RU2009117705A - Производные 2-аминокарбонилпиридина - Google Patents
Производные 2-аминокарбонилпиридина Download PDFInfo
- Publication number
- RU2009117705A RU2009117705A RU2009117705/04A RU2009117705A RU2009117705A RU 2009117705 A RU2009117705 A RU 2009117705A RU 2009117705/04 A RU2009117705/04 A RU 2009117705/04A RU 2009117705 A RU2009117705 A RU 2009117705A RU 2009117705 A RU2009117705 A RU 2009117705A
- Authority
- RU
- Russia
- Prior art keywords
- carbonyl
- amino
- carboxylic acid
- piperazine
- butyryl
- Prior art date
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- 150000001875 compounds Chemical class 0.000 claims abstract 19
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract 17
- 239000001257 hydrogen Substances 0.000 claims abstract 17
- 125000000217 alkyl group Chemical group 0.000 claims abstract 14
- 229910052736 halogen Inorganic materials 0.000 claims abstract 14
- 150000002367 halogens Chemical group 0.000 claims abstract 14
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims abstract 13
- 125000000623 heterocyclic group Chemical group 0.000 claims abstract 12
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims abstract 9
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims abstract 9
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims abstract 8
- 125000001399 1,2,3-triazolyl group Chemical group N1N=NC(=C1)* 0.000 claims abstract 6
- 125000001376 1,2,4-triazolyl group Chemical group N1N=C(N=C1)* 0.000 claims abstract 6
- 125000003545 alkoxy group Chemical group 0.000 claims abstract 6
- 125000003118 aryl group Chemical group 0.000 claims abstract 6
- 125000000753 cycloalkyl group Chemical group 0.000 claims abstract 6
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract 6
- 125000002883 imidazolyl group Chemical group 0.000 claims abstract 6
- 229910052757 nitrogen Inorganic materials 0.000 claims abstract 6
- 125000004433 nitrogen atom Chemical group N* 0.000 claims abstract 6
- 125000003226 pyrazolyl group Chemical group 0.000 claims abstract 6
- 229910052731 fluorine Inorganic materials 0.000 claims abstract 5
- 239000011737 fluorine Substances 0.000 claims abstract 5
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims abstract 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract 5
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims abstract 5
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims abstract 5
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims abstract 4
- 125000001424 substituent group Chemical group 0.000 claims abstract 4
- 125000004849 alkoxymethyl group Chemical group 0.000 claims abstract 3
- 125000001072 heteroaryl group Chemical group 0.000 claims abstract 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract 3
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 claims abstract 3
- -1 cyano, tetrazolyl Chemical group 0.000 claims 14
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 10
- 125000004063 butyryl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 8
- 150000003839 salts Chemical class 0.000 claims 6
- DURPTKYDGMDSBL-UHFFFAOYSA-N 1-butoxybutane Chemical compound CCCCOCCCC DURPTKYDGMDSBL-UHFFFAOYSA-N 0.000 claims 3
- 125000002947 alkylene group Chemical group 0.000 claims 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 3
- 150000002431 hydrogen Chemical class 0.000 claims 3
- 230000015572 biosynthetic process Effects 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- XCTDWWZNPWNEFT-QBGQUKIHSA-N (4s)-4-[(4,6-diphenylpyridine-2-carbonyl)amino]-5-(4-ethoxycarbonyl-2-methylpiperazin-1-yl)-5-oxopentanoic acid Chemical compound CC1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(C=2C=CC=CC=2)=CC(C=2C=CC=CC=2)=N1 XCTDWWZNPWNEFT-QBGQUKIHSA-N 0.000 claims 1
- QPNBCURWXXUXEF-DEOSSOPVSA-N (4s)-4-[(4,6-diphenylpyridine-2-carbonyl)amino]-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(C=2C=CC=CC=2)=CC(C=2C=CC=CC=2)=N1 QPNBCURWXXUXEF-DEOSSOPVSA-N 0.000 claims 1
- RHXCFGKAHLDDLX-QFIPXVFZSA-N (4s)-4-[(4-butyl-6-phenylpyridine-2-carbonyl)amino]-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxopentanoic acid Chemical compound C=1C(CCCC)=CC(C(=O)N[C@@H](CCC(O)=O)C(=O)N2CCN(CC2)C(=O)OCC)=NC=1C1=CC=CC=C1 RHXCFGKAHLDDLX-QFIPXVFZSA-N 0.000 claims 1
- BYXQKIASCCYOPC-QHCPKHFHSA-N (4s)-4-[(4-cyclopentyloxy-6-phenylpyridine-2-carbonyl)amino]-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OC2CCCC2)=CC(C=2C=CC=CC=2)=N1 BYXQKIASCCYOPC-QHCPKHFHSA-N 0.000 claims 1
- WRHOJDITGVDOKW-NRFANRHFSA-N (4s)-4-[(4-cyclopropyl-3-methoxy-6-phenylpyridine-2-carbonyl)amino]-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=NC(C=2C=CC=CC=2)=CC(C2CC2)=C1OC WRHOJDITGVDOKW-NRFANRHFSA-N 0.000 claims 1
- GFOSDJLHZPXBSN-NRFANRHFSA-N (4s)-4-[(4-cyclopropyl-6-phenylpyridine-2-carbonyl)amino]-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(C2CC2)=CC(C=2C=CC=CC=2)=N1 GFOSDJLHZPXBSN-NRFANRHFSA-N 0.000 claims 1
- SRHNGMCCGFZQCK-FQEVSTJZSA-N (4s)-4-[[4-(butylamino)-5-fluoro-6-phenylpyridine-2-carbonyl]amino]-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxopentanoic acid Chemical compound FC=1C(NCCCC)=CC(C(=O)N[C@@H](CCC(O)=O)C(=O)N2CCN(CC2)C(=O)OCC)=NC=1C1=CC=CC=C1 SRHNGMCCGFZQCK-FQEVSTJZSA-N 0.000 claims 1
- FQQYEPBNPSGNBP-QFIPXVFZSA-N (4s)-5-(4-butoxycarbonylpiperazin-1-yl)-4-[[4-(butylamino)-5-fluoro-6-phenylpyridine-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound FC=1C(NCCCC)=CC(C(=O)N[C@@H](CCC(O)=O)C(=O)N2CCN(CC2)C(=O)OCCCC)=NC=1C1=CC=CC=C1 FQQYEPBNPSGNBP-QFIPXVFZSA-N 0.000 claims 1
- QEFRJTODCVVAHC-IBGZPJMESA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[(4-methyl-6-phenylpyridine-2-carbonyl)amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(C)=CC(C=2C=CC=CC=2)=N1 QEFRJTODCVVAHC-IBGZPJMESA-N 0.000 claims 1
- HVGUOTMSTMNTTC-SBRHDKPSSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[4-(2-hydroxycyclohexyl)-6-phenylpyridine-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(C2C(CCCC2)O)=CC(C=2C=CC=CC=2)=N1 HVGUOTMSTMNTTC-SBRHDKPSSA-N 0.000 claims 1
- VJCPWAGJJGLJKV-FQEVSTJZSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[4-(2-hydroxyethylamino)-6-phenylpyridine-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(NCCO)=CC(C=2C=CC=CC=2)=N1 VJCPWAGJJGLJKV-FQEVSTJZSA-N 0.000 claims 1
- NUVFAJYGOMKURK-FQEVSTJZSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[4-(2-hydroxypropan-2-yl)-6-phenylpyridine-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(C(C)(C)O)=CC(C=2C=CC=CC=2)=N1 NUVFAJYGOMKURK-FQEVSTJZSA-N 0.000 claims 1
- WPFQVQBNOTZCOL-QFIPXVFZSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[4-(3-hydroxy-3-methylbut-1-ynyl)-6-phenylpyridine-2-carbonyl]amino]-5-oxopentanoic acid Chemical class C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(C#CC(C)(C)O)=CC(C=2C=CC=CC=2)=N1 WPFQVQBNOTZCOL-QFIPXVFZSA-N 0.000 claims 1
- GAFADFDCKOQSFX-QFIPXVFZSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[4-(3-hydroxy-3-methylbutyl)-6-phenylpyridine-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(CCC(C)(C)O)=CC(C=2C=CC=CC=2)=N1 GAFADFDCKOQSFX-QFIPXVFZSA-N 0.000 claims 1
- OFRWXZNZJUOQMD-NRFANRHFSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[4-(3-hydroxypropyl)-6-phenylpyridine-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(CCCO)=CC(C=2C=CC=CC=2)=N1 OFRWXZNZJUOQMD-NRFANRHFSA-N 0.000 claims 1
- BRVXRRXTDFQHIV-BOYUCYPVSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[4-(4-hydroxycyclohexyl)-6-phenylpyridine-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(C2CCC(O)CC2)=CC(C=2C=CC=CC=2)=N1 BRVXRRXTDFQHIV-BOYUCYPVSA-N 0.000 claims 1
- SGQFBTLJTXZSRH-VWLOTQADSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[4-(4-methoxyphenyl)-6-phenylpyridine-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(C=2C=CC(OC)=CC=2)=CC(C=2C=CC=CC=2)=N1 SGQFBTLJTXZSRH-VWLOTQADSA-N 0.000 claims 1
- XPURPJLTHKOEEK-QFIPXVFZSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[4-(furan-3-yl)-6-phenylpyridine-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(C2=COC=C2)=CC(C=2C=CC=CC=2)=N1 XPURPJLTHKOEEK-QFIPXVFZSA-N 0.000 claims 1
- IVFJKYRAXDEXQB-YADHBBJMSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[4-[(3r)-3-hydroxypyrrolidin-1-yl]-6-phenylpyridine-2-carbonyl]amino]-5-oxopentanoic acid Chemical class C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(N2C[C@H](O)CC2)=CC(C=2C=CC=CC=2)=N1 IVFJKYRAXDEXQB-YADHBBJMSA-N 0.000 claims 1
- HMAXEALCKDDPBD-GOTSBHOMSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[4-[(3s)-3-methoxypyrrolidin-1-yl]-6-phenylpyridine-2-carbonyl]amino]-5-oxopentanoic acid Chemical class C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(N2C[C@H](CC2)OC)=CC(C=2C=CC=CC=2)=N1 HMAXEALCKDDPBD-GOTSBHOMSA-N 0.000 claims 1
- WZJXPTJMTBGJBC-HRTMPFAESA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[4-[2-(hydroxymethyl)cyclopropyl]-6-phenylpyridine-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(C2C(C2)CO)=CC(C=2C=CC=CC=2)=N1 WZJXPTJMTBGJBC-HRTMPFAESA-N 0.000 claims 1
- PLFDVYGVXDPNBL-VNXZQDSDSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[4-[2-(methoxymethyl)cyclopropyl]-6-phenylpyridine-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(C2C(C2)COC)=CC(C=2C=CC=CC=2)=N1 PLFDVYGVXDPNBL-VNXZQDSDSA-N 0.000 claims 1
- BIQKKOINAXJTNV-DEOSSOPVSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[6-(2-fluorophenyl)-4-phenylpyridine-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(C=2C=CC=CC=2)=CC(C=2C(=CC=CC=2)F)=N1 BIQKKOINAXJTNV-DEOSSOPVSA-N 0.000 claims 1
- JAMAYJCOFZTPGV-VWLOTQADSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[6-(2-methylphenyl)-4-phenylpyridine-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(C=2C=CC=CC=2)=CC(C=2C(=CC=CC=2)C)=N1 JAMAYJCOFZTPGV-VWLOTQADSA-N 0.000 claims 1
- IRWPDMXYAABYNB-DEOSSOPVSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[6-(4-fluorophenyl)-4-phenylpyridine-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(C=2C=CC=CC=2)=CC(C=2C=CC(F)=CC=2)=N1 IRWPDMXYAABYNB-DEOSSOPVSA-N 0.000 claims 1
- JCGLHSOLYQOHMB-VWLOTQADSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-4-[[6-(4-methylphenyl)-4-phenylpyridine-2-carbonyl]amino]-5-oxopentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(C=2C=CC=CC=2)=CC(C=2C=CC(C)=CC=2)=N1 JCGLHSOLYQOHMB-VWLOTQADSA-N 0.000 claims 1
- GNYIINRQBKJSTM-NRFANRHFSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxo-4-[(4-phenyl-6-pyrazol-1-ylpyridine-2-carbonyl)amino]pentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(C=2C=CC=CC=2)=CC(N2N=CC=C2)=N1 GNYIINRQBKJSTM-NRFANRHFSA-N 0.000 claims 1
- JFRQAMKXNUBVCS-DEOSSOPVSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxo-4-[(6-phenyl-4-phenylsulfanylpyridine-2-carbonyl)amino]pentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(SC=2C=CC=CC=2)=CC(C=2C=CC=CC=2)=N1 JFRQAMKXNUBVCS-DEOSSOPVSA-N 0.000 claims 1
- LDHBMDPMNYAXQW-NRFANRHFSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxo-4-[(6-phenyl-4-propan-2-ylsulfanylpyridine-2-carbonyl)amino]pentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(SC(C)C)=CC(C=2C=CC=CC=2)=N1 LDHBMDPMNYAXQW-NRFANRHFSA-N 0.000 claims 1
- ZIYKZVFOIJOXLZ-NRFANRHFSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxo-4-[(6-phenyl-4-pyrazol-1-ylpyridine-2-carbonyl)amino]pentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(N2N=CC=C2)=CC(C=2C=CC=CC=2)=N1 ZIYKZVFOIJOXLZ-NRFANRHFSA-N 0.000 claims 1
- PQLLTFALOQNLHK-QFIPXVFZSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxo-4-[(6-phenyl-4-pyrrolidin-1-ylpyridine-2-carbonyl)amino]pentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(N2CCCC2)=CC(C=2C=CC=CC=2)=N1 PQLLTFALOQNLHK-QFIPXVFZSA-N 0.000 claims 1
- QJUNWXHDCUPTCR-QFIPXVFZSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxo-4-[(6-phenyl-4-thiophen-3-ylpyridine-2-carbonyl)amino]pentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(C2=CSC=C2)=CC(C=2C=CC=CC=2)=N1 QJUNWXHDCUPTCR-QFIPXVFZSA-N 0.000 claims 1
- XAVBSEZQKRGRGO-FQEVSTJZSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxo-4-[(6-phenylpyridine-2-carbonyl)amino]pentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC=CC(C=2C=CC=CC=2)=N1 XAVBSEZQKRGRGO-FQEVSTJZSA-N 0.000 claims 1
- BDQPPNXDFSYZOB-IAXKEJLGSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxo-4-[[4-(oxolan-3-yloxy)-6-phenylpyridine-2-carbonyl]amino]pentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(OC2COCC2)=CC(C=2C=CC=CC=2)=N1 BDQPPNXDFSYZOB-IAXKEJLGSA-N 0.000 claims 1
- FQIQKRJAHZTVST-NRFANRHFSA-N (4s)-5-(4-ethoxycarbonylpiperazin-1-yl)-5-oxo-4-[[6-phenyl-4-(propan-2-ylamino)pyridine-2-carbonyl]amino]pentanoic acid Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(O)=O)NC(=O)C1=CC(NC(C)C)=CC(C=2C=CC=CC=2)=N1 FQIQKRJAHZTVST-NRFANRHFSA-N 0.000 claims 1
- BBHSIQIPHSSBGI-QFIPXVFZSA-N butyl 4-[(2s)-2-[(4-chloro-5-fluoro-6-phenylpyridine-2-carbonyl)amino]-5-[(2-methylpropan-2-yl)oxy]-5-oxopentanoyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)[C@H](CCC(=O)OC(C)(C)C)NC(=O)C1=CC(Cl)=C(F)C(C=2C=CC=CC=2)=N1 BBHSIQIPHSSBGI-QFIPXVFZSA-N 0.000 claims 1
- WMCDOJNFNGMINJ-LSYYVWMOSA-N butyl 4-[(2s)-2-[[4-[(3s)-3-methoxypyrrolidin-1-yl]-6-phenylpyridine-2-carbonyl]amino]-3-methylbutanoyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCCC)CCN1C(=O)[C@H](C(C)C)NC(=O)C1=CC(N2C[C@H](CC2)OC)=CC(C=2C=CC=CC=2)=N1 WMCDOJNFNGMINJ-LSYYVWMOSA-N 0.000 claims 1
- AILAQOYFPLQIFN-UHFFFAOYSA-N butyl piperazine-1-carboxylate Chemical class CCCCOC(=O)N1CCNCC1 AILAQOYFPLQIFN-UHFFFAOYSA-N 0.000 claims 1
- GLUUGHFHXGJENI-UHFFFAOYSA-N diethylenediamine Natural products C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- MBBIOTQYLRAMCR-VWLOTQADSA-N ethyl 4-[(2s)-2-[(4,6-diphenylpyridine-2-carbonyl)amino]-3-(2h-tetrazol-5-yl)propanoyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@@H](NC(=O)C=1N=C(C=C(C=1)C=1C=CC=CC=1)C=1C=CC=CC=1)CC1=NNN=N1 MBBIOTQYLRAMCR-VWLOTQADSA-N 0.000 claims 1
- KMMDGSKYVOJXAE-MHZLTWQESA-N ethyl 4-[(2s)-2-[(4,6-diphenylpyridine-2-carbonyl)amino]-5-[(2-methylpropan-2-yl)oxy]-5-oxopentanoyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(=O)OC(C)(C)C)NC(=O)C1=CC(C=2C=CC=CC=2)=CC(C=2C=CC=CC=2)=N1 KMMDGSKYVOJXAE-MHZLTWQESA-N 0.000 claims 1
- BSPYJBULYHJYBH-FQEVSTJZSA-N ethyl 4-[(2s)-2-[(4-chloro-5-fluoro-6-phenylpyridine-2-carbonyl)amino]-5-[(2-methylpropan-2-yl)oxy]-5-oxopentanoyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(=O)OC(C)(C)C)NC(=O)C1=CC(Cl)=C(F)C(C=2C=CC=CC=2)=N1 BSPYJBULYHJYBH-FQEVSTJZSA-N 0.000 claims 1
- GSCMTKFKOWADKG-SANMLTNESA-N ethyl 4-[(2s)-2-[(4-cyclopentyloxy-6-phenylpyridine-2-carbonyl)amino]-5-[(2-methylpropan-2-yl)oxy]-5-oxopentanoyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(=O)OC(C)(C)C)NC(=O)C1=CC(OC2CCCC2)=CC(C=2C=CC=CC=2)=N1 GSCMTKFKOWADKG-SANMLTNESA-N 0.000 claims 1
- MJKOHOJITWLRLL-DEOSSOPVSA-N ethyl 4-[(2s)-2-[(4-cyclopropyl-3-methoxy-6-phenylpyridine-2-carbonyl)amino]-5-[(2-methylpropan-2-yl)oxy]-5-oxopentanoyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(=O)OC(C)(C)C)NC(=O)C1=NC(C=2C=CC=CC=2)=CC(C2CC2)=C1OC MJKOHOJITWLRLL-DEOSSOPVSA-N 0.000 claims 1
- KZNNXLKFQMOMNP-DEOSSOPVSA-N ethyl 4-[(2s)-2-[(4-cyclopropyl-6-phenylpyridine-2-carbonyl)amino]-5-[(2-methylpropan-2-yl)oxy]-5-oxopentanoyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(=O)OC(C)(C)C)NC(=O)C1=CC(C2CC2)=CC(C=2C=CC=CC=2)=N1 KZNNXLKFQMOMNP-DEOSSOPVSA-N 0.000 claims 1
- UDQPAHHZCBJMDI-QHCPKHFHSA-N ethyl 4-[(2s)-2-[[4-(2-hydroxyethylamino)-6-phenylpyridine-2-carbonyl]amino]-5-[(2-methylpropan-2-yl)oxy]-5-oxopentanoyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(=O)OC(C)(C)C)NC(=O)C1=CC(NCCO)=CC(C=2C=CC=CC=2)=N1 UDQPAHHZCBJMDI-QHCPKHFHSA-N 0.000 claims 1
- DMXOWLDCYAWFLN-QHCPKHFHSA-N ethyl 4-[(2s)-2-[[4-(2-hydroxypropan-2-yl)-6-phenylpyridine-2-carbonyl]amino]-5-[(2-methylpropan-2-yl)oxy]-5-oxopentanoyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(=O)OC(C)(C)C)NC(=O)C1=CC(C(C)(C)O)=CC(C=2C=CC=CC=2)=N1 DMXOWLDCYAWFLN-QHCPKHFHSA-N 0.000 claims 1
- MTZBKMQNJGVLJX-VWLOTQADSA-N ethyl 4-[(2s)-2-[[4-(3-hydroxy-3-methylbutyl)-6-phenylpyridine-2-carbonyl]amino]-5-[(2-methylpropan-2-yl)oxy]-5-oxopentanoyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(=O)OC(C)(C)C)NC(=O)C1=CC(CCC(C)(C)O)=CC(C=2C=CC=CC=2)=N1 MTZBKMQNJGVLJX-VWLOTQADSA-N 0.000 claims 1
- NWROUJFZRNUYMZ-DEOSSOPVSA-N ethyl 4-[(2s)-2-[[4-(3-hydroxypropyl)-6-phenylpyridine-2-carbonyl]amino]-5-[(2-methylpropan-2-yl)oxy]-5-oxopentanoyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(=O)OC(C)(C)C)NC(=O)C1=CC(CCCO)=CC(C=2C=CC=CC=2)=N1 NWROUJFZRNUYMZ-DEOSSOPVSA-N 0.000 claims 1
- AMIKBVLONDFCNU-NDEPHWFRSA-N ethyl 4-[(2s)-2-[[4-(4-methoxyphenyl)-6-phenylpyridine-2-carbonyl]amino]-5-[(2-methylpropan-2-yl)oxy]-5-oxopentanoyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(=O)OC(C)(C)C)NC(=O)C1=CC(C=2C=CC(OC)=CC=2)=CC(C=2C=CC=CC=2)=N1 AMIKBVLONDFCNU-NDEPHWFRSA-N 0.000 claims 1
- BJPCCRKHFCAUHV-VWLOTQADSA-N ethyl 4-[(2s)-2-[[4-(furan-3-yl)-6-phenylpyridine-2-carbonyl]amino]-5-[(2-methylpropan-2-yl)oxy]-5-oxopentanoyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(=O)OC(C)(C)C)NC(=O)C1=CC(C2=COC=C2)=CC(C=2C=CC=CC=2)=N1 BJPCCRKHFCAUHV-VWLOTQADSA-N 0.000 claims 1
- DTAYQRWEAGCYIU-STEQJIOHSA-N ethyl 4-[(2s)-2-[[4-[2-(hydroxymethyl)cyclopropyl]-6-phenylpyridine-2-carbonyl]amino]-5-[(2-methylpropan-2-yl)oxy]-5-oxopentanoyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(=O)OC(C)(C)C)NC(=O)C1=CC(C2C(C2)CO)=CC(C=2C=CC=CC=2)=N1 DTAYQRWEAGCYIU-STEQJIOHSA-N 0.000 claims 1
- UICCYVPSDHUOIV-NXFUPXHFSA-N ethyl 4-[(2s)-2-[[4-[2-(methoxymethyl)cyclopropyl]-6-phenylpyridine-2-carbonyl]amino]-3-[4-[(2-methylpropan-2-yl)oxycarbonyl]phenyl]propanoyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@@H](NC(=O)C=1N=C(C=C(C=1)C1C(C1)COC)C=1C=CC=CC=1)CC1=CC=C(C(=O)OC(C)(C)C)C=C1 UICCYVPSDHUOIV-NXFUPXHFSA-N 0.000 claims 1
- GMPPQAOLFMOLJQ-WNMGUVTHSA-N ethyl 4-[(2s)-2-[[4-[2-(methoxymethyl)cyclopropyl]-6-phenylpyridine-2-carbonyl]amino]-5-[(2-methylpropan-2-yl)oxy]-5-oxopentanoyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(=O)OC(C)(C)C)NC(=O)C1=CC(C2C(C2)COC)=CC(C=2C=CC=CC=2)=N1 GMPPQAOLFMOLJQ-WNMGUVTHSA-N 0.000 claims 1
- UVCHXAJLNIOHBA-DEOSSOPVSA-N ethyl 4-[(2s)-3-cyano-2-[(4,6-diphenylpyridine-2-carbonyl)amino]propanoyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CC#N)NC(=O)C1=CC(C=2C=CC=CC=2)=CC(C=2C=CC=CC=2)=N1 UVCHXAJLNIOHBA-DEOSSOPVSA-N 0.000 claims 1
- WBNDZCRUBNFUQX-DEOSSOPVSA-N ethyl 4-[(2s)-5-[(2-methylpropan-2-yl)oxy]-5-oxo-2-[(4-phenyl-6-pyrazol-1-ylpyridine-2-carbonyl)amino]pentanoyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(=O)OC(C)(C)C)NC(=O)C1=CC(C=2C=CC=CC=2)=CC(N2N=CC=C2)=N1 WBNDZCRUBNFUQX-DEOSSOPVSA-N 0.000 claims 1
- GDCJFMBFHCAPJA-MHZLTWQESA-N ethyl 4-[(2s)-5-[(2-methylpropan-2-yl)oxy]-5-oxo-2-[(6-phenyl-4-phenylsulfanylpyridine-2-carbonyl)amino]pentanoyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(=O)OC(C)(C)C)NC(=O)C1=CC(SC=2C=CC=CC=2)=CC(C=2C=CC=CC=2)=N1 GDCJFMBFHCAPJA-MHZLTWQESA-N 0.000 claims 1
- CJPMDRQYGDYCGC-DEOSSOPVSA-N ethyl 4-[(2s)-5-[(2-methylpropan-2-yl)oxy]-5-oxo-2-[(6-phenyl-4-propan-2-ylsulfanylpyridine-2-carbonyl)amino]pentanoyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(=O)OC(C)(C)C)NC(=O)C1=CC(SC(C)C)=CC(C=2C=CC=CC=2)=N1 CJPMDRQYGDYCGC-DEOSSOPVSA-N 0.000 claims 1
- OASGOSNPWXYBNH-DEOSSOPVSA-N ethyl 4-[(2s)-5-[(2-methylpropan-2-yl)oxy]-5-oxo-2-[(6-phenyl-4-pyrazol-1-ylpyridine-2-carbonyl)amino]pentanoyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(=O)OC(C)(C)C)NC(=O)C1=CC(N2N=CC=C2)=CC(C=2C=CC=CC=2)=N1 OASGOSNPWXYBNH-DEOSSOPVSA-N 0.000 claims 1
- KOQPUYDOWVDECV-VWLOTQADSA-N ethyl 4-[(2s)-5-[(2-methylpropan-2-yl)oxy]-5-oxo-2-[(6-phenyl-4-pyrrolidin-1-ylpyridine-2-carbonyl)amino]pentanoyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(=O)OC(C)(C)C)NC(=O)C1=CC(N2CCCC2)=CC(C=2C=CC=CC=2)=N1 KOQPUYDOWVDECV-VWLOTQADSA-N 0.000 claims 1
- DOUVHMUACLQZRM-VWLOTQADSA-N ethyl 4-[(2s)-5-[(2-methylpropan-2-yl)oxy]-5-oxo-2-[(6-phenyl-4-thiophen-3-ylpyridine-2-carbonyl)amino]pentanoyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(=O)OC(C)(C)C)NC(=O)C1=CC(C2=CSC=C2)=CC(C=2C=CC=CC=2)=N1 DOUVHMUACLQZRM-VWLOTQADSA-N 0.000 claims 1
- MTJZTLSBLLHONU-QHCPKHFHSA-N ethyl 4-[(2s)-5-[(2-methylpropan-2-yl)oxy]-5-oxo-2-[(6-phenylpyridine-2-carbonyl)amino]pentanoyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(=O)OC(C)(C)C)NC(=O)C1=CC=CC(C=2C=CC=CC=2)=N1 MTJZTLSBLLHONU-QHCPKHFHSA-N 0.000 claims 1
- BENYJPUKDINIQQ-DEOSSOPVSA-N ethyl 4-[(2s)-5-[(2-methylpropan-2-yl)oxy]-5-oxo-2-[[6-phenyl-4-(propan-2-ylamino)pyridine-2-carbonyl]amino]pentanoyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCC)CCN1C(=O)[C@H](CCC(=O)OC(C)(C)C)NC(=O)C1=CC(NC(C)C)=CC(C=2C=CC=CC=2)=N1 BENYJPUKDINIQQ-DEOSSOPVSA-N 0.000 claims 1
- 125000004494 ethyl ester group Chemical group 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- LNOQURRKNJKKBU-UHFFFAOYSA-N ethyl piperazine-1-carboxylate Chemical compound CCOC(=O)N1CCNCC1 LNOQURRKNJKKBU-UHFFFAOYSA-N 0.000 claims 1
- 125000001153 fluoro group Chemical group F* 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- RFIOZSIHFNEKFF-UHFFFAOYSA-N piperazine-1-carboxylic acid Chemical class OC(=O)N1CCNCC1 RFIOZSIHFNEKFF-UHFFFAOYSA-N 0.000 claims 1
- 208000019553 vascular disease Diseases 0.000 claims 1
- 0 C*c1nc(C(N[C@@](**)C(N(C*(C)C2)CC(C)(*)CN2C(C)=O)=O)=O)cc(N*)c1 Chemical compound C*c1nc(C(N[C@@](**)C(N(C*(C)C2)CC(C)(*)CN2C(C)=O)=O)=O)cc(N*)c1 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/803—Processes of preparation
- C07D213/807—Processes of preparation by oxidation of pyridines or condensed pyridines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IBPCT/IB2006/053773 | 2006-10-13 | ||
| IB2006053773 | 2006-10-13 | ||
| IBPCT/IB2006/053817 | 2006-10-17 | ||
| IB2006053817 | 2006-10-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2009117705A true RU2009117705A (ru) | 2010-11-20 |
Family
ID=39167796
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2009117705/04A RU2009117705A (ru) | 2006-10-13 | 2007-10-12 | Производные 2-аминокарбонилпиридина |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US8093250B2 (enExample) |
| EP (1) | EP2081903B1 (enExample) |
| JP (1) | JP5341763B2 (enExample) |
| KR (1) | KR101525260B1 (enExample) |
| AR (1) | AR063258A1 (enExample) |
| AU (1) | AU2007305925A1 (enExample) |
| BR (1) | BRPI0720193A2 (enExample) |
| CA (1) | CA2664579C (enExample) |
| CL (1) | CL2007002920A1 (enExample) |
| ES (1) | ES2473609T3 (enExample) |
| IL (1) | IL198059A0 (enExample) |
| MA (1) | MA30868B1 (enExample) |
| MX (1) | MX2009003724A (enExample) |
| NO (1) | NO20091838L (enExample) |
| RU (1) | RU2009117705A (enExample) |
| TW (1) | TW200823190A (enExample) |
| WO (1) | WO2008044217A2 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200640877A (en) | 2005-04-28 | 2006-12-01 | Actelion Pharmaceuticals Ltd | Pyrimidine derivatives |
| CL2007002920A1 (es) | 2006-10-13 | 2008-06-06 | Actelion Pharmaceuticals Ltd | Compuestos derivados de 2-aminocarbonilpiridina; composicion farmaceutica; y uso para el tratamiento de trastornos vasculares oclusivos. |
| AR063518A1 (es) | 2006-10-25 | 2009-01-28 | Actelion Pharmaceuticals Ltd | Derivados 2-fenil-6-aminocarbonil-pirimidina; composicion farmaceutica; y su uso para tratar y/o prevenir enfermedades vasculares perifericas viscerales, hepaticas y renales, enfermedades cardiovasculares y enfermedades cerebrovasculares asociados con la agregacion de plaquetas, incluyendo trombosis |
| HRP20120735T1 (hr) | 2007-11-29 | 2012-10-31 | Actelion Pharmaceuticals Ltd. | Derivati fosfonske kiseline i njihova uporaba kao antagonista p2y12 receptora |
| JP5539235B2 (ja) | 2008-02-29 | 2014-07-02 | エボテック・アーゲー | アミド化合物、組成物およびそれらの使用 |
| AR071652A1 (es) | 2008-04-11 | 2010-07-07 | Actelion Pharmaceuticals Ltd | Derivados 2- fenil-piridina substituidos |
| AR071653A1 (es) | 2008-04-11 | 2010-07-07 | Actelion Pharmaceuticals Ltd | Derivados 2-fenil-4-ciclopropil-pirimidina |
| JP5608655B2 (ja) * | 2008-09-18 | 2014-10-15 | エヴォテック アーゲー | Ｐ２ｘ３受容体活性のモジュレーター |
| ES2567311T3 (es) | 2009-04-08 | 2016-04-21 | Actelion Pharmaceuticals Ltd. | 6-(3-Aza-biciclo[3.1.0]hex-3-il)-2-fenil-pirimidinas como antagonistas del receptor de ADP |
| JP5536876B2 (ja) | 2009-04-22 | 2014-07-02 | アクテリオン ファーマシューティカルズ リミテッド | チアゾール誘導体及びｐ２ｙ１２受容体拮抗剤としてのそれらの使用 |
| EP2593434A1 (en) | 2010-07-16 | 2013-05-22 | Purdue Pharma LP | Pyridine compounds as sodium channel blockers |
| EP2750676B1 (en) | 2011-08-30 | 2018-01-10 | University of Utah Research Foundation | Methods and compositions for treating nephrogenic diabetes insipidus |
| US9206127B2 (en) | 2012-03-16 | 2015-12-08 | Purdue Pharm, L.P. | Substituted pyridines as sodium channel blockers |
| WO2014096941A1 (en) | 2012-12-20 | 2014-06-26 | Purdue Pharma L.P. | Cyclic sulfonamides as sodium channel blockers |
| US10730866B2 (en) | 2014-04-07 | 2020-08-04 | Purdue Pharma L.P. | Indole derivatives and use thereof |
| PL3515924T3 (pl) | 2016-09-22 | 2022-04-11 | Idorsia Pharmaceuticals Ltd | Krystaliczne postacie |
| BR112019014567A2 (pt) | 2017-03-15 | 2020-02-18 | Idorsia Pharmaceuticals Ltd | Antagonista do receptor p2y12 ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, uso de éster butílico do ácido |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5373586A (en) | 1976-12-09 | 1978-06-30 | Mitsubishi Chem Ind Ltd | New penicillin derivatives |
| CA2020437A1 (en) | 1989-07-05 | 1991-01-06 | Yoshihide Fuse | Cinnamamide derivative |
| IL123986A (en) * | 1997-04-24 | 2011-10-31 | Organon Nv | Medicinal compounds |
| KR100565701B1 (ko) * | 1997-07-31 | 2006-03-29 | 우베 고산 가부시키가이샤 | Ｎ-아실아미노산 아미드 화합물 및 그의 제조 중간체 |
| JP2003502314A (ja) * | 1999-06-14 | 2003-01-21 | イーライ・リリー・アンド・カンパニー | 化合物 |
| US6861424B2 (en) | 2001-06-06 | 2005-03-01 | Schering Aktiengesellschaft | Platelet adenosine diphosphate receptor antagonists |
| EP1578423B1 (en) * | 2002-12-11 | 2010-08-18 | Bayer Schering Pharma Aktiengesellschaft | 2-aminocarbonyl-quinoline compounds as platelet adenosine diphosphate receptor antagonists |
| TW200640877A (en) * | 2005-04-28 | 2006-12-01 | Actelion Pharmaceuticals Ltd | Pyrimidine derivatives |
| NZ568335A (en) | 2005-10-21 | 2011-07-29 | Actelion Pharmaceuticals Ltd | Piperazine derivatives as antimalarial agents |
| CL2007002920A1 (es) | 2006-10-13 | 2008-06-06 | Actelion Pharmaceuticals Ltd | Compuestos derivados de 2-aminocarbonilpiridina; composicion farmaceutica; y uso para el tratamiento de trastornos vasculares oclusivos. |
| AR063518A1 (es) | 2006-10-25 | 2009-01-28 | Actelion Pharmaceuticals Ltd | Derivados 2-fenil-6-aminocarbonil-pirimidina; composicion farmaceutica; y su uso para tratar y/o prevenir enfermedades vasculares perifericas viscerales, hepaticas y renales, enfermedades cardiovasculares y enfermedades cerebrovasculares asociados con la agregacion de plaquetas, incluyendo trombosis |
| HRP20120735T1 (hr) | 2007-11-29 | 2012-10-31 | Actelion Pharmaceuticals Ltd. | Derivati fosfonske kiseline i njihova uporaba kao antagonista p2y12 receptora |
| AR071652A1 (es) | 2008-04-11 | 2010-07-07 | Actelion Pharmaceuticals Ltd | Derivados 2- fenil-piridina substituidos |
| AR071653A1 (es) | 2008-04-11 | 2010-07-07 | Actelion Pharmaceuticals Ltd | Derivados 2-fenil-4-ciclopropil-pirimidina |
| ES2567311T3 (es) | 2009-04-08 | 2016-04-21 | Actelion Pharmaceuticals Ltd. | 6-(3-Aza-biciclo[3.1.0]hex-3-il)-2-fenil-pirimidinas como antagonistas del receptor de ADP |
| JP5536876B2 (ja) | 2009-04-22 | 2014-07-02 | アクテリオン ファーマシューティカルズ リミテッド | チアゾール誘導体及びｐ２ｙ１２受容体拮抗剤としてのそれらの使用 |
-
2007
- 2007-10-11 CL CL200702920A patent/CL2007002920A1/es unknown
- 2007-10-11 AR ARP070104514A patent/AR063258A1/es unknown
- 2007-10-12 JP JP2009531969A patent/JP5341763B2/ja not_active Expired - Fee Related
- 2007-10-12 TW TW096138326A patent/TW200823190A/zh unknown
- 2007-10-12 RU RU2009117705/04A patent/RU2009117705A/ru unknown
- 2007-10-12 AU AU2007305925A patent/AU2007305925A1/en not_active Withdrawn
- 2007-10-12 CA CA2664579A patent/CA2664579C/en active Active
- 2007-10-12 ES ES07826720.0T patent/ES2473609T3/es active Active
- 2007-10-12 MX MX2009003724A patent/MX2009003724A/es unknown
- 2007-10-12 BR BRPI0720193-1A patent/BRPI0720193A2/pt not_active IP Right Cessation
- 2007-10-12 KR KR1020097009599A patent/KR101525260B1/ko not_active Expired - Fee Related
- 2007-10-12 EP EP07826720.0A patent/EP2081903B1/en active Active
- 2007-10-12 WO PCT/IB2007/054155 patent/WO2008044217A2/en not_active Ceased
- 2007-10-12 US US12/445,352 patent/US8093250B2/en active Active
-
2009
- 2009-04-07 IL IL198059A patent/IL198059A0/en unknown
- 2009-05-06 MA MA31845A patent/MA30868B1/fr unknown
- 2009-05-12 NO NO20091838A patent/NO20091838L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| ES2473609T3 (es) | 2014-07-07 |
| WO2008044217A2 (en) | 2008-04-17 |
| JP2010505940A (ja) | 2010-02-25 |
| NO20091838L (no) | 2009-05-12 |
| MA30868B1 (fr) | 2009-11-02 |
| KR20090086075A (ko) | 2009-08-10 |
| CA2664579A1 (en) | 2008-04-17 |
| US8093250B2 (en) | 2012-01-10 |
| EP2081903B1 (en) | 2014-05-07 |
| JP5341763B2 (ja) | 2013-11-13 |
| IL198059A0 (en) | 2009-12-24 |
| EP2081903A2 (en) | 2009-07-29 |
| CL2007002920A1 (es) | 2008-06-06 |
| AR063258A1 (es) | 2009-01-14 |
| WO2008044217A3 (en) | 2008-06-19 |
| US20100035895A1 (en) | 2010-02-11 |
| TW200823190A (en) | 2008-06-01 |
| KR101525260B1 (ko) | 2015-06-02 |
| BRPI0720193A2 (pt) | 2013-12-31 |
| MX2009003724A (es) | 2009-04-22 |
| AU2007305925A1 (en) | 2008-04-17 |
| CA2664579C (en) | 2014-09-30 |
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