JP2021510697A5 - - Google Patents

Info

Publication number
JP2021510697A5
JP2021510697A5 JP2020538637A JP2020538637A JP2021510697A5 JP 2021510697 A5 JP2021510697 A5 JP 2021510697A5 JP 2020538637 A JP2020538637 A JP 2020538637A JP 2020538637 A JP2020538637 A JP 2020538637A JP 2021510697 A5 JP2021510697 A5 JP 2021510697A5
Authority
JP
Japan
Prior art keywords
antibody
pharmaceutical composition
variable region
chain variable
seq
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2020538637A
Other languages
English (en)
Japanese (ja)
Other versions
JP2021510697A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2019/013134 external-priority patent/WO2019140150A1/en
Publication of JP2021510697A publication Critical patent/JP2021510697A/ja
Publication of JP2021510697A5 publication Critical patent/JP2021510697A5/ja
Priority to JP2023202998A priority Critical patent/JP2024028805A/ja
Pending legal-status Critical Current

Links

JP2020538637A 2018-01-12 2019-01-11 がん処置のための坑il−8抗体及び坑pd−1抗体を用いる組合せ治療 Pending JP2021510697A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2023202998A JP2024028805A (ja) 2018-01-12 2023-11-30 がん処置のための坑il-8抗体及び坑pd-1抗体を用いる組合せ治療

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201862616716P 2018-01-12 2018-01-12
US62/616,716 2018-01-12
US201862650047P 2018-03-29 2018-03-29
US62/650,047 2018-03-29
US201862679412P 2018-06-01 2018-06-01
US62/679,412 2018-06-01
PCT/US2019/013134 WO2019140150A1 (en) 2018-01-12 2019-01-11 Combination therapy with anti-il-8 antibodies and anti-pd-1 antibodies for treating cancer

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2023202998A Division JP2024028805A (ja) 2018-01-12 2023-11-30 がん処置のための坑il-8抗体及び坑pd-1抗体を用いる組合せ治療

Publications (2)

Publication Number Publication Date
JP2021510697A JP2021510697A (ja) 2021-04-30
JP2021510697A5 true JP2021510697A5 (enExample) 2022-02-07

Family

ID=65279657

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2020538637A Pending JP2021510697A (ja) 2018-01-12 2019-01-11 がん処置のための坑il−8抗体及び坑pd−1抗体を用いる組合せ治療
JP2023202998A Withdrawn JP2024028805A (ja) 2018-01-12 2023-11-30 がん処置のための坑il-8抗体及び坑pd-1抗体を用いる組合せ治療

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2023202998A Withdrawn JP2024028805A (ja) 2018-01-12 2023-11-30 がん処置のための坑il-8抗体及び坑pd-1抗体を用いる組合せ治療

Country Status (12)

Country Link
US (2) US11572405B2 (enExample)
EP (1) EP3737696A1 (enExample)
JP (2) JP2021510697A (enExample)
KR (1) KR20200108868A (enExample)
CN (1) CN111770936A (enExample)
AU (1) AU2019207812A1 (enExample)
BR (1) BR112020013144A2 (enExample)
CA (1) CA3084370A1 (enExample)
IL (1) IL275940A (enExample)
MX (1) MX2020006171A (enExample)
SG (1) SG11202005323SA (enExample)
WO (1) WO2019140150A1 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HK1203971A1 (en) 2012-05-15 2015-11-06 Bristol-Myers Squibb Company Cancer immunotherapy by disrupting pd-1/pd-l1 signaling
JP2018514550A (ja) 2015-04-28 2018-06-07 ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company 抗pd−1抗体および抗ctla−4抗体を使用するpd−l1陰性黒色腫の処置
US20210206854A1 (en) * 2016-01-27 2021-07-08 Bristol-Myers Squibb Company Treatment of lung cancer using a combination of an anti-pd-1 antibody and another anti-cancer agent
CA3084370A1 (en) 2018-01-12 2019-07-18 Bristol-Myers Squibb Company Combination therapy with anti-il-8 antibodies and anti-pd-1 antibodies for treating cancer
WO2021202959A1 (en) * 2020-04-03 2021-10-07 Genentech, Inc. Therapeutic and diagnostic methods for cancer
AR122043A1 (es) * 2020-05-12 2022-08-03 Bristol Myers Squibb Co Dosificación y administración del anticuerpo anti-ctla-4 activable
WO2022063947A1 (en) * 2020-09-24 2022-03-31 Vib Vzw Combination of p2y6 inhibitors and immune checkpoint inhibitors
CN117222436A (zh) * 2020-12-11 2023-12-12 上海锦斯生物技术有限公司 一种经修饰的溶瘤病毒、包含经修饰的溶瘤病毒的组合物及其用途
WO2023192478A1 (en) * 2022-04-01 2023-10-05 Bristol-Myers Squibb Company Combination therapy with anti-il-8 antibodies and anti-pd-1 antibodies for treating cancer
CN119497573A (zh) * 2022-07-29 2025-02-21 金凤实验室 一种表达il-8的非人哺乳动物模型及其用途

Family Cites Families (101)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4376110A (en) 1980-08-04 1983-03-08 Hybritech, Incorporated Immunometric assays using monoclonal antibodies
US5204244A (en) 1987-10-27 1993-04-20 Oncogen Production of chimeric antibodies by homologous recombination
US5652338A (en) 1988-03-16 1997-07-29 The United States Of America As Represented By The Department Of Health And Human Services Neutrophil chemotactic factor
DE68920321T2 (de) 1988-05-02 1995-05-24 Us Health Verfahren zur herstellung eines menschlichen "neutrophil chemotactic factor"-polypeptids.
KR100197110B1 (ko) 1988-08-29 1999-06-15 로버트 란만 활성 사람 호중구 화학주성 인자 폴리펩티드의 제조방법
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
GB8823869D0 (en) 1988-10-12 1988-11-16 Medical Res Council Production of antibodies
US5175384A (en) 1988-12-05 1992-12-29 Genpharm International Transgenic mice depleted in mature t-cells and methods for making transgenic mice
US5427098A (en) 1988-12-22 1995-06-27 Biofield Corp. Noninvasive method for determining treatment based upon lesion cell proliferation measurements
GB8909218D0 (en) 1989-04-22 1989-06-07 Medical Res Council Improvements in or relating to enhancers
WO1991000906A1 (en) 1989-07-12 1991-01-24 Genetics Institute, Inc. Chimeric and transgenic animals capable of producing human antibodies
US6075181A (en) 1990-01-12 2000-06-13 Abgenix, Inc. Human antibodies derived from immunized xenomice
US6673986B1 (en) 1990-01-12 2004-01-06 Abgenix, Inc. Generation of xenogeneic antibodies
WO1996033735A1 (en) 1995-04-27 1996-10-31 Abgenix, Inc. Human antibodies derived from immunized xenomice
US6150584A (en) 1990-01-12 2000-11-21 Abgenix, Inc. Human antibodies derived from immunized xenomice
DE69120146T2 (de) 1990-01-12 1996-12-12 Cell Genesys Inc Erzeugung xenogener antikörper
ATE158021T1 (de) 1990-08-29 1997-09-15 Genpharm Int Produktion und nützung nicht-menschliche transgentiere zur produktion heterologe antikörper
US5770429A (en) 1990-08-29 1998-06-23 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US6300129B1 (en) 1990-08-29 2001-10-09 Genpharm International Transgenic non-human animals for producing heterologous antibodies
IE913192A1 (en) 1990-09-12 1992-02-25 Scripps Research Inst Active site of interleukin-8: polypeptide analogs and¹antibodies
US5780279A (en) 1990-12-03 1998-07-14 Genentech, Inc. Method of selection of proteolytic cleavage sites by directed evolution and phagemid display
CA2095633C (en) 1990-12-03 2003-02-04 Lisa J. Garrard Enrichment method for variant proteins with altered binding properties
US5440021A (en) 1991-03-29 1995-08-08 Chuntharapai; Anan Antibodies to human IL-8 type B receptor
US5776457A (en) 1991-03-29 1998-07-07 Genentech, Inc. Antibodies to human PF4A receptor and compositions thereof
ATE194385T1 (de) 1991-03-29 2000-07-15 Genentech Inc Menschliche pf4a rezeptoren und ihre verwendung
US5840856A (en) 1991-03-29 1998-11-24 Genentech, Inc. Antibodies to a human PF4 superfamily receptor
US5571702A (en) 1991-03-29 1996-11-05 Genentech, Inc. Amplification method for detection of human PF4A receptors
US5919896A (en) 1991-03-29 1999-07-06 Genentech, Inc. PF4A receptor
US5543503A (en) 1991-03-29 1996-08-06 Genentech Inc. Antibodies to human IL-8 type A receptor
US6087475A (en) 1991-12-19 2000-07-11 Genentech, Inc. PF4A receptor
ES2301158T3 (es) 1992-07-24 2008-06-16 Amgen Fremont Inc. Produccion de anticuerpos xenogenicos.
US5508717A (en) 1992-07-28 1996-04-16 Sony Corporation Computer pointing device with dynamic sensitivity
US6200558B1 (en) 1993-09-14 2001-03-13 The United States Of America As Represented By The Department Of Health And Human Services Biopolymer-bound nitric oxide-releasing compositions, pharmaceutical compositions incorporating same and methods of treating biological disorders using same
JPH08509612A (ja) 1993-04-26 1996-10-15 ジェンファーム インターナショナル インコーポレイテッド 異種抗体を産生することができるトランスジェニック非ヒト動物
US6448379B1 (en) 1993-09-14 2002-09-10 Chiron Corporation IL8 inhibitors
US5707622A (en) 1994-03-03 1998-01-13 Genentech, Inc. Methods for treating ulcerative colitis
US5874080A (en) 1994-03-03 1999-02-23 Genentech, Inc. Anti-IL-8 monoclonal antibodies for treatment of asthma
AU2466095A (en) 1994-04-28 1995-11-29 Music Vending, Inc. Music vending system
DE69535243T2 (de) 1994-07-13 2007-05-10 Chugai Seiyaku K.K. Gegen menschliches interleukin-8 gerichteter, rekonstituierter menschlicher antikörper
US5707621A (en) 1994-08-31 1998-01-13 Chugai Pharmaceutical Co., Ltd. Supression of nephritis-induced protein excretion by anti-IL-8
EP0806962A4 (en) 1995-01-23 2001-01-10 Univ California Methods for the treatment of acid aspiration-induced acute lung injury
WO1997039772A1 (fr) 1996-04-19 1997-10-30 Chugai Seiyaku Kabushiki Kaisha Remede contre l'arthrite rhumatoide contenant un anticorps anti-il-8 comme principe actif
US6497878B1 (en) 1996-04-23 2002-12-24 Chugai Seiyaku Kabushiki Kaisha Treatment of cerebral disorders by inhibition of IL-8 binding to receptor
WO1997049426A1 (fr) 1996-06-26 1997-12-31 Chugai Seiyaku Kabushiki Kaisha Medicaments destines aux lesions pulmonaires aigues dues a des causes indirectes, contenant un anticorps anti-il-8 comme principe actif
AU3048797A (en) 1996-10-22 1998-05-15 Chugai Seiyaku Kabushiki Kaisha Sepsis remedy comprising anti-il-8 antibody as active ingredient
US6870033B1 (en) 1997-02-21 2005-03-22 Genentech, Inc. Antibody fragment-polymer conjugates and humanized anti-IL-8 monoclonal antibodies
CN1068524C (zh) 1997-06-23 2001-07-18 叶庆炜 一种治疗顽症牛皮癣的药物
WO1999037779A1 (en) 1998-01-22 1999-07-29 Genentech, Inc. Antibody fragment-polymer conjugates and humanized anti-il-8 monoclonal antibodies and uses of same
EP1105427A2 (en) 1998-08-17 2001-06-13 Abgenix, Inc. Generation of modified molecules with increased serum half-lives
US6682736B1 (en) 1998-12-23 2004-01-27 Abgenix, Inc. Human monoclonal antibodies to CTLA-4
US6177077B1 (en) 1999-02-24 2001-01-23 Edward L. Tobinick TNT inhibitors for the treatment of neurological disorders
US6419944B2 (en) 1999-02-24 2002-07-16 Edward L. Tobinick Cytokine antagonists for the treatment of localized disorders
US6419934B1 (en) 1999-02-24 2002-07-16 Edward L. Tobinick TNF modulators for treating neurological disorders associated with viral infection
US6423321B2 (en) 1999-02-24 2002-07-23 Edward L. Tobinick Cytokine antagonists for the treatment of sensorineural hearing loss
US6015557A (en) 1999-02-24 2000-01-18 Tobinick; Edward L. Tumor necrosis factor antagonists for the treatment of neurological disorders
IL129180A0 (en) 1999-03-25 2000-02-17 Technion Res & Dev Foundation Method and pharmaceutical composition for wound healing
PL354286A1 (en) 1999-08-23 2003-12-29 Dana-Farber Cancer Institutedana-Farber Cancer Institute Pd-1, a receptor for b7-4, and uses therefor
JP5004390B2 (ja) 1999-08-23 2012-08-22 デイナ ファーバー キャンサー インスティチュート,インコーポレイテッド 新規b7−4分子およびその用途
EP1212422B1 (en) 1999-08-24 2007-02-21 Medarex, Inc. Human ctla-4 antibodies and their uses
US6794132B2 (en) 1999-10-02 2004-09-21 Biosite, Inc. Human antibodies
DE19952622A1 (de) 1999-11-02 2001-05-10 Bayer Ag Verfahren zur Herstellung von rekombinantem Interleukin-8 und Interleukin-8 Muteinen
US6680209B1 (en) 1999-12-06 2004-01-20 Biosite, Incorporated Human antibodies as diagnostic reagents
US6420346B1 (en) 2000-02-07 2002-07-16 Rappaport Family Institute For Research In The Medical Sciences Polynucleotides encoding MIP-1α, MCP-1, MIP-1β, Rantes and TNF-α, and methods for treating rheumatoid arthritis
AR030753A1 (es) 2000-09-25 2003-09-03 Smithkline Beecham Corp Uso de moduladores-proteina de il-8, groalfa, grobeta, grogamma, nap-2, y ena-78, para tratar infecciones viricas
US7408041B2 (en) 2000-12-08 2008-08-05 Alexion Pharmaceuticals, Inc. Polypeptides and antibodies derived from chronic lymphocytic leukemia cells and uses thereof
CA2436595C (en) 2000-12-08 2011-11-08 Alexion Pharmaceuticals, Inc. Chronic lymphocytic leukemia cell line and its use for producing an antibody
US20030068319A1 (en) 2001-03-23 2003-04-10 Menashe Bar-Eli Methods for inhibition of angiogenesis, tumor growth and metastasis by fully human anti-IL8 and anti-MUC18 in diverse types of tumors
JP2005520854A (ja) 2002-03-19 2005-07-14 アブジェニックス・インコーポレーテッド 慢性閉塞性肺疾患(copd)を治療するための方法
IL149820A0 (en) 2002-05-23 2002-11-10 Curetech Ltd Humanized immunomodulatory monoclonal antibodies for the treatment of neoplastic disease or immunodeficiency
NZ541050A (en) 2002-12-16 2010-06-25 Genmab As Human monoclonal antibodies against interleukin 8 (IL-8)
CN101899114A (zh) 2002-12-23 2010-12-01 惠氏公司 抗pd-1抗体及其用途
US20050142136A1 (en) 2003-10-23 2005-06-30 Lary Suva Anti-interleukin 8 therapy for tumor osteolysis
US20090145493A1 (en) 2004-11-23 2009-06-11 Pip Co., Ltd. Built-in wall water service box
MX2007013058A (es) 2005-04-20 2008-02-22 Amgen Fremont Inc Anticuerpos monoclonales de alta afinidad completamente humanos para interleucina-8 y epitopes para dichos anticuerpos.
DK2439273T3 (da) 2005-05-09 2019-06-03 Ono Pharmaceutical Co Humane monoklonale antistoffer til programmeret død-1(pd-1) og fremgangsmåder til behandling af cancer ved anvendelse af anti-pd-1- antistoffer alene eller i kombination med andre immunterapeutika
PT1907424E (pt) 2005-07-01 2015-10-09 Squibb & Sons Llc Anticorpos monoclonais humanos para o ligando 1 de morte programada (pd-l1)
BR122017025062B8 (pt) 2007-06-18 2021-07-27 Merck Sharp & Dohme anticorpo monoclonal ou fragmento de anticorpo para o receptor de morte programada humano pd-1, polinucleotídeo e composição compreendendo o referido anticorpo ou fragmento
WO2009014708A2 (en) 2007-07-23 2009-01-29 Cell Genesys, Inc. Pd-1 antibodies in combination with a cytokine-secreting cell and methods of use thereof
US20110105724A1 (en) 2007-08-16 2011-05-05 Stephanie Jane Clegg Novel compounds
EP2262837A4 (en) 2008-03-12 2011-04-06 Merck Sharp & Dohme PD-1 BINDING PROTEINS
AU2009288730B2 (en) 2008-08-25 2013-06-20 Amplimmune, Inc. Compositions of PD-1 antagonists and methods of use
EP3255060A1 (en) 2008-12-09 2017-12-13 F. Hoffmann-La Roche AG Anti-pd-l1 antibodies and their use to enhance t-cell function
PL2504364T3 (pl) 2009-11-24 2017-12-29 Medimmune Limited Ukierunkowane środki wiążące przeciwko B7-H1
US8907053B2 (en) 2010-06-25 2014-12-09 Aurigene Discovery Technologies Limited Immunosuppression modulating compounds
JP6072771B2 (ja) 2011-04-20 2017-02-01 メディミューン,エルエルシー B7−h1およびpd−1に結合する抗体およびその他の分子
CA2840018C (en) 2011-07-24 2019-07-16 Curetech Ltd. Variants of humanized immunomodulatory monoclonal antibodies
KR101764096B1 (ko) 2011-11-28 2017-08-02 메르크 파텐트 게엠베하 항-pd-l1 항체 및 그의 용도
JP2015509091A (ja) 2012-01-09 2015-03-26 ザ スクリプス リサーチ インスティテュート ヒト化抗体
CA2863224A1 (en) 2012-01-09 2013-07-18 The Scripps Research Institute Ultralong complementarity determining regions and uses thereof
WO2013166099A1 (en) 2012-05-01 2013-11-07 Glaxosmithkline Llc Novel antibodies
HK1203971A1 (en) 2012-05-15 2015-11-06 Bristol-Myers Squibb Company Cancer immunotherapy by disrupting pd-1/pd-l1 signaling
TWI612059B (zh) 2013-03-15 2018-01-21 美國禮來大藥廠 泛-ELR<sup>+</sup>CXC趨化因子抗體
WO2015017146A2 (en) 2013-07-18 2015-02-05 Fabrus, Inc. Antibodies with ultralong complementarity determining regions
CA2918370A1 (en) 2013-07-18 2015-01-22 Fabrus, Inc. Humanized antibodies with ultralong complementarity determining regions
EP3194440A1 (en) * 2014-09-15 2017-07-26 F. Hoffmann-La Roche AG Methods of treating cancer using pd-1 axis binding antagonist and il-17 binding antagonists
DK3303396T5 (da) * 2015-05-29 2024-10-07 Bristol Myers Squibb Co Antistoffer mod ox40 og anvendelser deraf
EP3423494A1 (en) * 2016-03-04 2019-01-09 Bristol-Myers Squibb Company Combination therapy with anti-cd73 antibodies
ES2954139T3 (es) * 2016-06-02 2023-11-20 Bristol Myers Squibb Co Bloqueo de PD-1 con nivolumab en el linfoma de Hodgkin refractario
SG10202101062YA (en) * 2016-06-02 2021-03-30 Bristol Myers Squibb Co Use of an anti-pd-1 antibody in combination with an anti-cd30 antibody in lymphoma treatment
JP2019517512A (ja) * 2016-06-03 2019-06-24 ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company 結腸直腸癌を有する患者の処置における抗pd−1抗体の使用
CA3084370A1 (en) 2018-01-12 2019-07-18 Bristol-Myers Squibb Company Combination therapy with anti-il-8 antibodies and anti-pd-1 antibodies for treating cancer

Similar Documents

Publication Publication Date Title
JP2021510697A5 (enExample)
Kelley et al. Antitumor activity of a monoclonal antibody directed against gastrin-releasing peptide in patients with small cell lung cancer
CN105873606B (zh) 用于治疗肿瘤的抗b7-h1抗体
JP2022501402A5 (enExample)
JP2021514969A5 (enExample)
JP2023516936A5 (enExample)
JP2018518454A5 (enExample)
JP2023507190A5 (enExample)
TW201922793A (zh) Pd-1抗體和vegfr抑制劑聯合治療小細胞肺癌的用途
KR102748255B1 (ko) 종양성 질병들에 대한 치료
O'Donnell et al. Combined modality radioimmunotherapy for human prostate cancer xenografts with taxanes and 90yttrium‐DOTA‐peptide‐ChL6
WO2021182573A1 (ja) 癌の治療及び/又は予防のための医薬品
JP2021511372A5 (enExample)
CN108079292A (zh) 一种抗pd-1抗体在制备治疗肝癌的药物中的用途
JP2020522512A5 (enExample)
JP2022541591A5 (enExample)
JP2019537619A5 (enExample)
JP2023502876A5 (enExample)
JP2023025036A (ja) がんの処置のためのアベルマブの投与レジメン
KR102769405B1 (ko) Igfbp-3 및 그것의 수용체와 관련되는 질환의 치료
JP2009544574A5 (enExample)
JP2023531200A5 (enExample)
Park et al. Concurrent transarterial radioembolization and combination atezolizumab/bevacizumab treatment of infiltrative hepatocellular carcinoma with portal vein tumor thrombosis: a case report
WO2025103377A1 (zh) 抗b7h3抗体-药物偶联物治疗癌症的方法
CN112915203A (zh) 喹啉衍生物与pd-1单抗的药物组合