MX350154B - Forma de dosificacion farmaceutica que comprende 6'-fluoro-(n-metil- o n,n-dimetil)-4-fenil-4', 9'-dihidro-3'h-espiro[ciclohexan-1,1'-pirano [3, 4, b]indol]-4-amina para el tratamiento de dolor nociceptivo. - Google Patents

Forma de dosificacion farmaceutica que comprende 6'-fluoro-(n-metil- o n,n-dimetil)-4-fenil-4', 9'-dihidro-3'h-espiro[ciclohexan-1,1'-pirano [3, 4, b]indol]-4-amina para el tratamiento de dolor nociceptivo.

Info

Publication number
MX350154B
MX350154B MX2013001289A MX2013001289A MX350154B MX 350154 B MX350154 B MX 350154B MX 2013001289 A MX2013001289 A MX 2013001289A MX 2013001289 A MX2013001289 A MX 2013001289A MX 350154 B MX350154 B MX 350154B
Authority
MX
Mexico
Prior art keywords
pyrano
indol
spiro
dihydro
cyclohexane
Prior art date
Application number
MX2013001289A
Other languages
English (en)
Other versions
MX2013001289A (es
Inventor
Bothmer John
Schiller Marc
Grüning Nadja
Hemani Ashish
Friedrich Ingo
Kirby Chris
Scholz Andreas
Original Assignee
Grünenthal Gmbh *
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=45556332&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX350154(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Grünenthal Gmbh * filed Critical Grünenthal Gmbh *
Publication of MX2013001289A publication Critical patent/MX2013001289A/es
Publication of MX350154B publication Critical patent/MX350154B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Neurosurgery (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La invención se relaciona con una forma de dosificación farmacéutica para administración una vez al día, la cual contiene 6'-fluoro-(N-metil- o N, N-dimetil-)4-fenil-4', 9'-dihidro-3 'H-espiro [ciclohexano-1, 1'-pirano[3, 4,b]indol]-4-amina o una sal fisiológicamente aceptable de la misma, para uso en el tratamiento de dolor nociceptivo, preferiblemente dolor nociceptivo agudo o dolor nociceptivo crónico.
MX2013001289A 2010-08-04 2011-08-04 Forma de dosificacion farmaceutica que comprende 6'-fluoro-(n-metil- o n,n-dimetil)-4-fenil-4', 9'-dihidro-3'h-espiro[ciclohexan-1,1'-pirano [3, 4, b]indol]-4-amina para el tratamiento de dolor nociceptivo. MX350154B (es)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US37064310P 2010-08-04 2010-08-04
US37063410P 2010-08-04 2010-08-04
US37064810P 2010-08-04 2010-08-04
EP10008116 2010-08-04
EP10008117 2010-08-04
EP10008115 2010-08-04
PCT/EP2011/003907 WO2012016697A2 (en) 2010-08-04 2011-08-04 Pharmaceutical dosage form comprising 6'-fluoro-(n-methyl- or n,n-dimethyl-)-4-phenyl-4',9'-dihydro-3'h-spiro[cyclohexane-1,1'-pyrano[3,4,b]indol]-4-amine for the treatment of nociceptive pain

Publications (2)

Publication Number Publication Date
MX2013001289A MX2013001289A (es) 2013-03-22
MX350154B true MX350154B (es) 2017-08-29

Family

ID=45556332

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2013001289A MX350154B (es) 2010-08-04 2011-08-04 Forma de dosificacion farmaceutica que comprende 6'-fluoro-(n-metil- o n,n-dimetil)-4-fenil-4', 9'-dihidro-3'h-espiro[ciclohexan-1,1'-pirano [3, 4, b]indol]-4-amina para el tratamiento de dolor nociceptivo.
MX2013001345A MX354686B (es) 2010-08-04 2011-08-04 Forma de dosificacion farmaceutica que comprende 6'-fluoro-(n-metil- o n,n-dimetil-)-4-fenil-4'.9'-dihidro-3'h-espi ro[ciclohexan-1,1'-pirano[3,4,b]indol]-4-amina para el tratamiento de dolor neuropatico.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2013001345A MX354686B (es) 2010-08-04 2011-08-04 Forma de dosificacion farmaceutica que comprende 6'-fluoro-(n-metil- o n,n-dimetil-)-4-fenil-4'.9'-dihidro-3'h-espi ro[ciclohexan-1,1'-pirano[3,4,b]indol]-4-amina para el tratamiento de dolor neuropatico.

Country Status (28)

Country Link
US (3) US20120034297A1 (es)
EP (3) EP2600851B1 (es)
JP (2) JP5792299B2 (es)
KR (2) KR20130097173A (es)
CN (2) CN103260610A (es)
AU (2) AU2011287955B2 (es)
BR (2) BR112013002734A2 (es)
CA (2) CA2805523C (es)
CL (2) CL2013000218A1 (es)
CO (2) CO6680626A2 (es)
DK (2) DK2600850T3 (es)
EC (2) ECSP13012422A (es)
ES (1) ES2675316T3 (es)
HR (2) HRP20180904T1 (es)
HU (1) HUE039328T2 (es)
IL (2) IL224155A (es)
LT (2) LT2600851T (es)
MX (2) MX350154B (es)
NZ (2) NZ605887A (es)
PE (2) PE20131096A1 (es)
PL (2) PL2600850T3 (es)
PT (1) PT2600851T (es)
RS (2) RS58017B1 (es)
RU (2) RU2638818C2 (es)
SI (2) SI2600850T1 (es)
TR (1) TR201808244T4 (es)
WO (2) WO2012016698A2 (es)
ZA (1) ZA201300655B (es)

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Also Published As

Publication number Publication date
ECSP13012423A (es) 2013-03-28
SI2600850T1 (sl) 2018-12-31
JP2013532697A (ja) 2013-08-19
US9289416B2 (en) 2016-03-22
CL2013000225A1 (es) 2013-04-01
WO2012016697A2 (en) 2012-02-09
RS57344B1 (sr) 2018-08-31
SI2600851T1 (en) 2018-07-31
AU2011287954B2 (en) 2015-07-09
US10912763B2 (en) 2021-02-09
RU2631481C2 (ru) 2017-09-22
CO6680626A2 (es) 2013-05-31
LT2600851T (lt) 2018-06-25
RU2013109137A (ru) 2014-09-10
DK2600851T3 (en) 2018-06-25
NZ605887A (en) 2014-08-29
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BR112013003677A2 (pt) 2016-09-06
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CA2805525A1 (en) 2012-02-09
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IL224154B (en) 2018-10-31
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