DK3409660T3 - Cyklisk aminderivat og farmaceutisk anvendelse deraf - Google Patents
Cyklisk aminderivat og farmaceutisk anvendelse deraf Download PDFInfo
- Publication number
- DK3409660T3 DK3409660T3 DK17744386.8T DK17744386T DK3409660T3 DK 3409660 T3 DK3409660 T3 DK 3409660T3 DK 17744386 T DK17744386 T DK 17744386T DK 3409660 T3 DK3409660 T3 DK 3409660T3
- Authority
- DK
- Denmark
- Prior art keywords
- pharmaceutical application
- cyclic
- derivative
- amin derivative
- cyclic amin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4525—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/38—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
- C07D211/96—Sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Biomedical Technology (AREA)
- Transplantation (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Toys (AREA)
- Portable Nailing Machines And Staplers (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2016015512 | 2016-01-29 | ||
| JP2016212629 | 2016-10-31 | ||
| PCT/JP2017/002924 WO2017131156A1 (ja) | 2016-01-29 | 2017-01-27 | 環状アミン誘導体及びその医薬用途 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3409660T3 true DK3409660T3 (da) | 2020-08-31 |
Family
ID=59398579
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK17744386.8T DK3409660T3 (da) | 2016-01-29 | 2017-01-27 | Cyklisk aminderivat og farmaceutisk anvendelse deraf |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US10364222B2 (da) |
| EP (1) | EP3409660B1 (da) |
| JP (1) | JP6807054B2 (da) |
| KR (1) | KR20180100573A (da) |
| CN (1) | CN108473426B (da) |
| AU (1) | AU2017210685B2 (da) |
| BR (1) | BR112018015125A2 (da) |
| CA (1) | CA3009971C (da) |
| DK (1) | DK3409660T3 (da) |
| ES (1) | ES2822606T3 (da) |
| HU (1) | HUE050744T2 (da) |
| IL (1) | IL260230B (da) |
| MX (1) | MX2018008454A (da) |
| MY (1) | MY195416A (da) |
| PH (1) | PH12018501434A1 (da) |
| PL (1) | PL3409660T3 (da) |
| PT (1) | PT3409660T (da) |
| RU (1) | RU2696862C1 (da) |
| SG (1) | SG11201805474PA (da) |
| TR (1) | TR201912580U5 (da) |
| TW (1) | TWI691486B (da) |
| WO (1) | WO2017131156A1 (da) |
| ZA (1) | ZA201804325B (da) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019022234A1 (ja) * | 2017-07-27 | 2019-01-31 | 東レ株式会社 | 炎症性腸疾患の治療剤又は予防剤 |
| CN110913859A (zh) * | 2017-07-27 | 2020-03-24 | 东丽株式会社 | 圆形脱毛症的治疗剂或预防剂 |
| TW201910312A (zh) * | 2017-07-28 | 2019-03-16 | 日商東麗股份有限公司 | 環狀胺衍生物及其醫藥用途 |
| TW201920137A (zh) * | 2017-08-31 | 2019-06-01 | 日商東麗股份有限公司 | 環狀胺衍生物及其醫藥用途 |
| TW201940476A (zh) | 2018-01-31 | 2019-10-16 | 日商東麗股份有限公司 | 環狀胺衍生物及其醫藥用途 |
| EP3765020A4 (en) | 2018-03-12 | 2021-09-22 | Escalier Biosciences B.V. | SPIROCYCLIC MMR-GAMMA MODULATORS |
| WO2019177996A1 (en) | 2018-03-12 | 2019-09-19 | Escalier Biosciences B.V. | Bicyclic ror-gamma modulators |
| CN111548303A (zh) * | 2020-06-28 | 2020-08-18 | 山东美泰医药有限公司 | 一种盐酸左布比卡因的杂质及其制备和分析方法 |
| CN113252831B (zh) * | 2021-05-20 | 2022-08-26 | 京博农化科技有限公司 | N-氯甲酰基-n-[4-（三氟甲氧基）苯基]氨基甲酸甲酯超高效液相色谱分析方法 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200642683A (en) | 2005-04-22 | 2006-12-16 | Sankyo Co | Heterocyclic compound |
| GB0510139D0 (en) | 2005-05-18 | 2005-06-22 | Addex Pharmaceuticals Sa | Novel compounds B1 |
| WO2009074829A1 (en) * | 2007-12-12 | 2009-06-18 | Astrazeneca Ab | Peptidyl nitriles and use thereof as dipeptidyl peptidase i inhibitors |
| EP2349484A2 (en) | 2008-07-15 | 2011-08-03 | Novartis AG | Heteroaryl derivatives as dgat1 inhibitors |
| WO2010096371A2 (en) | 2009-02-18 | 2010-08-26 | Boehringer Ingelheim International Gmbh | Heterocyclic compounds which modulate the cb2 receptor |
| WO2012027965A1 (en) | 2010-09-01 | 2012-03-08 | Glaxo Group Limited | Novel compounds |
| CA2816753A1 (en) | 2010-11-08 | 2012-05-18 | Lycera Corporation | N- sulfonylated tetrahydroquinolines and related bicyclic compounds inhibition of rory activity and the treatment of diseases |
| PE20141637A1 (es) | 2011-04-28 | 2014-11-20 | Japan Tobacco Inc | Compuesto de amida y aplicacion farmaceutica para el mismo |
| US9586928B2 (en) | 2011-05-16 | 2017-03-07 | The Scripps Research Institute | Modulators of the nuclear hormone receptor ROR |
| US9156837B2 (en) | 2011-07-29 | 2015-10-13 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
| GB201207406D0 (en) * | 2012-04-27 | 2012-06-13 | Glaxo Group Ltd | Novel compounds |
| CA2873877C (en) | 2012-05-31 | 2018-08-07 | Phenex Pharmaceuticals Ag | Carboxamide or sulfonamide substituted thiazoles and related derivatives as modulators for the orphan nuclear receptor ror[gamma] |
| KR20150127245A (ko) * | 2013-03-14 | 2015-11-16 | 켈탁시스, 인코퍼레이티드 | 류코트라이엔 a4 가수분해효소의 저해제 |
| WO2015103508A1 (en) * | 2014-01-06 | 2015-07-09 | Bristol-Myers Squibb Company | CARBOCYCLIC SULFONE RORγ MODULATORS |
| EP3092215B1 (en) * | 2014-01-06 | 2018-10-17 | Bristol-Myers Squibb Company | Cyclohexyl sulfone ror gamma modulators |
| WO2015129853A1 (ja) * | 2014-02-27 | 2015-09-03 | 東レ株式会社 | 環状アミン誘導体及びその医薬用途 |
-
2017
- 2017-01-25 TW TW106102788A patent/TWI691486B/zh active
- 2017-01-27 AU AU2017210685A patent/AU2017210685B2/en not_active Ceased
- 2017-01-27 ES ES17744386T patent/ES2822606T3/es active Active
- 2017-01-27 PT PT177443868T patent/PT3409660T/pt unknown
- 2017-01-27 CA CA3009971A patent/CA3009971C/en active Active
- 2017-01-27 HU HUE17744386A patent/HUE050744T2/hu unknown
- 2017-01-27 PL PL17744386T patent/PL3409660T3/pl unknown
- 2017-01-27 KR KR1020187019685A patent/KR20180100573A/ko active IP Right Grant
- 2017-01-27 CN CN201780008139.2A patent/CN108473426B/zh active Active
- 2017-01-27 BR BR112018015125-4A patent/BR112018015125A2/pt active Search and Examination
- 2017-01-27 JP JP2017507454A patent/JP6807054B2/ja active Active
- 2017-01-27 SG SG11201805474PA patent/SG11201805474PA/en unknown
- 2017-01-27 RU RU2018126968A patent/RU2696862C1/ru active
- 2017-01-27 MX MX2018008454A patent/MX2018008454A/es unknown
- 2017-01-27 WO PCT/JP2017/002924 patent/WO2017131156A1/ja active Application Filing
- 2017-01-27 EP EP17744386.8A patent/EP3409660B1/en active Active
- 2017-01-27 US US16/072,482 patent/US10364222B2/en active Active
- 2017-01-27 DK DK17744386.8T patent/DK3409660T3/da active
- 2017-01-27 MY MYPI2018000987A patent/MY195416A/en unknown
-
2018
- 2018-06-24 IL IL260230A patent/IL260230B/en active IP Right Grant
- 2018-06-27 ZA ZA2018/04325A patent/ZA201804325B/en unknown
- 2018-07-04 PH PH12018501434A patent/PH12018501434A1/en unknown
-
2019
- 2019-08-21 TR TR2019/12580U patent/TR201912580U5/tr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PT3409660T (pt) | 2020-07-31 |
| TW201731816A (zh) | 2017-09-16 |
| RU2696862C1 (ru) | 2019-08-07 |
| CN108473426A (zh) | 2018-08-31 |
| BR112018015125A2 (pt) | 2019-02-26 |
| AU2017210685B2 (en) | 2020-09-24 |
| AU2017210685A1 (en) | 2018-07-05 |
| WO2017131156A1 (ja) | 2017-08-03 |
| ES2822606T3 (es) | 2021-05-04 |
| US10364222B2 (en) | 2019-07-30 |
| MX2018008454A (es) | 2018-08-14 |
| TR201912580U5 (tr) | 2020-09-21 |
| IL260230A (en) | 2018-07-31 |
| IL260230B (en) | 2020-06-30 |
| TWI691486B (zh) | 2020-04-21 |
| EP3409660A4 (en) | 2019-06-26 |
| JPWO2017131156A1 (ja) | 2018-11-22 |
| HUE050744T2 (hu) | 2021-01-28 |
| EP3409660A1 (en) | 2018-12-05 |
| JP6807054B2 (ja) | 2021-01-06 |
| PL3409660T3 (pl) | 2021-01-25 |
| ZA201804325B (en) | 2019-09-25 |
| CA3009971C (en) | 2024-03-19 |
| US20180370916A1 (en) | 2018-12-27 |
| MY195416A (en) | 2023-01-20 |
| CN108473426B (zh) | 2021-09-07 |
| SG11201805474PA (en) | 2018-07-30 |
| KR20180100573A (ko) | 2018-09-11 |
| EP3409660B1 (en) | 2020-07-01 |
| PH12018501434A1 (en) | 2019-03-04 |
| CA3009971A1 (en) | 2017-08-03 |
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