BR112014017626A2 - métodos para tratar uma doença ou disfunção, métodos de identificação de um indivíduo, método para prever se um indivíduo com uma doença ou disfunção tem mais ou menos probabilidade para desenvolver toxicidade ao tratamento, método para determinar se um indivíduo com uma doença ou disfunção deve continuar ou suspender o tratamento que compreende um modulador de fgf19, método de otimização de eficácia terapêutica e método de ensaio - Google Patents
métodos para tratar uma doença ou disfunção, métodos de identificação de um indivíduo, método para prever se um indivíduo com uma doença ou disfunção tem mais ou menos probabilidade para desenvolver toxicidade ao tratamento, método para determinar se um indivíduo com uma doença ou disfunção deve continuar ou suspender o tratamento que compreende um modulador de fgf19, método de otimização de eficácia terapêutica e método de ensaioInfo
- Publication number
- BR112014017626A2 BR112014017626A2 BR112014017626A BR112014017626A BR112014017626A2 BR 112014017626 A2 BR112014017626 A2 BR 112014017626A2 BR 112014017626 A BR112014017626 A BR 112014017626A BR 112014017626 A BR112014017626 A BR 112014017626A BR 112014017626 A2 BR112014017626 A2 BR 112014017626A2
- Authority
- BR
- Brazil
- Prior art keywords
- dysfunction
- disease
- individual
- methods
- treatment
- Prior art date
Links
- 238000000034 method Methods 0.000 title 5
- 201000010099 disease Diseases 0.000 title 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 3
- 230000004064 dysfunction Effects 0.000 title 3
- 238000003556 assay Methods 0.000 title 1
- 238000005457 optimization Methods 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
- 230000001988 toxicity Effects 0.000 title 1
- 231100000419 toxicity Toxicity 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Zoology (AREA)
- Microbiology (AREA)
- Analytical Chemistry (AREA)
- Wood Science & Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Engineering & Computer Science (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261587885P | 2012-01-18 | 2012-01-18 | |
| PCT/US2013/022103 WO2013109856A2 (en) | 2012-01-18 | 2013-01-18 | Methods of using fgf19 modulators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112014017626A2 true BR112014017626A2 (pt) | 2018-05-22 |
Family
ID=47604273
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112014017626A BR112014017626A2 (pt) | 2012-01-18 | 2013-01-18 | métodos para tratar uma doença ou disfunção, métodos de identificação de um indivíduo, método para prever se um indivíduo com uma doença ou disfunção tem mais ou menos probabilidade para desenvolver toxicidade ao tratamento, método para determinar se um indivíduo com uma doença ou disfunção deve continuar ou suspender o tratamento que compreende um modulador de fgf19, método de otimização de eficácia terapêutica e método de ensaio |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US20130183294A1 (enExample) |
| EP (1) | EP2804630B1 (enExample) |
| JP (2) | JP2015506944A (enExample) |
| KR (1) | KR20140119114A (enExample) |
| CN (1) | CN104168920A (enExample) |
| BR (1) | BR112014017626A2 (enExample) |
| CA (1) | CA2862424A1 (enExample) |
| HK (1) | HK1201199A1 (enExample) |
| MX (1) | MX2014008699A (enExample) |
| RU (1) | RU2014133547A (enExample) |
| WO (1) | WO2013109856A2 (enExample) |
Families Citing this family (25)
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| EP2726511B1 (en) | 2011-07-01 | 2019-08-07 | NGM Biopharmaceuticals, Inc. | Compositions, uses and methods for treatment of metabolic disorders and diseases |
| EP2925775B1 (en) | 2012-11-28 | 2020-09-16 | NGM Biopharmaceuticals, Inc. | Compositions and methods for treatment of metabolic disorders and diseases |
| US9290557B2 (en) | 2012-11-28 | 2016-03-22 | Ngm Biopharmaceuticals, Inc. | Compositions comprising variants and fusions of FGF19 polypeptides |
| US9273107B2 (en) | 2012-12-27 | 2016-03-01 | Ngm Biopharmaceuticals, Inc. | Uses and methods for modulating bile acid homeostasis and treatment of bile acid disorders and diseases |
| KR102724421B1 (ko) | 2012-12-27 | 2024-10-30 | 엔지엠 바이오파마슈티컬스, 아이엔씨. | 담즙산 항상성의 조절 및 담즙산 질환 및 질병의 치료 방법 |
| WO2015057963A1 (en) | 2013-10-18 | 2015-04-23 | Eisai R&D Management Co., Ltd. | Fgfr4 inhibitors |
| WO2015061421A1 (en) * | 2013-10-22 | 2015-04-30 | Metselex, Inc. | Deuterated bile acids |
| KR102178945B1 (ko) * | 2013-10-28 | 2020-11-13 | 엔지엠 바이오파마슈티컬스, 아이엔씨. | 암 모델 및 관련 방법 |
| US9566315B2 (en) * | 2013-11-01 | 2017-02-14 | Oregon Health & Science University | Normalization of the enterohepatic circulation in animals with a chimeric humanized liver |
| SI3097122T1 (sl) | 2014-01-24 | 2020-07-31 | Ngm Biopharmaceuticals, Inc. | Protitelesa, ki se vežejo v domeni beta klotho 2, in metode za njihovo uporabo |
| WO2015183890A2 (en) | 2014-05-28 | 2015-12-03 | Ngm Biopharmaceuticals, Inc. | Methods and compositions for the treatment of metabolic disorders and diseases |
| CA2951153A1 (en) | 2014-06-16 | 2015-12-23 | Ngm Biopharmaceuticals, Inc. | Methods and uses for modulating bile acid homeostasis and treatment of bile acid disorders and diseases |
| GB201416015D0 (en) * | 2014-09-10 | 2014-10-22 | Univ Warwick | Biomarker |
| CN107108711B (zh) | 2014-10-23 | 2021-11-23 | 恩格姆生物制药公司 | 包含肽变异体的药物组合物及其使用方法 |
| US10434144B2 (en) | 2014-11-07 | 2019-10-08 | Ngm Biopharmaceuticals, Inc. | Methods for treatment of bile acid-related disorders and prediction of clinical sensitivity to treatment of bile acid-related disorders |
| JP6431622B2 (ja) | 2015-04-14 | 2018-11-28 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 結晶性fgfr4阻害剤化合物およびその使用 |
| US10800843B2 (en) | 2015-07-29 | 2020-10-13 | Ngm Biopharmaceuticals, Inc. | Beta klotho-binding proteins |
| JP6728352B2 (ja) | 2015-11-09 | 2020-07-22 | エヌジーエム バイオファーマシューティカルス,インコーポレーテッド | 胆汁酸に関係した障害の治療方法 |
| JP7372740B2 (ja) | 2016-05-10 | 2023-11-01 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 細胞生存性及び/又は細胞増殖を低減するための薬物の組み合わせ |
| CA3034399A1 (en) | 2016-08-26 | 2018-03-01 | Ngm Biopharmaceuticals, Inc. | Methods of treating fibroblast growth factor 19-mediated cancers and tumors |
| CN109709220B (zh) * | 2017-10-25 | 2021-09-17 | 中国科学院大连化学物理研究所 | 一种用于诊断膀胱癌的联合标志物及试剂盒和应用 |
| CN109722480B (zh) * | 2018-05-17 | 2022-04-26 | 上海交通大学 | 一种非小细胞肺癌检测试剂盒及其应用 |
| JP7193114B2 (ja) * | 2018-08-29 | 2022-12-20 | 学校法人同志社 | 胆汁酸サイクルの観察方法 |
| CN110558256B (zh) * | 2019-10-09 | 2020-06-26 | 中国水产科学研究院黄海水产研究所 | 一种程序化调控红鳍东方鲀胆汁酸分泌的营养学方法 |
| CN114106161A (zh) * | 2020-08-28 | 2022-03-01 | 安源医药科技(上海)有限公司 | 针对SARS-CoV-2冠状病毒S蛋白的抗体及其用途 |
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-
2013
- 2013-01-18 MX MX2014008699A patent/MX2014008699A/es unknown
- 2013-01-18 RU RU2014133547A patent/RU2014133547A/ru not_active Application Discontinuation
- 2013-01-18 HK HK15101805.6A patent/HK1201199A1/xx unknown
- 2013-01-18 CN CN201380014996.5A patent/CN104168920A/zh active Pending
- 2013-01-18 WO PCT/US2013/022103 patent/WO2013109856A2/en not_active Ceased
- 2013-01-18 US US13/745,647 patent/US20130183294A1/en not_active Abandoned
- 2013-01-18 BR BR112014017626A patent/BR112014017626A2/pt not_active IP Right Cessation
- 2013-01-18 EP EP13701354.6A patent/EP2804630B1/en not_active Not-in-force
- 2013-01-18 CA CA2862424A patent/CA2862424A1/en not_active Abandoned
- 2013-01-18 JP JP2014553444A patent/JP2015506944A/ja not_active Withdrawn
- 2013-01-18 KR KR1020147022466A patent/KR20140119114A/ko not_active Ceased
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2017
- 2017-05-30 US US15/608,603 patent/US20170342488A1/en not_active Abandoned
- 2017-10-04 JP JP2017194423A patent/JP2018065787A/ja active Pending
Also Published As
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|---|---|
| WO2013109856A3 (en) | 2013-11-14 |
| EP2804630A2 (en) | 2014-11-26 |
| RU2014133547A (ru) | 2016-03-10 |
| JP2018065787A (ja) | 2018-04-26 |
| JP2015506944A (ja) | 2015-03-05 |
| HK1201199A1 (en) | 2015-08-28 |
| CN104168920A (zh) | 2014-11-26 |
| CA2862424A1 (en) | 2013-07-25 |
| US20170342488A1 (en) | 2017-11-30 |
| EP2804630B1 (en) | 2017-10-18 |
| KR20140119114A (ko) | 2014-10-08 |
| WO2013109856A2 (en) | 2013-07-25 |
| US20130183294A1 (en) | 2013-07-18 |
| MX2014008699A (es) | 2014-11-21 |
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