RU2015105786A - Комбинированная терапия ингибиторами igf1r и pi3k - Google Patents
Комбинированная терапия ингибиторами igf1r и pi3k Download PDFInfo
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- RU2015105786A RU2015105786A RU2015105786A RU2015105786A RU2015105786A RU 2015105786 A RU2015105786 A RU 2015105786A RU 2015105786 A RU2015105786 A RU 2015105786A RU 2015105786 A RU2015105786 A RU 2015105786A RU 2015105786 A RU2015105786 A RU 2015105786A
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- Prior art keywords
- cancer
- inhibitor
- igf1r
- seq
- amino acid
- Prior art date
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- 102100039688 Insulin-like growth factor 1 receptor Human genes 0.000 title claims abstract 24
- 229940043441 phosphoinositide 3-kinase inhibitor Drugs 0.000 title claims abstract 20
- 239000012828 PI3K inhibitor Substances 0.000 title claims abstract 14
- 101001034652 Homo sapiens Insulin-like growth factor 1 receptor Proteins 0.000 title 1
- 238000002648 combination therapy Methods 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 claims abstract 29
- 201000011510 cancer Diseases 0.000 claims abstract 19
- 125000003275 alpha amino acid group Chemical group 0.000 claims abstract 18
- 239000003112 inhibitor Substances 0.000 claims abstract 17
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims abstract 9
- 150000001875 compounds Chemical class 0.000 claims abstract 8
- 239000002935 phosphatidylinositol 3 kinase inhibitor Substances 0.000 claims abstract 6
- 150000003839 salts Chemical class 0.000 claims abstract 6
- OAWXZFGKDDFTGS-BYPYZUCNSA-N (2s)-pyrrolidine-1,2-dicarboxylic acid Chemical compound OC(=O)[C@@H]1CCCN1C(O)=O OAWXZFGKDDFTGS-BYPYZUCNSA-N 0.000 claims abstract 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims abstract 3
- 102000038030 PI3Ks Human genes 0.000 claims abstract 3
- 108091007960 PI3Ks Proteins 0.000 claims abstract 3
- 230000002401 inhibitory effect Effects 0.000 claims abstract 3
- ZWVZORIKUNOTCS-OAQYLSRUSA-N chembl401930 Chemical compound C1([C@H](O)CNC2=C(C(NC=C2)=O)C=2NC=3C=C(C=C(C=3N=2)C)N2CCOCC2)=CC=CC(Cl)=C1 ZWVZORIKUNOTCS-OAQYLSRUSA-N 0.000 claims 21
- 238000000034 method Methods 0.000 claims 21
- 206010006187 Breast cancer Diseases 0.000 claims 8
- 208000026310 Breast neoplasm Diseases 0.000 claims 8
- 206010033128 Ovarian cancer Diseases 0.000 claims 4
- 208000032839 leukemia Diseases 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 230000035772 mutation Effects 0.000 claims 4
- 206010060971 Astrocytoma malignant Diseases 0.000 claims 3
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- 208000032612 Glial tumor Diseases 0.000 claims 2
- 101000605639 Homo sapiens Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Proteins 0.000 claims 2
- 206010025557 Malignant fibrous histiocytoma of bone Diseases 0.000 claims 2
- 208000033761 Myelogenous Chronic BCR-ABL Positive Leukemia Diseases 0.000 claims 2
- 102100038332 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Human genes 0.000 claims 2
- 201000000582 Retinoblastoma Diseases 0.000 claims 2
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 2
- 230000001154 acute effect Effects 0.000 claims 2
- 230000003321 amplification Effects 0.000 claims 2
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- 239000002552 dosage form Substances 0.000 claims 2
- 229940121647 egfr inhibitor Drugs 0.000 claims 2
- 238000009472 formulation Methods 0.000 claims 2
- 201000007116 gestational trophoblastic neoplasm Diseases 0.000 claims 2
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- 208000003174 Brain Neoplasms Diseases 0.000 claims 1
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- 208000032027 Essential Thrombocythemia Diseases 0.000 claims 1
- 206010017533 Fungal infection Diseases 0.000 claims 1
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- 206010021042 Hypopharyngeal cancer Diseases 0.000 claims 1
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- 208000007766 Kaposi sarcoma Diseases 0.000 claims 1
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- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 claims 1
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- 208000007571 Ovarian Epithelial Carcinoma Diseases 0.000 claims 1
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- 208000000821 Parathyroid Neoplasms Diseases 0.000 claims 1
- 206010050487 Pinealoblastoma Diseases 0.000 claims 1
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- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 208000008601 Polycythemia Diseases 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 208000004337 Salivary Gland Neoplasms Diseases 0.000 claims 1
- 206010061934 Salivary gland cancer Diseases 0.000 claims 1
- 206010039491 Sarcoma Diseases 0.000 claims 1
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- 208000024770 Thyroid neoplasm Diseases 0.000 claims 1
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- 230000003187 abdominal effect Effects 0.000 claims 1
- 208000009621 actinic keratosis Diseases 0.000 claims 1
- 208000020990 adrenal cortex carcinoma Diseases 0.000 claims 1
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- 201000002143 bronchus adenoma Diseases 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
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- 208000032852 chronic lymphocytic leukemia Diseases 0.000 claims 1
- 210000001072 colon Anatomy 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 201000002758 colorectal adenoma Diseases 0.000 claims 1
- 201000007241 cutaneous T cell lymphoma Diseases 0.000 claims 1
- 208000017763 cutaneous neuroendocrine carcinoma Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 201000008184 embryoma Diseases 0.000 claims 1
- 201000004101 esophageal cancer Diseases 0.000 claims 1
- 210000002603 extrahepatic bile duct Anatomy 0.000 claims 1
- 201000008819 extrahepatic bile duct carcinoma Diseases 0.000 claims 1
- 230000002538 fungal effect Effects 0.000 claims 1
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- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 1
- 201000000334 ureter transitional cell carcinoma Diseases 0.000 claims 1
- 210000003932 urinary bladder Anatomy 0.000 claims 1
- 210000004291 uterus Anatomy 0.000 claims 1
- 210000001215 vagina Anatomy 0.000 claims 1
- 230000004400 visual pathway Effects 0.000 claims 1
- 210000000239 visual pathway Anatomy 0.000 claims 1
- 101710184277 Insulin-like growth factor 1 receptor Proteins 0.000 abstract 4
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261673809P | 2012-07-20 | 2012-07-20 | |
| US61/673,809 | 2012-07-20 | ||
| US201361759490P | 2013-02-01 | 2013-02-01 | |
| US61/759,490 | 2013-02-01 | ||
| PCT/US2013/051345 WO2014015280A1 (en) | 2012-07-20 | 2013-07-19 | Combination therapy of inhibitors for igf1 r and pi3k |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2015105786A true RU2015105786A (ru) | 2016-09-10 |
Family
ID=48875809
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2015105786A RU2015105786A (ru) | 2012-07-20 | 2013-07-19 | Комбинированная терапия ингибиторами igf1r и pi3k |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US8980259B2 (enExample) |
| EP (1) | EP2875050A1 (enExample) |
| JP (1) | JP2015524414A (enExample) |
| KR (1) | KR20150041783A (enExample) |
| CN (1) | CN104822703A (enExample) |
| AU (1) | AU2013292298A1 (enExample) |
| BR (1) | BR112015001212A2 (enExample) |
| CA (1) | CA2879219A1 (enExample) |
| MX (1) | MX2015000746A (enExample) |
| RU (1) | RU2015105786A (enExample) |
| WO (1) | WO2014015280A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20150002623A (ko) * | 2012-03-30 | 2015-01-07 | 노파르티스 아게 | 신경모세포종, 유잉 육종 또는 횡문근육종의 치료에 사용하기 위한 화합물 |
| EP3104890A1 (en) * | 2014-02-11 | 2016-12-21 | Novartis AG | Pharmaceutical combinations comprising a pi3k inhibitor for the treatment of cancer |
| CN107250108B (zh) | 2015-02-05 | 2020-11-27 | 特尔诺沃有限公司 | 用于治疗癌症的irs/stat3双重调节剂与抗癌剂的组合 |
| EP3294417B1 (en) * | 2015-05-08 | 2021-10-13 | Memorial Sloan Kettering Cancer Center | Compositions and methods for treatment of glioma |
| CN107573416A (zh) * | 2016-06-30 | 2018-01-12 | 中国科学院深圳先进技术研究院 | 抗igf1r和cd3特异性双靶向抗体、含该双靶向抗体表达盒的微环dna及应用 |
| TW201815787A (zh) | 2016-09-23 | 2018-05-01 | 美商基利科學股份有限公司 | 磷脂醯肌醇3-激酶抑制劑 |
| TW201825465A (zh) | 2016-09-23 | 2018-07-16 | 美商基利科學股份有限公司 | 磷脂醯肌醇3-激酶抑制劑 |
| TW201813963A (zh) | 2016-09-23 | 2018-04-16 | 美商基利科學股份有限公司 | 磷脂醯肌醇3-激酶抑制劑 |
| CN113512116B (zh) * | 2020-04-10 | 2022-09-20 | 苏州普乐康医药科技有限公司 | 一种抗igf-1r抗体及其应用 |
| CN116925023B (zh) * | 2023-07-18 | 2025-11-21 | 江苏桐孚高新材料有限公司 | 2-全氟烷基-4h-吡喃-4-酮衍生物的改进合成方法 |
Family Cites Families (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5595756A (en) * | 1993-12-22 | 1997-01-21 | Inex Pharmaceuticals Corporation | Liposomal compositions for enhanced retention of bioactive agents |
| FR2714383B1 (fr) | 1993-12-29 | 1996-02-09 | Centre Nat Rech Scient | Contrôle de l'expression de gènes. |
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-
2013
- 2013-03-13 US US13/799,076 patent/US8980259B2/en active Active
- 2013-07-19 RU RU2015105786A patent/RU2015105786A/ru not_active Application Discontinuation
- 2013-07-19 MX MX2015000746A patent/MX2015000746A/es unknown
- 2013-07-19 BR BR112015001212A patent/BR112015001212A2/pt not_active IP Right Cessation
- 2013-07-19 CN CN201380038110.0A patent/CN104822703A/zh active Pending
- 2013-07-19 EP EP13742142.6A patent/EP2875050A1/en not_active Withdrawn
- 2013-07-19 WO PCT/US2013/051345 patent/WO2014015280A1/en not_active Ceased
- 2013-07-19 JP JP2015523289A patent/JP2015524414A/ja active Pending
- 2013-07-19 AU AU2013292298A patent/AU2013292298A1/en not_active Abandoned
- 2013-07-19 KR KR1020157003218A patent/KR20150041783A/ko not_active Withdrawn
- 2013-07-19 CA CA2879219A patent/CA2879219A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20140023661A1 (en) | 2014-01-23 |
| MX2015000746A (es) | 2015-09-10 |
| EP2875050A1 (en) | 2015-05-27 |
| CN104822703A (zh) | 2015-08-05 |
| AU2013292298A1 (en) | 2015-02-05 |
| WO2014015280A1 (en) | 2014-01-23 |
| CA2879219A1 (en) | 2014-01-23 |
| JP2015524414A (ja) | 2015-08-24 |
| KR20150041783A (ko) | 2015-04-17 |
| US8980259B2 (en) | 2015-03-17 |
| BR112015001212A2 (pt) | 2017-08-01 |
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| Date | Code | Title | Description |
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| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
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