RU2014133547A - Способы применения модуляторов fgf19 - Google Patents
Способы применения модуляторов fgf19 Download PDFInfo
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- RU2014133547A RU2014133547A RU2014133547A RU2014133547A RU2014133547A RU 2014133547 A RU2014133547 A RU 2014133547A RU 2014133547 A RU2014133547 A RU 2014133547A RU 2014133547 A RU2014133547 A RU 2014133547A RU 2014133547 A RU2014133547 A RU 2014133547A
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- Prior art keywords
- individual
- bile acid
- biomarkers
- levels
- fgf19
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- 102100031734 Fibroblast growth factor 19 Human genes 0.000 title claims abstract 41
- 101000846394 Homo sapiens Fibroblast growth factor 19 Proteins 0.000 title claims abstract 41
- 238000000034 method Methods 0.000 claims abstract 59
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract 48
- 239000003613 bile acid Substances 0.000 claims abstract 47
- HSINOMROUCMIEA-FGVHQWLLSA-N (2s,4r)-4-[(3r,5s,6r,7r,8s,9s,10s,13r,14s,17r)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]-2-methylpentanoic acid Chemical compound C([C@@]12C)C[C@@H](O)C[C@H]1[C@@H](CC)[C@@H](O)[C@@H]1[C@@H]2CC[C@]2(C)[C@@H]([C@H](C)C[C@H](C)C(O)=O)CC[C@H]21 HSINOMROUCMIEA-FGVHQWLLSA-N 0.000 claims abstract 45
- 239000000090 biomarker Substances 0.000 claims abstract 38
- 230000004060 metabolic process Effects 0.000 claims abstract 38
- 238000011282 treatment Methods 0.000 claims abstract 25
- 201000010099 disease Diseases 0.000 claims abstract 24
- 208000035475 disorder Diseases 0.000 claims abstract 24
- 125000003275 alpha amino acid group Chemical group 0.000 claims 11
- 239000005557 antagonist Substances 0.000 claims 5
- 231100000419 toxicity Toxicity 0.000 claims 5
- 230000001988 toxicity Effects 0.000 claims 5
- 102000004190 Enzymes Human genes 0.000 claims 3
- 108090000790 Enzymes Proteins 0.000 claims 3
- 230000000694 effects Effects 0.000 claims 3
- 210000004185 liver Anatomy 0.000 claims 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 101710169336 5'-deoxyadenosine deaminase Proteins 0.000 claims 2
- 102000055025 Adenosine deaminases Human genes 0.000 claims 2
- 102100036475 Alanine aminotransferase 1 Human genes 0.000 claims 2
- 108010082126 Alanine transaminase Proteins 0.000 claims 2
- 108010003415 Aspartate Aminotransferases Proteins 0.000 claims 2
- 102000004625 Aspartate Aminotransferases Human genes 0.000 claims 2
- 108091035707 Consensus sequence Proteins 0.000 claims 2
- 101710107035 Gamma-glutamyltranspeptidase Proteins 0.000 claims 2
- 101710173228 Glutathione hydrolase proenzyme Proteins 0.000 claims 2
- 108091007491 NSP3 Papain-like protease domains Proteins 0.000 claims 2
- 102000012086 alpha-L-Fucosidase Human genes 0.000 claims 2
- 108010061314 alpha-L-Fucosidase Proteins 0.000 claims 2
- 102000006640 gamma-Glutamyltransferase Human genes 0.000 claims 2
- 230000002062 proliferating effect Effects 0.000 claims 2
- 210000002966 serum Anatomy 0.000 claims 2
- 231100000331 toxic Toxicity 0.000 claims 2
- 230000002588 toxic effect Effects 0.000 claims 2
- 102100028162 ATP-binding cassette sub-family C member 3 Human genes 0.000 claims 1
- 102100028282 Bile salt export pump Human genes 0.000 claims 1
- 206010012735 Diarrhoea Diseases 0.000 claims 1
- 102000004641 Fetal Proteins Human genes 0.000 claims 1
- 108010003471 Fetal Proteins Proteins 0.000 claims 1
- 102100027844 Fibroblast growth factor receptor 4 Human genes 0.000 claims 1
- 101000986633 Homo sapiens ATP-binding cassette sub-family C member 3 Proteins 0.000 claims 1
- 101000917134 Homo sapiens Fibroblast growth factor receptor 4 Proteins 0.000 claims 1
- SMEROWZSTRWXGI-UHFFFAOYSA-N Lithocholsaeure Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)CC2 SMEROWZSTRWXGI-UHFFFAOYSA-N 0.000 claims 1
- -1 MRP2 Proteins 0.000 claims 1
- 108010093662 Member 11 Subfamily B ATP Binding Cassette Transporter Proteins 0.000 claims 1
- 101001122350 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial Proteins 0.000 claims 1
- 238000008050 Total Bilirubin Reagent Methods 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 230000018044 dehydration Effects 0.000 claims 1
- 238000006297 dehydration reaction Methods 0.000 claims 1
- KXGVEGMKQFWNSR-LLQZFEROSA-N deoxycholic acid Chemical compound C([C@H]1CC2)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)[C@@H](O)C1 KXGVEGMKQFWNSR-LLQZFEROSA-N 0.000 claims 1
- 229960003964 deoxycholic acid Drugs 0.000 claims 1
- KXGVEGMKQFWNSR-UHFFFAOYSA-N deoxycholic acid Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)C(O)C2 KXGVEGMKQFWNSR-UHFFFAOYSA-N 0.000 claims 1
- 230000037406 food intake Effects 0.000 claims 1
- 235000012631 food intake Nutrition 0.000 claims 1
- 230000002209 hydrophobic effect Effects 0.000 claims 1
- SMEROWZSTRWXGI-HVATVPOCSA-N lithocholic acid Chemical compound C([C@H]1CC2)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)CC1 SMEROWZSTRWXGI-HVATVPOCSA-N 0.000 claims 1
- 238000005457 optimization Methods 0.000 claims 1
- 108091033319 polynucleotide Proteins 0.000 claims 1
- 102000040430 polynucleotide Human genes 0.000 claims 1
- 239000002157 polynucleotide Substances 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 231100000272 reduced body weight Toxicity 0.000 claims 1
- 238000012502 risk assessment Methods 0.000 claims 1
- 208000026775 severe diarrhea Diseases 0.000 claims 1
- 150000003384 small molecules Chemical class 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 230000003247 decreasing effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Wood Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Zoology (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Endocrinology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Steroid Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261587885P | 2012-01-18 | 2012-01-18 | |
| US61/587,885 | 2012-01-18 | ||
| PCT/US2013/022103 WO2013109856A2 (en) | 2012-01-18 | 2013-01-18 | Methods of using fgf19 modulators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2014133547A true RU2014133547A (ru) | 2016-03-10 |
Family
ID=47604273
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2014133547A RU2014133547A (ru) | 2012-01-18 | 2013-01-18 | Способы применения модуляторов fgf19 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US20130183294A1 (enExample) |
| EP (1) | EP2804630B1 (enExample) |
| JP (2) | JP2015506944A (enExample) |
| KR (1) | KR20140119114A (enExample) |
| CN (1) | CN104168920A (enExample) |
| BR (1) | BR112014017626A2 (enExample) |
| CA (1) | CA2862424A1 (enExample) |
| HK (1) | HK1201199A1 (enExample) |
| MX (1) | MX2014008699A (enExample) |
| RU (1) | RU2014133547A (enExample) |
| WO (1) | WO2013109856A2 (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103649127B (zh) | 2011-07-01 | 2021-03-19 | 恩格姆生物制药公司 | 用于代谢病症和疾病治疗的组合物、应用和方法 |
| US9290557B2 (en) | 2012-11-28 | 2016-03-22 | Ngm Biopharmaceuticals, Inc. | Compositions comprising variants and fusions of FGF19 polypeptides |
| HK1214832A1 (zh) | 2012-11-28 | 2016-08-05 | 恩格姆生物制药公司 | 用於代謝病症和疾病治療的組合物和方法 |
| US9273107B2 (en) | 2012-12-27 | 2016-03-01 | Ngm Biopharmaceuticals, Inc. | Uses and methods for modulating bile acid homeostasis and treatment of bile acid disorders and diseases |
| RU2675514C2 (ru) | 2012-12-27 | 2018-12-19 | ЭнДжиЭм БАЙОФАРМАСЬЮТИКАЛЗ, ИНК. | Способы модуляции гомеостаза желчных кислот и лечение расстройств и заболеваний, ассоциированных с желчными кислотами |
| HUE039268T2 (hu) | 2013-10-18 | 2018-12-28 | Eisai R&D Man Co Ltd | Pirimidin FGFR4 inhibitorok |
| WO2015061421A1 (en) * | 2013-10-22 | 2015-04-30 | Metselex, Inc. | Deuterated bile acids |
| CN113769114A (zh) * | 2013-10-28 | 2021-12-10 | 恩格姆生物制药公司 | 癌症模型及相关方法 |
| US9566315B2 (en) * | 2013-11-01 | 2017-02-14 | Oregon Health & Science University | Normalization of the enterohepatic circulation in animals with a chimeric humanized liver |
| LT3097122T (lt) | 2014-01-24 | 2020-07-27 | Ngm Biopharmaceuticals, Inc. | Antikūnai, surišantys beta kloto domeną 2, ir jų panaudojimo būdai |
| WO2015183890A2 (en) | 2014-05-28 | 2015-12-03 | Ngm Biopharmaceuticals, Inc. | Methods and compositions for the treatment of metabolic disorders and diseases |
| CA2951153A1 (en) | 2014-06-16 | 2015-12-23 | Ngm Biopharmaceuticals, Inc. | Methods and uses for modulating bile acid homeostasis and treatment of bile acid disorders and diseases |
| GB201416015D0 (en) * | 2014-09-10 | 2014-10-22 | Univ Warwick | Biomarker |
| JP6949711B2 (ja) | 2014-10-23 | 2021-10-20 | エヌジーエム バイオファーマシューティカルス，インコーポレーテッド | ペプチドバリアントを含む医薬組成物及びその使用方法 |
| US10434144B2 (en) | 2014-11-07 | 2019-10-08 | Ngm Biopharmaceuticals, Inc. | Methods for treatment of bile acid-related disorders and prediction of clinical sensitivity to treatment of bile acid-related disorders |
| EP3283465B1 (en) | 2015-04-14 | 2021-01-06 | Eisai R&D Management Co., Ltd. | Crystalline fgfr4 inhibitor compound and uses thereof |
| US10800843B2 (en) | 2015-07-29 | 2020-10-13 | Ngm Biopharmaceuticals, Inc. | Beta klotho-binding proteins |
| AU2016353988B2 (en) | 2015-11-09 | 2019-09-26 | Ngm Biopharmaceuticals, Inc. | Methods for treatment of bile acid-related disorders |
| US11357769B2 (en) | 2016-05-10 | 2022-06-14 | Eisai R&D Management Co., Ltd. | Drug combinations for reducing cell viability and/or cell proliferation |
| AU2017315459B2 (en) | 2016-08-26 | 2023-06-29 | Ngm Biopharmaceuticals, Inc. | Methods of treating fibroblast growth factor 19-mediated cancers and tumors |
| CN109709220B (zh) * | 2017-10-25 | 2021-09-17 | 中国科学院大连化学物理研究所 | 一种用于诊断膀胱癌的联合标志物及试剂盒和应用 |
| CN109722480B (zh) * | 2018-05-17 | 2022-04-26 | 上海交通大学 | 一种非小细胞肺癌检测试剂盒及其应用 |
| JP7193114B2 (ja) * | 2018-08-29 | 2022-12-20 | 学校法人同志社 | 胆汁酸サイクルの観察方法 |
| CN110558256B (zh) * | 2019-10-09 | 2020-06-26 | 中国水产科学研究院黄海水产研究所 | 一种程序化调控红鳍东方鲀胆汁酸分泌的营养学方法 |
| CN114106161A (zh) * | 2020-08-28 | 2022-03-01 | 安源医药科技（上海）有限公司 | 针对SARS-CoV-2冠状病毒S蛋白的抗体及其用途 |
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-
2013
- 2013-01-18 US US13/745,647 patent/US20130183294A1/en not_active Abandoned
- 2013-01-18 KR KR1020147022466A patent/KR20140119114A/ko not_active Ceased
- 2013-01-18 JP JP2014553444A patent/JP2015506944A/ja not_active Withdrawn
- 2013-01-18 BR BR112014017626A patent/BR112014017626A2/pt not_active IP Right Cessation
- 2013-01-18 MX MX2014008699A patent/MX2014008699A/es unknown
- 2013-01-18 EP EP13701354.6A patent/EP2804630B1/en not_active Not-in-force
- 2013-01-18 CN CN201380014996.5A patent/CN104168920A/zh active Pending
- 2013-01-18 RU RU2014133547A patent/RU2014133547A/ru not_active Application Discontinuation
- 2013-01-18 WO PCT/US2013/022103 patent/WO2013109856A2/en not_active Ceased
- 2013-01-18 HK HK15101805.6A patent/HK1201199A1/xx unknown
- 2013-01-18 CA CA2862424A patent/CA2862424A1/en not_active Abandoned
-
2017
- 2017-05-30 US US15/608,603 patent/US20170342488A1/en not_active Abandoned
- 2017-10-04 JP JP2017194423A patent/JP2018065787A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO2013109856A3 (en) | 2013-11-14 |
| CA2862424A1 (en) | 2013-07-25 |
| KR20140119114A (ko) | 2014-10-08 |
| BR112014017626A2 (pt) | 2018-05-22 |
| MX2014008699A (es) | 2014-11-21 |
| WO2013109856A2 (en) | 2013-07-25 |
| EP2804630B1 (en) | 2017-10-18 |
| CN104168920A (zh) | 2014-11-26 |
| JP2015506944A (ja) | 2015-03-05 |
| JP2018065787A (ja) | 2018-04-26 |
| US20130183294A1 (en) | 2013-07-18 |
| HK1201199A1 (en) | 2015-08-28 |
| US20170342488A1 (en) | 2017-11-30 |
| EP2804630A2 (en) | 2014-11-26 |
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