando proteínas de fusão |
| CA2986575A1 (en) | 2015-05-21 | 2016-11-24 | Harpoon Therapeutics, Inc. | Trispecific binding proteins and methods of use |
| SG10201913682QA (en) * | 2015-06-25 | 2020-03-30 | Icell Gene Therapeutics Llc | CHIMERIC ANTIGEN RECEPTORS (CARs), COMPOSITIONS AND METHODS OF USE THEREOF |
| WO2017087723A1 (en) * | 2015-11-19 | 2017-05-26 | The Regents Of The University Of California | Conditionally repressible immune cell receptors and methods of use thereof |
| EP3399991A4 (en) * | 2016-01-08 | 2019-08-07 | The Regents of The University of California | REQUIRES ACTIVE HETERODIMER POLYPEPTIDES AND METHOD FOR USE THEREOF |
| WO2017192536A1 (en) | 2016-05-02 | 2017-11-09 | University Of Kansas | Eliminating mhc restriction from the t cell receptor as a strategy for immunotherapy |
| SG11201810327XA (en) | 2016-05-20 | 2018-12-28 | Harpoon Therapeutics Inc | Single domain serum albumin binding protein |
| US11623958B2 (en) | 2016-05-20 | 2023-04-11 | Harpoon Therapeutics, Inc. | Single chain variable fragment CD3 binding proteins |
| GB201609604D0 (en) * | 2016-06-01 | 2016-07-13 | Ucl Business Plc | Cell |
| AU2017306432A1 (en) | 2016-08-02 | 2019-03-21 | TCR2 Therapeutics Inc. | Compositions and methods for TCR reprogramming using fusion proteins |
| AU2017338846B2 (en) * | 2016-10-04 | 2020-09-24 | Precision Biosciences, Inc. | Co-stimulatory domains for use in genetically-modified cells |
| CA3036745A1 (en) | 2016-10-07 | 2018-04-12 | TCR2 Therapeutics Inc. | Compositions and methods for t-cell receptors reprogramming using fusion proteins |
| CA3044593A1 (en) | 2016-11-22 | 2018-05-31 | TCR2 Therapeutics Inc. | Compositions and methods for tcr reprogramming using fusion proteins |
| AU2017363278B2 (en) | 2016-11-22 | 2022-10-27 | National University Of Singapore | Blockade of CD7 expression and chimeric antigen receptors for immunotherapy of T-cell malignancies |
| KR102275008B1 (ko) | 2016-11-23 | 2021-07-13 | 하푼 테라퓨틱스, 인크. | 전립선 특이 막 항원 결합 단백질 |
| KR20190087539A (ko) | 2016-11-23 | 2019-07-24 | 하푼 테라퓨틱스, 인크. | Psma 표적화 삼중특이성 단백질 및 사용 방법 |
| US11535668B2 (en) | 2017-02-28 | 2022-12-27 | Harpoon Therapeutics, Inc. | Inducible monovalent antigen binding protein |
| WO2018164948A1 (en) * | 2017-03-09 | 2018-09-13 | The Scripps Research Institute | Vectors with self-directed cpf1-dependent switches |
| EP3621994A4 (en) | 2017-05-12 | 2020-12-30 | Harpoon Therapeutics, Inc. | MESOTHELIN BINDING PROTEINS |
| CN110913908B (zh) | 2017-05-12 | 2022-05-27 | 哈普恩治疗公司 | 靶向msln的三特异性蛋白质及使用方法 |
| AU2018270078A1 (en) * | 2017-05-15 | 2019-11-07 | Autolus Limited | A cell comprising a chimeric antigen receptor (CAR) |
| JP2020524512A (ja) | 2017-06-21 | 2020-08-20 | アイセル・ジーン・セラピューティクス・エルエルシー | キメラ抗体受容体(CARs)の組成物およびその使用方法 |
| CA3071282A1 (en) | 2017-08-10 | 2019-02-14 | National University Of Singapore | T cell receptor-deficient chimeric antigen receptor t-cells and methods of use thereof |
| EP3684408A1 (en) | 2017-09-19 | 2020-07-29 | Massachusetts Institute of Technology | Compositions for chimeric antigen receptor t cell therapy and uses thereof |
| CN111630070B (zh) | 2017-10-13 | 2024-07-30 | 哈普恩治疗公司 | 三特异性蛋白质及使用方法 |
| IL315737A (en) | 2017-10-13 | 2024-11-01 | Harpoon Therapeutics Inc | B-cell maturation antigen-binding proteins |
| WO2019079486A1 (en) * | 2017-10-18 | 2019-04-25 | Intrexon Corporation | POLYPEPTIDE COMPOSITIONS COMPRISING SPACERS |
| WO2019076486A1 (en) * | 2017-10-19 | 2019-04-25 | Cellectis | TARGETED GENE INTEGRATION OF NK INHIBITOR GENES FOR ENHANCED IMMUNE CELL THERAPY |
| GB201717524D0 (en) | 2017-10-25 | 2017-12-06 | Autolus Ltd | Vectors |
| MA51158A (fr) * | 2017-12-14 | 2020-10-21 | Bluebird Bio Inc | Récepteurs daric nkg2d |
| WO2019122046A1 (en) * | 2017-12-21 | 2019-06-27 | F. Hoffmann-La Roche Ag | Universal reporter cell assay for specificity test of novel antigen binding moieties |
| WO2019134036A1 (en) | 2018-01-03 | 2019-07-11 | Qu Biologics Inc. | Innate targeting of adoptive cellular therapies |
| KR20200130709A (ko) | 2018-03-06 | 2020-11-19 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | 전립선-특이 막 항원 car 및 이의 사용 방법 |
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| CA3100386A1 (en) | 2018-05-23 | 2019-11-28 | National University Of Singapore | Blockade of cd2 surface expression and expression of chimeric antigen receptors for immunotherapy of t-cell malignancies |
| CN112292147A (zh) * | 2018-06-19 | 2021-01-29 | 南京传奇生物科技有限公司 | 工程化的细胞及其用途 |
| WO2020061482A1 (en) | 2018-09-21 | 2020-03-26 | Harpoon Therapeutics, Inc. | Egfr binding proteins and methods of use |
| EP3856771A4 (en) | 2018-09-25 | 2022-06-29 | Harpoon Therapeutics, Inc. | Dll3 binding proteins and methods of use |
| JP7557882B2 (ja) | 2018-09-28 | 2024-09-30 | マサチューセッツ インスティテュート オブ テクノロジー | コラーゲンに局在化される免疫調節分子およびその方法 |
| WO2020097193A1 (en) | 2018-11-06 | 2020-05-14 | The Regents Of The University Of California | Chimeric antigen receptors for phagocytosis |
| WO2020152197A1 (en) | 2019-01-23 | 2020-07-30 | Miltenyi Biotec B.V. & Co. KG | A combination of compositions for elimination and enhanced engraftment of hematopoietic stem cells in the bone marrow of a subject |
| EP3931208A1 (en) | 2019-03-01 | 2022-01-05 | Allogene Therapeutics, Inc. | Chimeric cytokine receptors bearing a pd-1 ectodomain |
| MY206523A (en) | 2019-03-01 | 2024-12-19 | Allogene Therapeutics Inc | Constitutively active chimeric cytokine receptors |
| US11026973B2 (en) | 2019-04-30 | 2021-06-08 | Myeloid Therapeutics, Inc. | Engineered phagocytic receptor compositions and methods of use thereof |
| CN110079504A (zh) * | 2019-05-06 | 2019-08-02 | 山东大学第二医院 | 一种含有不稳定结构域的car-t细胞及其制备方法和调节car-t细胞功能方法 |
| WO2020263399A1 (en) | 2019-06-26 | 2020-12-30 | Massachusetts Institute Of Technology | Immunomodulatory fusion protein-metal hydroxide complexes and methods thereof |
| MX2022002613A (es) | 2019-09-03 | 2022-06-02 | Myeloid Therapeutics Inc | Metodos y composiciones para la integracion del genoma. |
| WO2021061648A1 (en) | 2019-09-23 | 2021-04-01 | Massachusetts Institute Of Technology | Methods and compositions for stimulation of endogenous t cell responses |
| MX2022005443A (es) * | 2019-11-05 | 2022-08-10 | Janssen Biotech Inc | Terapia con células t car dirigidas a bcma contra el mieloma múltiple. |
| US10980836B1 (en) | 2019-12-11 | 2021-04-20 | Myeloid Therapeutics, Inc. | Therapeutic cell compositions and methods of manufacturing and use thereof |
| US20230100000A1 (en) | 2020-02-04 | 2023-03-30 | Miltenyi Biotec B.V. & Co. KG | Immune cell expressing adapter chimeric antigen receptor for sensing soluble antigens |
| KR20220144841A (ko) | 2020-02-21 | 2022-10-27 | 하푼 테라퓨틱스, 인크. | Flt3 결합 단백질 및 사용 방법 |
| IL295470A (en) | 2020-02-24 | 2022-10-01 | Allogene Therapeutics Inc | Bcma car-t cells with enhanced activities |
| US20210340524A1 (en) | 2020-05-01 | 2021-11-04 | Massachusetts Institute Of Technology | Methods for identifying chimeric antigen receptor-targeting ligands and uses thereof |
| WO2021221782A1 (en) | 2020-05-01 | 2021-11-04 | Massachusetts Institute Of Technology | Chimeric antigen receptor-targeting ligands and uses thereof |
| US12286465B2 (en) | 2020-05-28 | 2025-04-29 | Miltenyi Biotec B.V. & Co. KG | Chimeric antigen receptor with a spacer comprising C2-set Ig-like domains |
| CN112080527A (zh) * | 2020-09-16 | 2020-12-15 | 南京市第一医院 | 重组表达载体、耗竭减少的嵌合抗原受体t细胞及其应用 |
| AU2021376354A1 (en) | 2020-11-04 | 2023-06-22 | Myeloid Therapeutics, Inc. | Engineered chimeric fusion protein compositions and methods of use thereof |
| WO2022096664A1 (en) | 2020-11-09 | 2022-05-12 | Miltenyi Biotec B.V. & Co. KG | Methods and compositions for eliminating engineered immune cells |
| WO2022133169A1 (en) | 2020-12-18 | 2022-06-23 | Century Therapeutics, Inc. | Chimeric antigen receptor systems with adaptable receptor specificity |
| JP2024505248A (ja) * | 2021-01-29 | 2024-02-05 | アウトペース バイオ インコーポレイテッド | 小分子によって調節される細胞シグナル伝達発現システム |
| AU2022237618A1 (en) | 2021-03-17 | 2023-10-12 | Myeloid Therapeutics, Inc. | Engineered chimeric fusion protein compositions and methods of use thereof |
| CA3218780A1 (en) | 2021-05-11 | 2022-11-17 | Daniel Getts | Methods and compositions for genomic integration |
| US20250235477A1 (en) | 2021-10-06 | 2025-07-24 | Miltenyi Biotec B.V. & Co. KG | Method for targeted gene insertion into immune cells |
| WO2023081715A1 (en) | 2021-11-03 | 2023-05-11 | Viracta Therapeutics, Inc. | Combination of car t-cell therapy with btk inhibitors and methods of use thereof |
| EP4602171A1 (en) | 2022-10-15 | 2025-08-20 | Miltenyi Biotec B.V. & Co. KG | Transduction of gammadelta t cells with pseudotyped retroviral vectors |
| IL320157A (en) * | 2022-10-18 | 2025-06-01 | Kite Pharma Inc | CAR-T constructs comprising a novel CD19 linker in combination with IL18 and methods of using the same |
| CN116023507A (zh) * | 2022-10-25 | 2023-04-28 | 中国医学科学院基础医学研究所 | 嵌合抗原受体巨噬细胞在实体肿瘤免疫治疗中的应用 |
| WO2024227145A1 (en) * | 2023-04-27 | 2024-10-31 | Memorial Sloan-Kettering Cancer Center | Enhanced fusion polypeptide for immunotherapy |
| KR102764613B1 (ko) * | 2024-03-28 | 2025-02-12 | 한양대학교 에리카산학협력단 | NaPi2b 특이적 CAR-T를 포함하는 난소암 치료용 약학 조성물 |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012079000A1 (en) * | 2010-12-09 | 2012-06-14 | The Trustees Of The University Of Pennsylvania | Use of chimeric antigen receptor-modified t cells to treat cancer |
| WO2014127261A1 (en) * | 2013-02-15 | 2014-08-21 | The Regents Of The University Of California | Chimeric antigen receptor and methods of use thereof |
| WO2014138704A1 (en) * | 2013-03-07 | 2014-09-12 | Baylor College Of Medicine | Targeting cd138 in cancer |
| WO2014145252A2 (en) * | 2013-03-15 | 2014-09-18 | Milone Michael C | Targeting cytotoxic cells with chimeric receptors for adoptive immunotherapy |
| WO2014153270A1 (en) * | 2013-03-16 | 2014-09-25 | Novartis Ag | Treatment of cancer using humanized anti-cd19 chimeric antigen receptor |
| WO2014152177A1 (en) * | 2013-03-15 | 2014-09-25 | Anthrogenesis Corporation | Modified t lymphocytes |
-
2015
- 2015-10-07 EP EP15778276.4A patent/EP3204491A1/en not_active Withdrawn
- 2015-10-07 RU RU2017115808A patent/RU2017115808A/ru not_active Application Discontinuation
- 2015-10-07 WO PCT/EP2015/073197 patent/WO2016055551A1/en not_active Ceased
- 2015-10-07 BR BR112017007003A patent/BR112017007003A2/pt not_active IP Right Cessation
- 2015-10-07 CN CN201580066604.9A patent/CN107109368A/zh active Pending
- 2015-10-07 AU AU2015330017A patent/AU2015330017A1/en not_active Abandoned
- 2015-10-07 CA CA2963327A patent/CA2963327A1/en not_active Abandoned
- 2015-10-07 MX MX2017004603A patent/MX2017004603A/es unknown
- 2015-10-07 JP JP2017518478A patent/JP2017531430A/ja active Pending
- 2015-10-07 US US15/517,708 patent/US10472613B2/en active Active
- 2015-10-07 KR KR1020177012493A patent/KR20170068539A/ko not_active Withdrawn
-
2017
- 2017-03-28 IL IL251429A patent/IL251429A0/en unknown
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012079000A1 (en) * | 2010-12-09 | 2012-06-14 | The Trustees Of The University Of Pennsylvania | Use of chimeric antigen receptor-modified t cells to treat cancer |
| WO2014127261A1 (en) * | 2013-02-15 | 2014-08-21 | The Regents Of The University Of California | Chimeric antigen receptor and methods of use thereof |
| WO2014138704A1 (en) * | 2013-03-07 | 2014-09-12 | Baylor College Of Medicine | Targeting cd138 in cancer |
| WO2014145252A2 (en) * | 2013-03-15 | 2014-09-18 | Milone Michael C | Targeting cytotoxic cells with chimeric receptors for adoptive immunotherapy |
| WO2014152177A1 (en) * | 2013-03-15 | 2014-09-25 | Anthrogenesis Corporation | Modified t lymphocytes |
| WO2014153270A1 (en) * | 2013-03-16 | 2014-09-25 | Novartis Ag | Treatment of cancer using humanized anti-cd19 chimeric antigen receptor |
Non-Patent Citations (3)
| Title |
|---|
| FEDOROV VICTOR D: "NOVEL APPROACHES TO ENHANCE THE SPECIFICITY AND SAFETY OF ENGINEERED T CELLS", CANCER JOURNAL, vol. VOL:20, NR:2,, JPN5017009057, 2014, US, pages 160 - 165, ISSN: 0004099397 * |
| FEDOROV VICTOR D: "PD-1- AND CTLA-4-BASED INHIBITORY CHIMERIC ANTIGEN RECEPTORS (ICARS) DIVERT OFF-TARGET 以下備考", SCIENCE TRANSLATIONAL MEDICINE, vol. VOL:5, NR:215,, JPN5017009058, 11 December 2013 (2013-12-11), US, pages 1 - 25, ISSN: 0004099398 * |
| MICHAEL C JENSEN: "DESIGN AND IMPLEMENTATION OF ADOPTIVE THERAPY WITH CHIMERIC ANTIGEN RECEPTOR-MODIFIED T CELLS", IMMUNOLOGICAL REVIEWS, vol. VOL:257, NR:1, SPECIAL ISSUE,, JPN5017009059, 13 December 2013 (2013-12-13), pages 127 - 144, ISSN: 0004099399 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2021514677A (ja) * | 2018-03-02 | 2021-06-17 | アロジーン セラピューティクス,インコーポレイテッド | 誘導性キメラサイトカイン受容体 |
| JP2024074801A (ja) * | 2018-03-02 | 2024-05-31 | アロジーン セラピューティクス,インコーポレイテッド | 誘導性キメラサイトカイン受容体 |
| JP7526101B2 (ja) | 2018-03-02 | 2024-07-31 | アロジーン セラピューティクス,インコーポレイテッド | 誘導性キメラサイトカイン受容体 |
| JP2022535138A (ja) * | 2019-06-07 | 2022-08-04 | ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア | Cd28および4-1bbに個々に連結したデュアルcarを発現するt細胞 |
Also Published As
| Publication number | Publication date |
|---|---|
| IL251429A0 (en) | 2017-05-29 |
| KR20170068539A (ko) | 2017-06-19 |
| MX2017004603A (es) | 2017-06-30 |
| RU2017115808A (ru) | 2018-11-13 |
| RU2017115808A3 (enExample) | 2019-04-24 |
| US20170292118A1 (en) | 2017-10-12 |
| BR112017007003A2 (pt) | 2017-12-19 |
| WO2016055551A1 (en) | 2016-04-14 |
| AU2015330017A1 (en) | 2017-04-27 |
| CA2963327A1 (en) | 2016-04-14 |
| US10472613B2 (en) | 2019-11-12 |
| CN107109368A (zh) | 2017-08-29 |
| EP3204491A1 (en) | 2017-08-16 |
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