AU2006315163A1 - Extracellular matrix components for expansion or differentiation of hepatic progenitors - Google Patents

Extracellular matrix components for expansion or differentiation of hepatic progenitors Download PDF

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Publication number
AU2006315163A1
AU2006315163A1 AU2006315163A AU2006315163A AU2006315163A1 AU 2006315163 A1 AU2006315163 A1 AU 2006315163A1 AU 2006315163 A AU2006315163 A AU 2006315163A AU 2006315163 A AU2006315163 A AU 2006315163A AU 2006315163 A1 AU2006315163 A1 AU 2006315163A1
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cells
collagen
hepatic
cell
hepatic progenitors
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AU2006315163A
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Randall E. Mcclelland
Lola M. Reid
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University of North Carolina at Chapel Hill
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University of North Carolina at Chapel Hill
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    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/067Hepatocytes
    • C12N5/0672Stem cells; Progenitor cells; Precursor cells; Oval cells
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    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0607Non-embryonic pluripotent stem cells, e.g. MASC
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    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0603Embryonic cells ; Embryoid bodies
    • C12N5/0606Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
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    • C12N2500/00Specific components of cell culture medium
    • C12N2500/90Serum-free medium, which may still contain naturally-sourced components
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    • C12N2502/00Coculture with; Conditioned medium produced by
    • C12N2502/14Coculture with; Conditioned medium produced by hepatocytes
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    • C12N2533/50Proteins
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    • C12N2533/00Supports or coatings for cell culture, characterised by material
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    • C12N2533/52Fibronectin; Laminin
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    • C12N2533/00Supports or coatings for cell culture, characterised by material
    • C12N2533/50Proteins
    • C12N2533/54Collagen; Gelatin
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    • C12N2533/00Supports or coatings for cell culture, characterised by material
    • C12N2533/90Substrates of biological origin, e.g. extracellular matrix, decellularised tissue

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Reproductive Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Materials For Medical Uses (AREA)
AU2006315163A 2005-11-16 2006-11-15 Extracellular matrix components for expansion or differentiation of hepatic progenitors Abandoned AU2006315163A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US73687305P 2005-11-16 2005-11-16
US60/736,873 2005-11-16
PCT/US2006/060904 WO2007059501A2 (en) 2005-11-16 2006-11-15 Extracellular matrix components for expansion or differentiation of hepatic progenitors

Publications (1)

Publication Number Publication Date
AU2006315163A1 true AU2006315163A1 (en) 2007-05-24

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ID=38049393

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2006315163A Abandoned AU2006315163A1 (en) 2005-11-16 2006-11-15 Extracellular matrix components for expansion or differentiation of hepatic progenitors

Country Status (13)

Country Link
US (2) US20070155009A1 (https=)
EP (1) EP1954804A4 (https=)
JP (1) JP2009515558A (https=)
KR (1) KR20080097985A (https=)
CN (1) CN101384705A (https=)
AU (1) AU2006315163A1 (https=)
BR (1) BRPI0618724A2 (https=)
CA (1) CA2630355A1 (https=)
CR (1) CR10073A (https=)
IL (1) IL191533A0 (https=)
RU (1) RU2008124158A (https=)
TW (1) TW200730627A (https=)
WO (1) WO2007059501A2 (https=)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020045260A1 (en) * 2000-10-17 2002-04-18 Shih-Chieh Hung Method of isolating mesenchymal stem cells
US8084023B2 (en) 2007-01-22 2011-12-27 The Board Of Trustees Of The University Of Arkansas Maintenance and propagation of mesenchymal stem cells
CA2680254A1 (en) * 2007-03-06 2008-09-12 University Of North Carolina At Chapel Hill Complexes of hyaluronans, other matrix components, hormones and growth factors for maintenance, expansion and/or differentiation of hepatic cells
AU2008266992A1 (en) * 2007-06-15 2008-12-24 University Of North Carolina At Chapel Hill Paracrine signals from mesenchymal feeder cells and regulating expansion and differentiation of hepatic progenitors using same
JP2010534065A (ja) * 2007-07-20 2010-11-04 セルアーティス アーベー ヒト胚盤胞幹細胞に、胚体内胚葉(DE‐hep)を介して由来する新規な肝細胞の集団
US8372643B2 (en) * 2007-12-06 2013-02-12 Agency For Science, Technology And Research Method for extracellular matrix mediated differentiation and proliferation of stem cells
RU2010152354A (ru) * 2008-05-22 2012-06-27 Веста Терапьютикс, Инк. (Us) Способ дифференцировки клеток-предшественников млекопитающих в инсулин-продуцирующие островковые клетки поджелудочной железы
US8298584B2 (en) * 2008-12-30 2012-10-30 Collagen Matrix, Inc. Biopolymeric membrane for wound protection and repair
US20100227393A1 (en) * 2009-03-06 2010-09-09 Eric Lagasse Liver stem cells: isolation of hepatic progenitor cells from the human gall bladder
CA3169831C (en) * 2009-10-30 2025-11-18 Sapienza Universita Di Roma Pluripodent Stem Cells from the Extrahepatic Biliary Tree and Methods for Their Isolation
WO2011077894A1 (ja) * 2009-12-25 2011-06-30 Scivax株式会社 スフェロイド形成促進方法およびスフェロイド形成促進培地
JPWO2011102532A1 (ja) * 2010-02-16 2013-06-17 国立大学法人九州大学 誘導肝細胞
CA2798458C (en) * 2010-05-07 2022-04-19 University Of North Carolina At Chapel Hill Method of engrafting cells from solid tissues
CA2810444A1 (en) 2010-09-07 2012-03-15 The Board Of Regents Of The University Of Texas System Tissue-specific differentiation matrices and uses thereof
WO2012064606A2 (en) * 2010-11-10 2012-05-18 Wake Forest University Health Sciences Tissue-specific extracellular matrix with or without tissue protein components for cell culture
BR112015010256A2 (pt) * 2012-11-08 2017-07-11 Arthrodynamic Tech Animal Health Division Inc meio para cultivar, preservar e administrar células regenerativas
US9533013B2 (en) 2013-03-13 2017-01-03 University Of North Carolina At Chapel Hill Method of treating pancreatic and liver conditions by endoscopic-mediated (or laparoscopic-mediated) transplantation of stem cells into/onto bile duct walls of particular regions of the biliary tree
CA2908225A1 (en) * 2013-04-08 2014-10-16 National Institutes Of Biomedical Innovation, Health And Nutrition Method for culturing hepatoblast-like cells and culture product thereof
JP6278324B2 (ja) * 2014-07-16 2018-02-21 国立大学法人大阪大学 ラミニンフラグメントの細胞培養基質活性増強方法
CN108431209B (zh) * 2015-06-12 2023-02-10 新加坡科技研究局 肝脏干细胞的衍生和成熟肝细胞类型及其用途
JP6755085B2 (ja) * 2015-11-10 2020-09-16 日機装株式会社 細胞支持複合体および細胞支持複合体の製造方法
WO2017082026A1 (ja) * 2015-11-10 2017-05-18 日機装株式会社 細胞支持複合体および細胞支持複合体の製造方法
RU2618989C1 (ru) * 2016-03-09 2017-05-11 Федеральное государственное бюджетное образовательное учреждение высшего образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) Способ лечения печеночной недостаточности
US20170369849A1 (en) * 2016-05-11 2017-12-28 The University Of North Carolina At Chapel Hill Compositions and methods for bioengineered tissues
KR101895669B1 (ko) * 2016-06-22 2018-09-05 한국과학기술원 접착성 헤파린과 콜라겐을 이용한 줄기세포의 배양방법
GB2569463A (en) * 2016-07-18 2019-06-19 Harvard College Human lymphoid tissue-on-chip
CN106434532A (zh) * 2016-12-22 2017-02-22 叶宗耀 一种培养肝细胞的培养基及其制备方法
JP7165326B2 (ja) * 2016-12-28 2022-11-04 株式会社高研 高強度コラーゲンスポンジ
CN115948331B (zh) * 2022-10-17 2024-10-22 中国人民解放军西部战区总医院 一种从小鼠胆囊中分离获取间充质干细胞的方法
WO2025244838A1 (en) * 2024-05-21 2025-11-27 Corning Incorporated Improved collagen coatings

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6069005A (en) * 1991-08-07 2000-05-30 Albert Einstein College Of Medicine Of Yeshwa University Hapatoblasts and method of isolating same
AU667680B2 (en) * 1991-08-07 1996-04-04 Albert Einstein College Of Medicine Of Yeshiva University Proliferation of hepatocyte precursors
DE4222345A1 (de) * 1992-07-08 1994-01-13 Augustinus Dr Med Bader Verfahren zum Züchten einer Zellart im Kokulturverfahren mit Leberzellen
HK1046930B (zh) * 1999-01-19 2012-08-10 查珀尔希尔北卡罗来纳大学 人肝脏祖先
US20020187133A1 (en) * 1999-10-01 2002-12-12 Hiroshi Kubota Methods of isolating bipotent hepatic progenitor cells
US7456017B2 (en) * 1999-10-01 2008-11-25 University Of North Carolina At Chapel Hill Processes for clonal growth of hepatic progenitor cells
PL372619A1 (en) * 2002-03-15 2005-07-25 University Of North Carolina At Chapel Hill Primitive and proximal hepatic stem cells
CA2680254A1 (en) * 2007-03-06 2008-09-12 University Of North Carolina At Chapel Hill Complexes of hyaluronans, other matrix components, hormones and growth factors for maintenance, expansion and/or differentiation of hepatic cells

Also Published As

Publication number Publication date
CN101384705A (zh) 2009-03-11
WO2007059501A3 (en) 2007-09-13
CA2630355A1 (en) 2007-05-24
EP1954804A4 (en) 2009-03-04
KR20080097985A (ko) 2008-11-06
RU2008124158A (ru) 2010-01-10
EP1954804A2 (en) 2008-08-13
US20100093077A1 (en) 2010-04-15
JP2009515558A (ja) 2009-04-16
WO2007059501A2 (en) 2007-05-24
BRPI0618724A2 (pt) 2011-09-06
US20070155009A1 (en) 2007-07-05
IL191533A0 (en) 2008-12-29
CR10073A (es) 2008-10-10
TW200730627A (en) 2007-08-16

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