RU2011105409A - Способ лечения атрофической возрастной макулярной дегенерации - Google Patents
Способ лечения атрофической возрастной макулярной дегенерации Download PDFInfo
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- 238000000034 method Methods 0.000 title claims abstract 3
- 206010064930 age-related macular degeneration Diseases 0.000 title 1
- 208000002780 macular degeneration Diseases 0.000 title 1
- 238000012377 drug delivery Methods 0.000 claims abstract 27
- 239000003795 chemical substances by application Substances 0.000 claims abstract 14
- 229960000397 bevacizumab Drugs 0.000 claims abstract 8
- 229920000642 polymer Polymers 0.000 claims abstract 8
- 238000002347 injection Methods 0.000 claims abstract 6
- 239000007924 injection Substances 0.000 claims abstract 6
- 150000002148 esters Chemical class 0.000 claims abstract 4
- 150000003839 salts Chemical class 0.000 claims abstract 4
- WLCZTRVUXYALDD-IBGZPJMESA-N 7-[[(2s)-2,6-bis(2-methoxyethoxycarbonylamino)hexanoyl]amino]heptoxy-methylphosphinic acid Chemical compound COCCOC(=O)NCCCC[C@H](NC(=O)OCCOC)C(=O)NCCCCCCCOP(C)(O)=O WLCZTRVUXYALDD-IBGZPJMESA-N 0.000 claims abstract 2
- 102100030289 Chronophin Human genes 0.000 claims abstract 2
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical class OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 claims abstract 2
- 101150062722 PDXP gene Proteins 0.000 claims abstract 2
- 108010073929 Vascular Endothelial Growth Factor A Proteins 0.000 claims abstract 2
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims abstract 2
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims abstract 2
- 229920001577 copolymer Polymers 0.000 claims abstract 2
- 230000007850 degeneration Effects 0.000 claims abstract 2
- 239000000203 mixture Substances 0.000 claims abstract 2
- 229960003407 pegaptanib Drugs 0.000 claims abstract 2
- 229960003876 ranibizumab Drugs 0.000 claims abstract 2
- 239000004066 vascular targeting agent Substances 0.000 claims abstract 2
- 206010029113 Neovascularisation Diseases 0.000 claims 1
- 210000001525 retina Anatomy 0.000 claims 1
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- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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Abstract
1. Биосовместимая система доставки лекарственного средства, содержащая антинеоваскулярный агент, представляющий собой антиваскулярный агент фактора роста эндотелия сосудов (анти-ФРЭС), выбранный из группы, состоящей из бевацизумаба, ранибизумаба и пегаптаниба и их производных, сложных эфиров, солей и смесей, и полимерный носитель, ассоциированный с антинеоваскулярным агентом, где полимерный носитель представляет собой сополимер молочной и гликолевой кислот (ПЛГП), для применения в способе лечения сухой возрастной дегенерации желтого пятна (сухая ВДЖП), включающем этап введения системы доставки лекарственного средства в глаз пациента с сухой ВДЖП, таким образом вылечивая сухую ВДЖП. ! 2. Система доставки лекарственного средства для применения по п.1, где антинеоваскулярный агент ассоциирован с полимерным носителем, будучи диспергирован гомогенно в полимерном носителе. ! 3. Система доставки лекарственного средства для применения по п.1, где этап введения выполняют посредством инъекции антинеоваскулярного агента внутрь передней области глаза. ! 4. Система доставки лекарственного средства для применения по п.1, где этап введения выполняют посредством инъекции антинеоваскулярного агента внутрь задней области глаза. ! 5. Система доставки лекарственного средства для применения по п.4, где этап введения выполняют посредством инъекции антинеоваскулярного агента в полость стекловидного тела. ! 6. Система доставки лекарственного средства для применения по п.1, где антинеоваскулярный агент представляет собой бевацизумаб или его производное, сложный эфир или соль. ! 7. Система доставки лекарственного средства для п
Claims (14)
1. Биосовместимая система доставки лекарственного средства, содержащая антинеоваскулярный агент, представляющий собой антиваскулярный агент фактора роста эндотелия сосудов (анти-ФРЭС), выбранный из группы, состоящей из бевацизумаба, ранибизумаба и пегаптаниба и их производных, сложных эфиров, солей и смесей, и полимерный носитель, ассоциированный с антинеоваскулярным агентом, где полимерный носитель представляет собой сополимер молочной и гликолевой кислот (ПЛГП), для применения в способе лечения сухой возрастной дегенерации желтого пятна (сухая ВДЖП), включающем этап введения системы доставки лекарственного средства в глаз пациента с сухой ВДЖП, таким образом вылечивая сухую ВДЖП.
2. Система доставки лекарственного средства для применения по п.1, где антинеоваскулярный агент ассоциирован с полимерным носителем, будучи диспергирован гомогенно в полимерном носителе.
3. Система доставки лекарственного средства для применения по п.1, где этап введения выполняют посредством инъекции антинеоваскулярного агента внутрь передней области глаза.
4. Система доставки лекарственного средства для применения по п.1, где этап введения выполняют посредством инъекции антинеоваскулярного агента внутрь задней области глаза.
5. Система доставки лекарственного средства для применения по п.4, где этап введения выполняют посредством инъекции антинеоваскулярного агента в полость стекловидного тела.
6. Система доставки лекарственного средства для применения по п.1, где антинеоваскулярный агент представляет собой бевацизумаб или его производное, сложный эфир или соль.
7. Система доставки лекарственного средства для применения по п.6, где система доставки лекарственного средства содержит от приблизительно 5 мкг до приблизительно 3 мг бевацизумаба.
8. Система доставки лекарственного средства для применения по п.7, где система доставки лекарственного средства высвобождает в среднем от приблизительно 10 нг до приблизительно 40 мкг бевацизумаба в течение периода 24 ч, предпочтительно в среднем от приблизительно 14 мкг до приблизительно 28 мкг бевацизумаба в течение периода 24 ч, более предпочтительно в среднем от приблизительно 7 мкг до приблизительно 14 мкг бевацизумаба в течение периода 24 ч.
9. Система доставки лекарственного средства для применения по п.1, где у пациента в одном глазу сухая ВДЖП, а в другом глазу влажная ВДЖП.
10. Система доставки лекарственного средства для применения по п.9, где сухую ВДЖП вылечивают посредством предотвращения или замедления развития сухой ВДЖП во влажную ВДЖП в обработанном глазу.
11. Система доставки лекарственного средства для применения по п.9, где сухую ВДЖП вылечивают посредством предупреждения или замедления возникновения неоваскуляризации сетчатки в инъецированном глазу с сухой ВДЖП.
12. Система доставки лекарственного средства для применения по п.1, где система доставки лекарственного средства имеет вязкость от приблизительно 130000 сПз до приблизительно 300000 сПз при скорости сдвига приблизительно 0,1/с при приблизительно 25°С.
13. Система доставки лекарственного средства для применения по п.1, где система доставки лекарственного средства инъецирована при помощи 25-30 мерного шприца.
14. Система доставки лекарственного средства для применения по п.1, где систему вводят во внутриглазную область, выбранную из группы внутриглазных областей, состоящей из субтеноновой, субконъюнктивальной, супрахориоидальной, интрасклеральной, интравитреальной и ретробульбарной внутриглазных областей.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12/176,238 | 2008-07-18 | ||
| US12/176,238 US8821870B2 (en) | 2008-07-18 | 2008-07-18 | Method for treating atrophic age related macular degeneration |
| PCT/US2009/050373 WO2010009034A2 (en) | 2008-07-18 | 2009-07-13 | Method for treating atrophic age related macular degeneration |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2014115647A Division RU2668371C2 (ru) | 2008-07-18 | 2009-07-13 | Способ лечения атрофической возрастной макулярной дегенерации |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| RU2011105409A true RU2011105409A (ru) | 2012-08-27 |
| RU2521338C2 RU2521338C2 (ru) | 2014-06-27 |
| RU2521338C9 RU2521338C9 (ru) | 2014-09-10 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2011105409/15A RU2521338C9 (ru) | 2008-07-18 | 2009-07-13 | Способ лечения атрофической возрастной макулярной дегенерации |
| RU2014115647A RU2668371C2 (ru) | 2008-07-18 | 2009-07-13 | Способ лечения атрофической возрастной макулярной дегенерации |
| RU2018133133A RU2018133133A (ru) | 2008-07-18 | 2018-09-19 | Способ лечения атрофической возрастной макулярной дегенерации |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2014115647A RU2668371C2 (ru) | 2008-07-18 | 2009-07-13 | Способ лечения атрофической возрастной макулярной дегенерации |
| RU2018133133A RU2018133133A (ru) | 2008-07-18 | 2018-09-19 | Способ лечения атрофической возрастной макулярной дегенерации |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US8821870B2 (ru) |
| EP (4) | EP3950002A1 (ru) |
| JP (3) | JP2011528656A (ru) |
| KR (1) | KR20110047196A (ru) |
| CN (2) | CN107412778A (ru) |
| AU (1) | AU2009271168B2 (ru) |
| BR (1) | BRPI0915981A2 (ru) |
| CA (1) | CA2731270C (ru) |
| ES (3) | ES2897560T3 (ru) |
| RU (3) | RU2521338C9 (ru) |
| WO (1) | WO2010009034A2 (ru) |
Families Citing this family (84)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090148527A1 (en) * | 2007-12-07 | 2009-06-11 | Robinson Michael R | Intraocular formulation |
| US20070202186A1 (en) | 2006-02-22 | 2007-08-30 | Iscience Interventional Corporation | Apparatus and formulations for suprachoroidal drug delivery |
| US8197435B2 (en) | 2006-05-02 | 2012-06-12 | Emory University | Methods and devices for drug delivery to ocular tissue using microneedle |
| US8039010B2 (en) | 2006-11-03 | 2011-10-18 | Allergan, Inc. | Sustained release intraocular drug delivery systems comprising a water soluble therapeutic agent and a release modifier |
| US8821870B2 (en) * | 2008-07-18 | 2014-09-02 | Allergan, Inc. | Method for treating atrophic age related macular degeneration |
| US8623395B2 (en) | 2010-01-29 | 2014-01-07 | Forsight Vision4, Inc. | Implantable therapeutic device |
| PL2391419T3 (pl) | 2009-01-29 | 2019-12-31 | Forsight Vision4, Inc. | Dostarczanie leku do tylnego odcinka |
| IN2012DN03361A (ru) * | 2009-10-01 | 2015-10-23 | Evonik Degussa Corp | |
| US20120301478A1 (en) * | 2010-01-14 | 2012-11-29 | Yuichiro Ogura | Pharmaceutical for Preventing or Treating Disorders Accompanied by Ocular Angiogenesis and/or Elevated Ocular Vascular Permeability |
| US20130210876A1 (en) * | 2010-01-21 | 2013-08-15 | Allergan, Inc | Alpha-2 adrenergic agonist having long duration of intraocular pressure-lowering effect |
| JP2013518051A (ja) * | 2010-01-21 | 2013-05-20 | アラーガン インコーポレイテッド | 長時間の眼圧低下効果を有するアルファ−２アドレナリンアゴニスト |
| US10166142B2 (en) | 2010-01-29 | 2019-01-01 | Forsight Vision4, Inc. | Small molecule delivery with implantable therapeutic device |
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