PT3409660T - Derivado de amina cíclica e utilização farmacêutica do mesmo - Google Patents
Derivado de amina cíclica e utilização farmacêutica do mesmoInfo
- Publication number
- PT3409660T PT3409660T PT177443868T PT17744386T PT3409660T PT 3409660 T PT3409660 T PT 3409660T PT 177443868 T PT177443868 T PT 177443868T PT 17744386 T PT17744386 T PT 17744386T PT 3409660 T PT3409660 T PT 3409660T
- Authority
- PT
- Portugal
- Prior art keywords
- amine derivative
- pharmaceutical use
- cyclic amine
- cyclic
- pharmaceutical
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4525—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/38—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
- C07D211/96—Sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Biomedical Technology (AREA)
- Transplantation (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Toys (AREA)
- Portable Nailing Machines And Staplers (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2016015512 | 2016-01-29 | ||
| JP2016212629 | 2016-10-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT3409660T true PT3409660T (pt) | 2020-07-31 |
Family
ID=59398579
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT177443868T PT3409660T (pt) | 2016-01-29 | 2017-01-27 | Derivado de amina cíclica e utilização farmacêutica do mesmo |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US10364222B2 (pt) |
| EP (1) | EP3409660B1 (pt) |
| JP (1) | JP6807054B2 (pt) |
| CN (1) | CN108473426B (pt) |
| AU (1) | AU2017210685B2 (pt) |
| BR (1) | BR112018015125A2 (pt) |
| CA (1) | CA3009971C (pt) |
| DK (1) | DK3409660T3 (pt) |
| ES (1) | ES2822606T3 (pt) |
| HU (1) | HUE050744T2 (pt) |
| IL (1) | IL260230B (pt) |
| MX (1) | MX2018008454A (pt) |
| MY (1) | MY195416A (pt) |
| PH (1) | PH12018501434A1 (pt) |
| PL (1) | PL3409660T3 (pt) |
| PT (1) | PT3409660T (pt) |
| RU (1) | RU2696862C1 (pt) |
| SG (1) | SG11201805474PA (pt) |
| TR (1) | TR201912580U5 (pt) |
| TW (1) | TWI691486B (pt) |
| WO (1) | WO2017131156A1 (pt) |
| ZA (1) | ZA201804325B (pt) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019022234A1 (ja) * | 2017-07-27 | 2019-01-31 | 東レ株式会社 | 炎症性腸疾患の治療剤又は予防剤 |
| CN110913859A (zh) * | 2017-07-27 | 2020-03-24 | 东丽株式会社 | 圆形脱毛症的治疗剂或预防剂 |
| WO2019022223A1 (ja) * | 2017-07-28 | 2019-01-31 | 東レ株式会社 | 環状アミン誘導体及びその医薬用途 |
| TW201920137A (zh) * | 2017-08-31 | 2019-06-01 | 日商東麗股份有限公司 | 環狀胺衍生物及其醫藥用途 |
| MX2020007297A (es) | 2018-01-31 | 2020-09-10 | Toray Industries | Derivado de amina ciclica y uso medico del mismo. |
| US11230555B2 (en) | 2018-03-12 | 2022-01-25 | Escalier Biosciences B.V. | Bicyclic RORγ modulators |
| CN112118841A (zh) | 2018-03-12 | 2020-12-22 | 爱思凯利尔生物科学私人有限责任公司 | 螺环ROR-γ调节剂 |
| CN111548303A (zh) * | 2020-06-28 | 2020-08-18 | 山东美泰医药有限公司 | 一种盐酸左布比卡因的杂质及其制备和分析方法 |
| CN113252831B (zh) * | 2021-05-20 | 2022-08-26 | 京博农化科技有限公司 | N-氯甲酰基-n-[4-（三氟甲氧基）苯基]氨基甲酸甲酯超高效液相色谱分析方法 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPWO2006115188A1 (ja) | 2005-04-22 | 2008-12-18 | 第一三共株式会社 | ヘテロ環化合物 |
| GB0510139D0 (en) | 2005-05-18 | 2005-06-22 | Addex Pharmaceuticals Sa | Novel compounds B1 |
| AU2008334444B2 (en) * | 2007-12-12 | 2011-12-15 | Astrazeneca Ab | Peptidyl nitriles and use thereof as dipeptidyl peptidase I inhibitors |
| WO2010007046A2 (en) | 2008-07-15 | 2010-01-21 | Novartis Ag | Organic compounds |
| WO2010096371A2 (en) | 2009-02-18 | 2010-08-26 | Boehringer Ingelheim International Gmbh | Heterocyclic compounds which modulate the cb2 receptor |
| WO2012027965A1 (en) * | 2010-09-01 | 2012-03-08 | Glaxo Group Limited | Novel compounds |
| EP2638014B1 (en) | 2010-11-08 | 2017-01-04 | Lycera Corporation | N-sulfonylated tetrahydroquinolines and related bicyclic compounds for inhibition of ror-gamma activity and the treatment of diseases |
| KR101964478B1 (ko) | 2011-04-28 | 2019-04-01 | 니뽄 다바코 산교 가부시키가이샤 | 아미드 화합물 및 그의 의약 용도 |
| WO2012158784A2 (en) | 2011-05-16 | 2012-11-22 | Theodore Mark Kamenecka | Modulators of the nuclear hormone receptor ror |
| EP2738170B1 (en) | 2011-07-29 | 2017-08-30 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
| GB201207406D0 (en) | 2012-04-27 | 2012-06-13 | Glaxo Group Ltd | Novel compounds |
| UA117913C2 (uk) * | 2012-05-31 | 2018-10-25 | Фінекс Фармас'Ютікалс Аг | КАРБОКСАМІД- АБО СУЛЬФОНАМІДЗАМІЩЕНІ ТІАЗОЛИ ТА СПОРІДНЕНІ ПОХІДНІ ЯК МОДУЛЯТОРИ ОРФАНОВОГО ЯДЕРНОГО РЕЦЕПТОРА RORγ |
| MX2015011677A (es) * | 2013-03-14 | 2016-07-08 | Celtaxsys Inc | Inhibidores de leucotrieno a4 hidrolasa. |
| US9771320B2 (en) * | 2014-01-06 | 2017-09-26 | Bristol-Myers Squibb Company | Carbocyclic sulfone RORγ modulators |
| ES2704460T3 (es) * | 2014-01-06 | 2019-03-18 | Bristol Myers Squibb Co | Moduladores de ROR gamma de ciclohexilsulfona |
| WO2015129853A1 (ja) * | 2014-02-27 | 2015-09-03 | 東レ株式会社 | 環状アミン誘導体及びその医薬用途 |
-
2017
- 2017-01-25 TW TW106102788A patent/TWI691486B/zh active
- 2017-01-27 BR BR112018015125-4A patent/BR112018015125A2/pt active Search and Examination
- 2017-01-27 AU AU2017210685A patent/AU2017210685B2/en not_active Ceased
- 2017-01-27 JP JP2017507454A patent/JP6807054B2/ja active Active
- 2017-01-27 HU HUE17744386A patent/HUE050744T2/hu unknown
- 2017-01-27 MY MYPI2018000987A patent/MY195416A/en unknown
- 2017-01-27 RU RU2018126968A patent/RU2696862C1/ru active
- 2017-01-27 ES ES17744386T patent/ES2822606T3/es active Active
- 2017-01-27 US US16/072,482 patent/US10364222B2/en active Active
- 2017-01-27 CA CA3009971A patent/CA3009971C/en active Active
- 2017-01-27 PT PT177443868T patent/PT3409660T/pt unknown
- 2017-01-27 PL PL17744386T patent/PL3409660T3/pl unknown
- 2017-01-27 WO PCT/JP2017/002924 patent/WO2017131156A1/ja active Application Filing
- 2017-01-27 DK DK17744386.8T patent/DK3409660T3/da active
- 2017-01-27 SG SG11201805474PA patent/SG11201805474PA/en unknown
- 2017-01-27 EP EP17744386.8A patent/EP3409660B1/en active Active
- 2017-01-27 CN CN201780008139.2A patent/CN108473426B/zh active Active
- 2017-01-27 MX MX2018008454A patent/MX2018008454A/es unknown
-
2018
- 2018-06-24 IL IL260230A patent/IL260230B/en active IP Right Grant
- 2018-06-27 ZA ZA2018/04325A patent/ZA201804325B/en unknown
- 2018-07-04 PH PH12018501434A patent/PH12018501434A1/en unknown
-
2019
- 2019-08-21 TR TR2019/12580U patent/TR201912580U5/tr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR20180100573A (ko) | 2018-09-11 |
| CN108473426A (zh) | 2018-08-31 |
| CA3009971C (en) | 2024-03-19 |
| AU2017210685B2 (en) | 2020-09-24 |
| JP6807054B2 (ja) | 2021-01-06 |
| US10364222B2 (en) | 2019-07-30 |
| EP3409660A4 (en) | 2019-06-26 |
| ZA201804325B (en) | 2019-09-25 |
| MX2018008454A (es) | 2018-08-14 |
| IL260230A (en) | 2018-07-31 |
| HUE050744T2 (hu) | 2021-01-28 |
| JPWO2017131156A1 (ja) | 2018-11-22 |
| SG11201805474PA (en) | 2018-07-30 |
| CA3009971A1 (en) | 2017-08-03 |
| WO2017131156A1 (ja) | 2017-08-03 |
| TR201912580U5 (tr) | 2020-09-21 |
| PL3409660T3 (pl) | 2021-01-25 |
| ES2822606T3 (es) | 2021-05-04 |
| MY195416A (en) | 2023-01-20 |
| AU2017210685A1 (en) | 2018-07-05 |
| TWI691486B (zh) | 2020-04-21 |
| TW201731816A (zh) | 2017-09-16 |
| CN108473426B (zh) | 2021-09-07 |
| BR112018015125A2 (pt) | 2019-02-26 |
| US20180370916A1 (en) | 2018-12-27 |
| PH12018501434A1 (en) | 2019-03-04 |
| RU2696862C1 (ru) | 2019-08-07 |
| EP3409660A1 (en) | 2018-12-05 |
| EP3409660B1 (en) | 2020-07-01 |
| IL260230B (en) | 2020-06-30 |
| DK3409660T3 (da) | 2020-08-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ZA201705293B (en) | Cyclic amine derivative and pharmaceutical use thereof | |
| HK1232224A1 (zh) | 取代脲衍生物及其在藥物中的應用 | |
| HK1259145A1 (zh) | 3-脫氧衍生物及其藥物組合物 | |
| PT3409660T (pt) | Derivado de amina cíclica e utilização farmacêutica do mesmo | |
| HK1252026A1 (zh) | 藥物組合及其應用 | |
| IL272385A (en) | Drug compound and methods of preparation | |
| PT3050877T (pt) | Derivado de amina cíclica e sua utilização farmacêutica | |
| HK1232211A1 (zh) | 二甲基吡啶胺衍生物及其醫藥用途 | |
| ZA201901263B (en) | Crystals of cyclic amine derivative and pharmaceutical use thereof | |
| EP3406620A4 (en) | CYCLIC DERIVATIVE OF DICAFOYLSPERMIDINE AND USE THEREOF | |
| ZA202000959B (en) | Adamantylmethylamine derivative and use thereof as pharmaceutical | |
| EP3275879A4 (en) | Cyclic amine derivative and use thereof for medical purposes | |
| IL275991A (en) | A cyclic amine derivative and its medicinal use | |
| EP3275878A4 (en) | Cyclic amine derivative and use thereof for medical purposes | |
| GB201419354D0 (en) | Pharmaceutical extracts and uses thereof |