RU2012104214A - Противовирусные соединения и способы их получения и применения - Google Patents
Противовирусные соединения и способы их получения и применения Download PDFInfo
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- RU2012104214A RU2012104214A RU2012104214/04A RU2012104214A RU2012104214A RU 2012104214 A RU2012104214 A RU 2012104214A RU 2012104214/04 A RU2012104214/04 A RU 2012104214/04A RU 2012104214 A RU2012104214 A RU 2012104214A RU 2012104214 A RU2012104214 A RU 2012104214A
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- 150000001875 compounds Chemical class 0.000 title claims abstract 48
- 230000000840 anti-viral effect Effects 0.000 title claims abstract 3
- 238000000034 method Methods 0.000 title claims 4
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims abstract 24
- 229910052757 nitrogen Inorganic materials 0.000 claims abstract 20
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract 16
- 239000001257 hydrogen Substances 0.000 claims abstract 16
- 229910052736 halogen Inorganic materials 0.000 claims abstract 15
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims abstract 15
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract 9
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims abstract 8
- 125000004433 nitrogen atom Chemical group N* 0.000 claims abstract 8
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims abstract 7
- 229910052760 oxygen Inorganic materials 0.000 claims abstract 7
- 239000001301 oxygen Substances 0.000 claims abstract 7
- 125000003118 aryl group Chemical group 0.000 claims abstract 6
- 125000001072 heteroaryl group Chemical group 0.000 claims abstract 6
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims abstract 5
- 229910052799 carbon Inorganic materials 0.000 claims abstract 5
- GLUUGHFHXGJENI-UHFFFAOYSA-N diethylenediamine Natural products C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 claims abstract 5
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims abstract 4
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 claims abstract 4
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims abstract 4
- 229910052785 arsenic Inorganic materials 0.000 claims abstract 4
- RQNWIZPPADIBDY-UHFFFAOYSA-N arsenic atom Chemical compound [As] RQNWIZPPADIBDY-UHFFFAOYSA-N 0.000 claims abstract 4
- 150000001540 azides Chemical group 0.000 claims abstract 4
- 125000004122 cyclic group Chemical group 0.000 claims abstract 4
- -1 nitro, amino Chemical group 0.000 claims abstract 4
- 229910052698 phosphorus Inorganic materials 0.000 claims abstract 4
- 239000011574 phosphorus Substances 0.000 claims abstract 4
- 229910052710 silicon Inorganic materials 0.000 claims abstract 4
- 239000010703 silicon Substances 0.000 claims abstract 4
- 125000001424 substituent group Chemical group 0.000 claims abstract 4
- 229910052717 sulfur Inorganic materials 0.000 claims abstract 4
- 239000011593 sulfur Substances 0.000 claims abstract 4
- 125000000623 heterocyclic group Chemical group 0.000 claims abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract 3
- 150000004885 piperazines Chemical class 0.000 claims abstract 3
- 150000002367 halogens Chemical group 0.000 claims 14
- ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical compound NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 claims 10
- 150000002431 hydrogen Chemical class 0.000 claims 9
- 125000006727 (C1-C6) alkenyl group Chemical group 0.000 claims 6
- 125000006728 (C1-C6) alkynyl group Chemical group 0.000 claims 6
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 6
- CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Natural products CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 claims 5
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims 5
- 150000001408 amides Chemical class 0.000 claims 5
- ICCBZGUDUOMNOF-UHFFFAOYSA-N azidoamine Chemical compound NN=[N+]=[N-] ICCBZGUDUOMNOF-UHFFFAOYSA-N 0.000 claims 5
- 239000004202 carbamide Substances 0.000 claims 5
- 150000007942 carboxylates Chemical class 0.000 claims 5
- 125000004093 cyano group Chemical group *C#N 0.000 claims 5
- SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 claims 5
- 239000012948 isocyanate Substances 0.000 claims 5
- 150000002513 isocyanates Chemical class 0.000 claims 5
- 150000002527 isonitriles Chemical class 0.000 claims 5
- 150000002540 isothiocyanates Chemical class 0.000 claims 5
- 150000002825 nitriles Chemical class 0.000 claims 5
- 150000003568 thioethers Chemical class 0.000 claims 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 4
- 208000036142 Viral infection Diseases 0.000 claims 2
- 206010022000 influenza Diseases 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 230000009385 viral infection Effects 0.000 claims 2
- 108090001074 Nucleocapsid Proteins Proteins 0.000 claims 1
- JYEKSOWFHRHPEW-UHFFFAOYSA-N [3-(2,6-dichlorophenyl)-5-methyl-1,2-oxazol-4-yl]-[4-(4-nitrophenyl)piperazin-1-yl]methanone Chemical compound CC=1ON=C(C=2C(=CC=CC=2Cl)Cl)C=1C(=O)N(CC1)CCN1C1=CC=C([N+]([O-])=O)C=C1 JYEKSOWFHRHPEW-UHFFFAOYSA-N 0.000 claims 1
- FTZRPWBVXTZBNA-UHFFFAOYSA-N [3-(2-chlorophenyl)-5-methyl-1,2-oxazol-4-yl]-[4-(4-nitrophenyl)piperazin-1-yl]methanone Chemical compound CC=1ON=C(C=2C(=CC=CC=2)Cl)C=1C(=O)N(CC1)CCN1C1=CC=C([N+]([O-])=O)C=C1 FTZRPWBVXTZBNA-UHFFFAOYSA-N 0.000 claims 1
- XWTLFVNGNKRDQT-UHFFFAOYSA-N [3-(4-azidophenyl)-5-methyl-1,2-oxazol-4-yl]-[4-(2-chloro-4-nitrophenyl)piperazin-1-yl]methanone Chemical compound CC=1ON=C(C=2C=CC(=CC=2)N=[N+]=[N-])C=1C(=O)N(CC1)CCN1C1=CC=C([N+]([O-])=O)C=C1Cl XWTLFVNGNKRDQT-UHFFFAOYSA-N 0.000 claims 1
- NOQAKFBEYVGMLL-UHFFFAOYSA-N [3-[(4-aminophenyl)methyl]-1,2-oxazol-4-yl]-[4-(2-chloro-4-nitrophenyl)piperazin-1-yl]methanone Chemical compound C1=CC(N)=CC=C1CC1=NOC=C1C(=O)N1CCN(C=2C(=CC(=CC=2)[N+]([O-])=O)Cl)CC1 NOQAKFBEYVGMLL-UHFFFAOYSA-N 0.000 claims 1
- MPNXWVURGRCHGY-UHFFFAOYSA-N [4-(2-chloro-4-nitrophenyl)-2-methylpiperazin-1-yl]-(5-methyl-3-phenyl-1,2-oxazol-4-yl)methanone Chemical compound CC1CN(C=2C(=CC(=CC=2)[N+]([O-])=O)Cl)CCN1C(=O)C1=C(C)ON=C1C1=CC=CC=C1 MPNXWVURGRCHGY-UHFFFAOYSA-N 0.000 claims 1
- CONGFKLDVHXNQW-UHFFFAOYSA-N [4-(2-chloro-4-nitrophenyl)-2-methylpiperazin-1-yl]-[3-(2-chlorophenyl)-5-methyl-1,2-oxazol-4-yl]methanone Chemical compound CC1CN(C=2C(=CC(=CC=2)[N+]([O-])=O)Cl)CCN1C(=O)C1=C(C)ON=C1C1=CC=CC=C1Cl CONGFKLDVHXNQW-UHFFFAOYSA-N 0.000 claims 1
- OWXBJAPOSQSWAO-UHFFFAOYSA-N [4-(2-chloro-4-nitrophenyl)piperazin-1-yl]-(5-methyl-3-phenyl-1,2-oxazol-4-yl)methanone Chemical compound CC=1ON=C(C=2C=CC=CC=2)C=1C(=O)N(CC1)CCN1C1=CC=C([N+]([O-])=O)C=C1Cl OWXBJAPOSQSWAO-UHFFFAOYSA-N 0.000 claims 1
- MVZDVDKOXKQGDM-UHFFFAOYSA-N [4-(2-chloro-4-nitrophenyl)piperazin-1-yl]-[3-(2-chlorophenyl)-5-methyl-1,2-oxazol-4-yl]methanone Chemical compound CC=1ON=C(C=2C(=CC=CC=2)Cl)C=1C(=O)N(CC1)CCN1C1=CC=C([N+]([O-])=O)C=C1Cl MVZDVDKOXKQGDM-UHFFFAOYSA-N 0.000 claims 1
- FNZOHHJCUYQDHV-UHFFFAOYSA-N [4-(2-chloro-4-nitrophenyl)piperazin-1-yl]-[3-(4-hydroxyphenyl)-5-methyl-1,2-oxazol-4-yl]methanone Chemical compound CC=1ON=C(C=2C=CC(O)=CC=2)C=1C(=O)N(CC1)CCN1C1=CC=C([N+]([O-])=O)C=C1Cl FNZOHHJCUYQDHV-UHFFFAOYSA-N 0.000 claims 1
- 238000009825 accumulation Methods 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 150000002545 isoxazoles Chemical class 0.000 claims 1
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 102000010410 Nogo Proteins Human genes 0.000 abstract 1
- 108010077641 Nogo Proteins Proteins 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 0 Cc1c(*)c(*)ccc1 Chemical compound Cc1c(*)c(*)ccc1 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/18—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pulmonology (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23143109P | 2009-08-05 | 2009-08-05 | |
| US61/231,431 | 2009-08-05 | ||
| PCT/CN2010/001187 WO2011015037A1 (en) | 2009-08-05 | 2010-08-05 | Antiviral compounds and methods of making and using there of cross reference to related applications |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2012104214A true RU2012104214A (ru) | 2013-09-10 |
Family
ID=43543887
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2012104214/04A RU2012104214A (ru) | 2009-08-05 | 2010-08-05 | Противовирусные соединения и способы их получения и применения |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP2462138B1 (enExample) |
| JP (1) | JP2013501008A (enExample) |
| KR (1) | KR20120092567A (enExample) |
| CN (1) | CN102596946B (enExample) |
| AU (1) | AU2010281265A1 (enExample) |
| BR (1) | BR112012002331A2 (enExample) |
| CA (1) | CA2770140A1 (enExample) |
| IL (1) | IL217745A0 (enExample) |
| IN (1) | IN2012DN01254A (enExample) |
| MX (1) | MX2012001504A (enExample) |
| RU (1) | RU2012104214A (enExample) |
| SG (1) | SG178106A1 (enExample) |
| WO (1) | WO2011015037A1 (enExample) |
Families Citing this family (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0918249D0 (en) | 2009-10-19 | 2009-12-02 | Respivert Ltd | Compounds |
| WO2011147198A1 (en) * | 2010-05-28 | 2011-12-01 | Versitech Limited | Compounds and methods for treatment of proliferative diseases |
| JP5902172B2 (ja) | 2010-09-08 | 2016-04-13 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | 広範囲のインフルエンザ抗ウイルス薬としての新規ピペラジン類似体 |
| CN103209977A (zh) * | 2010-09-28 | 2013-07-17 | 百时美施贵宝公司 | 作为广谱抗流感病毒剂的带有取代的杂芳基的新的哌嗪类似物 |
| UY33337A (es) | 2010-10-18 | 2011-10-31 | Respivert Ltd | DERIVADOS SUSTITUIDOS DE 1H-PIRAZOL[ 3,4-d]PIRIMIDINA COMO INHIBIDORES DE LAS FOSFOINOSITIDA 3-QUINASAS |
| WO2012088266A2 (en) | 2010-12-22 | 2012-06-28 | Incyte Corporation | Substituted imidazopyridazines and benzimidazoles as inhibitors of fgfr3 |
| GB201104267D0 (en) | 2011-03-14 | 2011-04-27 | Cancer Rec Tech Ltd | Pyrrolopyridineamino derivatives |
| US20140011700A1 (en) * | 2011-03-25 | 2014-01-09 | Bristol-Myers Squibb Company | Three-dimensional structure of h1n1 nucleoprotein in complex with antiviral compounds |
| KR101369584B1 (ko) * | 2011-04-19 | 2014-03-06 | 일양약품주식회사 | 페닐-이속사졸 유도체 및 그의 제조방법 |
| CN102432555A (zh) * | 2011-09-09 | 2012-05-02 | 中国科学院广州生物医药与健康研究院 | 1,2,3-三氮唑-4（5）羧酰胺类化合物及其应用 |
| AU2013234081B2 (en) | 2012-03-13 | 2017-02-02 | Respivert Limited | Crystalline PI3 kinase inhibitors |
| US9676734B2 (en) | 2012-05-18 | 2017-06-13 | Vironova Influenza Ab | Compounds and methods |
| BR112014028632B1 (pt) * | 2012-05-18 | 2020-01-28 | Vironova Ab | composto, composição farmacêutica, e, método para preparar um composto |
| HUE042374T2 (hu) | 2012-06-13 | 2019-06-28 | Incyte Holdings Corp | Szubsztituált triciklusos vegyületek mint FGFR inhibitorok |
| US9388185B2 (en) | 2012-08-10 | 2016-07-12 | Incyte Holdings Corporation | Substituted pyrrolo[2,3-b]pyrazines as FGFR inhibitors |
| GB201216018D0 (en) | 2012-09-07 | 2012-10-24 | Cancer Rec Tech Ltd | Pharmacologically active compounds |
| US9266892B2 (en) | 2012-12-19 | 2016-02-23 | Incyte Holdings Corporation | Fused pyrazoles as FGFR inhibitors |
| TW201522341A (zh) | 2013-03-15 | 2015-06-16 | Respivert Ltd | 化合物 |
| AR095353A1 (es) | 2013-03-15 | 2015-10-07 | Respivert Ltd | Compuesto |
| KR102469849B1 (ko) | 2013-04-19 | 2022-11-23 | 인사이트 홀딩스 코포레이션 | Fgfr 저해제로서 이환식 헤테로사이클 |
| ES2724577T3 (es) * | 2013-07-30 | 2019-09-12 | Janssen Sciences Ireland Unlimited Co | Análogos de piridina-piperazinilo sustituidos como compuestos antivirales de RSV |
| GB201314452D0 (en) | 2013-08-13 | 2013-09-25 | Ostara Biomedical Ltd | Embryo implantation |
| GB201415569D0 (en) | 2014-09-03 | 2014-10-15 | C4X Discovery Ltd | Therapeutic Compounds |
| US10851105B2 (en) | 2014-10-22 | 2020-12-01 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
| GB201501302D0 (en) | 2015-01-27 | 2015-03-11 | Ostara Biomedical Ltd | Embryo implantation |
| WO2016134294A1 (en) | 2015-02-20 | 2016-08-25 | Incyte Corporation | Bicyclic heterocycles as fgfr4 inhibitors |
| MA41551A (fr) | 2015-02-20 | 2017-12-26 | Incyte Corp | Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4 |
| AU2016219822B2 (en) | 2015-02-20 | 2020-07-09 | Incyte Holdings Corporation | Bicyclic heterocycles as FGFR inhibitors |
| GB201517523D0 (en) | 2015-10-05 | 2015-11-18 | Ostara Biomedical Ltd | Methods and compositions for managing reproduction |
| GB201601703D0 (en) | 2016-01-29 | 2016-03-16 | C4X Discovery Ltd | Therapeutic compounds |
| CN107056762B (zh) * | 2016-12-22 | 2020-08-28 | 四川百利药业有限责任公司 | 一种用作抗流感病毒的双羰基类似物 |
| WO2018141854A1 (en) | 2017-02-02 | 2018-08-09 | Janssen Vaccines & Prevention B.V. | Piperazine derivatives for influenza virus inhibition |
| CA3052353A1 (en) * | 2017-02-02 | 2018-08-09 | Janssen Vaccines & Prevention B.V. | Piperazine derivatives for influenza virus inhibition |
| AR111960A1 (es) | 2017-05-26 | 2019-09-04 | Incyte Corp | Formas cristalinas de un inhibidor de fgfr y procesos para su preparación |
| TWI793151B (zh) | 2017-08-23 | 2023-02-21 | 瑞士商諾華公司 | 3-(1-氧異吲哚啉-2-基)之氫吡啶-2,6-二酮衍生物及其用途 |
| EP4309737A3 (en) | 2018-05-04 | 2024-03-27 | Incyte Corporation | Solid forms of an fgfr inhibitor and processes for preparing the same |
| EP3788046B1 (en) | 2018-05-04 | 2025-12-10 | Incyte Corporation | Salts of an fgfr inhibitor |
| RS64759B1 (sr) | 2018-07-10 | 2023-11-30 | Novartis Ag | 3-(5-hidroksi-1-oksoizoindolin-2-il)piperidin-2,6-dion derivati i njihova primena u lečenju bolesti zavisnih od cink prsta 2 (ikzf2) iz porodice ikaros |
| AR116109A1 (es) | 2018-07-10 | 2021-03-31 | Novartis Ag | Derivados de 3-(5-amino-1-oxoisoindolin-2-il)piperidina-2,6-diona y usos de los mismos |
| EP3911640A4 (en) | 2019-01-18 | 2022-10-26 | Astrazeneca AB | PCSK9 INHIBITORS AND METHODS OF USE THEREOF |
| US11628162B2 (en) | 2019-03-08 | 2023-04-18 | Incyte Corporation | Methods of treating cancer with an FGFR inhibitor |
| US11591329B2 (en) | 2019-07-09 | 2023-02-28 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
| TWI765323B (zh) * | 2019-08-22 | 2022-05-21 | 大陸商四川海思科製藥有限公司 | 抗流感病毒化合物及其製備方法和用途 |
| US12122767B2 (en) | 2019-10-01 | 2024-10-22 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
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| JP7720840B2 (ja) | 2019-12-04 | 2025-08-08 | インサイト・コーポレイション | Ｆｇｆｒ阻害剤としての三環式複素環 |
| KR20220131900A (ko) | 2019-12-04 | 2022-09-29 | 인사이트 코포레이션 | Fgfr 억제제의 유도체 |
| US12012409B2 (en) | 2020-01-15 | 2024-06-18 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
| AU2021224588B2 (en) | 2020-02-18 | 2024-07-18 | Gilead Sciences, Inc. | Antiviral compounds |
| TWI883391B (zh) | 2020-02-18 | 2025-05-11 | 美商基利科學股份有限公司 | 抗病毒化合物 |
| TWI775313B (zh) | 2020-02-18 | 2022-08-21 | 美商基利科學股份有限公司 | 抗病毒化合物 |
| WO2021204924A1 (en) | 2020-04-09 | 2021-10-14 | Vironova Medical Ab | Compounds for use in the treatment of hypercytokinemia |
| WO2021204923A1 (en) | 2020-04-09 | 2021-10-14 | Vironova Medical Ab | Antiviral agents |
| CA3215903A1 (en) | 2021-04-12 | 2022-10-20 | Incyte Corporation | Combination therapy comprising an fgfr inhibitor and a nectin-4 targeting agent |
| KR20230170745A (ko) | 2021-04-16 | 2023-12-19 | 길리애드 사이언시즈, 인코포레이티드 | 아미드를 사용한 카르바뉴클레오시드를 제조하는 방법 |
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| US12116380B2 (en) | 2021-08-18 | 2024-10-15 | Gilead Sciences, Inc. | Phospholipid compounds and methods of making and using the same |
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| JPH05117150A (ja) | 1991-10-25 | 1993-05-14 | Sanwa Kagaku Kenkyusho Co Ltd | 抗ウイルス剤 |
| KR200293242Y1 (ko) * | 2002-04-18 | 2002-11-01 | 전이범 | 산소 절단기호스 |
| DE10236564A1 (de) * | 2002-08-08 | 2004-05-19 | Ursapharm Arzneimittel Gmbh & Co. Kg | Verwendung von papaverinartigem Vasodilatator und pharmazeutische Zusammensetzung |
| EP1919882A2 (en) * | 2005-02-17 | 2008-05-14 | Synta Pharmaceuticals Corporation | Isoxazole combretastatin derivatives for the treatment of proliferative disorders |
| AU2008345225A1 (en) * | 2007-12-21 | 2009-07-09 | University Of Rochester | Method for altering the lifespan of eukaryotic organisms |
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- 2010-08-05 CA CA2770140A patent/CA2770140A1/en not_active Abandoned
- 2010-08-05 CN CN201080044361.6A patent/CN102596946B/zh active Active
- 2010-08-05 JP JP2012523184A patent/JP2013501008A/ja active Pending
- 2010-08-05 AU AU2010281265A patent/AU2010281265A1/en not_active Abandoned
- 2010-08-05 IN IN1254DEN2012 patent/IN2012DN01254A/en unknown
- 2010-08-05 BR BR112012002331A patent/BR112012002331A2/pt not_active IP Right Cessation
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- 2010-08-05 WO PCT/CN2010/001187 patent/WO2011015037A1/en not_active Ceased
- 2010-08-05 SG SG2012005450A patent/SG178106A1/en unknown
- 2010-08-05 MX MX2012001504A patent/MX2012001504A/es not_active Application Discontinuation
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| CN102596946B (zh) | 2015-06-17 |
| EP2462138B1 (en) | 2014-09-24 |
| SG178106A1 (en) | 2012-03-29 |
| KR20120092567A (ko) | 2012-08-21 |
| EP2462138A4 (en) | 2013-01-23 |
| IN2012DN01254A (enExample) | 2015-05-15 |
| CA2770140A1 (en) | 2011-02-10 |
| WO2011015037A1 (en) | 2011-02-10 |
| AU2010281265A2 (en) | 2012-04-05 |
| EP2462138A1 (en) | 2012-06-13 |
| BR112012002331A2 (pt) | 2019-09-24 |
| IL217745A0 (en) | 2012-03-29 |
| CN102596946A (zh) | 2012-07-18 |
| AU2010281265A1 (en) | 2012-03-22 |
| MX2012001504A (es) | 2012-06-01 |
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