RU2010114050A - Применение пептида рецептора il-1 индивидуально или в комбинации с октадециловым эфиром d-ala-gln в качестве терапевтического средства - Google Patents
Применение пептида рецептора il-1 индивидуально или в комбинации с октадециловым эфиром d-ala-gln в качестве терапевтического средства Download PDFInfo
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Abstract
1. Комбинация пептидов Lys-Ile-Cys-Ile-Arg-Ile-Gln-Ile-Ser-OH и октадециловый эфир D-Ala-Gln или их солей или гидратов. ! 2. Комбинация по п.1, где пептиды содержатся в комбинации в количестве от 30% по массе к 70% по массе до 70% по массе к 30% по массе. ! 3. Комбинация по п.1 для применения в лекарственном средстве. ! 4. Применение пептида Lys-Ile-Cys-Ile-Arg-Ile-Gln-Ile-Ser-OH или комбинации по п.1, или 2, или 3 для получения фармацевтической композиции для лечения и/или профилактики злокачественной опухоли, аутоиммунных заболеваний, фиброзов, воспалительных заболеваний, нейродегенеративных заболеваний, инфекционных заболеваний, заболеваний легких, заболеваний сердца и сосудов и болезней обмена веществ. ! 5. Применение пептида по п.4, где инфекционное заболевание выбрано из инфекции Mycobacterium tuberculosis и инфекционных заболеваний, вызванных инфекцией Mycobacterium tuberculosis, выбранных из инфекционных заболеваний легкого, центральной нервной системы, лимфатической системы, системы кровообращения, мочеполовой системы, костей, суставов и кожи. ! 6. Применение пептида Lys-Ile-Cys-Ile-Arg-Ile-Gln-Ile-Ser-OH для получения состава для перорального введения новорожденным, детям ясельного возраста и/или детям дошкольного возраста. ! 7. Применение пептида Lys-Ile-Cys-Ile-Arg-Ile-Gln-Ile-Ser-OH для получения лиофилизированного состава или буферного жидкого состава. ! 8. Фармацевтическая композиция, содержащая пептид Lys-Ile-Cys-Ile-Arg-Ile-Gln-Ile-Ser-OH или комбинация по п.1, по меньшей мере, совместно с одним фармацевтически приемлемым носителем, криопротектором, лиопротектором, эксципиентом и/или разбавителем. ! 9. Фармацевтическая композиция по п.8 в форме лиофилизата или жидкого буферного раствора. ! 10. Фармацевтическая композиция п�
Claims (12)
1. Комбинация пептидов Lys-Ile-Cys-Ile-Arg-Ile-Gln-Ile-Ser-OH и октадециловый эфир D-Ala-Gln или их солей или гидратов.
2. Комбинация по п.1, где пептиды содержатся в комбинации в количестве от 30% по массе к 70% по массе до 70% по массе к 30% по массе.
3. Комбинация по п.1 для применения в лекарственном средстве.
4. Применение пептида Lys-Ile-Cys-Ile-Arg-Ile-Gln-Ile-Ser-OH или комбинации по п.1, или 2, или 3 для получения фармацевтической композиции для лечения и/или профилактики злокачественной опухоли, аутоиммунных заболеваний, фиброзов, воспалительных заболеваний, нейродегенеративных заболеваний, инфекционных заболеваний, заболеваний легких, заболеваний сердца и сосудов и болезней обмена веществ.
5. Применение пептида по п.4, где инфекционное заболевание выбрано из инфекции Mycobacterium tuberculosis и инфекционных заболеваний, вызванных инфекцией Mycobacterium tuberculosis, выбранных из инфекционных заболеваний легкого, центральной нервной системы, лимфатической системы, системы кровообращения, мочеполовой системы, костей, суставов и кожи.
6. Применение пептида Lys-Ile-Cys-Ile-Arg-Ile-Gln-Ile-Ser-OH для получения состава для перорального введения новорожденным, детям ясельного возраста и/или детям дошкольного возраста.
7. Применение пептида Lys-Ile-Cys-Ile-Arg-Ile-Gln-Ile-Ser-OH для получения лиофилизированного состава или буферного жидкого состава.
8. Фармацевтическая композиция, содержащая пептид Lys-Ile-Cys-Ile-Arg-Ile-Gln-Ile-Ser-OH или комбинация по п.1, по меньшей мере, совместно с одним фармацевтически приемлемым носителем, криопротектором, лиопротектором, эксципиентом и/или разбавителем.
9. Фармацевтическая композиция по п.8 в форме лиофилизата или жидкого буферного раствора.
10. Фармацевтическая композиция по п.8 или 9, пригодная для внутривенного введения, перорального введения или для введения посредством ингаляции.
11. Фармацевтическая композиция по п.8 или 9 в форме состава искусственного материнского молока или заменителя материнского молока, пригодная для пероральной доставки новорожденным, детям ясельного возраста и/или детям дошкольного возраста.
12. Фармацевтическая композиция по п.8 или 9, пригодная для лечения и/или профилактики злокачественной опухоли, аутоиммунного заболевания, фиброза, воспалительного заболевания, нейродегенеративного заболевания, инфекционного заболевания, заболевания легких, заболевания сердца и сосудов или болезни обмена веществ.
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| AU2010324527A1 (en) * | 2009-11-24 | 2012-07-19 | Commonwealth Scientific And Industrial Research Organisation | Methods, kits and reagents for diagnosing, aiding diagnosis and/or monitoring progression of a neurological disorder |
| WO2015077334A2 (en) * | 2013-11-19 | 2015-05-28 | The Brigham And Women's Hospital, Inc. | Therapies for left ventricular non-compaction and dilated cardiomyopathy |
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