RU2007148195A - Пероральные дозированные формы о-десметилвенлафаксин сукцината повышенной биодоступности с отсроченным высвобождением - Google Patents
Пероральные дозированные формы о-десметилвенлафаксин сукцината повышенной биодоступности с отсроченным высвобождением Download PDFInfo
- Publication number
- RU2007148195A RU2007148195A RU2007148195/15A RU2007148195A RU2007148195A RU 2007148195 A RU2007148195 A RU 2007148195A RU 2007148195/15 A RU2007148195/15 A RU 2007148195/15A RU 2007148195 A RU2007148195 A RU 2007148195A RU 2007148195 A RU2007148195 A RU 2007148195A
- Authority
- RU
- Russia
- Prior art keywords
- composition containing
- increased bioavailability
- bioavailability
- combustion engine
- internal combustion
- Prior art date
Links
- 206010012186 Delayed delivery Diseases 0.000 title 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 title 1
- 239000000203 mixture Substances 0.000 claims abstract 35
- 239000011248 coating agent Substances 0.000 claims abstract 14
- 238000000576 coating method Methods 0.000 claims abstract 14
- 239000002552 dosage form Substances 0.000 claims abstract 14
- 238000002485 combustion reaction Methods 0.000 claims abstract 13
- 238000013270 controlled release Methods 0.000 claims abstract 13
- ORUUBRMVQCKYHB-UHFFFAOYSA-N butanedioic acid;4-[2-(dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]phenol Chemical compound OC(=O)CCC(O)=O.C1CCCCC1(O)C(CN(C)C)C1=CC=C(O)C=C1 ORUUBRMVQCKYHB-UHFFFAOYSA-N 0.000 claims abstract 9
- 239000004480 active ingredient Substances 0.000 claims abstract 8
- 230000003111 delayed effect Effects 0.000 claims abstract 6
- 239000001856 Ethyl cellulose Substances 0.000 claims abstract 4
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims abstract 4
- 235000019325 ethyl cellulose Nutrition 0.000 claims abstract 4
- 229920001249 ethyl cellulose Polymers 0.000 claims abstract 4
- 239000006185 dispersion Substances 0.000 claims abstract 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims abstract 2
- 238000013268 sustained release Methods 0.000 claims abstract 2
- 239000012730 sustained-release form Substances 0.000 claims abstract 2
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims 6
- 239000002702 enteric coating Substances 0.000 claims 5
- 238000009505 enteric coating Methods 0.000 claims 5
- 239000000454 talc Substances 0.000 claims 4
- 229910052623 talc Inorganic materials 0.000 claims 4
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims 3
- 239000008108 microcrystalline cellulose Substances 0.000 claims 3
- 229940016286 microcrystalline cellulose Drugs 0.000 claims 3
- DOOTYTYQINUNNV-UHFFFAOYSA-N Triethyl citrate Chemical compound CCOC(=O)CC(O)(C(=O)OCC)CC(=O)OCC DOOTYTYQINUNNV-UHFFFAOYSA-N 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 230000002496 gastric effect Effects 0.000 claims 2
- 239000011159 matrix material Substances 0.000 claims 2
- 229920000642 polymer Polymers 0.000 claims 2
- 239000001069 triethyl citrate Substances 0.000 claims 2
- VMYFZRTXGLUXMZ-UHFFFAOYSA-N triethyl citrate Natural products CCOC(=O)C(O)(C(=O)OCC)C(=O)OCC VMYFZRTXGLUXMZ-UHFFFAOYSA-N 0.000 claims 2
- 235000013769 triethyl citrate Nutrition 0.000 claims 2
- 229920003138 Eudragit® L 30 D-55 Polymers 0.000 claims 1
- 206010047700 Vomiting Diseases 0.000 claims 1
- GDCRSXZBSIRSFR-UHFFFAOYSA-N ethyl prop-2-enoate;2-methylprop-2-enoic acid Chemical compound CC(=C)C(O)=O.CCOC(=O)C=C GDCRSXZBSIRSFR-UHFFFAOYSA-N 0.000 claims 1
- 239000000314 lubricant Substances 0.000 claims 1
- 229940126601 medicinal product Drugs 0.000 claims 1
- 229920003145 methacrylic acid copolymer Polymers 0.000 claims 1
- 229940117841 methacrylic acid copolymer Drugs 0.000 claims 1
- 238000009512 pharmaceutical packaging Methods 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 239000011253 protective coating Substances 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Emergency Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US69962305P | 2005-07-15 | 2005-07-15 | |
| US60/699,623 | 2005-07-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2007148195A true RU2007148195A (ru) | 2009-08-20 |
Family
ID=37669348
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2007148195/15A RU2007148195A (ru) | 2005-07-15 | 2006-07-13 | Пероральные дозированные формы о-десметилвенлафаксин сукцината повышенной биодоступности с отсроченным высвобождением |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US20070014859A1 (enExample) |
| EP (1) | EP1904040A2 (enExample) |
| JP (1) | JP2009501233A (enExample) |
| KR (1) | KR20080025405A (enExample) |
| CN (1) | CN101247791A (enExample) |
| AR (1) | AR054833A1 (enExample) |
| AU (1) | AU2006270315A1 (enExample) |
| BR (1) | BRPI0613484A2 (enExample) |
| CA (1) | CA2612960A1 (enExample) |
| CR (1) | CR9626A (enExample) |
| EC (1) | ECSP088106A (enExample) |
| GT (1) | GT200600307A (enExample) |
| IL (1) | IL188313A0 (enExample) |
| MX (1) | MX2008000666A (enExample) |
| NO (1) | NO20080088L (enExample) |
| PE (1) | PE20070192A1 (enExample) |
| RU (1) | RU2007148195A (enExample) |
| SV (1) | SV2008002612A (enExample) |
| TW (1) | TW200740427A (enExample) |
| WO (1) | WO2007011619A2 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE602006021142D1 (de) | 2005-02-03 | 2011-05-19 | Gen Hospital Corp | Verfahren zur behandlung von gefitinib-resistentem krebs |
| JP2008534592A (ja) * | 2005-03-31 | 2008-08-28 | ワイス | Ｏ−デスメチルベンラファキシンおよびバゼドキシフェンの組み合わせ生成物およびその使用 |
| US20080175873A1 (en) * | 2005-06-02 | 2008-07-24 | Biovail Laboratories International S.R.L. | Modified release composition of at least one form of venlafaxine |
| PE20070763A1 (es) | 2005-11-04 | 2007-08-08 | Wyeth Corp | COMBINACIONES ANTINEOPLASICAS DE UN INHIBIDOR DE mTOR, TRASTUZUMAB Y/O HKI-272 |
| BRPI0619449A2 (pt) | 2005-12-05 | 2011-03-29 | Wyeth Corp | processo para a sìntese estereosseletiva de uma (4s ou 4r)-4-benzil-3-[2r ou 2s]-(1-hidroxicicloexil)-(metoxifenil) acetil]-1,3-oxazolidin-2-ona e de um enantiÈmero de uma 2-fenil-2-(1-hidroxicicloalquil) etilamina ou seu sal e compostos |
| TW200806282A (en) * | 2006-05-05 | 2008-02-01 | Wyeth Corp | Solid dosage formulations |
| US20100210719A1 (en) * | 2007-07-12 | 2010-08-19 | Dr. Reddy's Laboratories Ltd. | O-desmethylvenlafaxine |
| AU2008314489B2 (en) * | 2007-10-16 | 2014-12-04 | Alphapharm Pty Ltd | Controlled-release pharmaceutical formulation |
| US8022216B2 (en) | 2007-10-17 | 2011-09-20 | Wyeth Llc | Maleate salts of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide and crystalline forms thereof |
| TR201004720T1 (tr) * | 2007-12-10 | 2010-11-22 | Wyeth Llc | Majör depresif bozukluğun tedavisi için o-desmetil venlafaksin |
| ES2692769T3 (es) | 2008-06-17 | 2018-12-05 | Wyeth Llc | Combinaciones antineoplásicas que contienen HKI-272 y vinorelbina |
| CN109464445A (zh) | 2008-08-04 | 2019-03-15 | 惠氏有限责任公司 | 4-苯胺基-3-氰基喹啉和卡培他滨的抗肿瘤组合 |
| CN101716168B (zh) * | 2008-10-09 | 2014-09-17 | 北京德众万全医药科技有限公司 | 一种含有去甲文拉法新的盐的药物组合物及其制备方法 |
| EP2191822A1 (en) * | 2008-11-26 | 2010-06-02 | LEK Pharmaceuticals d.d. | Controlled release pharmaceutical compositions comprising O-desmethyl-venlafaxine |
| LT3000467T (lt) | 2009-04-06 | 2023-04-11 | Wyeth Llc | Krūties vėžio gydymo schema naudojant neratinibą |
| WO2011056741A2 (en) * | 2009-11-09 | 2011-05-12 | Wyeth Llc | Coated drug spheroids and uses thereof for eliminating or reducing conditions such as emesis and diarrhea |
| CA2792352C (en) * | 2010-03-31 | 2015-06-23 | Wockhardt Limited | Modified release dosage form comprising desvenlafaxine or salts thereof |
| CN102085197B (zh) * | 2010-12-14 | 2013-08-14 | 北京万生药业有限责任公司 | 一种文拉法辛缓释制剂及其制备方法 |
| MX2013011884A (es) | 2011-04-12 | 2013-11-21 | Lupin Ltd | Composiciones farmaceuticas de liberacion modificada de desvenlafaxina. |
| CN111008356B (zh) * | 2019-11-13 | 2023-06-16 | 成都理工大学 | 一种基于WTSVD算法扣除背景的γ能谱集分析方法 |
| CN114288273B (zh) * | 2022-02-11 | 2022-10-18 | 桂林华信制药有限公司 | 一种盐酸文拉法辛缓释胶囊及其生产工艺 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6274171B1 (en) * | 1996-03-25 | 2001-08-14 | American Home Products Corporation | Extended release formulation of venlafaxine hydrochloride |
| WO2000076955A1 (en) * | 1999-06-15 | 2000-12-21 | American Home Products Corporation | Enantiomers of o-desmethyl venlafaxine |
| AR021347A1 (es) * | 1999-10-20 | 2002-07-17 | Cipla Ltd | Una composicion farmaceutica que contiene acido(s) bisfosfoncio o sal(es) del mismo y un proceso de preparacion de la misma |
| EP1487429A2 (en) * | 2002-03-28 | 2004-12-22 | Synthon B.V. | Compositions of venlafaxine base |
| US6703044B1 (en) * | 2002-10-25 | 2004-03-09 | Dexcel Pharma Tech, Ltd | Venlafaxine formulations |
| ATE344659T1 (de) * | 2003-05-02 | 2006-11-15 | Dexcel Ltd | Tablettenzubereitung mit verlängerter freisetzung von venlafaxin |
| US20050175698A1 (en) * | 2004-02-06 | 2005-08-11 | Wyeth | Multiparticulate O-desmethylvenlafaxine salts and uses thereof |
| US8394409B2 (en) * | 2004-07-01 | 2013-03-12 | Intellipharmaceutics Corp. | Controlled extended drug release technology |
-
2006
- 2006-07-13 CN CNA2006800258002A patent/CN101247791A/zh active Pending
- 2006-07-13 SV SV2006002612A patent/SV2008002612A/es unknown
- 2006-07-13 EP EP06787061A patent/EP1904040A2/en not_active Withdrawn
- 2006-07-13 AR ARP060103012A patent/AR054833A1/es unknown
- 2006-07-13 JP JP2008521581A patent/JP2009501233A/ja not_active Withdrawn
- 2006-07-13 BR BRPI0613484A patent/BRPI0613484A2/pt not_active IP Right Cessation
- 2006-07-13 PE PE2006000833A patent/PE20070192A1/es not_active Application Discontinuation
- 2006-07-13 MX MX2008000666A patent/MX2008000666A/es not_active Application Discontinuation
- 2006-07-13 RU RU2007148195/15A patent/RU2007148195A/ru unknown
- 2006-07-13 AU AU2006270315A patent/AU2006270315A1/en not_active Abandoned
- 2006-07-13 KR KR1020087001067A patent/KR20080025405A/ko not_active Withdrawn
- 2006-07-13 GT GT200600307A patent/GT200600307A/es unknown
- 2006-07-13 WO PCT/US2006/027106 patent/WO2007011619A2/en not_active Ceased
- 2006-07-13 CA CA002612960A patent/CA2612960A1/en not_active Abandoned
- 2006-07-13 US US11/486,324 patent/US20070014859A1/en not_active Abandoned
- 2006-07-13 TW TW095125660A patent/TW200740427A/zh unknown
-
2007
- 2007-12-20 CR CR9626A patent/CR9626A/es not_active Application Discontinuation
- 2007-12-20 IL IL188313A patent/IL188313A0/en unknown
-
2008
- 2008-01-07 NO NO20080088A patent/NO20080088L/no not_active Application Discontinuation
- 2008-01-14 EC EC2008008106A patent/ECSP088106A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2007011619A3 (en) | 2007-06-21 |
| PE20070192A1 (es) | 2007-03-16 |
| WO2007011619A2 (en) | 2007-01-25 |
| CA2612960A1 (en) | 2007-01-25 |
| EP1904040A2 (en) | 2008-04-02 |
| AU2006270315A1 (en) | 2007-01-25 |
| CR9626A (es) | 2008-04-10 |
| US20070014859A1 (en) | 2007-01-18 |
| ECSP088106A (es) | 2008-02-20 |
| KR20080025405A (ko) | 2008-03-20 |
| NO20080088L (no) | 2008-04-02 |
| MX2008000666A (es) | 2008-03-13 |
| JP2009501233A (ja) | 2009-01-15 |
| GT200600307A (es) | 2008-04-24 |
| CN101247791A (zh) | 2008-08-20 |
| SV2008002612A (es) | 2008-08-29 |
| TW200740427A (en) | 2007-11-01 |
| AR054833A1 (es) | 2007-07-18 |
| BRPI0613484A2 (pt) | 2016-11-16 |
| IL188313A0 (en) | 2008-04-13 |
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