IT201700057899A1 - Co-attivatori dei recettori MOP e NOP nel trattamento della dipendenza da droghe e/o psicostimolanti - Google Patents
Co-attivatori dei recettori MOP e NOP nel trattamento della dipendenza da droghe e/o psicostimolantiInfo
- Publication number
- IT201700057899A1 IT201700057899A1 IT102017000057899A IT201700057899A IT201700057899A1 IT 201700057899 A1 IT201700057899 A1 IT 201700057899A1 IT 102017000057899 A IT102017000057899 A IT 102017000057899A IT 201700057899 A IT201700057899 A IT 201700057899A IT 201700057899 A1 IT201700057899 A1 IT 201700057899A1
- Authority
- IT
- Italy
- Prior art keywords
- psychostimulants
- mop
- activators
- treatment
- drug addiction
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
Landscapes
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT102017000057899A IT201700057899A1 (it) | 2017-05-29 | 2017-05-29 | Co-attivatori dei recettori MOP e NOP nel trattamento della dipendenza da droghe e/o psicostimolanti |
PCT/EP2018/063884 WO2018219847A1 (en) | 2017-05-29 | 2018-05-28 | Co-activators of mop and nop receptors in the treatment of addiction to drugs and/or psychostimulants |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT102017000057899A IT201700057899A1 (it) | 2017-05-29 | 2017-05-29 | Co-attivatori dei recettori MOP e NOP nel trattamento della dipendenza da droghe e/o psicostimolanti |
Publications (1)
Publication Number | Publication Date |
---|---|
IT201700057899A1 true IT201700057899A1 (it) | 2018-11-29 |
Family
ID=59974806
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IT102017000057899A IT201700057899A1 (it) | 2017-05-29 | 2017-05-29 | Co-attivatori dei recettori MOP e NOP nel trattamento della dipendenza da droghe e/o psicostimolanti |
Country Status (2)
Country | Link |
---|---|
IT (1) | IT201700057899A1 (it) |
WO (1) | WO2018219847A1 (it) |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5075341A (en) * | 1989-12-01 | 1991-12-24 | The Mclean Hospital Corporation | Treatment for cocaine abuse |
WO2016116280A1 (en) * | 2015-01-23 | 2016-07-28 | Grünenthal GmbH | Cebranopadol for treating pain in subjects with impaired hepatic and/or impaired renal function |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0432945A1 (en) | 1989-12-12 | 1991-06-19 | Warner-Lambert Company | A transdermal delivery system for treatment of cocaine and heroin addiction |
DE102005016460A1 (de) | 2005-04-11 | 2006-10-19 | Grünenthal GmbH | Spriocyclische Cyclohexanderivate zur Behandlung von Substanzabhängigkeit |
PE20131096A1 (es) | 2010-08-04 | 2013-10-10 | Gruenenthal Chemie | Forma de dosificacion farmaceutica que comprende 6'-fluoro-(n-metil-o n,n-dimetil)-4-fenil-4',9-dihidro-3'h-espiro[ciclohxan-1,1'-pirano[3,4,b]indol]-4-amina para el tratamiento de dolor neuropatico |
US20180021304A1 (en) | 2015-02-02 | 2018-01-25 | Ratiopharm Gmbh | Composition comprising cebranopadol in a dissolved form |
-
2017
- 2017-05-29 IT IT102017000057899A patent/IT201700057899A1/it unknown
-
2018
- 2018-05-28 WO PCT/EP2018/063884 patent/WO2018219847A1/en active Application Filing
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5075341A (en) * | 1989-12-01 | 1991-12-24 | The Mclean Hospital Corporation | Treatment for cocaine abuse |
WO2016116280A1 (en) * | 2015-01-23 | 2016-07-28 | Grünenthal GmbH | Cebranopadol for treating pain in subjects with impaired hepatic and/or impaired renal function |
Non-Patent Citations (11)
Title |
---|
"Cochrane Database of Systematic Reviews : Reviews", 8 July 2009, JOHN WILEY & SONS, LTD, Chichester, UK, article LINDA GOWING ET AL: "Buprenorphine for the management of opioid withdrawal : Reviews", XP055427372, DOI: 10.1002/14651858.CD002025.pub4 * |
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; JACOBSON, A. E.: "Biological evaluation of compounds for their physical dependence potential and abuse liability. XIX. Drug evaluation committee of the College on Problems of Drug Dependence, Inc. (1995)", XP002775875, retrieved from STN Database accession no. 1996:482970 * |
GERTA CAMI-KOBECI ET AL: "Structural Determinants of Opioid and NOP Receptor Activity in Derivatives of Buprenorphine", JOURNAL OF MEDICINAL CHEMISTRY, vol. 54, no. 19, 13 October 2011 (2011-10-13), pages 6531 - 6537, XP055035005, ISSN: 0022-2623, DOI: 10.1021/jm2003238 * |
GIORDANO DE GUGLIELMO ET AL: "Cebranopadol Blocks the Escalation of Cocaine Intake and Conditioned Reinstatement of Cocaine Seeking in Rats", JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, vol. 362, no. 3, 23 June 2017 (2017-06-23), US, pages 378 - 384, XP055426810, ISSN: 0022-3565, DOI: 10.1124/jpet.117.241042 * |
JACOBSON, A. E.: "Biological evaluation of compounds for their physical dependence potential and abuse liability. XIX. Drug evaluation committee of the College on Problems of Drug Dependence, Inc. (1995)", NIDA RESEARCH MONOGRAPH , 162(PROBLEMS OF DRUG DEPENDENCE, 1995), 363-376 CODEN: MIDAD4; ISSN: 0361-8595, 1996 * |
L. TOLL ET AL: "Comparison of the Antinociceptive and Antirewarding Profiles of Novel Bifunctional Nociceptin Receptor/ -Opioid Receptor Ligands: Implications for Therapeutic Applications", JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, vol. 331, no. 3, 22 September 2009 (2009-09-22), US, pages 954 - 964, XP055268411, ISSN: 0022-3565, DOI: 10.1124/jpet.109.157446 * |
QIANWEI SHEN ET AL: "Cebranopadol, a Mixed Opioid Agonist, Reduces Cocaine Self-administration through Nociceptin Opioid and Mu Opioid Receptors", FRONTIERS IN PSYCHIATRY, vol. 8, 13 November 2017 (2017-11-13), XP055426806, DOI: 10.3389/fpsyt.2017.00234 * |
R. B. RAFFA ET AL: "Cebranopadol: novel dual opioid/NOP receptor agonist analgesic", JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS., vol. 42, no. 1, 24 October 2016 (2016-10-24), GB, pages 8 - 17, XP055427058, ISSN: 0269-4727, DOI: 10.1111/jcpt.12461 * |
SARAH F. CORDERY ET AL: "A non-rewarding, non-aversive buprenorphine/naltrexone combination attenuates drug-primed reinstatement to cocaine and morphine in rats in a conditioned place preference paradigm : Bup/naltrex: relapse therapy", ADDICTION BIOLOGY, vol. 19, no. 4, 14 December 2012 (2012-12-14), GB, pages 575 - 586, XP055427077, ISSN: 1355-6215, DOI: 10.1111/adb.12020 * |
STEFAN SCHUNK ET AL: "Discovery of a Potent Analgesic NOP and Opioid Receptor Agonist: Cebranopadol", ACS MEDICINAL CHEMISTRY LETTERS, vol. 5, no. 8, 14 August 2014 (2014-08-14), United States, pages 857 - 862, XP055262358, ISSN: 1948-5875, DOI: 10.1021/ml500117c * |
T. V. KHROYAN ET AL: "The First Universal Opioid Ligand, (2S)-2-[(5R,6R,7R,14S)-N-cyclopropylmethyl-4,5-epoxy-6,14-ethano-3-hydroxy-6-methoxymorphinan-7-yl]-3,3-dimethylpentan-2-ol (BU08028): Characterization of the In Vitro Profile and In Vivo Behavioral Effects in Mouse Models of Acute Pain and Cocaine-Induced Reward", JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, vol. 336, no. 3, 1 March 2011 (2011-03-01), US, pages 952 - 961, XP055426904, ISSN: 0022-3565, DOI: 10.1124/jpet.110.175620 * |
Also Published As
Publication number | Publication date |
---|---|
WO2018219847A1 (en) | 2018-12-06 |
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