RU2008124158A - Внеклеточные матриксные компоненты для экспансии и дифференцировки гепатических клеток-предшественников - Google Patents
Внеклеточные матриксные компоненты для экспансии и дифференцировки гепатических клеток-предшественников Download PDFInfo
- Publication number
- RU2008124158A RU2008124158A RU2008124158/13A RU2008124158A RU2008124158A RU 2008124158 A RU2008124158 A RU 2008124158A RU 2008124158/13 A RU2008124158/13 A RU 2008124158/13A RU 2008124158 A RU2008124158 A RU 2008124158A RU 2008124158 A RU2008124158 A RU 2008124158A
- Authority
- RU
- Russia
- Prior art keywords
- hepatic
- extracellular matrix
- collagen
- type iii
- precursors
- Prior art date
Links
- 230000002440 hepatic effect Effects 0.000 title claims abstract 19
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 title claims abstract 14
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 title claims abstract 14
- 210000002744 extracellular matrix Anatomy 0.000 title claims abstract 14
- 210000004027 cell Anatomy 0.000 title claims 10
- 230000004069 differentiation Effects 0.000 title 1
- 238000000034 method Methods 0.000 claims abstract 37
- 210000004185 liver Anatomy 0.000 claims abstract 12
- 210000000130 stem cell Anatomy 0.000 claims abstract 10
- 102000001187 Collagen Type III Human genes 0.000 claims abstract 9
- 108010069502 Collagen Type III Proteins 0.000 claims abstract 9
- 102000007547 Laminin Human genes 0.000 claims abstract 8
- 108010085895 Laminin Proteins 0.000 claims abstract 8
- 229920002971 Heparan sulfate Polymers 0.000 claims abstract 6
- 102000004266 Collagen Type IV Human genes 0.000 claims abstract 5
- 108010042086 Collagen Type IV Proteins 0.000 claims abstract 5
- SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 claims abstract 4
- 229920001287 Chondroitin sulfate Polymers 0.000 claims abstract 4
- 229920002683 Glycosaminoglycan Polymers 0.000 claims abstract 4
- 229940059329 chondroitin sulfate Drugs 0.000 claims abstract 4
- 229920002674 hyaluronan Polymers 0.000 claims abstract 4
- 238000012258 culturing Methods 0.000 claims abstract 3
- 210000003897 hepatic stem cell Anatomy 0.000 claims abstract 3
- 229920000045 Dermatan sulfate Polymers 0.000 claims abstract 2
- 102000016942 Elastin Human genes 0.000 claims abstract 2
- 108010014258 Elastin Proteins 0.000 claims abstract 2
- 102000016359 Fibronectins Human genes 0.000 claims abstract 2
- 108010067306 Fibronectins Proteins 0.000 claims abstract 2
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims abstract 2
- AVJBPWGFOQAPRH-FWMKGIEWSA-L dermatan sulfate Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@H](OS([O-])(=O)=O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](C([O-])=O)O1 AVJBPWGFOQAPRH-FWMKGIEWSA-L 0.000 claims abstract 2
- 229940051593 dermatan sulfate Drugs 0.000 claims abstract 2
- 229920002549 elastin Polymers 0.000 claims abstract 2
- 210000003999 epithelial cell of bile duct Anatomy 0.000 claims abstract 2
- 229920000669 heparin Polymers 0.000 claims abstract 2
- 229960002897 heparin Drugs 0.000 claims abstract 2
- KIUKXJAPPMFGSW-MNSSHETKSA-N hyaluronan Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)C1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H](C(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-MNSSHETKSA-N 0.000 claims abstract 2
- 229940099552 hyaluronan Drugs 0.000 claims abstract 2
- 238000000338 in vitro Methods 0.000 claims abstract 2
- 239000002243 precursor Substances 0.000 claims 12
- 102000008186 Collagen Human genes 0.000 claims 2
- 108010035532 Collagen Proteins 0.000 claims 2
- 229920001436 collagen Polymers 0.000 claims 2
- 239000002198 insoluble material Substances 0.000 claims 2
- 210000001519 tissue Anatomy 0.000 claims 2
- 241001529936 Murinae Species 0.000 claims 1
- 210000000648 angioblast Anatomy 0.000 claims 1
- 230000001605 fetal effect Effects 0.000 claims 1
- 230000001902 propagating effect Effects 0.000 claims 1
- 239000004017 serum-free culture medium Substances 0.000 claims 1
- 241000894007 species Species 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/067—Hepatocytes
- C12N5/0672—Stem cells; Progenitor cells; Precursor cells; Oval cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0607—Non-embryonic pluripotent stem cells, e.g. MASC
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0603—Embryonic cells ; Embryoid bodies
- C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/02—Coculture with; Conditioned medium produced by embryonic cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/03—Coculture with; Conditioned medium produced by non-embryonic pluripotent stem cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/14—Coculture with; Conditioned medium produced by hepatocytes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/50—Proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/50—Proteins
- C12N2533/52—Fibronectin; Laminin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/50—Proteins
- C12N2533/54—Collagen; Gelatin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/70—Polysaccharides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/90—Substrates of biological origin, e.g. extracellular matrix, decellularised tissue
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Developmental Biology & Embryology (AREA)
- Gynecology & Obstetrics (AREA)
- Reproductive Health (AREA)
- Gastroenterology & Hepatology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Materials For Medical Uses (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US73687305P | 2005-11-16 | 2005-11-16 | |
| US60/736,873 | 2005-11-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2008124158A true RU2008124158A (ru) | 2010-01-10 |
Family
ID=38049393
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2008124158/13A RU2008124158A (ru) | 2005-11-16 | 2006-11-15 | Внеклеточные матриксные компоненты для экспансии и дифференцировки гепатических клеток-предшественников |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US20070155009A1 (https=) |
| EP (1) | EP1954804A4 (https=) |
| JP (1) | JP2009515558A (https=) |
| KR (1) | KR20080097985A (https=) |
| CN (1) | CN101384705A (https=) |
| AU (1) | AU2006315163A1 (https=) |
| BR (1) | BRPI0618724A2 (https=) |
| CA (1) | CA2630355A1 (https=) |
| CR (1) | CR10073A (https=) |
| IL (1) | IL191533A0 (https=) |
| RU (1) | RU2008124158A (https=) |
| TW (1) | TW200730627A (https=) |
| WO (1) | WO2007059501A2 (https=) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020045260A1 (en) * | 2000-10-17 | 2002-04-18 | Shih-Chieh Hung | Method of isolating mesenchymal stem cells |
| US8084023B2 (en) | 2007-01-22 | 2011-12-27 | The Board Of Trustees Of The University Of Arkansas | Maintenance and propagation of mesenchymal stem cells |
| CA2680254A1 (en) * | 2007-03-06 | 2008-09-12 | University Of North Carolina At Chapel Hill | Complexes of hyaluronans, other matrix components, hormones and growth factors for maintenance, expansion and/or differentiation of hepatic cells |
| AU2008266992A1 (en) * | 2007-06-15 | 2008-12-24 | University Of North Carolina At Chapel Hill | Paracrine signals from mesenchymal feeder cells and regulating expansion and differentiation of hepatic progenitors using same |
| JP2010534065A (ja) * | 2007-07-20 | 2010-11-04 | セルアーティス アーベー | ヒト胚盤胞幹細胞に、胚体内胚葉（ＤＥ‐ｈｅｐ）を介して由来する新規な肝細胞の集団 |
| US8372643B2 (en) * | 2007-12-06 | 2013-02-12 | Agency For Science, Technology And Research | Method for extracellular matrix mediated differentiation and proliferation of stem cells |
| RU2010152354A (ru) * | 2008-05-22 | 2012-06-27 | Веста Терапьютикс, Инк. (Us) | Способ дифференцировки клеток-предшественников млекопитающих в инсулин-продуцирующие островковые клетки поджелудочной железы |
| US8298584B2 (en) * | 2008-12-30 | 2012-10-30 | Collagen Matrix, Inc. | Biopolymeric membrane for wound protection and repair |
| US20100227393A1 (en) * | 2009-03-06 | 2010-09-09 | Eric Lagasse | Liver stem cells: isolation of hepatic progenitor cells from the human gall bladder |
| CA3169831C (en) * | 2009-10-30 | 2025-11-18 | Sapienza Universita Di Roma | Pluripodent Stem Cells from the Extrahepatic Biliary Tree and Methods for Their Isolation |
| WO2011077894A1 (ja) * | 2009-12-25 | 2011-06-30 | Ｓｃｉｖａｘ株式会社 | スフェロイド形成促進方法およびスフェロイド形成促進培地 |
| JPWO2011102532A1 (ja) * | 2010-02-16 | 2013-06-17 | 国立大学法人九州大学 | 誘導肝細胞 |
| CA2798458C (en) * | 2010-05-07 | 2022-04-19 | University Of North Carolina At Chapel Hill | Method of engrafting cells from solid tissues |
| CA2810444A1 (en) | 2010-09-07 | 2012-03-15 | The Board Of Regents Of The University Of Texas System | Tissue-specific differentiation matrices and uses thereof |
| WO2012064606A2 (en) * | 2010-11-10 | 2012-05-18 | Wake Forest University Health Sciences | Tissue-specific extracellular matrix with or without tissue protein components for cell culture |
| BR112015010256A2 (pt) * | 2012-11-08 | 2017-07-11 | Arthrodynamic Tech Animal Health Division Inc | meio para cultivar, preservar e administrar células regenerativas |
| US9533013B2 (en) | 2013-03-13 | 2017-01-03 | University Of North Carolina At Chapel Hill | Method of treating pancreatic and liver conditions by endoscopic-mediated (or laparoscopic-mediated) transplantation of stem cells into/onto bile duct walls of particular regions of the biliary tree |
| CA2908225A1 (en) * | 2013-04-08 | 2014-10-16 | National Institutes Of Biomedical Innovation, Health And Nutrition | Method for culturing hepatoblast-like cells and culture product thereof |
| JP6278324B2 (ja) * | 2014-07-16 | 2018-02-21 | 国立大学法人大阪大学 | ラミニンフラグメントの細胞培養基質活性増強方法 |
| CN108431209B (zh) * | 2015-06-12 | 2023-02-10 | 新加坡科技研究局 | 肝脏干细胞的衍生和成熟肝细胞类型及其用途 |
| JP6755085B2 (ja) * | 2015-11-10 | 2020-09-16 | 日機装株式会社 | 細胞支持複合体および細胞支持複合体の製造方法 |
| WO2017082026A1 (ja) * | 2015-11-10 | 2017-05-18 | 日機装株式会社 | 細胞支持複合体および細胞支持複合体の製造方法 |
| RU2618989C1 (ru) * | 2016-03-09 | 2017-05-11 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) | Способ лечения печеночной недостаточности |
| US20170369849A1 (en) * | 2016-05-11 | 2017-12-28 | The University Of North Carolina At Chapel Hill | Compositions and methods for bioengineered tissues |
| KR101895669B1 (ko) * | 2016-06-22 | 2018-09-05 | 한국과학기술원 | 접착성 헤파린과 콜라겐을 이용한 줄기세포의 배양방법 |
| GB2569463A (en) * | 2016-07-18 | 2019-06-19 | Harvard College | Human lymphoid tissue-on-chip |
| CN106434532A (zh) * | 2016-12-22 | 2017-02-22 | 叶宗耀 | 一种培养肝细胞的培养基及其制备方法 |
| JP7165326B2 (ja) * | 2016-12-28 | 2022-11-04 | 株式会社高研 | 高強度コラーゲンスポンジ |
| CN115948331B (zh) * | 2022-10-17 | 2024-10-22 | 中国人民解放军西部战区总医院 | 一种从小鼠胆囊中分离获取间充质干细胞的方法 |
| WO2025244838A1 (en) * | 2024-05-21 | 2025-11-27 | Corning Incorporated | Improved collagen coatings |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6069005A (en) * | 1991-08-07 | 2000-05-30 | Albert Einstein College Of Medicine Of Yeshwa University | Hapatoblasts and method of isolating same |
| AU667680B2 (en) * | 1991-08-07 | 1996-04-04 | Albert Einstein College Of Medicine Of Yeshiva University | Proliferation of hepatocyte precursors |
| DE4222345A1 (de) * | 1992-07-08 | 1994-01-13 | Augustinus Dr Med Bader | Verfahren zum Züchten einer Zellart im Kokulturverfahren mit Leberzellen |
| HK1046930B (zh) * | 1999-01-19 | 2012-08-10 | 查珀尔希尔北卡罗来纳大学 | 人肝脏祖先 |
| US20020187133A1 (en) * | 1999-10-01 | 2002-12-12 | Hiroshi Kubota | Methods of isolating bipotent hepatic progenitor cells |
| US7456017B2 (en) * | 1999-10-01 | 2008-11-25 | University Of North Carolina At Chapel Hill | Processes for clonal growth of hepatic progenitor cells |
| PL372619A1 (en) * | 2002-03-15 | 2005-07-25 | University Of North Carolina At Chapel Hill | Primitive and proximal hepatic stem cells |
| CA2680254A1 (en) * | 2007-03-06 | 2008-09-12 | University Of North Carolina At Chapel Hill | Complexes of hyaluronans, other matrix components, hormones and growth factors for maintenance, expansion and/or differentiation of hepatic cells |
-
2006
- 2006-11-15 JP JP2008541461A patent/JP2009515558A/ja not_active Withdrawn
- 2006-11-15 RU RU2008124158/13A patent/RU2008124158A/ru not_active Application Discontinuation
- 2006-11-15 KR KR1020087014599A patent/KR20080097985A/ko not_active Withdrawn
- 2006-11-15 AU AU2006315163A patent/AU2006315163A1/en not_active Abandoned
- 2006-11-15 CN CNA2006800509212A patent/CN101384705A/zh active Pending
- 2006-11-15 US US11/560,049 patent/US20070155009A1/en not_active Abandoned
- 2006-11-15 CA CA002630355A patent/CA2630355A1/en not_active Abandoned
- 2006-11-15 EP EP06839887A patent/EP1954804A4/en not_active Withdrawn
- 2006-11-15 WO PCT/US2006/060904 patent/WO2007059501A2/en not_active Ceased
- 2006-11-15 BR BRPI0618724-2A patent/BRPI0618724A2/pt not_active IP Right Cessation
- 2006-11-16 TW TW095142412A patent/TW200730627A/zh unknown
-
2008
- 2008-05-18 IL IL191533A patent/IL191533A0/en unknown
- 2008-06-16 CR CR10073A patent/CR10073A/es not_active Application Discontinuation
-
2009
- 2009-10-02 US US12/572,711 patent/US20100093077A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CN101384705A (zh) | 2009-03-11 |
| WO2007059501A3 (en) | 2007-09-13 |
| CA2630355A1 (en) | 2007-05-24 |
| EP1954804A4 (en) | 2009-03-04 |
| AU2006315163A1 (en) | 2007-05-24 |
| KR20080097985A (ko) | 2008-11-06 |
| EP1954804A2 (en) | 2008-08-13 |
| US20100093077A1 (en) | 2010-04-15 |
| JP2009515558A (ja) | 2009-04-16 |
| WO2007059501A2 (en) | 2007-05-24 |
| BRPI0618724A2 (pt) | 2011-09-06 |
| US20070155009A1 (en) | 2007-07-05 |
| IL191533A0 (en) | 2008-12-29 |
| CR10073A (es) | 2008-10-10 |
| TW200730627A (en) | 2007-08-16 |
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