RU2014118448A - Адсорбенты для перорального введения - Google Patents

Адсорбенты для перорального введения Download PDF

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RU2014118448A
RU2014118448A RU2014118448/15A RU2014118448A RU2014118448A RU 2014118448 A RU2014118448 A RU 2014118448A RU 2014118448/15 A RU2014118448/15 A RU 2014118448/15A RU 2014118448 A RU2014118448 A RU 2014118448A RU 2014118448 A RU2014118448 A RU 2014118448A
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oral administration
uremic toxin
administration according
activated carbon
toxin adsorbent
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RU2014118448/15A
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RU2583934C2 (ru
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Ясуми НИСИВАКИ
Такаси МУРАКАМИ
Нобуаки ЭТО
Кэйитиро ИМАЙДЗУМИ
Акихито ОХТАКИ
Кэндзи СИМАДЗАКИ
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Тейдзин Фарма Лимитед
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/44—Elemental carbon, e.g. charcoal, carbon black
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/02—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material
    • B01J20/20—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising free carbon; comprising carbon obtained by carbonising processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28002—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their physical properties
    • B01J20/28004—Sorbent size or size distribution, e.g. particle size
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28014—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their form
    • B01J20/28023—Fibres or filaments
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28054—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their surface properties or porosity
    • B01J20/28057—Surface area, e.g. B.E.T specific surface area
    • B01J20/28066—Surface area, e.g. B.E.T specific surface area being more than 1000 m2/g
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28054—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their surface properties or porosity
    • B01J20/28069—Pore volume, e.g. total pore volume, mesopore volume, micropore volume
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28054—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their surface properties or porosity
    • B01J20/28078—Pore diameter
    • B01J20/2808—Pore diameter being less than 2 nm, i.e. micropores or nanopores
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
    • C01B32/00—Carbon; Compounds thereof
    • C01B32/30—Active carbon
    • C01B32/312—Preparation
    • C01B32/336—Preparation characterised by gaseous activating agents
    • D—TEXTILES; PAPER
    • D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
    • D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
    • D01F9/00—Artificial filaments or the like of other substances; Manufacture thereof; Apparatus specially adapted for the manufacture of carbon filaments
    • D01F9/08—Artificial filaments or the like of other substances; Manufacture thereof; Apparatus specially adapted for the manufacture of carbon filaments of inorganic material
    • D01F9/12—Carbon filaments; Apparatus specially adapted for the manufacture thereof
    • D01F9/14—Carbon filaments; Apparatus specially adapted for the manufacture thereof by decomposition of organic filaments

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  • Chemical & Material Sciences (AREA)
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  • Organic Chemistry (AREA)
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Abstract

1. Адсорбент уремического токсина для перорального введения, включающий в качестве активного ингредиента активированные углеродные волокна.2. Адсорбент уремического токсина для перорального введения по п. 1, при этом активированные углеродные волокна имеют объем микропор 0,1-2,0 мл/г.3. Адсорбент уремического токсина для перорального введения по п. 1, при этом активированные углеродные волокна имеют длину 15 мкм или больше и объем микропор 0,5-1,0 мл/г.4. Адсорбент уремического токсина для перорального введения по любому из пп. 1-3 для лечения или предупреждения болезней почек или осложнений диализа.5. Адсорбент уремического токсина для перорального введения по любому из пп. 1-3, который вводят в суточной дозе 1-3000 мг.6. Адсорбент уремического токсина для перорального введения по п. 4, который вводят в суточной дозе 1-3000 мг.7. Активированное углеродное волокно с диаметром поперечного сечения волокна 5-50 мкм, длиной волокна 15 мкм или больше, удельной поверхностью, определенной методом BET, 1400-2700 м/г, общим объемом пор 0,8-1,8 мл/г и объемом микропор 0,5-1,0 мл/г.

Claims (7)

1. Адсорбент уремического токсина для перорального введения, включающий в качестве активного ингредиента активированные углеродные волокна.
2. Адсорбент уремического токсина для перорального введения по п. 1, при этом активированные углеродные волокна имеют объем микропор 0,1-2,0 мл/г.
3. Адсорбент уремического токсина для перорального введения по п. 1, при этом активированные углеродные волокна имеют длину 15 мкм или больше и объем микропор 0,5-1,0 мл/г.
4. Адсорбент уремического токсина для перорального введения по любому из пп. 1-3 для лечения или предупреждения болезней почек или осложнений диализа.
5. Адсорбент уремического токсина для перорального введения по любому из пп. 1-3, который вводят в суточной дозе 1-3000 мг.
6. Адсорбент уремического токсина для перорального введения по п. 4, который вводят в суточной дозе 1-3000 мг.
7. Активированное углеродное волокно с диаметром поперечного сечения волокна 5-50 мкм, длиной волокна 15 мкм или больше, удельной поверхностью, определенной методом BET, 1400-2700 м2/г, общим объемом пор 0,8-1,8 мл/г и объемом микропор 0,5-1,0 мл/г.
RU2014118448/15A 2011-10-07 2012-10-05 Адсорбенты для перорального введения RU2583934C2 (ru)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP2011222949 2011-10-07
JP2011-222949 2011-10-07
JP2012-181466 2012-08-20
JP2012181466 2012-08-20
PCT/JP2012/075897 WO2013051680A1 (ja) 2011-10-07 2012-10-05 経口投与用吸着剤

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RU2014118448A true RU2014118448A (ru) 2015-11-20
RU2583934C2 RU2583934C2 (ru) 2016-05-10

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EP (1) EP2772261B1 (ru)
JP (1) JP5781164B2 (ru)
KR (1) KR101890458B1 (ru)
CN (1) CN103841981B (ru)
AR (1) AR088255A1 (ru)
AU (1) AU2012319495B2 (ru)
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CA2851215C (en) 2021-01-19
AU2012319495A1 (en) 2014-04-24
JP5781164B2 (ja) 2015-09-16
SI2772261T1 (en) 2018-02-28
RU2583934C2 (ru) 2016-05-10
WO2013051680A1 (ja) 2013-04-11
SG11201401320QA (en) 2014-07-30
KR101890458B1 (ko) 2018-08-21
HRP20171970T1 (hr) 2018-02-09
AU2012319495B2 (en) 2017-07-20
US9682046B2 (en) 2017-06-20
IL231680A0 (en) 2014-05-28
ZA201402500B (en) 2015-03-25
NZ623528A (en) 2016-04-29
KR20140072077A (ko) 2014-06-12
MX362027B (es) 2019-01-04
JPWO2013051680A1 (ja) 2015-03-30
HUE036432T2 (hu) 2018-07-30
TW201328700A (zh) 2013-07-16
MY167387A (en) 2018-08-16
CN103841981A (zh) 2014-06-04
EP2772261A1 (en) 2014-09-03
EP2772261A4 (en) 2015-09-30
PL2772261T3 (pl) 2018-06-29
LT2772261T (lt) 2018-02-12
BR112014008230A2 (pt) 2017-04-11
US20140242147A1 (en) 2014-08-28
CN103841981B (zh) 2016-11-16
TWI625122B (zh) 2018-06-01
RS56902B1 (sr) 2018-05-31
PT2772261T (pt) 2018-01-08
CY1119877T1 (el) 2018-06-27
ES2655176T3 (es) 2018-02-19
CA2851215A1 (en) 2013-04-11
ME02959B (me) 2018-07-20
AR088255A1 (es) 2014-05-21
NO2772261T3 (ru) 2018-04-21
EP2772261B1 (en) 2017-11-22
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