JP2015500639A5 - - Google Patents
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- Publication number
- JP2015500639A5 JP2015500639A5 JP2014544878A JP2014544878A JP2015500639A5 JP 2015500639 A5 JP2015500639 A5 JP 2015500639A5 JP 2014544878 A JP2014544878 A JP 2014544878A JP 2014544878 A JP2014544878 A JP 2014544878A JP 2015500639 A5 JP2015500639 A5 JP 2015500639A5
- Authority
- JP
- Japan
- Prior art keywords
- dgla
- fatty acid
- seed oil
- ete
- eta
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 229910052799 carbon Inorganic materials 0.000 claims 39
- 235000014113 dietary fatty acids Nutrition 0.000 claims 38
- 239000000194 fatty acid Substances 0.000 claims 38
- 229930195729 fatty acid Natural products 0.000 claims 38
- HOBAELRKJCKHQD-UHFFFAOYSA-N (8Z,11Z,14Z)-8,11,14-eicosatrienoic acid Natural products CCCCCC=CCC=CCC=CCCCCCCC(O)=O HOBAELRKJCKHQD-UHFFFAOYSA-N 0.000 claims 30
- HOBAELRKJCKHQD-QNEBEIHSSA-N dihomo-γ-linolenic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/CCCCCCC(O)=O HOBAELRKJCKHQD-QNEBEIHSSA-N 0.000 claims 30
- 238000000034 method Methods 0.000 claims 28
- AHANXAKGNAKFSK-PDBXOOCHSA-N all-cis-icosa-11,14,17-trienoic acid Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCCCC(O)=O AHANXAKGNAKFSK-PDBXOOCHSA-N 0.000 claims 26
- 235000015112 vegetable and seed oil Nutrition 0.000 claims 22
- 241000196324 Embryophyta Species 0.000 claims 18
- 235000020664 gamma-linolenic acid Nutrition 0.000 claims 18
- VZCCETWTMQHEPK-QNEBEIHSSA-N gamma-linolenic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/CCCCC(O)=O VZCCETWTMQHEPK-QNEBEIHSSA-N 0.000 claims 15
- 239000000203 mixture Substances 0.000 claims 14
- HQPCSDADVLFHHO-LTKCOYKYSA-N all-cis-8,11,14,17-icosatetraenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/CCCCCCC(O)=O HQPCSDADVLFHHO-LTKCOYKYSA-N 0.000 claims 13
- -1 carbon fatty acids Chemical class 0.000 claims 10
- 235000021298 Dihomo-γ-linolenic acid Nutrition 0.000 claims 5
- 150000004665 fatty acids Chemical class 0.000 claims 5
- 206010061218 Inflammation Diseases 0.000 claims 4
- IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 claims 4
- 206010028980 Neoplasm Diseases 0.000 claims 4
- DTOSIQBPPRVQHS-PDBXOOCHSA-N alpha-linolenic acid Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCC(O)=O DTOSIQBPPRVQHS-PDBXOOCHSA-N 0.000 claims 4
- 201000011510 cancer Diseases 0.000 claims 4
- 125000004432 carbon atom Chemical group C* 0.000 claims 4
- 239000013078 crystal Substances 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- IQLUYYHUNSSHIY-HZUMYPAESA-N eicosatetraenoic acid Chemical compound CCCCCCCCCCC\C=C\C=C\C=C\C=C\C(O)=O IQLUYYHUNSSHIY-HZUMYPAESA-N 0.000 claims 4
- PRHHYVQTPBEDFE-UHFFFAOYSA-N eicosatrienoic acid Natural products CCCCCC=CCC=CCCCCC=CCCCC(O)=O PRHHYVQTPBEDFE-UHFFFAOYSA-N 0.000 claims 4
- 230000004054 inflammatory process Effects 0.000 claims 4
- 230000000926 neurological effect Effects 0.000 claims 4
- 208000020016 psychiatric disease Diseases 0.000 claims 4
- 230000000241 respiratory effect Effects 0.000 claims 4
- 208000017520 skin disease Diseases 0.000 claims 4
- 239000002904 solvent Substances 0.000 claims 4
- 238000000194 supercritical-fluid extraction Methods 0.000 claims 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 3
- 235000021588 free fatty acids Nutrition 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 239000003921 oil Substances 0.000 claims 3
- 235000019198 oils Nutrition 0.000 claims 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims 2
- 102000004190 Enzymes Human genes 0.000 claims 2
- 108090000790 Enzymes Proteins 0.000 claims 2
- OPGOLNDOMSBSCW-CLNHMMGSSA-N Fursultiamine hydrochloride Chemical compound Cl.C1CCOC1CSSC(\CCO)=C(/C)N(C=O)CC1=CN=C(C)N=C1N OPGOLNDOMSBSCW-CLNHMMGSSA-N 0.000 claims 2
- 125000005907 alkyl ester group Chemical group 0.000 claims 2
- 235000020661 alpha-linolenic acid Nutrition 0.000 claims 2
- 210000000748 cardiovascular system Anatomy 0.000 claims 2
- 230000002526 effect on cardiovascular system Effects 0.000 claims 2
- VZCCETWTMQHEPK-UHFFFAOYSA-N gamma-Linolensaeure Natural products CCCCCC=CCC=CCC=CCCCCC(O)=O VZCCETWTMQHEPK-UHFFFAOYSA-N 0.000 claims 2
- 229960002733 gamolenic acid Drugs 0.000 claims 2
- 230000001939 inductive effect Effects 0.000 claims 2
- 229960004488 linolenic acid Drugs 0.000 claims 2
- 230000003340 mental effect Effects 0.000 claims 2
- 235000020660 omega-3 fatty acid Nutrition 0.000 claims 2
- 229940012843 omega-3 fatty acid Drugs 0.000 claims 2
- 235000020665 omega-6 fatty acid Nutrition 0.000 claims 2
- 229940033080 omega-6 fatty acid Drugs 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- JIWBIWFOSCKQMA-UHFFFAOYSA-N stearidonic acid Natural products CCC=CCC=CCC=CCC=CCCCCC(O)=O JIWBIWFOSCKQMA-UHFFFAOYSA-N 0.000 claims 2
- 241001071905 Echium Species 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- 241000295545 Hackelia Species 0.000 claims 1
- 102000004882 Lipase Human genes 0.000 claims 1
- 108090001060 Lipase Proteins 0.000 claims 1
- 239000004367 Lipase Substances 0.000 claims 1
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 claims 1
- 241000219925 Oenothera Species 0.000 claims 1
- 235000004496 Oenothera biennis Nutrition 0.000 claims 1
- 241001180933 Trichodesma <angiosperm> Species 0.000 claims 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 150000007860 aryl ester derivatives Chemical class 0.000 claims 1
- 239000010473 blackcurrant seed oil Substances 0.000 claims 1
- 235000021324 borage oil Nutrition 0.000 claims 1
- 239000010474 borage seed oil Substances 0.000 claims 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 239000004202 carbamide Substances 0.000 claims 1
- 239000003610 charcoal Substances 0.000 claims 1
- 238000013375 chromatographic separation Methods 0.000 claims 1
- 238000001816 cooling Methods 0.000 claims 1
- 238000002425 crystallisation Methods 0.000 claims 1
- 230000008025 crystallization Effects 0.000 claims 1
- 230000000911 decarboxylating effect Effects 0.000 claims 1
- CYQFCXCEBYINGO-IAGOWNOFSA-N delta1-THC Chemical compound C1=C(C)CC[C@H]2C(C)(C)OC3=CC(CCCCC)=CC(O)=C3[C@@H]21 CYQFCXCEBYINGO-IAGOWNOFSA-N 0.000 claims 1
- 230000001877 deodorizing effect Effects 0.000 claims 1
- 238000004821 distillation Methods 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 125000004494 ethyl ester group Chemical group 0.000 claims 1
- 238000005194 fractionation Methods 0.000 claims 1
- PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerol group Chemical group OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 238000004128 high performance liquid chromatography Methods 0.000 claims 1
- 230000003301 hydrolyzing effect Effects 0.000 claims 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 235000019421 lipase Nutrition 0.000 claims 1
- 150000004702 methyl esters Chemical class 0.000 claims 1
- 238000002156 mixing Methods 0.000 claims 1
- 239000006014 omega-3 oil Substances 0.000 claims 1
- 239000003960 organic solvent Substances 0.000 claims 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 239000000377 silicon dioxide Substances 0.000 claims 1
- 238000000638 solvent extraction Methods 0.000 claims 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
- 230000008719 thickening Effects 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161564652P | 2011-11-29 | 2011-11-29 | |
| US61/564,652 | 2011-11-29 | ||
| US201261711585P | 2012-10-09 | 2012-10-09 | |
| US61/711,585 | 2012-10-09 | ||
| PCT/US2012/067030 WO2013082265A1 (en) | 2011-11-29 | 2012-11-29 | Compositions comprising 20-carbon fatty acids and methods of making and using same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015500639A JP2015500639A (ja) | 2015-01-08 |
| JP2015500639A5 true JP2015500639A5 (cg-RX-API-DMAC7.html) | 2016-01-21 |
Family
ID=48536046
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014544878A Pending JP2015500639A (ja) | 2011-11-29 | 2012-11-29 | ２０−炭素脂肪酸を含む組成物ならびにその製造方法および使用方法 |
Country Status (15)
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0907413D0 (en) | 2009-04-29 | 2009-06-10 | Equateq Ltd | Novel methods |
| US8293790B2 (en) | 2011-10-19 | 2012-10-23 | Dignity Sciences Limited | Pharmaceutical compositions comprising DGLA and benzoyl peroxide and methods of use thereof |
| BR112014013098A2 (pt) | 2011-11-29 | 2017-06-13 | Dignity Sciences Ltd | composições compreendendo ácidos graxos que têm 20 carbonos e métodos de produção e uso dos mesmos |
| GB201301626D0 (en) | 2013-01-30 | 2013-03-13 | Dignity Sciences Ltd | Composition comprising 15-OHEPA and methods of using the same |
| CN105899485B (zh) | 2013-11-15 | 2018-10-19 | 尊严科学有限公司 | 多不饱和羟基脂肪酸的药学上可接受的盐 |
| PL3101138T3 (pl) | 2013-12-04 | 2021-10-25 | Nippon Suisan Kaisha, Ltd. | Olej drobnoustrojowy, sposób wytwarzania oleju drobnoustrojowego, stężony olej drobnoustrojowy oraz sposób wytwarzania stężonego oleju drobnoustrojowego |
| MX375328B (es) | 2014-06-04 | 2025-03-06 | Ds Biopharma Ltd | Composiciones farmacéuticas que comprenden ácido dihomo-gamma-linolénico (dgla) y uso de las mismas |
| MA41120A (fr) | 2014-12-02 | 2017-10-10 | Afimmune Ltd | Compositions comprenant le 15-hepe et méthodes de traitement ou de prévention de la fibrose à l'aide de celles-ci |
| JP2018520197A (ja) | 2015-07-21 | 2018-07-26 | アフィミューン リミテッド | 癌及び神経疾患の治療または予防において使用するための、１５−ｈｅｐｅを含む組成物 |
| CA2997091C (en) * | 2015-08-31 | 2020-06-16 | Nippon Suisan Kaisha, Ltd. | Free-polyunsaturated-fatty-acid-containing composition and method for manufacturing same |
| CN108697680A (zh) | 2015-12-18 | 2018-10-23 | 艾菲穆恩有限公司 | 包含15-hepe的组合物及其使用方法 |
| CN105535064A (zh) * | 2016-01-19 | 2016-05-04 | 佛山科学技术学院 | 一种琉璃苣深加工方法及其深加工产物 |
| CN109796328B (zh) * | 2019-03-14 | 2022-03-25 | 浙江工业大学 | 一种高纯度香榧籽油金松酸的分离方法 |
| US20210315851A1 (en) | 2020-04-03 | 2021-10-14 | Afimmune Limited | Compositions comprising 15-hepe and methods of treating or preventing hematologic disorders, and/or related diseases |
| CN113004977A (zh) * | 2021-02-25 | 2021-06-22 | 华侨大学 | 高纯度多不饱和鱼油的制备方法以及鱿鱼油加工方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH663951A5 (fr) * | 1984-10-10 | 1988-01-29 | Nestle Sa | Procede d'enrichissement selectif en acides gras polyinsatures d'un melange contenant des acides gras fractions enrichies obtenues et compositions les contenant. |
| CH669208A5 (fr) * | 1986-12-17 | 1989-02-28 | Nestle Sa | Procede de fractionnement en continu d'un melange d'acides gras. |
| PL336077A1 (en) * | 1997-04-11 | 2000-06-05 | Calgene Llc | Methods of and compositions for synthesising long-chain polyunsaturated fatty acids in plants |
| US5968809A (en) * | 1997-04-11 | 1999-10-19 | Abbot Laboratories | Methods and compositions for synthesis of long chain poly-unsaturated fatty acids |
| JP3425622B2 (ja) * | 2000-03-30 | 2003-07-14 | 独立行政法人産業技術総合研究所 | ラビリンチュラ属菌を用いた高度不飽和脂肪酸含有培養物および高度不飽和脂肪酸含有油脂の製造方法 |
| WO2005047479A2 (en) * | 2003-11-12 | 2005-05-26 | E.I. Dupont De Nemours And Company | Delta-15 desaturases suitable for altering levels of polyunsaturated fatty acids in oilseed plants and oleaginous yeast |
| ES2529572T3 (es) | 2004-04-22 | 2015-02-23 | Commonwealth Scientific And Industrial Research Organisation | Síntesis de ácidos grasos poliinsaturados de cadena larga por células recombinantes |
| DK2006389T3 (en) * | 2006-04-13 | 2017-08-28 | Nippon Suisan Kaisha Ltd | Process for preparing concentrated polyunsaturated fatty acid oil |
| US20080125487A1 (en) | 2006-11-17 | 2008-05-29 | Tapas Das | Elongase gene and uses thereof |
| US20080213357A1 (en) * | 2007-02-12 | 2008-09-04 | Andrew Bruce Hebard | Plant Derived Lipid Useful for Nutraceutical and Cosemeceutical Applications |
| US8455035B2 (en) | 2008-04-25 | 2013-06-04 | Basf Plant Science Gmbh | Plant seed oil |
| US8188335B2 (en) * | 2009-07-17 | 2012-05-29 | Abbott Laboratories | Δ9-elongase for production of polyunsaturated fatty acid-enriched oils |
| BR112014013098A2 (pt) | 2011-11-29 | 2017-06-13 | Dignity Sciences Ltd | composições compreendendo ácidos graxos que têm 20 carbonos e métodos de produção e uso dos mesmos |
-
2012
- 2012-11-29 BR BR112014013098A patent/BR112014013098A2/pt not_active IP Right Cessation
- 2012-11-29 RU RU2014126356A patent/RU2014126356A/ru not_active Application Discontinuation
- 2012-11-29 JP JP2014544878A patent/JP2015500639A/ja active Pending
- 2012-11-29 EP EP12854347.7A patent/EP2785852A4/en not_active Withdrawn
- 2012-11-29 US US13/688,998 patent/US9096815B2/en not_active Expired - Fee Related
- 2012-11-29 AU AU2012345942A patent/AU2012345942A1/en not_active Abandoned
- 2012-11-29 WO PCT/US2012/067030 patent/WO2013082265A1/en not_active Ceased
- 2012-11-29 CN CN201280066370.4A patent/CN104114709A/zh active Pending
- 2012-11-29 SG SG11201402653QA patent/SG11201402653QA/en unknown
- 2012-11-29 MX MX2014006478A patent/MX2014006478A/es unknown
- 2012-11-29 CA CA2856715A patent/CA2856715A1/en not_active Abandoned
- 2012-11-29 KR KR1020147017339A patent/KR20140113921A/ko not_active Withdrawn
-
2014
- 2014-05-22 IL IL232748A patent/IL232748A0/en unknown
- 2014-05-23 ZA ZA2014/03784A patent/ZA201403784B/en unknown
- 2014-05-29 PH PH12014501212A patent/PH12014501212A1/en unknown
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