RU2012115681A - Детекция множества мишеней в биологических образцах - Google Patents
Детекция множества мишеней в биологических образцах Download PDFInfo
- Publication number
- RU2012115681A RU2012115681A RU2012115681/10A RU2012115681A RU2012115681A RU 2012115681 A RU2012115681 A RU 2012115681A RU 2012115681/10 A RU2012115681/10 A RU 2012115681/10A RU 2012115681 A RU2012115681 A RU 2012115681A RU 2012115681 A RU2012115681 A RU 2012115681A
- Authority
- RU
- Russia
- Prior art keywords
- targets
- group
- signals
- probes
- biological sample
- Prior art date
Links
- 239000012472 biological sample Substances 0.000 title claims abstract 26
- 238000001514 detection method Methods 0.000 title claims abstract 7
- 239000000523 sample Substances 0.000 claims abstract 65
- 238000000034 method Methods 0.000 claims abstract 44
- 238000012986 modification Methods 0.000 claims abstract 6
- 230000004048 modification Effects 0.000 claims abstract 6
- 238000001069 Raman spectroscopy Methods 0.000 claims abstract 4
- 239000012634 fragment Substances 0.000 claims abstract 2
- 230000015572 biosynthetic process Effects 0.000 claims 5
- 239000003153 chemical reaction reagent Substances 0.000 claims 4
- 238000004132 cross linking Methods 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 102000004169 proteins and genes Human genes 0.000 claims 3
- 229920002477 rna polymer Polymers 0.000 claims 3
- 239000013043 chemical agent Substances 0.000 claims 2
- 150000007523 nucleic acids Chemical group 0.000 claims 2
- 108020004414 DNA Proteins 0.000 claims 1
- 102000053602 DNA Human genes 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 108091034117 Oligonucleotide Proteins 0.000 claims 1
- 150000004676 glycans Chemical class 0.000 claims 1
- -1 hapten Proteins 0.000 claims 1
- 239000005556 hormone Substances 0.000 claims 1
- 229940088597 hormone Drugs 0.000 claims 1
- 150000002632 lipids Chemical class 0.000 claims 1
- 230000004807 localization Effects 0.000 claims 1
- 230000000873 masking effect Effects 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 229920001282 polysaccharide Polymers 0.000 claims 1
- 239000005017 polysaccharide Substances 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 238000012800 visualization Methods 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12/582,745 US9677125B2 (en) | 2009-10-21 | 2009-10-21 | Detection of plurality of targets in biological samples |
| US12/582,745 | 2009-10-21 | ||
| PCT/EP2010/065876 WO2011048184A1 (en) | 2009-10-21 | 2010-10-21 | Detection of plurality of targets in biological samples |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2012115681A true RU2012115681A (ru) | 2013-11-27 |
Family
ID=43103438
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2012115681/10A RU2012115681A (ru) | 2009-10-21 | 2010-10-21 | Детекция множества мишеней в биологических образцах |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US9677125B2 (https=) |
| EP (1) | EP2491132B1 (https=) |
| JP (1) | JP2013507941A (https=) |
| KR (1) | KR20120088716A (https=) |
| CN (1) | CN102803510A (https=) |
| AU (1) | AU2010309739A1 (https=) |
| BR (1) | BR112012009481A2 (https=) |
| CA (1) | CA2777421A1 (https=) |
| IN (1) | IN2012DN03156A (https=) |
| RU (1) | RU2012115681A (https=) |
| WO (1) | WO2011048184A1 (https=) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4249605B1 (en) | 2011-12-22 | 2024-08-28 | President And Fellows Of Harvard College | Methods for analyte detection |
| US9176032B2 (en) | 2011-12-23 | 2015-11-03 | General Electric Company | Methods of analyzing an H and E stained biological sample |
| US8568991B2 (en) | 2011-12-23 | 2013-10-29 | General Electric Company | Photoactivated chemical bleaching of dyes |
| KR101460439B1 (ko) * | 2012-05-14 | 2014-11-12 | 서울대학교산학협력단 | 나노프로브 및 이를 이용한 표적 물질 검출방법 |
| WO2013187765A2 (en) * | 2012-06-14 | 2013-12-19 | Erasmus University Medical Center Rotterdam | Methods, reagents and kits for detecting minimal residual disease |
| US10677802B2 (en) * | 2012-12-17 | 2020-06-09 | Ge Healthcare Bio-Sciences Corp. | Chemical bleaching of dyes using radical photoinitiators |
| JP2016513794A (ja) | 2013-03-06 | 2016-05-16 | ゼネラル・エレクトリック・カンパニイ | Ｈ＆ｅ染色された生体試料を分析する方法 |
| WO2014204578A1 (en) | 2013-06-21 | 2014-12-24 | The General Hospital Corporation | Using rna-guided foki nucleases (rfns) to increase specificity for rna-guided genome editing |
| CN112301024A (zh) | 2013-03-15 | 2021-02-02 | 通用医疗公司 | 使用RNA引导的FokI核酸酶(RFN)提高RNA引导的基因组编辑的特异性 |
| US10760064B2 (en) | 2013-03-15 | 2020-09-01 | The General Hospital Corporation | RNA-guided targeting of genetic and epigenomic regulatory proteins to specific genomic loci |
| CA2907493A1 (en) † | 2013-04-30 | 2014-11-13 | California Institute Of Technology | Multiplex labeling of molecules by sequential hybridization barcoding |
| CA2919833A1 (en) | 2013-07-30 | 2015-02-05 | President And Fellows Of Harvard College | Quantitative dna-based imaging and super-resolution imaging |
| US9322051B2 (en) | 2013-10-07 | 2016-04-26 | General Electric Company | Probing of biological samples |
| CN106459995B (zh) | 2013-11-07 | 2020-02-21 | 爱迪塔斯医药有限公司 | 使用统治型gRNA的CRISPR相关方法和组合物 |
| US10294510B2 (en) * | 2014-03-11 | 2019-05-21 | President And Fellows Of Harvard College | High-throughput and highly multiplexed imaging with programmable nucleic acid probes |
| US9909167B2 (en) | 2014-06-23 | 2018-03-06 | The Board Of Trustees Of The Leland Stanford Junior University | On-slide staining by primer extension |
| EP4328322A3 (en) | 2014-07-30 | 2024-05-22 | President and Fellows of Harvard College | Probe library construction |
| US9926546B2 (en) | 2015-08-28 | 2018-03-27 | The General Hospital Corporation | Engineered CRISPR-Cas9 nucleases |
| US9512446B1 (en) | 2015-08-28 | 2016-12-06 | The General Hospital Corporation | Engineered CRISPR-Cas9 nucleases |
| AU2017302300B2 (en) | 2016-07-27 | 2023-08-17 | The Board Of Trustees Of The Leland Stanford Junior University | Highly-multiplexed fluorescent imaging |
| US12421540B2 (en) | 2016-08-01 | 2025-09-23 | California Institute Of Technology | Sequential probing of molecular targets based on pseudo-color barcodes with embedded error correction mechanism |
| CN106290877A (zh) * | 2016-09-08 | 2017-01-04 | 北京海思特临床检验所有限公司 | 急性髓系白血病粒细胞抗原表达量检测试剂盒及检测方法 |
| CN106290812A (zh) * | 2016-09-08 | 2017-01-04 | 北京海思特临床检验所有限公司 | B细胞恶性肿瘤相关抗原表达量检测试剂盒及检测方法 |
| CN118345145A (zh) | 2016-12-09 | 2024-07-16 | 乌尔蒂维尤股份有限公司 | 用于使用标记的核酸成像剂进行多路复用成像的改进方法 |
| US11788123B2 (en) | 2017-05-26 | 2023-10-17 | President And Fellows Of Harvard College | Systems and methods for high-throughput image-based screening |
| WO2019109046A1 (en) * | 2017-11-30 | 2019-06-06 | Arrakis Therapeutics, Inc. | Nucleic acid-binding photoprobes and uses thereof |
| JP6999527B2 (ja) * | 2018-09-25 | 2022-01-18 | 株式会社日立ハイテク | 試験方法、分注装置 |
| US12331320B2 (en) | 2018-10-10 | 2025-06-17 | The Research Foundation For The State University Of New York | Genome edited cancer cell vaccines |
| EP3894583A4 (en) | 2018-12-13 | 2022-11-09 | President and Fellows of Harvard College | AMPLIFICATION METHODS AND SYSTEMS FOR MERFISH AND OTHER APPLICATIONS |
| US11397179B2 (en) | 2018-12-31 | 2022-07-26 | Robert Bosch Gmbh | PH-modulated imaging of targets close to a solid surface |
| JP7405400B2 (ja) * | 2019-11-20 | 2023-12-26 | Ｎｅｃソリューションイノベータ株式会社 | 核酸分子およびその用途 |
| US12492427B2 (en) | 2020-06-18 | 2025-12-09 | Resolve Biosciences Gmbh | Multiplex method for detecting different analytes in a sample |
| US20240212150A1 (en) * | 2021-04-16 | 2024-06-27 | Advanced Cel Diagnostics, Inc. | Materials and methods related to image processing |
| CN118103710A (zh) * | 2021-08-09 | 2024-05-28 | 安元有限公司 | 用于检测临床前阿兹海默氏病的组合物、试剂盒和方法 |
| EP4474793A1 (en) * | 2023-06-09 | 2024-12-11 | Leica Biosystems Richmond, Inc. | Automated melanin bleaching |
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| JP2009232707A (ja) * | 2008-03-26 | 2009-10-15 | Canon Inc | 一塩基多型の検出法及びプローブ固定担体 |
-
2009
- 2009-10-21 US US12/582,745 patent/US9677125B2/en active Active
-
2010
- 2010-10-21 CN CN2010800583058A patent/CN102803510A/zh active Pending
- 2010-10-21 EP EP10768028.2A patent/EP2491132B1/en active Active
- 2010-10-21 BR BR112012009481A patent/BR112012009481A2/pt not_active IP Right Cessation
- 2010-10-21 CA CA2777421A patent/CA2777421A1/en not_active Abandoned
- 2010-10-21 RU RU2012115681/10A patent/RU2012115681A/ru not_active Application Discontinuation
- 2010-10-21 KR KR1020127010261A patent/KR20120088716A/ko not_active Withdrawn
- 2010-10-21 IN IN3156DEN2012 patent/IN2012DN03156A/en unknown
- 2010-10-21 WO PCT/EP2010/065876 patent/WO2011048184A1/en not_active Ceased
- 2010-10-21 AU AU2010309739A patent/AU2010309739A1/en not_active Abandoned
- 2010-10-21 JP JP2012534702A patent/JP2013507941A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CN102803510A (zh) | 2012-11-28 |
| CA2777421A1 (en) | 2011-04-28 |
| EP2491132B1 (en) | 2018-03-21 |
| AU2010309739A1 (en) | 2012-05-03 |
| IN2012DN03156A (https=) | 2015-09-18 |
| WO2011048184A1 (en) | 2011-04-28 |
| US20110092381A1 (en) | 2011-04-21 |
| JP2013507941A (ja) | 2013-03-07 |
| US9677125B2 (en) | 2017-06-13 |
| EP2491132A1 (en) | 2012-08-29 |
| BR112012009481A2 (pt) | 2016-11-29 |
| KR20120088716A (ko) | 2012-08-08 |
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