RU2015144689A - Композиция для инъекций с замедленным высвобождением и способ ее применения для лечения воспаления в суставах и связанной с такими воспалениями боли - Google Patents
Композиция для инъекций с замедленным высвобождением и способ ее применения для лечения воспаления в суставах и связанной с такими воспалениями боли Download PDFInfo
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- RU2015144689A RU2015144689A RU2015144689A RU2015144689A RU2015144689A RU 2015144689 A RU2015144689 A RU 2015144689A RU 2015144689 A RU2015144689 A RU 2015144689A RU 2015144689 A RU2015144689 A RU 2015144689A RU 2015144689 A RU2015144689 A RU 2015144689A
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- microparticles
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- pharmaceutical composition
- drug
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Links
- 238000000034 method Methods 0.000 title claims 30
- 239000007924 injection Substances 0.000 title claims 12
- 206010061218 Inflammation Diseases 0.000 title claims 9
- 230000004054 inflammatory process Effects 0.000 title claims 8
- 208000002193 Pain Diseases 0.000 title claims 7
- 239000000203 mixture Substances 0.000 title claims 6
- 239000011859 microparticle Substances 0.000 claims 41
- 239000008194 pharmaceutical composition Substances 0.000 claims 31
- 229940079593 drug Drugs 0.000 claims 30
- 239000003814 drug Substances 0.000 claims 30
- 229920000642 polymer Polymers 0.000 claims 23
- 239000003246 corticosteroid Substances 0.000 claims 16
- 229960002714 fluticasone Drugs 0.000 claims 12
- MGNNYOODZCAHBA-GQKYHHCASA-N fluticasone Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@@H](C)[C@@](C(=O)SCF)(O)[C@@]2(C)C[C@@H]1O MGNNYOODZCAHBA-GQKYHHCASA-N 0.000 claims 12
- 239000004372 Polyvinyl alcohol Substances 0.000 claims 11
- 239000002552 dosage form Substances 0.000 claims 11
- 238000002347 injection Methods 0.000 claims 11
- 229920002451 polyvinyl alcohol Polymers 0.000 claims 11
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N Lactic Acid Natural products CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims 10
- 229920000954 Polyglycolide Polymers 0.000 claims 10
- 229920001610 polycaprolactone Polymers 0.000 claims 10
- 239000004633 polyglycolic acid Substances 0.000 claims 10
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 claims 9
- 239000002253 acid Substances 0.000 claims 8
- 229960000289 fluticasone propionate Drugs 0.000 claims 7
- WMWTYOKRWGGJOA-CENSZEJFSA-N fluticasone propionate Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@@H](C)[C@@](C(=O)SCF)(OC(=O)CC)[C@@]2(C)C[C@@H]1O WMWTYOKRWGGJOA-CENSZEJFSA-N 0.000 claims 7
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims 6
- 229920002988 biodegradable polymer Polymers 0.000 claims 6
- 239000004621 biodegradable polymer Substances 0.000 claims 6
- 239000013078 crystal Substances 0.000 claims 6
- 238000004090 dissolution Methods 0.000 claims 6
- 239000005038 ethylene vinyl acetate Substances 0.000 claims 6
- VPVXHAANQNHFSF-UHFFFAOYSA-N 1,4-dioxan-2-one Chemical compound O=C1COCCO1 VPVXHAANQNHFSF-UHFFFAOYSA-N 0.000 claims 5
- ZNLAHAOCFKBYRH-UHFFFAOYSA-N 1,4-dioxane-2,3-dione Chemical compound O=C1OCCOC1=O ZNLAHAOCFKBYRH-UHFFFAOYSA-N 0.000 claims 5
- YKVIWISPFDZYOW-UHFFFAOYSA-N 6-Decanolide Chemical compound CCCCC1CCCCC(=O)O1 YKVIWISPFDZYOW-UHFFFAOYSA-N 0.000 claims 5
- 229920001577 copolymer Polymers 0.000 claims 5
- 238000010438 heat treatment Methods 0.000 claims 5
- 229920000052 poly(p-xylylene) Polymers 0.000 claims 5
- 239000004626 polylactic acid Substances 0.000 claims 5
- YFHICDDUDORKJB-UHFFFAOYSA-N trimethylene carbonate Chemical compound O=C1OCCCO1 YFHICDDUDORKJB-UHFFFAOYSA-N 0.000 claims 5
- 150000002148 esters Chemical class 0.000 claims 4
- 239000001630 malic acid Substances 0.000 claims 4
- DQXBYHZEEUGOBF-UHFFFAOYSA-N but-3-enoic acid;ethene Chemical compound C=C.OC(=O)CC=C DQXBYHZEEUGOBF-UHFFFAOYSA-N 0.000 claims 3
- 230000003111 delayed effect Effects 0.000 claims 3
- 239000003937 drug carrier Substances 0.000 claims 3
- 239000007943 implant Substances 0.000 claims 3
- 229920001200 poly(ethylene-vinyl acetate) Polymers 0.000 claims 3
- 229920000747 poly(lactic acid) Polymers 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 239000000243 solution Substances 0.000 claims 3
- 238000013268 sustained release Methods 0.000 claims 3
- 239000012730 sustained-release form Substances 0.000 claims 3
- 239000012738 dissolution medium Substances 0.000 claims 2
- 231100000241 scar Toxicity 0.000 claims 2
- 239000002904 solvent Substances 0.000 claims 2
- 210000001519 tissue Anatomy 0.000 claims 2
- 210000004127 vitreous body Anatomy 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- JRHWHSJDIILJAT-UHFFFAOYSA-N 2-hydroxypentanoic acid Chemical compound CCCC(O)C(O)=O JRHWHSJDIILJAT-UHFFFAOYSA-N 0.000 claims 1
- SJZRECIVHVDYJC-UHFFFAOYSA-N 4-hydroxybutyric acid Chemical compound OCCCC(O)=O SJZRECIVHVDYJC-UHFFFAOYSA-N 0.000 claims 1
- 206010012688 Diabetic retinal oedema Diseases 0.000 claims 1
- 206010012692 Diabetic uveitis Diseases 0.000 claims 1
- 206010023330 Keloid scar Diseases 0.000 claims 1
- 208000008930 Low Back Pain Diseases 0.000 claims 1
- 206010003246 arthritis Diseases 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 238000000576 coating method Methods 0.000 claims 1
- 230000006835 compression Effects 0.000 claims 1
- 238000007906 compression Methods 0.000 claims 1
- 208000006111 contracture Diseases 0.000 claims 1
- 201000011190 diabetic macular edema Diseases 0.000 claims 1
- 238000001035 drying Methods 0.000 claims 1
- 230000003902 lesion Effects 0.000 claims 1
- 210000004705 lumbosacral region Anatomy 0.000 claims 1
- 210000005036 nerve Anatomy 0.000 claims 1
- 201000008482 osteoarthritis Diseases 0.000 claims 1
- 230000000306 recurrent effect Effects 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 210000001032 spinal nerve Anatomy 0.000 claims 1
- 210000000115 thoracic cavity Anatomy 0.000 claims 1
- 125000006839 xylylene group Chemical group 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Ophthalmology & Optometry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361804185P | 2013-03-21 | 2013-03-21 | |
| US61/804,185 | 2013-03-21 | ||
| PCT/US2014/031502 WO2014153541A1 (en) | 2013-03-21 | 2014-03-21 | Injectable sustained release composition and method of using the same for treating inflammation in joints and pain associated therewith |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2015144689A true RU2015144689A (ru) | 2017-04-25 |
| RU2015144689A3 RU2015144689A3 (cg-RX-API-DMAC7.html) | 2018-03-19 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2015144689A RU2015144689A (ru) | 2013-03-21 | 2014-03-21 | Композиция для инъекций с замедленным высвобождением и способ ее применения для лечения воспаления в суставах и связанной с такими воспалениями боли |
Country Status (16)
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| EP (2) | EP3981388A1 (cg-RX-API-DMAC7.html) |
| JP (3) | JP6230691B2 (cg-RX-API-DMAC7.html) |
| KR (2) | KR102069473B1 (cg-RX-API-DMAC7.html) |
| CN (2) | CN105517536B (cg-RX-API-DMAC7.html) |
| AU (2) | AU2014235854B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BR112015024234B1 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2907765C (cg-RX-API-DMAC7.html) |
| CL (1) | CL2015002826A1 (cg-RX-API-DMAC7.html) |
| IL (2) | IL287731B2 (cg-RX-API-DMAC7.html) |
| MX (1) | MX378109B (cg-RX-API-DMAC7.html) |
| NZ (1) | NZ713029A (cg-RX-API-DMAC7.html) |
| RU (1) | RU2015144689A (cg-RX-API-DMAC7.html) |
| SG (2) | SG10201604814WA (cg-RX-API-DMAC7.html) |
| TW (1) | TWI686213B (cg-RX-API-DMAC7.html) |
| WO (1) | WO2014153541A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105517536B (zh) | 2013-03-21 | 2019-08-16 | 优普顺药物公司美国分部 | 可注射的持续释放组合物及其用于治疗关节炎症及相关疼痛的方法 |
| SG10201902407PA (en) * | 2014-09-19 | 2019-04-29 | Eupraxia Pharmaceuticals Inc | Injectable microparticles for hyper-localized release of therapeutic agents |
| GB201505527D0 (en) | 2015-03-31 | 2015-05-13 | Jmedtech Pte Ltd | Composition |
| CN115337254A (zh) * | 2015-07-23 | 2022-11-15 | 爱瑞制药公司 | 用于治疗眼病的玻璃体内药物递送系统 |
| WO2017066423A1 (en) * | 2015-10-13 | 2017-04-20 | Flexion Therapeutics, Inc. | Corticosteroid formulations for maintaining corticosteroid synovial fluid concentrations |
| BR112018008415A2 (en) | 2015-10-27 | 2018-10-30 | Eupraxia Pharmaceuticals Inc. | sustained release formulations of local anesthetics |
| DE102016216182A1 (de) * | 2016-08-29 | 2018-03-01 | Tetec Tissue Engineering Technologies Ag | Kombination, insbesondere zum Behandeln eines Knorpeldefekts |
| EP3595776A4 (en) * | 2017-03-17 | 2020-09-30 | Flexion Therapeutics, Inc. | FLUTICASONE SUSTAINED-RELEASE FORMULATIONS AND THEIR PROCEDURES FOR USE |
| CN111432807A (zh) | 2017-10-06 | 2020-07-17 | 铸造疗法股份有限公司 | 用于控制释放治疗剂的可植入贮库 |
| WO2019079323A1 (en) * | 2017-10-17 | 2019-04-25 | California Institute Of Technology | UNDERGROUND IMAGING OF DIELECTRIC STRUCTURES AND EMPTYES BY NARROW-BAND ELECTROMAGNETIC RESONANT DIFFUSION |
| CN109073743A (zh) * | 2017-12-18 | 2018-12-21 | 深圳市大疆创新科技有限公司 | 弱目标检测方法、微波雷达传感器及无人机 |
| CN111655303A (zh) | 2018-01-08 | 2020-09-11 | 铸造疗法股份有限公司 | 经由治疗剂的控制递送用于治疗腔内癌症的装置、系统和方法 |
| CN112367980A (zh) | 2018-05-12 | 2021-02-12 | 铸造疗法股份有限公司 | 用于控制释放治疗剂的可植入贮库 |
| WO2019222856A1 (en) | 2018-05-24 | 2019-11-28 | Nureva Inc. | Method, apparatus and computer-readable media to manage semi-constant (persistent) sound sources in microphone pickup/focus zones |
| CA3087238A1 (en) | 2018-05-24 | 2019-11-28 | Celanese EVA Performance Polymers Corporation | Implantable device for sustained release of a macromolecular drug compound |
| CN119236191A (zh) | 2018-05-24 | 2025-01-03 | 塞拉尼斯伊娃高性能聚合物公司 | 用于持续释放大分子药物化合物的可植入器件 |
| WO2020047013A1 (en) | 2018-08-28 | 2020-03-05 | Foundry Therapeutics, Inc. | Polymer implants |
| JP7547364B2 (ja) * | 2019-04-10 | 2024-09-09 | ユープラシア ファーマシューティカルズ インク． | 所望の粒子径分布および形態の薬物結晶を作製するためのプロセス |
| GB202000840D0 (en) | 2020-01-21 | 2020-03-04 | Cell Guidance Systems Ltd | Compositions and methods |
| BR112023022439A2 (pt) | 2021-04-26 | 2023-12-26 | Celanese Eva Performance Polymers Llc | Dispositivo implantável para liberação sustentada de um composto de fármaco macromolecular |
| CN119630398A (zh) * | 2022-08-16 | 2025-03-14 | 勃林格殷格翰国际有限公司 | 眼内用尼达尼布的药物制剂 |
| IL319996A (en) | 2022-10-04 | 2025-06-01 | Eupraxia Pharmaceuticals Inc | Use of long-acting fluticasone propionate injectable suspensions for treating and preventing inflammations of the gastrointestinal tract |
| WO2025006497A1 (en) | 2023-06-26 | 2025-01-02 | Eupraxia Pharmaceuticals Inc. | Long-acting intra-articular dosage forms containing fluticasone propionate and use thereof |
Family Cites Families (148)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2515898A (en) | 1947-09-15 | 1950-07-18 | Lilly Co Eli | Procaine penicillin and therapeutic compositions |
| US2627491A (en) | 1950-07-15 | 1953-02-03 | Wyeth Corp | Penicillin salts of substituted alkylene diamines |
| US3993073A (en) | 1969-04-01 | 1976-11-23 | Alza Corporation | Novel drug delivery device |
| US3867519A (en) | 1972-04-27 | 1975-02-18 | Alza Corp | Bioerodible drug delivery device |
| US4105776A (en) | 1976-06-21 | 1978-08-08 | E. R. Squibb & Sons, Inc. | Proline derivatives and related compounds |
| GB1523965A (en) | 1976-03-19 | 1978-09-06 | Ici Ltd | Pharmaceutical compositions containing steroids |
| DE2805106A1 (de) | 1978-02-07 | 1979-08-16 | Hoechst Ag | Mikrokapseln aus polyvinylalkohol mit fluessigem, wasserunloeslichem fuellgut und verfahren zu deren herstellung |
| IT1205604B (it) | 1981-06-23 | 1989-03-23 | Pierrel Spa | Procedimento per la eliminazione totale o parziale di acido aspartico e acido glutammico da idrolisati proteici e micele di amminoacidi con conseguete ottenimento di miscele di aminoacidi ad alto valore nutrizionale |
| US4316906A (en) | 1978-08-11 | 1982-02-23 | E. R. Squibb & Sons, Inc. | Mercaptoacyl derivatives of substituted prolines |
| IL58849A (en) | 1978-12-11 | 1983-03-31 | Merck & Co Inc | Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them |
| US4231938A (en) | 1979-06-15 | 1980-11-04 | Merck & Co., Inc. | Hypocholesteremic fermentation products and process of preparation |
| US4452025A (en) | 1979-07-18 | 1984-06-05 | Lew Hyok S | Self-interlocking grille |
| US4508729A (en) | 1979-12-07 | 1985-04-02 | Adir | Substituted iminodiacids, their preparation and pharmaceutical compositions containing them |
| US4444784A (en) | 1980-08-05 | 1984-04-24 | Merck & Co., Inc. | Antihypercholesterolemic compounds |
| MX7065E (es) | 1980-06-06 | 1987-04-10 | Sankyo Co | Un procedimiento microbiologico para preparar derivados de ml-236b |
| US4344949A (en) | 1980-10-03 | 1982-08-17 | Warner-Lambert Company | Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids |
| ZA817261B (en) | 1980-10-23 | 1982-09-29 | Schering Corp | Carboxyalkyl dipeptides,processes for their production and pharmaceutical compositions containing them |
| US4337201A (en) | 1980-12-04 | 1982-06-29 | E. R. Squibb & Sons, Inc. | Phosphinylalkanoyl substituted prolines |
| US4410520A (en) | 1981-11-09 | 1983-10-18 | Ciba-Geigy Corporation | 3-Amino-[1]-benzazepin-2-one-1-alkanoic acids |
| US4439196A (en) | 1982-03-18 | 1984-03-27 | Merck & Co., Inc. | Osmotic drug delivery system |
| GB2128984B (en) | 1982-05-12 | 1985-05-22 | Hoffmann La Roche | Diaza-bicyclic compounds |
| US4542025A (en) | 1982-07-29 | 1985-09-17 | The Stolle Research And Development Corporation | Injectable, long-acting microparticle formulation for the delivery of anti-inflammatory agents |
| US4530840A (en) | 1982-07-29 | 1985-07-23 | The Stolle Research And Development Corporation | Injectable, long-acting microparticle formulation for the delivery of anti-inflammatory agents |
| US4739073A (en) | 1983-11-04 | 1988-04-19 | Sandoz Pharmaceuticals Corp. | Intermediates in the synthesis of indole analogs of mevalonolactone and derivatives thereof |
| US4888176A (en) | 1984-05-21 | 1989-12-19 | Massachusetts Institute Of Technology | Controlled drug delivery high molecular weight polyanhydrides |
| US4757128A (en) | 1986-08-01 | 1988-07-12 | Massachusetts Institute Of Technology | High molecular weight polyanhydride and preparation thereof |
| JPS60100516A (ja) | 1983-11-04 | 1985-06-04 | Takeda Chem Ind Ltd | 徐放型マイクロカプセルの製造法 |
| US4623588A (en) | 1984-02-06 | 1986-11-18 | Biotek, Inc. | Controlled release composite core coated microparticles |
| US4568559A (en) | 1984-02-06 | 1986-02-04 | Biotek, Inc. | Composite core coated microparticles and process of preparing same |
| JPS61191609U (cg-RX-API-DMAC7.html) | 1985-05-20 | 1986-11-28 | ||
| US4940727A (en) | 1986-06-23 | 1990-07-10 | Merck & Co., Inc. | Novel HMG-CoA reductase inhibitors |
| US5116870A (en) | 1986-06-23 | 1992-05-26 | Merck & Co., Inc. | HMG-CoA reductase inhibitors |
| US4789724A (en) | 1986-10-17 | 1988-12-06 | Massachusetts Institute Of Technology | Preparation of anhydride copolymers |
| JPS63122620A (ja) | 1986-11-12 | 1988-05-26 | Sanraku Inc | ポリ乳酸マイクロスフエア及びその製造方法 |
| US5310572A (en) | 1987-02-03 | 1994-05-10 | Dow Corning Corporation | Process for forming a coated active agent-containing article |
| US5091378A (en) | 1987-05-22 | 1992-02-25 | E. R. Squibb & Sons, Inc. | Phosphorus-containing HMG-CoA reductase inhibitors, new intermediates and method |
| US5017716A (en) | 1987-05-22 | 1991-05-21 | E.R. Squibb & Sons, Inc. | Phosphorous-containing HMG-CoA reductase inhibitors, new intermediates and method |
| US4904646A (en) | 1987-05-22 | 1990-02-27 | E. R. Squibb & Sons, Inc. | Phosphorus-containing HMG-COA reductase inhibitors |
| US4857311A (en) | 1987-07-31 | 1989-08-15 | Massachusetts Institute Of Technology | Polyanhydrides with improved hydrolytic degradation properties |
| US4997837A (en) | 1987-09-08 | 1991-03-05 | Warner-Lambert Company | 6-(((substituted)pyridin-3-yl)alkyl)-and alkenyl)-tetrahydro-4-hydroxypyran-2-one inhibitors of cholesterol biosynthesis |
| US4906624A (en) | 1987-09-08 | 1990-03-06 | Warner-Lambert Company | 6-(((Substituted)pyridin-3-yl)alkyl)-and alkenyl)-tetrahydro-4-hydroxypyran-2-one inhibitors of cholesterol biosynthesis |
| US4929620A (en) | 1987-12-10 | 1990-05-29 | Warner-Lambert Company | 5-pyrimidinyl-3,5-dihydroxy-6-heptenoic acid compounds useful as inhibitors of cholesterol biosynthesis |
| US4994494A (en) | 1987-12-21 | 1991-02-19 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | HMG-COA reductase inhibitors |
| US4939143A (en) | 1987-12-21 | 1990-07-03 | Rorer Pharmaceutical Corporation | Substituted cyclohexene derivatives as HMG-CoA reductase inhibitors |
| US5001144A (en) | 1987-12-21 | 1991-03-19 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Substituted cyclohexene derivatives as HMG-CoA reductase inhibitors |
| US4900754A (en) | 1987-12-21 | 1990-02-13 | Rorer Pharmaceutical Corp. | HMG-COA reductase inhibitors |
| US5001128A (en) | 1987-12-21 | 1991-03-19 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | HMG-COA reductase inhibitors |
| US4946864A (en) | 1988-02-01 | 1990-08-07 | Merck & Co., Inc. | Novel HMG-CoA reductase inhibitors |
| US5021453A (en) | 1988-03-02 | 1991-06-04 | Merck & Co., Inc. | 3-keto HMG-CoA reductase inhibitors |
| EP0331250B1 (en) | 1988-03-02 | 1994-04-13 | Merck & Co. Inc. | Antihypercholesterolemic agents |
| US4920109A (en) | 1988-04-18 | 1990-04-24 | Merck & Co., Inc. | Antifungal compositions and method of controlling mycotic infections |
| US5271946A (en) | 1988-04-20 | 1993-12-21 | Asta Pharma Aktiengesellschaft | Controlled release azelastine-containing pharmaceutical compositions |
| MC2025A1 (fr) | 1988-04-20 | 1990-04-25 | Asta Pharma Ag | Medicament contenant de l'azelastine et capable de liberer celle-ci de facon controlee |
| US5166171A (en) | 1988-05-13 | 1992-11-24 | Hoechst Aktiengesellschaft | 6-phenoxymethyl-4-hydroxytetrahydropyran-2-ones and 6-thiphenoxymethyl-4-hydroxytetrahydropyran-2-ones and the corresponding dihydroxycarboxylic acid derivatives, salts and esters, and in treating hypercholesterolemia |
| US4897402A (en) | 1988-06-29 | 1990-01-30 | Merck & Co., Inc. | 5-oxa, 5-thia, 5-aza HmG-CoA reductase inhibitors |
| US4963538A (en) | 1988-06-29 | 1990-10-16 | Merck & Co., Inc. | 5-oxygenated HMG-CoA reductase inhibitors |
| IT1226726B (it) | 1988-07-29 | 1991-02-05 | Zambon Spa | Composti attivi come inibitori della biosintesi del colesterolo. |
| US5196440A (en) | 1988-07-29 | 1993-03-23 | Zambon Group S.P.A. | Compounds active as inhibitors of the cholesterol biosynthesis |
| DE3832570A1 (de) | 1988-09-24 | 1990-03-29 | Hoechst Ag | 7-substituierte derivate der 3,5-dihydroxyhept-6-insaeure, verfahren zur ihrer herstellung, ihre verwendung als arzneimittel, sowie zwischenprodukte |
| US4950675A (en) | 1988-12-21 | 1990-08-21 | Warner-Lambert Company | Pyridine di-mevalono-lactones as inhibitors of cholesterol biosynthesis |
| US4957940A (en) | 1988-12-21 | 1990-09-18 | Warner-Lambert Company | Bicyclo heptane and bicyclo octane substituted inhibitors of cholesterol synthesis |
| US4906657A (en) | 1988-12-21 | 1990-03-06 | Warner-Lambert Company | Bicyclo heptane and bicyclo octane substituted inhibitors of cholesterol synthesis |
| US4923861A (en) | 1989-02-07 | 1990-05-08 | Warner-Lambert Company | 6-(2-(2-(Substituted amino)-3-quinolinyl) ethenyl and ethyl) tetrahydro-4-hydroxypyran-2-one inhibitors of cholesterol biosynthesis |
| US5130306A (en) | 1989-03-13 | 1992-07-14 | Merck & Co., Inc. | 5-Oxygenated HMG-COA reductase inhibitors |
| US5132312A (en) | 1989-03-27 | 1992-07-21 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Substituted cyclohexene derivatives as HMG-CoA reductase inhibitors |
| US5133974A (en) | 1989-05-05 | 1992-07-28 | Kv Pharmaceutical Company | Extended release pharmaceutical formulations |
| US4970231A (en) | 1989-06-09 | 1990-11-13 | Merck & Co., Inc. | 4-substituted HMG-CoA reductase inhibitors |
| US5102911A (en) | 1989-06-09 | 1992-04-07 | Merck & Co, Inc. | 4-Substituted HMG-CoA reductase inhibitors |
| PH30995A (en) | 1989-07-07 | 1997-12-23 | Novartis Inc | Sustained release formulations of water soluble peptides. |
| FI94339C (fi) | 1989-07-21 | 1995-08-25 | Warner Lambert Co | Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi |
| US4992429A (en) | 1989-08-24 | 1991-02-12 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Novel HMG-COA reductase inhibitors |
| US5098931A (en) | 1989-08-31 | 1992-03-24 | Merck & Co., Inc. | 7-substituted HMG-CoA reductase inhibitors |
| US4946860A (en) | 1989-11-03 | 1990-08-07 | Rorer Pharmaceutical Corporation | Benzothiopyranyl derivatives as HMG-CoA reductase inhibitors |
| IT1237793B (it) | 1989-12-21 | 1993-06-17 | Zambon Spa | Composti attivi come inibitori dell'enzima hmg-coa reduttasi |
| US5025000A (en) | 1990-03-02 | 1991-06-18 | E. R. Squibb & Sons, Inc. | Phosphorus-containing HMG-CoA reductase inhibitor compounds |
| US5084287A (en) | 1990-03-15 | 1992-01-28 | Warner-Lambert Company | Pharmaceutically useful micropellets with a drug-coated core and controlled-release polymeric coat |
| US5622985A (en) | 1990-06-11 | 1997-04-22 | Bristol-Myers Squibb Company | Method for preventing a second heart attack employing an HMG CoA reductase inhibitor |
| US5091185A (en) | 1990-06-20 | 1992-02-25 | Monsanto Company | Coated veterinary implants |
| US5112857A (en) | 1990-09-04 | 1992-05-12 | Merck & Co., Inc. | Hmg-coa reductase inhibitor metabolites |
| US5378475A (en) | 1991-02-21 | 1995-01-03 | University Of Kentucky Research Foundation | Sustained release drug delivery devices |
| US5182298A (en) | 1991-03-18 | 1993-01-26 | Merck & Co., Inc. | Cholesterol lowering agents |
| US5654009A (en) | 1991-03-25 | 1997-08-05 | Fujisawa Pharmaceutical Co., Ltd. | Delayed action preparation |
| US5256689A (en) | 1991-05-10 | 1993-10-26 | Merck & Co., Inc. | Cholesterol lowering compounds |
| US5135935A (en) | 1991-05-17 | 1992-08-04 | Merck & Co., Inc. | Squalene synthetase inhibitors |
| US5286497A (en) | 1991-05-20 | 1994-02-15 | Carderm Capital L.P. | Diltiazem formulation |
| US5250435A (en) | 1991-06-04 | 1993-10-05 | Merck & Co., Inc. | Mutant strains of Aspergillus terreus for producing 7-[1,2,6,7,8,8a(R)-hexa-hydro-2(S),6(R)-dimethyl-8(S)-hydroxy-1(S)-naphthyl]-3(R),5(R)-dihydroxyheptanoic acid (triol acid),I) |
| US5202327A (en) | 1991-07-10 | 1993-04-13 | E. R. Squibb & Sons, Inc. | Phosphorus-containing hmg-coa reductase inhibitors |
| DE69223601T2 (de) | 1991-08-19 | 1998-06-18 | Eastman Kodak Co | Photografisches papier mit geringer sauerstoffdurchlässigkeit |
| CA2079509C (en) | 1991-10-01 | 2002-05-14 | Shigeyuki Takada | Prolonged release microparticle preparation and production of the same |
| HU217629B (hu) | 1991-12-12 | 2000-03-28 | Novartis Ag. | Eljárás fluvasztatint tartalmazó stabilizált gyógyszerkészítmények előállítására |
| US5260332A (en) | 1992-02-07 | 1993-11-09 | Merci & Co., Inc. | Cholesterol lowering compounds |
| US5262435A (en) | 1992-02-10 | 1993-11-16 | Merck & Co., Inc. | Cholesterol lowering compounds |
| US5286895A (en) | 1992-02-19 | 1994-02-15 | Merck & Co., Inc. | Cholesterol lowering compounds |
| US5302604A (en) | 1992-03-09 | 1994-04-12 | Merck & Co., Inc. | Cholesterol lowering compounds produced by directed biosynthesis |
| US5369125A (en) | 1992-07-17 | 1994-11-29 | Merck & Co., Inc. | Cholesterol-lowering agents |
| US5283256A (en) | 1992-07-22 | 1994-02-01 | Merck & Co., Inc. | Cholesterol-lowering agents |
| US5922340A (en) | 1992-09-10 | 1999-07-13 | Children's Medical Center Corporation | High load formulations and methods for providing prolonged local anesthesia |
| CA2144407C (en) | 1992-09-10 | 2000-05-30 | Charles B. Berde | Biodegradable polymer matrices for sustained delivery of local anesthetic agents |
| US5700485A (en) | 1992-09-10 | 1997-12-23 | Children's Medical Center Corporation | Prolonged nerve blockade by the combination of local anesthetic and glucocorticoid |
| US5317031A (en) | 1992-10-19 | 1994-05-31 | Merck & Co., Inc. | Cholesterol lowering compounds |
| KR100201352B1 (ko) | 1995-03-16 | 1999-06-15 | 성재갑 | 단일주사 백신 제형 |
| SE505146C2 (sv) | 1995-10-19 | 1997-06-30 | Biogram Ab | Partiklar för fördröjd frisättning |
| US6046187A (en) | 1996-09-16 | 2000-04-04 | Children's Medical Center Corporation | Formulations and methods for providing prolonged local anesthesia |
| ID21762A (id) | 1996-09-24 | 1999-07-22 | Lilly Co Eli | Formulasi partikel bersaput |
| AU7389098A (en) | 1997-05-16 | 1998-12-08 | Brigham And Women's Hospital | Local anesthetic formulations |
| CA2407154A1 (en) | 2000-04-27 | 2001-11-01 | Verion, Inc | Zero order release and temperature-controlled microcapsules and process for the preparation thereof |
| CA2424936A1 (en) | 2000-10-06 | 2002-04-11 | Jagotec Ag | Vaccine composition comprising an immunologically active substance embedded in microparticles consisting of starch with reduced molecular weight |
| FR2816411B1 (fr) | 2000-11-03 | 2003-07-04 | Inst Nat Sante Rech Med | Moyens de detection de la transformation pathologique de la proteine app et leurs applications |
| AR031880A1 (es) | 2000-11-03 | 2003-10-08 | Control Delivery Systems | Dispositivo de liberacion sustentada implantable para administrar localmente un medicamento |
| GB0027357D0 (en) | 2000-11-09 | 2000-12-27 | Bradford Particle Design Plc | Particle formation methods and their products |
| US20030152637A1 (en) | 2001-01-25 | 2003-08-14 | Mark Chasin | Local anesthetic, and method of use |
| EP1408876A4 (en) | 2001-06-22 | 2004-09-22 | Durect Corp | ZERO ORDER COAXIAL IMPLANTS WITH EXTENDED RELEASE |
| EP1585500B8 (en) * | 2002-12-20 | 2017-07-26 | Auritec Pharmaceuticals | Coated particles for sustained-release pharmaceutical administration |
| EP1583519A1 (en) | 2002-12-20 | 2005-10-12 | St. James Associates Llc/Faber Research Series | High pressure compaction for pharmaceutical formulations |
| US20040208833A1 (en) | 2003-02-04 | 2004-10-21 | Elan Pharma International Ltd. | Novel fluticasone formulations |
| US20040191326A1 (en) | 2003-03-31 | 2004-09-30 | Reo Joseph P. | Taste-masking vehicle for coated oxazolidinone particles |
| US7063862B2 (en) | 2003-06-03 | 2006-06-20 | Biokey, Inc. | Pharmaceutical composition and method for treating |
| EP1656199B1 (en) | 2003-07-31 | 2016-01-06 | Sol-Gel Technologies Ltd. | Microcapsules loaded with active ingredients and a method for their preparation |
| CN1856296A (zh) * | 2003-09-30 | 2006-11-01 | 阿库斯菲尔公司 | 可注射的、口服、或局部用缓释药物制剂 |
| US20070224278A1 (en) | 2003-11-12 | 2007-09-27 | Lyons Robert T | Low immunogenicity corticosteroid compositions |
| RU2262355C1 (ru) | 2004-02-09 | 2005-10-20 | Уракова Наталья Александровна | Способ лечения артрита методом внутрисуставной инъекции суспензии лекарственных средств |
| CN1679515A (zh) | 2004-04-06 | 2005-10-12 | 孙永海 | 镇痛药物缓释高分子微球及制备方法 |
| FR2891459B1 (fr) * | 2005-09-30 | 2007-12-28 | Flamel Technologies Sa | Microparticules a liberation modifiee d'au moins un principe actif et forme galenique orale en comprenant |
| US20090082321A1 (en) * | 2007-09-21 | 2009-03-26 | Allergan, Inc. | Steroid containing drug delivery systems |
| WO2008048770A1 (en) | 2006-10-17 | 2008-04-24 | Lipothera, Inc. | Methods, compositions, and formulations for the treatment of thyroid eye disease |
| SE0700404L (sv) | 2007-02-19 | 2008-08-20 | Xylophane Ab | Polymerfilm eller -beläggning innefattande hemicellulosa |
| WO2008119033A1 (en) * | 2007-03-27 | 2008-10-02 | Eurand, Inc. | Pharmaceutical compositions comprising an active substance from the substituted benzhydrylpiperazine family |
| WO2008124634A1 (en) * | 2007-04-04 | 2008-10-16 | Massachusetts Institute Of Technology | Polymer-encapsulated reverse micelles |
| US20080317805A1 (en) * | 2007-06-19 | 2008-12-25 | Mckay William F | Locally administrated low doses of corticosteroids |
| AU2008268222B2 (en) | 2007-06-25 | 2013-12-12 | Otsuka Pharmaceutical Co., Ltd. | Microspheres having core/shell structure |
| US8846068B2 (en) | 2008-04-18 | 2014-09-30 | Warsaw Orthopedic, Inc. | Methods and compositions for treating post-operative pain comprising a local anesthetic |
| US9637840B2 (en) * | 2008-07-18 | 2017-05-02 | Prosonix Limited | Process for improving crystallinity |
| WO2010017265A2 (en) | 2008-08-07 | 2010-02-11 | Calosyn Pharma | Injectable extended release compositions and methods of treating arthritis using same |
| JP2010111592A (ja) * | 2008-11-04 | 2010-05-20 | Aska Pharmaceutical Co Ltd | プロピオン酸フルチカゾンを含む局所投与剤 |
| US20110081420A1 (en) | 2009-10-07 | 2011-04-07 | Zyga Technology, Inc. | Method of forming prolonged-release injectable steroids |
| EP2515864A4 (en) | 2009-12-23 | 2013-09-11 | Psivida Inc | DELAYED RELEASE DELIVERY DEVICES |
| KR101423237B1 (ko) | 2010-05-04 | 2014-07-30 | 주식회사 삼양바이오팜 | 탐스로신 또는 이의 약학적으로 허용 가능한 염을 포함하는 방출 제어용 약학 조성물, 및 이를 포함하는 경구용 제제 |
| UA111162C2 (uk) * | 2010-08-04 | 2016-04-11 | Флекшен Терап'Ютікс, Інк. | Ін'єкційна композиція ацетоніду триамцинолону для лікування болю |
| CN102070895B (zh) | 2010-11-17 | 2013-03-27 | 无锡中科光远生物材料有限公司 | 一种核壳结构微胶囊及其制备方法 |
| JP6083936B2 (ja) | 2011-03-11 | 2017-02-22 | 大阪ガスケミカル株式会社 | 徐放性粒子の製造方法 |
| CA2853965A1 (en) | 2011-11-03 | 2013-05-10 | Gtx, Inc. | Pharmaceutical compositions of selective androgen receptor modulators and methods of use thereof |
| US20150044271A1 (en) | 2012-02-27 | 2015-02-12 | O-Ray Pharma, Inc. | Solid drug implants for intracochlear delivery of therapeutics for the treatment of otic disorders |
| EP3808339B1 (en) | 2012-05-03 | 2025-11-12 | Alcon Inc. | Pharmaceutical nanoparticles showing improved mucosal transport |
| NZ728721A (en) | 2012-05-03 | 2018-05-25 | Kala Pharmaceuticals Inc | Pharmaceutical nanoparticles showing improved mucosal transport |
| US8765725B2 (en) | 2012-05-08 | 2014-07-01 | Aciex Therapeutics, Inc. | Preparations of hydrophobic therapeutic agents, methods of manufacture and use thereof |
| CN105517536B (zh) | 2013-03-21 | 2019-08-16 | 优普顺药物公司美国分部 | 可注射的持续释放组合物及其用于治疗关节炎症及相关疼痛的方法 |
| SG10201902407PA (en) | 2014-09-19 | 2019-04-29 | Eupraxia Pharmaceuticals Inc | Injectable microparticles for hyper-localized release of therapeutic agents |
| US9957233B1 (en) | 2016-08-05 | 2018-05-01 | Calitor Sciences, Llc | Process for preparing substituted quinolin-4-ol compounds |
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