RU2010151725A - Аминокислотные последовательности, направленные против cхcr4 и других gpcr, и соединения, включаюшие их - Google Patents
Аминокислотные последовательности, направленные против cхcr4 и других gpcr, и соединения, включаюшие их Download PDFInfo
- Publication number
- RU2010151725A RU2010151725A RU2010151725/10A RU2010151725A RU2010151725A RU 2010151725 A RU2010151725 A RU 2010151725A RU 2010151725/10 A RU2010151725/10 A RU 2010151725/10A RU 2010151725 A RU2010151725 A RU 2010151725A RU 2010151725 A RU2010151725 A RU 2010151725A
- Authority
- RU
- Russia
- Prior art keywords
- amino acid
- acid sequences
- seq
- polypeptide
- differences
- Prior art date
Links
- 101000922348 Homo sapiens C-X-C chemokine receptor type 4 Proteins 0.000 title claims abstract 22
- 150000001413 amino acids Chemical group 0.000 title claims 33
- 150000001875 compounds Chemical class 0.000 title claims 2
- 102100031650 C-X-C chemokine receptor type 4 Human genes 0.000 title 1
- 102000003688 G-Protein-Coupled Receptors Human genes 0.000 title 1
- 108090000045 G-Protein-Coupled Receptors Proteins 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims abstract 29
- 229920001184 polypeptide Polymers 0.000 claims abstract 27
- 102000004196 processed proteins & peptides Human genes 0.000 claims abstract 27
- 102000053523 human CXCR4 Human genes 0.000 claims abstract 21
- 108010003723 Single-Domain Antibodies Proteins 0.000 claims abstract 16
- 101000617130 Homo sapiens Stromal cell-derived factor 1 Proteins 0.000 claims abstract 4
- 102000043525 human CXCL12 Human genes 0.000 claims abstract 4
- 238000000034 method Methods 0.000 claims abstract 4
- 235000002198 Annona diversifolia Nutrition 0.000 claims abstract 2
- 241000282842 Lama glama Species 0.000 claims abstract 2
- 108010046377 Whey Proteins Proteins 0.000 claims abstract 2
- 102000007544 Whey Proteins Human genes 0.000 claims abstract 2
- 230000027455 binding Effects 0.000 claims abstract 2
- 239000002975 chemoattractant Substances 0.000 claims abstract 2
- 238000012875 competitive assay Methods 0.000 claims abstract 2
- 230000000694 effects Effects 0.000 claims abstract 2
- 230000003053 immunization Effects 0.000 claims abstract 2
- 239000004094 surface-active agent Substances 0.000 claims abstract 2
- 238000005406 washing Methods 0.000 claims abstract 2
- 235000021119 whey protein Nutrition 0.000 claims abstract 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 81
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 3
- 239000002773 nucleotide Chemical group 0.000 claims 2
- 125000003729 nucleotide group Chemical group 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 238000012216 screening Methods 0.000 claims 2
- 208000030507 AIDS Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 150000007523 nucleic acids Chemical group 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Pulmonology (AREA)
- Psychiatry (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5384708P | 2008-05-16 | 2008-05-16 | |
| US61/053,847 | 2008-05-16 | ||
| US10214208P | 2008-10-02 | 2008-10-02 | |
| US61/102,142 | 2008-10-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2010151725A true RU2010151725A (ru) | 2012-06-27 |
Family
ID=40974643
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2010151725/10A RU2010151725A (ru) | 2008-05-16 | 2009-05-18 | Аминокислотные последовательности, направленные против cхcr4 и других gpcr, и соединения, включаюшие их |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US9212226B2 (OSRAM) |
| EP (1) | EP2285833B1 (OSRAM) |
| JP (1) | JP6034023B2 (OSRAM) |
| KR (1) | KR20110020825A (OSRAM) |
| CN (1) | CN102099378B (OSRAM) |
| AU (1) | AU2009248049B2 (OSRAM) |
| BR (1) | BRPI0911984A2 (OSRAM) |
| CA (1) | CA2724208C (OSRAM) |
| IL (1) | IL209176A0 (OSRAM) |
| MX (1) | MX2010012518A (OSRAM) |
| NZ (1) | NZ589036A (OSRAM) |
| RU (1) | RU2010151725A (OSRAM) |
| WO (1) | WO2009138519A1 (OSRAM) |
| ZA (1) | ZA201008180B (OSRAM) |
Families Citing this family (76)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9512236B2 (en) | 2006-12-19 | 2016-12-06 | Ablynx N.V. | Amino acid sequences directed against GPCRS and polypeptides comprising the same for the treatment of GPCR-related diseases and disorders |
| MX2010012518A (es) | 2008-05-16 | 2010-12-06 | Ablynx Nv | Secuencias de aminoacidos dirigidas contra cxcr4 y otros receptores acoplados a proteina g y compuestos que comprenden los mismos. |
| EP2352764B1 (en) * | 2008-10-14 | 2018-03-28 | Ablynx N.V. | AMINO ACID SEQUENCES TARGETING HUMAN CD4 and CXCR4, CCR5, TLR4, ALPHAV INTEGRIN, BETA3-INTEGRIN,BETA1-INTEGRIN, HUMAN ALPHA2-INTEGRIN, CD81, SR-BI, CLAUDIN-1, CLAUDIN-6 AND/OR CLAUDIN-9, RESPECTIVELY, AND NEUTRALIZING VIRAL ENTRY |
| CN102257003B (zh) | 2008-12-19 | 2017-04-05 | 埃博灵克斯股份有限公司 | 用于产生针对细胞相关抗原如p2x7、cxcr7或cxcr4的免疫球蛋白的基因免疫 |
| WO2011042398A1 (en) | 2009-10-09 | 2011-04-14 | Ablynx Nv | Immunoglobulin single variable domain directed against human cxcr4 and other cell associated proteins and methods to generate them |
| WO2011083141A2 (en) * | 2010-01-08 | 2011-07-14 | Ablynx Nv | Method for generation of immunoglobulin sequences by using lipoprotein particles |
| US8937164B2 (en) | 2010-03-26 | 2015-01-20 | Ablynx N.V. | Biological materials related to CXCR7 |
| EP2371863A1 (en) * | 2010-03-30 | 2011-10-05 | Pierre Fabre Médicament | Humanized anti CXCR4 antibodies for the treatment of cancer |
| WO2011161266A1 (en) | 2010-06-25 | 2011-12-29 | Ablynx Nv | Improved immunoglobulin single variable domains and constructs thereof directed against cxcr4 |
| GB201014715D0 (en) | 2010-09-06 | 2010-10-20 | Vib Vzw | Nanobodies stabilizing functional conformational states of GPCRS |
| EP2621953B1 (en) | 2010-09-30 | 2017-04-05 | Ablynx N.V. | Biological materials related to c-met |
| US11644471B2 (en) * | 2010-09-30 | 2023-05-09 | Ablynx N.V. | Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobulin single variable domains |
| ES2723775T3 (es) | 2010-11-08 | 2019-09-02 | Ablynx Nv | Polipéptidos que se unen a CXCR2 |
| FR2970781B1 (fr) * | 2011-01-25 | 2013-02-08 | Centre Nat Rech Scient | Procede de fabrication d'un support d'analyse et utilisation pour la detection de toxines |
| CN103917560B (zh) | 2011-03-28 | 2017-05-24 | 埃博灵克斯股份有限公司 | 双特异性抗‑cxcr7免疫球蛋白单可变结构域 |
| UA117218C2 (uk) | 2011-05-05 | 2018-07-10 | Мерк Патент Гмбх | Поліпептид, спрямований проти il-17a, il-17f та/або il17-a/f |
| CA2839834A1 (en) * | 2011-06-21 | 2012-12-27 | Vib Vzw | Binding domains directed against gpcr:g protein complexes and uses derived thereof |
| PL2723769T5 (pl) | 2011-06-23 | 2022-10-17 | Ablynx Nv | Techniki przewidywania, wykrywania i redukcji niespecyficznej interferencji białka w testach z udziałem pojedynczych domen zmiennych immunoglobuliny |
| EP4350345A3 (en) | 2011-06-23 | 2024-07-24 | Ablynx N.V. | Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobin single variable domains |
| EP4218933A1 (en) | 2011-06-23 | 2023-08-02 | Ablynx NV | Serum albumin binding proteins |
| EP3363812A1 (en) | 2011-06-23 | 2018-08-22 | Ablynx NV | Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobin single variable domains |
| EP3626739A1 (en) | 2011-06-24 | 2020-03-25 | Stephen D. Gillies | Light chain immunoglobulin fusion proteins and methods of use thereof |
| JP6219287B2 (ja) | 2011-09-30 | 2017-10-25 | アブリンクス エン.ヴェー. | c−Metに関連する生物学的物質 |
| US9346884B2 (en) | 2011-09-30 | 2016-05-24 | Ablynx N.V. | Biological materials related to c-Met |
| KR102762747B1 (ko) * | 2011-10-17 | 2025-02-05 | 리제너론 파마슈티칼스 인코포레이티드 | 제한된 면역글로불린 중쇄 마우스 |
| US9328174B2 (en) * | 2012-05-09 | 2016-05-03 | Novartis Ag | Chemokine receptor binding polypeptides |
| US11339208B1 (en) | 2012-05-31 | 2022-05-24 | United States Of America As Represented By The Secretary Of The Air Force | Camelidae single-domain antibodies against Yersinia pestis and methods of use |
| CN102993295A (zh) * | 2012-09-29 | 2013-03-27 | 张文彬 | 双峰驼褪黑素受体、编码基因及其获取方法 |
| UY35144A (es) | 2012-11-20 | 2014-06-30 | Novartis Ag | Miméticos lineales sintéticos de apelina para el tratamiento de insuficiencia cardiaca |
| WO2015026884A1 (en) * | 2013-08-21 | 2015-02-26 | Boehringer Ingelheim International Gmbh | Cx3cr1-targeting imaging agents and their use in the diagnosis and treatment of disease |
| ES2900852T3 (es) | 2014-05-16 | 2022-03-18 | Ablynx Nv | Métodos de detección y/o medición de anticuerpos anti-fármaco, en particular anticuerpos anti-fármaco que se presentan durante el tratamiento |
| SG10201810124PA (en) | 2014-05-16 | 2018-12-28 | Ablynx Nv | Improved immunoglobulin variable domains |
| KR20250099289A (ko) * | 2014-05-16 | 2025-07-01 | 아블린쓰 엔.브이. | 개선된 면역글로불린 가변 도메인 |
| WO2016156570A1 (en) | 2015-04-02 | 2016-10-06 | Ablynx N.V. | Bispecific cxcr4-cd-4 polypeptides with potent anti-hiv activity |
| NO2768984T3 (OSRAM) | 2015-11-12 | 2018-06-09 | ||
| EP3374392B1 (en) | 2015-11-13 | 2021-11-24 | Ablynx NV | Improved serum albumin-binding immunoglobulin variable domains |
| EA038179B1 (ru) | 2015-11-18 | 2021-07-20 | Мерк Шарп И Доум Корп. | Ctla4-связывающие вещества |
| BR112018010085A2 (pt) | 2015-11-18 | 2018-11-13 | Merck Sharp & Dohme | ligantes de pd1/ctla4 |
| CA3132021C (en) | 2015-11-18 | 2024-03-12 | Merck Sharp & Dohme Corp. | Pd1 and/or lag3 binders |
| CA3005488A1 (en) | 2015-11-18 | 2017-05-26 | Ablynx Nv | Improved serum albumin binders |
| EP3414268A1 (en) | 2016-02-12 | 2018-12-19 | Ablynx NV | Method for the production of immunoglobulin single variable domains |
| WO2017220989A1 (en) | 2016-06-20 | 2017-12-28 | Kymab Limited | Anti-pd-l1 and il-2 cytokines |
| ES2926014T3 (es) | 2016-06-23 | 2022-10-21 | Ablynx Nv | Ensayos farmacocinéticos mejorados para dominios variables individuales de inmunoglobulina |
| TWI781108B (zh) | 2016-07-20 | 2022-10-21 | 比利時商健生藥品公司 | 抗gprc5d抗體、結合gprc5d與cd3之雙特異性抗原結合分子及其用途 |
| RU2765384C2 (ru) | 2016-12-07 | 2022-01-28 | Аблинкс Нв | Улучшенные одиночные вариабельные домены иммуноглобулина, связывающиеся с сывороточным альбумином |
| DK3571225T3 (da) | 2017-01-17 | 2024-11-04 | Ablynx Nv | Forbedrede serumalbuminbindere |
| BR112019014600A2 (pt) | 2017-01-17 | 2020-02-18 | Ablynx N.V. | Ligantes de albumina sérica melhorados |
| US12480957B2 (en) | 2017-03-31 | 2025-11-25 | Ablynx N.V. | Method of screening for anti-drug antibodies against immunoglobulin single variable domain-based drugs |
| WO2019124951A1 (en) | 2017-12-19 | 2019-06-27 | Gpcr Therapeutics, Inc. | Gpcr heteromer inhibitors and uses thereof |
| BR112020015112A2 (pt) | 2018-01-26 | 2021-04-06 | Regeneron Pharmaceuticals, Inc. | Anticorpos anti-tmprss2 e fragmentos que ligam antígenos |
| CN113416258B (zh) | 2019-10-24 | 2023-08-29 | 北京免疫方舟医药科技有限公司 | 一种多特异性抗体及其制备方法和用途 |
| WO2021163076A1 (en) | 2020-02-10 | 2021-08-19 | Regeneron Pharmaceuticals, Inc. | ANTl-TMPRSS2 ANTIBODIES AND ANTIGEN-BINDING FRAGMENTS |
| CR20220552A (es) | 2020-04-02 | 2023-01-17 | Regeneron Pharma | Anticuerpos contra glicoproteína de espícula anti-sars-cov-2 y fragmentos de unión al antígeno |
| US20240043504A1 (en) | 2020-05-26 | 2024-02-08 | Regeneron Pharmaceuticals, Inc. | Anti-SARS-CoV-2-Spike Glycoprotein Antibodies and Antigen-Binding Fragments |
| CN111596070B (zh) * | 2020-06-10 | 2023-05-12 | 宁波大学 | 一种三疣梭子蟹原肌球蛋白过敏检测试剂的应用 |
| WO2022187626A1 (en) | 2021-03-05 | 2022-09-09 | Regeneron Pharmaceuticals, Inc. | Anti-sars-cov-2-variant-spike glycoprotein antibodies and antigen-binding fragments |
| WO2023287875A1 (en) | 2021-07-14 | 2023-01-19 | Regeneron Pharmaceuticals, Inc. | Anti-sars-cov-2-spike glycoprotein antibodies and antigen-binding fragments |
| TW202337497A (zh) | 2022-02-18 | 2023-10-01 | 中國大陸商重慶明道浩悅生物科技有限公司 | 鼻內調配物及抗sars-cov-2棘蛋白抗體 |
| TW202423965A (zh) | 2022-07-27 | 2024-06-16 | 比利時商艾伯霖克斯公司 | 與新生兒fc受體的特定表位結合之多肽 |
| AR130869A1 (es) | 2022-10-25 | 2025-01-29 | Ablynx Nv | Polipéptidos de variantes de fc diseñados por glicoingeniería con función efectora aumentada |
| TW202440614A (zh) | 2022-12-23 | 2024-10-16 | 比利時商艾伯霖克斯公司 | 基於蛋白質的接合載體 |
| CN120529914A (zh) | 2023-01-09 | 2025-08-22 | 奥德赛治疗股份有限公司 | 抗tnfr2抗原结合蛋白及其用途 |
| CN115960269A (zh) * | 2023-01-30 | 2023-04-14 | 上海甲贝医药科技有限公司 | 一种重组长效人cxcr4&pd-1双靶点抗体融合蛋白及其制备方法 |
| CN120712282A (zh) | 2023-02-17 | 2025-09-26 | 阿布林克斯有限公司 | 结合新生儿fc受体的多肽 |
| TW202444757A (zh) | 2023-03-14 | 2024-11-16 | 美商奧迪希治療公司 | 抗cd25抗原結合蛋白及其用途 |
| AU2024273077A1 (en) | 2023-05-17 | 2025-11-13 | Odyssey Therapeutics, Inc. | Modified single-domain antibodies |
| AR133108A1 (es) | 2023-06-29 | 2025-08-27 | Odyssey Therapeutics Inc | Proteínas de unión a antígeno anti-trailr2 y sus usos |
| TW202517676A (zh) | 2023-07-05 | 2025-05-01 | 比利時商艾伯霖克斯公司 | 用於治療IgG相關疾病及病症之改良FcRn拮抗劑 |
| WO2025041077A1 (en) | 2023-08-23 | 2025-02-27 | Sanofi | Ctla-4-based lysosomal degraders and uses thereof |
| WO2025061919A1 (en) | 2023-09-22 | 2025-03-27 | Ablynx Nv | Bi- and multivalent albumin binders |
| TW202530265A (zh) | 2023-10-13 | 2025-08-01 | 美商奧迪希治療公司 | 抗cdh17抗原結合蛋白及其用途 |
| TW202535925A (zh) | 2023-10-25 | 2025-09-16 | 比利時商艾伯霖克斯公司 | 具有增強的Fc受體結合之Fc結構域變體 |
| WO2025099632A1 (en) | 2023-11-08 | 2025-05-15 | Sanofi | Cd25 based lysosomal degrader and uses thereof |
| WO2025217240A1 (en) | 2024-04-10 | 2025-10-16 | Odyssey Therapeutics, Inc. | Anti-tnfr2 antigen-binding proteins and uses thereof |
| WO2025255435A2 (en) | 2024-06-07 | 2025-12-11 | Odyssey Therapeutics, Inc. | Antigen-binding proteins against serum albumin and uses thereof |
| WO2025255558A2 (en) | 2024-06-07 | 2025-12-11 | Odyssey Therapeutics, Inc. | Anti-thymic stromal lymphopoietin (tslp) antigen-binding proteins and uses thereof |
Family Cites Families (67)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4559157A (en) | 1983-04-21 | 1985-12-17 | Creative Products Resource Associates, Ltd. | Cosmetic applicator useful for skin moisturizing |
| LU84979A1 (fr) | 1983-08-30 | 1985-04-24 | Oreal | Composition cosmetique ou pharmaceutique sous forme aqueuse ou anhydre dont la phase grasse contient un polyether oligomere et polyethers oligomeres nouveaux |
| US4820508A (en) | 1987-06-23 | 1989-04-11 | Neutrogena Corporation | Skin protective composition |
| US4992478A (en) | 1988-04-04 | 1991-02-12 | Warner-Lambert Company | Antiinflammatory skin moisturizing composition and method of preparing same |
| US4938949A (en) | 1988-09-12 | 1990-07-03 | University Of New York | Treatment of damaged bone marrow and dosage units therefor |
| WO1990005144A1 (en) | 1988-11-11 | 1990-05-17 | Medical Research Council | Single domain ligands, receptors comprising said ligands, methods for their production, and use of said ligands and receptors |
| SE509359C2 (sv) | 1989-08-01 | 1999-01-18 | Cemu Bioteknik Ab | Användning av stabiliserade protein- eller peptidkonjugat för framställning av ett läkemedel |
| GB8928874D0 (en) | 1989-12-21 | 1990-02-28 | Celltech Ltd | Humanised antibodies |
| WO1992002551A1 (en) | 1990-08-02 | 1992-02-20 | B.R. Centre Limited | Methods for the production of proteins with a desired function |
| EP0605522B1 (en) | 1991-09-23 | 1999-06-23 | Medical Research Council | Methods for the production of humanized antibodies |
| DE69318016D1 (de) | 1992-05-08 | 1998-05-20 | Creative Biomolecules Inc | Mehrwertige Chimäre Proteine Anologe und Verfahren zu deren Anwendungen |
| CA2258518C (en) | 1996-06-27 | 2011-11-22 | Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw | Recognition molecules interacting specifically with the active site or cleft of a target molecule |
| BR9907241A (pt) | 1998-01-26 | 2000-10-17 | Unilever Nv | Biblioteca de expressão, processo para preparar a mesma, uso de uma fonte não imunizada de sequências de ácido nucleico, e, processos para preparar fragmentos de anticorpos e, para preparar um anticorpo |
| DE1068357T1 (de) | 1998-03-30 | 2001-07-19 | Northwest Biotherapeutics, Inc. | Therapeutische und diagnostische anwendungen welche auf der rolle von cxcr-4 in der tumorgenese basieren |
| ATE276359T1 (de) | 1999-01-19 | 2004-10-15 | Unilever Nv | Verfahren zur herstellung von antikörperfragmenten |
| US6849425B1 (en) | 1999-10-14 | 2005-02-01 | Ixsys, Inc. | Methods of optimizing antibody variable region binding affinity |
| DE60041564D1 (de) | 1999-12-24 | 2009-03-26 | Genentech Inc | Verfahren und Zusammensetzungen zur Verlängerung der Entsorgungshalbwertszeit von biowirksamen Verbindungen |
| WO2002057445A1 (en) | 2000-05-26 | 2002-07-25 | National Research Council Of Canada | Single-domain brain-targeting antibody fragments derived from llama antibodies |
| CA2380443C (en) | 2000-05-26 | 2013-03-12 | Ginette Dubuc | Single-domain antigen-binding antibody fragments derived from llama antibodies |
| US7018812B2 (en) | 2000-11-03 | 2006-03-28 | Duke University | Modified G-protein coupled receptors |
| US7054297B1 (en) | 2000-12-28 | 2006-05-30 | Cisco Technology, Inc. | Distribution of packets to high data rate communications devices using multicast protocols |
| CA2440582A1 (en) | 2001-03-09 | 2002-10-03 | Dyax Corp. | Serum albumin binding moieties |
| GB0110029D0 (en) | 2001-04-24 | 2001-06-13 | Grosveld Frank | Transgenic animal |
| US20060073141A1 (en) | 2001-06-28 | 2006-04-06 | Domantis Limited | Compositions and methods for treating inflammatory disorders |
| EP1433793A4 (en) | 2001-09-13 | 2006-01-25 | Inst Antibodies Co Ltd | METHOD FOR CREATING A CAMEL ANTIBODY LIBRARY |
| JP2005289809A (ja) | 2001-10-24 | 2005-10-20 | Vlaams Interuniversitair Inst Voor Biotechnologie Vzw (Vib Vzw) | 突然変異重鎖抗体 |
| US7871619B2 (en) | 2001-11-30 | 2011-01-18 | Chemocentryx, Inc. | Compositions and methods for detecting and treating diseases and conditions related to chemokine receptors |
| US7442512B2 (en) * | 2001-11-30 | 2008-10-28 | Chemocentryx, Inc. | Compositions and methods for detecting and treating diseases and conditions related to chemokine receptors |
| WO2003050531A2 (en) * | 2001-12-11 | 2003-06-19 | Algonomics N.V. | Method for displaying loops from immunoglobulin domains in different contexts |
| JP4323317B2 (ja) | 2001-12-21 | 2009-09-02 | フラームス・インテルウニフェルシタイル・インステイチュート・フォール・ビオテヒノロヒー・ヴェーゼットウェー(ヴェーイーベー・ヴェーゼットウェー) | 可変領域配列のクローニング方法 |
| EP1461085A2 (en) | 2002-01-03 | 2004-09-29 | Vlaams Interuniversitair Instituut voor Biotechnologie vzw. | Immunoconjugates useful for treatment of tumours |
| AU2003209059A1 (en) * | 2002-02-08 | 2003-09-02 | Genetastix Corporation | Human monoclonal antibodies against membrane proteins |
| US7211240B2 (en) | 2002-03-01 | 2007-05-01 | Bracco International B.V. | Multivalent constructs for therapeutic and diagnostic applications |
| US20060002935A1 (en) | 2002-06-28 | 2006-01-05 | Domantis Limited | Tumor Necrosis Factor Receptor 1 antagonists and methods of use therefor |
| EP1558650A2 (en) * | 2002-11-08 | 2005-08-03 | Ablynx N.V. | Camelidae antibodies against immunoglobulin e and use thereof for the treatment of allergic disorders |
| GB0228210D0 (en) | 2002-12-03 | 2003-01-08 | Babraham Inst | Single chain antibodies |
| ES2374068T3 (es) | 2002-12-03 | 2012-02-13 | Ucb Pharma, S.A. | Ensayo para identificar células productoras de anticuerpos. |
| GB0312481D0 (en) | 2003-05-30 | 2003-07-09 | Celltech R&D Ltd | Antibodies |
| AU2003264053A1 (en) | 2003-08-12 | 2005-03-10 | William M. Yarbrough | Treatment for acne vulgaris and method of use |
| ES2385829T3 (es) | 2003-08-20 | 2012-08-01 | Ucb Pharma, S.A. | Métodos para obtener anticuerpos |
| US20050279676A1 (en) | 2004-06-21 | 2005-12-22 | Izzy Zuhair A | Fluid filter assembly for a dispensing faucet |
| LT2311874T (lt) | 2004-07-22 | 2017-11-27 | Erasmus University Medical Center Rotterdam | Rišančiosios molekulės |
| US7180370B2 (en) | 2004-09-01 | 2007-02-20 | Micron Technology, Inc. | CMOS amplifiers with frequency compensating capacitors |
| US7563443B2 (en) | 2004-09-17 | 2009-07-21 | Domantis Limited | Monovalent anti-CD40L antibody polypeptides and compositions thereof |
| US20080107601A1 (en) | 2004-10-13 | 2008-05-08 | Ablynx N.V. | Nanobodies Tm Against Amyloid-Beta and Polypeptides Comprising the Same for the Treatment of Degenerative Neural Diseases Such as Alzheimer's Disease |
| WO2006040154A2 (en) | 2004-10-14 | 2006-04-20 | Dublin City University | Prokaryotic two hybrid system |
| WO2006047417A2 (en) | 2004-10-21 | 2006-05-04 | University Of Florida Research Foundation, Inc. | Detection of cannabinoid receptor biomarkers and uses thereof |
| EP1844073A1 (en) | 2005-01-31 | 2007-10-17 | Ablynx N.V. | Method for generating variable domain sequences of heavy chain antibodies |
| WO2006089141A2 (en) * | 2005-02-18 | 2006-08-24 | Dana-Farber Cancer Institute | Antibodies against cxcr4 and methods of use thereof |
| WO2006116319A2 (en) | 2005-04-21 | 2006-11-02 | Chemocentryx, Inc. | Reagents that bind ccx-ckr2 |
| AU2006301426A1 (en) * | 2005-10-11 | 2007-04-19 | Ablynx N.V. | NanobodiesTM and polypeptides against EGFR and IGF-IR |
| WO2007055823A2 (en) | 2005-10-28 | 2007-05-18 | Multispan, Inc. | Gpcr expressing cell lines and antibodies |
| DK1954274T3 (da) | 2005-11-10 | 2011-01-31 | Chemocentryx Inc | Substituerede quinoloner og fremgangsmåder til anvendelse |
| EP2010568A1 (en) | 2006-04-14 | 2009-01-07 | Ablynx N.V. | Dp-78-like nanobodies |
| EP2069402A2 (en) | 2006-09-08 | 2009-06-17 | Ablynx N.V. | Serum albumin binding proteins with long half-lives |
| US8088895B2 (en) | 2006-10-18 | 2012-01-03 | Chemocentryx, Inc. | Antibodies that bind CXCR7 epitopes |
| US20080267949A1 (en) | 2006-12-05 | 2008-10-30 | Ablynx N.V. | Peptides capable of binding to serum proteins |
| US9512236B2 (en) | 2006-12-19 | 2016-12-06 | Ablynx N.V. | Amino acid sequences directed against GPCRS and polypeptides comprising the same for the treatment of GPCR-related diseases and disorders |
| EP2115004A2 (en) | 2006-12-19 | 2009-11-11 | Ablynx N.V. | Amino acid sequences directed against gpcrs and polypeptides comprising the same for the treatment of gpcr-related diseases and disorders |
| MX2010012518A (es) | 2008-05-16 | 2010-12-06 | Ablynx Nv | Secuencias de aminoacidos dirigidas contra cxcr4 y otros receptores acoplados a proteina g y compuestos que comprenden los mismos. |
| WO2010010119A1 (en) | 2008-07-22 | 2010-01-28 | Ablynx Nv | Amino acid sequences directed against multitarget scavenger receptors and polypeptides |
| EP2352764B1 (en) | 2008-10-14 | 2018-03-28 | Ablynx N.V. | AMINO ACID SEQUENCES TARGETING HUMAN CD4 and CXCR4, CCR5, TLR4, ALPHAV INTEGRIN, BETA3-INTEGRIN,BETA1-INTEGRIN, HUMAN ALPHA2-INTEGRIN, CD81, SR-BI, CLAUDIN-1, CLAUDIN-6 AND/OR CLAUDIN-9, RESPECTIVELY, AND NEUTRALIZING VIRAL ENTRY |
| CN102257003B (zh) | 2008-12-19 | 2017-04-05 | 埃博灵克斯股份有限公司 | 用于产生针对细胞相关抗原如p2x7、cxcr7或cxcr4的免疫球蛋白的基因免疫 |
| WO2010141986A1 (en) | 2009-06-09 | 2010-12-16 | Mabdesign Pty Ltd | Novel antibodies and uses therefor |
| US8937164B2 (en) | 2010-03-26 | 2015-01-20 | Ablynx N.V. | Biological materials related to CXCR7 |
| WO2011143231A2 (en) | 2010-05-10 | 2011-11-17 | The Broad Institute | High throughput paired-end sequencing of large-insert clone libraries |
| CN103917560B (zh) | 2011-03-28 | 2017-05-24 | 埃博灵克斯股份有限公司 | 双特异性抗‑cxcr7免疫球蛋白单可变结构域 |
-
2009
- 2009-05-18 MX MX2010012518A patent/MX2010012518A/es not_active Application Discontinuation
- 2009-05-18 AU AU2009248049A patent/AU2009248049B2/en active Active
- 2009-05-18 US US12/992,982 patent/US9212226B2/en active Active
- 2009-05-18 NZ NZ589036A patent/NZ589036A/en not_active IP Right Cessation
- 2009-05-18 CN CN200980127612.4A patent/CN102099378B/zh active Active
- 2009-05-18 BR BRPI0911984A patent/BRPI0911984A2/pt not_active IP Right Cessation
- 2009-05-18 EP EP09745851.7A patent/EP2285833B1/en active Active
- 2009-05-18 CA CA2724208A patent/CA2724208C/en active Active
- 2009-05-18 RU RU2010151725/10A patent/RU2010151725A/ru not_active Application Discontinuation
- 2009-05-18 JP JP2011508949A patent/JP6034023B2/ja active Active
- 2009-05-18 KR KR1020107028173A patent/KR20110020825A/ko not_active Withdrawn
- 2009-05-18 WO PCT/EP2009/056026 patent/WO2009138519A1/en not_active Ceased
-
2010
- 2010-11-07 IL IL209176A patent/IL209176A0/en unknown
- 2010-11-15 ZA ZA2010/08180A patent/ZA201008180B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ZA201008180B (en) | 2011-09-28 |
| EP2285833A1 (en) | 2011-02-23 |
| AU2009248049A1 (en) | 2009-11-19 |
| US9212226B2 (en) | 2015-12-15 |
| US20110206660A1 (en) | 2011-08-25 |
| JP6034023B2 (ja) | 2016-11-30 |
| CN102099378A (zh) | 2011-06-15 |
| CA2724208A1 (en) | 2009-11-19 |
| IL209176A0 (en) | 2011-01-31 |
| MX2010012518A (es) | 2010-12-06 |
| EP2285833B1 (en) | 2014-12-17 |
| BRPI0911984A2 (pt) | 2016-09-20 |
| CN102099378B (zh) | 2016-01-20 |
| WO2009138519A1 (en) | 2009-11-19 |
| KR20110020825A (ko) | 2011-03-03 |
| AU2009248049B2 (en) | 2015-07-23 |
| CA2724208C (en) | 2018-02-06 |
| JP2011523550A (ja) | 2011-08-18 |
| NZ589036A (en) | 2012-07-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2010151725A (ru) | Аминокислотные последовательности, направленные против cхcr4 и других gpcr, и соединения, включаюшие их | |
| JP2011523550A5 (OSRAM) | ||
| US10233234B2 (en) | Binding moieties for biofilm remediation | |
| RU2006127314A (ru) | Вакцина, стимулирующая рост, основанная на нейтрализующем эпитопе | |
| JP2010516290A5 (OSRAM) | ||
| JP2000511881A (ja) | グルカゴン様ペプチド―2アナログ | |
| WO2007002261A3 (en) | IL-1β BINDING ANTIBODIES AND FRAGMENTS THEREOF | |
| TW201129379A (en) | Anti-Orai1 antigen binding proteins and uses thereof | |
| Zhuang et al. | Identification of AFB1-interacting proteins and interactions between RPSA and AFB1 | |
| WO2017192594A1 (en) | Binding moieties for biofilm remediation | |
| WO2016154491A1 (en) | Binding moieties for biofilm remediation | |
| CN102066416A (zh) | 肽、拟肽及其衍生物、它们的生产方法以及它们用于制备治疗和/或预防活性的药物组合物的用途 | |
| JP2009513118A5 (OSRAM) | ||
| CN116075524A (zh) | 转铁蛋白受体结合蛋白 | |
| TWI300414B (en) | Modified peptide yy and conjugates thereof | |
| CN101870981B (zh) | 血红素加氧酶-1的表达、纯化方法与抗原表位 | |
| WO2004067564B1 (en) | Compositions against cancer antigen liv-1 and uses thereof | |
| JPS61264000A (ja) | 標識ペプチドによるタンパク質の合成 | |
| CN113461810B (zh) | 一种抗新型冠状病毒刺突蛋白的全人源单克隆抗体及其应用 | |
| CN1781936A (zh) | B淋巴细胞刺激因子抑制肽及其筛选、制备方法 | |
| CN118324860A (zh) | 一种基于天然环肽骨架构建噬菌体展示环肽库 | |
| CN103539846B (zh) | 一种环状的合成多肽f及其抗菌抗病毒应用 | |
| CN105254719A (zh) | 金黄色葡萄球菌trap蛋白的cd4+t细胞表位鉴定及其重组表位疫苗 | |
| JP2008509659A5 (OSRAM) | ||
| Beleid et al. | Helical peptides derived from lactoferrin bind hepatitis C virus envelope protein E2 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20130912 |