RU2014126356A - Композиции, содержащие жирные кислоты с цепью из 20 атомов углерода, и способы их получения и применения - Google Patents
Композиции, содержащие жирные кислоты с цепью из 20 атомов углерода, и способы их получения и применения Download PDFInfo
- Publication number
- RU2014126356A RU2014126356A RU2014126356A RU2014126356A RU2014126356A RU 2014126356 A RU2014126356 A RU 2014126356A RU 2014126356 A RU2014126356 A RU 2014126356A RU 2014126356 A RU2014126356 A RU 2014126356A RU 2014126356 A RU2014126356 A RU 2014126356A
- Authority
- RU
- Russia
- Prior art keywords
- fatty acids
- carbon atoms
- chain
- seed oil
- gla
- Prior art date
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- 235000014113 dietary fatty acids Nutrition 0.000 title claims abstract 47
- 239000000194 fatty acid Substances 0.000 title claims abstract 47
- 229930195729 fatty acid Natural products 0.000 title claims abstract 47
- 150000004665 fatty acids Chemical class 0.000 title claims abstract 47
- 238000000034 method Methods 0.000 title claims abstract 37
- 239000000203 mixture Substances 0.000 title claims 17
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 title claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims abstract 54
- 235000015112 vegetable and seed oil Nutrition 0.000 claims abstract 22
- OPGOLNDOMSBSCW-CLNHMMGSSA-N Fursultiamine hydrochloride Chemical compound Cl.C1CCOC1CSSC(\CCO)=C(/C)N(C=O)CC1=CN=C(C)N=C1N OPGOLNDOMSBSCW-CLNHMMGSSA-N 0.000 claims abstract 21
- JIWBIWFOSCKQMA-UHFFFAOYSA-N stearidonic acid Natural products CCC=CCC=CCC=CCC=CCCCCC(O)=O JIWBIWFOSCKQMA-UHFFFAOYSA-N 0.000 claims abstract 21
- HOBAELRKJCKHQD-UHFFFAOYSA-N (8Z,11Z,14Z)-8,11,14-eicosatrienoic acid Natural products CCCCCC=CCC=CCC=CCCCCCCC(O)=O HOBAELRKJCKHQD-UHFFFAOYSA-N 0.000 claims abstract 20
- 235000021298 Dihomo-γ-linolenic acid Nutrition 0.000 claims abstract 20
- HOBAELRKJCKHQD-QNEBEIHSSA-N dihomo-γ-linolenic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/CCCCCCC(O)=O HOBAELRKJCKHQD-QNEBEIHSSA-N 0.000 claims abstract 20
- AHANXAKGNAKFSK-PDBXOOCHSA-N all-cis-icosa-11,14,17-trienoic acid Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCCCC(O)=O AHANXAKGNAKFSK-PDBXOOCHSA-N 0.000 claims abstract 19
- 235000020661 alpha-linolenic acid Nutrition 0.000 claims abstract 19
- IQLUYYHUNSSHIY-HZUMYPAESA-N eicosatetraenoic acid Chemical compound CCCCCCCCCCC\C=C\C=C\C=C\C=C\C(O)=O IQLUYYHUNSSHIY-HZUMYPAESA-N 0.000 claims abstract 19
- PRHHYVQTPBEDFE-UHFFFAOYSA-N eicosatrienoic acid Natural products CCCCCC=CCC=CCCCCC=CCCCC(O)=O PRHHYVQTPBEDFE-UHFFFAOYSA-N 0.000 claims abstract 19
- 235000020664 gamma-linolenic acid Nutrition 0.000 claims abstract 19
- 102000004190 Enzymes Human genes 0.000 claims abstract 4
- 108090000790 Enzymes Proteins 0.000 claims abstract 4
- 229910052799 carbon Inorganic materials 0.000 claims abstract 3
- 238000000194 supercritical-fluid extraction Methods 0.000 claims abstract 3
- 239000003960 organic solvent Substances 0.000 claims abstract 2
- DTOSIQBPPRVQHS-PDBXOOCHSA-N alpha-linolenic acid Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCC(O)=O DTOSIQBPPRVQHS-PDBXOOCHSA-N 0.000 claims 34
- 241000196324 Embryophyta Species 0.000 claims 18
- VZCCETWTMQHEPK-UHFFFAOYSA-N gamma-Linolensaeure Natural products CCCCCC=CCC=CCC=CCCCCC(O)=O VZCCETWTMQHEPK-UHFFFAOYSA-N 0.000 claims 17
- VZCCETWTMQHEPK-QNEBEIHSSA-N gamma-linolenic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/CCCCC(O)=O VZCCETWTMQHEPK-QNEBEIHSSA-N 0.000 claims 17
- 229960002733 gamolenic acid Drugs 0.000 claims 17
- 229960004488 linolenic acid Drugs 0.000 claims 17
- 239000003921 oil Substances 0.000 claims 7
- 235000019198 oils Nutrition 0.000 claims 7
- IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 claims 4
- 230000015572 biosynthetic process Effects 0.000 claims 4
- 239000013078 crystal Substances 0.000 claims 4
- 239000002904 solvent Substances 0.000 claims 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 3
- 230000032050 esterification Effects 0.000 claims 3
- 238000005886 esterification reaction Methods 0.000 claims 3
- 150000002148 esters Chemical class 0.000 claims 3
- 235000021588 free fatty acids Nutrition 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims 2
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical class CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 claims 2
- 238000001816 cooling Methods 0.000 claims 2
- 150000005690 diesters Chemical class 0.000 claims 2
- 238000000605 extraction Methods 0.000 claims 2
- 235000020660 omega-3 fatty acid Nutrition 0.000 claims 2
- 229940012843 omega-3 fatty acid Drugs 0.000 claims 2
- 239000006014 omega-3 oil Substances 0.000 claims 2
- 235000020665 omega-6 fatty acid Nutrition 0.000 claims 2
- 229940033080 omega-6 fatty acid Drugs 0.000 claims 2
- 150000003138 primary alcohols Chemical class 0.000 claims 2
- 208000034656 Contusions Diseases 0.000 claims 1
- 241001071905 Echium Species 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- 102000004882 Lipase Human genes 0.000 claims 1
- 108090001060 Lipase Proteins 0.000 claims 1
- 239000004367 Lipase Substances 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 241000219925 Oenothera Species 0.000 claims 1
- 235000004496 Oenothera biennis Nutrition 0.000 claims 1
- 241001180933 Trichodesma <angiosperm> Species 0.000 claims 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 125000005907 alkyl ester group Chemical group 0.000 claims 1
- 150000007860 aryl ester derivatives Chemical class 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- 239000010473 blackcurrant seed oil Substances 0.000 claims 1
- 235000021324 borage oil Nutrition 0.000 claims 1
- 239000010474 borage seed oil Substances 0.000 claims 1
- 208000034526 bruise Diseases 0.000 claims 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 239000004202 carbamide Substances 0.000 claims 1
- 239000003610 charcoal Substances 0.000 claims 1
- 238000013375 chromatographic separation Methods 0.000 claims 1
- 238000002425 crystallisation Methods 0.000 claims 1
- 230000008025 crystallization Effects 0.000 claims 1
- 238000006114 decarboxylation reaction Methods 0.000 claims 1
- 230000001877 deodorizing effect Effects 0.000 claims 1
- -1 deprotonated malonic acid diester Chemical class 0.000 claims 1
- 238000004821 distillation Methods 0.000 claims 1
- 230000002526 effect on cardiovascular system Effects 0.000 claims 1
- 125000004494 ethyl ester group Chemical group 0.000 claims 1
- 239000012530 fluid Substances 0.000 claims 1
- 238000005194 fractionation Methods 0.000 claims 1
- PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerol group Chemical group OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 1
- 125000004404 heteroalkyl group Chemical group 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 238000004128 high performance liquid chromatography Methods 0.000 claims 1
- 230000007062 hydrolysis Effects 0.000 claims 1
- 238000006460 hydrolysis reaction Methods 0.000 claims 1
- 230000002757 inflammatory effect Effects 0.000 claims 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 235000019421 lipase Nutrition 0.000 claims 1
- 230000003340 mental effect Effects 0.000 claims 1
- 238000003328 mesylation reaction Methods 0.000 claims 1
- 150000004702 methyl esters Chemical class 0.000 claims 1
- 238000002156 mixing Methods 0.000 claims 1
- 230000000926 neurological effect Effects 0.000 claims 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 208000020016 psychiatric disease Diseases 0.000 claims 1
- 230000000241 respiratory effect Effects 0.000 claims 1
- 239000000377 silicon dioxide Substances 0.000 claims 1
- 235000012239 silicon dioxide Nutrition 0.000 claims 1
- 208000017520 skin disease Diseases 0.000 claims 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
- 150000003626 triacylglycerols Chemical class 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11C—FATTY ACIDS FROM FATS, OILS OR WAXES; CANDLES; FATS, OILS OR FATTY ACIDS BY CHEMICAL MODIFICATION OF FATS, OILS, OR FATTY ACIDS OBTAINED THEREFROM
- C11C3/00—Fats, oils, or fatty acids by chemical modification of fats, oils, or fatty acids obtained therefrom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11C—FATTY ACIDS FROM FATS, OILS OR WAXES; CANDLES; FATS, OILS OR FATTY ACIDS BY CHEMICAL MODIFICATION OF FATS, OILS, OR FATTY ACIDS OBTAINED THEREFROM
- C11C1/00—Preparation of fatty acids from fats, fatty oils, or waxes; Refining the fatty acids
- C11C1/005—Splitting up mixtures of fatty acids into their constituents
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11C—FATTY ACIDS FROM FATS, OILS OR WAXES; CANDLES; FATS, OILS OR FATTY ACIDS BY CHEMICAL MODIFICATION OF FATS, OILS, OR FATTY ACIDS OBTAINED THEREFROM
- C11C1/00—Preparation of fatty acids from fats, fatty oils, or waxes; Refining the fatty acids
- C11C1/007—Preparation of fatty acids from fats, fatty oils, or waxes; Refining the fatty acids using organic solvents
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11C—FATTY ACIDS FROM FATS, OILS OR WAXES; CANDLES; FATS, OILS OR FATTY ACIDS BY CHEMICAL MODIFICATION OF FATS, OILS, OR FATTY ACIDS OBTAINED THEREFROM
- C11C1/00—Preparation of fatty acids from fats, fatty oils, or waxes; Refining the fatty acids
- C11C1/02—Preparation of fatty acids from fats, fatty oils, or waxes; Refining the fatty acids from fats or fatty oils
- C11C1/025—Preparation of fatty acids from fats, fatty oils, or waxes; Refining the fatty acids from fats or fatty oils by saponification and release of fatty acids
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11C—FATTY ACIDS FROM FATS, OILS OR WAXES; CANDLES; FATS, OILS OR FATTY ACIDS BY CHEMICAL MODIFICATION OF FATS, OILS, OR FATTY ACIDS OBTAINED THEREFROM
- C11C1/00—Preparation of fatty acids from fats, fatty oils, or waxes; Refining the fatty acids
- C11C1/08—Refining
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11C—FATTY ACIDS FROM FATS, OILS OR WAXES; CANDLES; FATS, OILS OR FATTY ACIDS BY CHEMICAL MODIFICATION OF FATS, OILS, OR FATTY ACIDS OBTAINED THEREFROM
- C11C3/00—Fats, oils, or fatty acids by chemical modification of fats, oils, or fatty acids obtained therefrom
- C11C3/003—Fats, oils, or fatty acids by chemical modification of fats, oils, or fatty acids obtained therefrom by esterification of fatty acids with alcohols
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6409—Fatty acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6409—Fatty acids
- C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6409—Fatty acids
- C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
- C12P7/6431—Linoleic acids [18:2[n-6]]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6436—Fatty acid esters
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Zoology (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pulmonology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Dermatology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Fats And Perfumes (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161564652P | 2011-11-29 | 2011-11-29 | |
| US61/564,652 | 2011-11-29 | ||
| US201261711585P | 2012-10-09 | 2012-10-09 | |
| US61/711,585 | 2012-10-09 | ||
| PCT/US2012/067030 WO2013082265A1 (en) | 2011-11-29 | 2012-11-29 | Compositions comprising 20-carbon fatty acids and methods of making and using same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2014126356A true RU2014126356A (ru) | 2016-01-27 |
Family
ID=48536046
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2014126356A RU2014126356A (ru) | 2011-11-29 | 2012-11-29 | Композиции, содержащие жирные кислоты с цепью из 20 атомов углерода, и способы их получения и применения |
Country Status (15)
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0907413D0 (en) | 2009-04-29 | 2009-06-10 | Equateq Ltd | Novel methods |
| US8293790B2 (en) | 2011-10-19 | 2012-10-23 | Dignity Sciences Limited | Pharmaceutical compositions comprising DGLA and benzoyl peroxide and methods of use thereof |
| MX2014006478A (es) | 2011-11-29 | 2015-02-12 | Dignity Sciences Ltd | Composiciones que comprenden acidos grasos de carbono-20 y metodos para elaborar y usar los mismos. |
| GB201301626D0 (en) | 2013-01-30 | 2013-03-13 | Dignity Sciences Ltd | Composition comprising 15-OHEPA and methods of using the same |
| WO2015071766A1 (en) | 2013-11-15 | 2015-05-21 | Dignity Sciences Limited | Pharmaceutically acceptable salts of polyunsaturated hydroxy fatty acids |
| ES2875965T3 (es) | 2013-12-04 | 2021-11-11 | Nippon Suisan Kaisha Ltd | Aceite microbiano que contiene ácido dihomo-gamma-linolénico y biomasa microbiana que contiene ácido dihomo-gamma-linolénico |
| AU2015270418B2 (en) | 2014-06-04 | 2020-08-06 | Ds Biopharma Limited | Pharmaceutical compositions comprising DGLA and use of same |
| MA41120A (fr) | 2014-12-02 | 2017-10-10 | Afimmune Ltd | Compositions comprenant le 15-hepe et méthodes de traitement ou de prévention de la fibrose à l'aide de celles-ci |
| JP2018520197A (ja) | 2015-07-21 | 2018-07-26 | アフィミューン リミテッド | 癌及び神経疾患の治療または予防において使用するための、１５−ｈｅｐｅを含む組成物 |
| AU2016317523B2 (en) * | 2015-08-31 | 2019-12-12 | Nippon Suisan Kaisha, Ltd. | Free polyunsaturated fatty acid-containing composition and manufacturing method therefor |
| KR20180094516A (ko) | 2015-12-18 | 2018-08-23 | 애피뮨 리미티드 | 15-hepe를 포함하는 조성물 및 이를 사용하는 방법 |
| CN105535064A (zh) * | 2016-01-19 | 2016-05-04 | 佛山科学技术学院 | 一种琉璃苣深加工方法及其深加工产物 |
| CN109796328B (zh) * | 2019-03-14 | 2022-03-25 | 浙江工业大学 | 一种高纯度香榧籽油金松酸的分离方法 |
| US20210315851A1 (en) | 2020-04-03 | 2021-10-14 | Afimmune Limited | Compositions comprising 15-hepe and methods of treating or preventing hematologic disorders, and/or related diseases |
| CN113004977A (zh) * | 2021-02-25 | 2021-06-22 | 华侨大学 | 高纯度多不饱和鱼油的制备方法以及鱿鱼油加工方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH663951A5 (fr) * | 1984-10-10 | 1988-01-29 | Nestle Sa | Procede d'enrichissement selectif en acides gras polyinsatures d'un melange contenant des acides gras fractions enrichies obtenues et compositions les contenant. |
| CH669208A5 (fr) * | 1986-12-17 | 1989-02-28 | Nestle Sa | Procede de fractionnement en continu d'un melange d'acides gras. |
| US5968809A (en) * | 1997-04-11 | 1999-10-19 | Abbot Laboratories | Methods and compositions for synthesis of long chain poly-unsaturated fatty acids |
| TR199902474T2 (xx) * | 1997-04-11 | 2000-02-21 | Calgene Llc | Bitkilerde uzun zincirli �ok-doymam�� ya�l� asitlerin sentezi i�in y�ntemler ve bile�imler. |
| JP3425622B2 (ja) * | 2000-03-30 | 2003-07-14 | 独立行政法人産業技術総合研究所 | ラビリンチュラ属菌を用いた高度不飽和脂肪酸含有培養物および高度不飽和脂肪酸含有油脂の製造方法 |
| CA2542574C (en) * | 2003-11-12 | 2014-03-18 | E. I. Du Pont De Nemours And Company | Delta-15 desaturases suitable for altering levels of polyunsaturated fatty acids in oleaginous plants and yeast |
| US7807849B2 (en) | 2004-04-22 | 2010-10-05 | Commonwealth Scientific And Industrial Research Organisation | Synthesis of long-chain polyunsaturated fatty acids by recombinant cells |
| DK2006389T3 (en) * | 2006-04-13 | 2017-08-28 | Nippon Suisan Kaisha Ltd | Process for preparing concentrated polyunsaturated fatty acid oil |
| US20080125487A1 (en) * | 2006-11-17 | 2008-05-29 | Tapas Das | Elongase gene and uses thereof |
| US20080213357A1 (en) * | 2007-02-12 | 2008-09-04 | Andrew Bruce Hebard | Plant Derived Lipid Useful for Nutraceutical and Cosemeceutical Applications |
| US8455035B2 (en) * | 2008-04-25 | 2013-06-04 | Basf Plant Science Gmbh | Plant seed oil |
| US8188335B2 (en) * | 2009-07-17 | 2012-05-29 | Abbott Laboratories | Δ9-elongase for production of polyunsaturated fatty acid-enriched oils |
| MX2014006478A (es) | 2011-11-29 | 2015-02-12 | Dignity Sciences Ltd | Composiciones que comprenden acidos grasos de carbono-20 y metodos para elaborar y usar los mismos. |
-
2012
- 2012-11-29 MX MX2014006478A patent/MX2014006478A/es unknown
- 2012-11-29 EP EP12854347.7A patent/EP2785852A4/en not_active Withdrawn
- 2012-11-29 CN CN201280066370.4A patent/CN104114709A/zh active Pending
- 2012-11-29 RU RU2014126356A patent/RU2014126356A/ru not_active Application Discontinuation
- 2012-11-29 KR KR1020147017339A patent/KR20140113921A/ko not_active Withdrawn
- 2012-11-29 BR BR112014013098A patent/BR112014013098A2/pt not_active IP Right Cessation
- 2012-11-29 SG SG11201402653QA patent/SG11201402653QA/en unknown
- 2012-11-29 AU AU2012345942A patent/AU2012345942A1/en not_active Abandoned
- 2012-11-29 US US13/688,998 patent/US9096815B2/en not_active Expired - Fee Related
- 2012-11-29 JP JP2014544878A patent/JP2015500639A/ja active Pending
- 2012-11-29 CA CA2856715A patent/CA2856715A1/en not_active Abandoned
- 2012-11-29 WO PCT/US2012/067030 patent/WO2013082265A1/en not_active Ceased
-
2014
- 2014-05-22 IL IL232748A patent/IL232748A0/en unknown
- 2014-05-23 ZA ZA2014/03784A patent/ZA201403784B/en unknown
- 2014-05-29 PH PH12014501212A patent/PH12014501212A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2015500639A (ja) | 2015-01-08 |
| BR112014013098A2 (pt) | 2017-06-13 |
| SG11201402653QA (en) | 2014-06-27 |
| WO2013082265A1 (en) | 2013-06-06 |
| ZA201403784B (en) | 2015-09-30 |
| CN104114709A (zh) | 2014-10-22 |
| US9096815B2 (en) | 2015-08-04 |
| KR20140113921A (ko) | 2014-09-25 |
| IL232748A0 (en) | 2014-07-31 |
| MX2014006478A (es) | 2015-02-12 |
| EP2785852A4 (en) | 2015-11-04 |
| CA2856715A1 (en) | 2013-06-06 |
| US20130331448A1 (en) | 2013-12-12 |
| AU2012345942A1 (en) | 2014-06-12 |
| EP2785852A1 (en) | 2014-10-08 |
| PH12014501212A1 (en) | 2014-09-08 |
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| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
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