RU2005137175A - Производные сложного эфира и амида 2-цианопропановой кислоты и способы их применения - Google Patents

Производные сложного эфира и амида 2-цианопропановой кислоты и способы их применения Download PDF

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RU2005137175A
RU2005137175A RU2005137175/04A RU2005137175A RU2005137175A RU 2005137175 A RU2005137175 A RU 2005137175A RU 2005137175/04 A RU2005137175/04 A RU 2005137175/04A RU 2005137175 A RU2005137175 A RU 2005137175A RU 2005137175 A RU2005137175 A RU 2005137175A
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RU
Russia
Prior art keywords
methyl
naphthyl
methoxyphenyl
cyano
propanoate
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RU2005137175/04A
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English (en)
Russian (ru)
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Томас Дж КАГГИАНО (US)
Томас Дж КАГГИАНО
Энтони А БРАЗЗАЛЕ (US)
Энтони А БРАЗЗАЛЕ
Уилль м Джей МУР (US)
Уилльям Джей МУР
Каллейн Янгхи КИМ (US)
Каллейн Янгхи КИМ
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Уайт (Us)
Уайт
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Publication of RU2005137175A publication Critical patent/RU2005137175A/ru

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    • C07C323/00Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/62Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
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    • C07C255/19Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same saturated acyclic carbon skeleton
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RU2005137175/04A 2003-04-30 2004-04-30 Производные сложного эфира и амида 2-цианопропановой кислоты и способы их применения RU2005137175A (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US46656703P 2003-04-30 2003-04-30
US60/466,567 2003-04-30
US10/833,678 2004-04-28
US10/833,678 US20050004164A1 (en) 2003-04-30 2004-04-28 2-Cyanopropanoic acid amide and ester derivatives and methods of their use

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RU2005137175A true RU2005137175A (ru) 2006-05-27

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US (2) US20050004164A1 (https=)
EP (1) EP1620102B1 (https=)
JP (1) JP2006526630A (https=)
KR (1) KR20060015556A (https=)
AR (1) AR044762A1 (https=)
AT (1) ATE418335T1 (https=)
AU (1) AU2004236216A1 (https=)
BR (1) BRPI0409921A (https=)
CA (1) CA2523235A1 (https=)
CO (1) CO5700755A2 (https=)
CR (1) CR8041A (https=)
DE (1) DE602004018629D1 (https=)
MX (1) MXPA05011581A (https=)
NO (1) NO20054969L (https=)
RU (1) RU2005137175A (https=)
TW (1) TW200508217A (https=)
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Families Citing this family (33)

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Publication number Priority date Publication date Assignee Title
SE9904723D0 (sv) 1999-12-22 1999-12-22 Carlsson A Research Ab New modulators of dopamine neurotransmission II
SE9904724D0 (sv) 1999-12-22 1999-12-22 Carlsson A Research Ab New modulators of dopamine neurotransmission I
USRE46117E1 (en) 1999-12-22 2016-08-23 Teva Pharmaceuticals International Gmbh Modulators of dopamine neurotransmission
US7544350B2 (en) 2002-11-22 2009-06-09 Hallstar Innovations Corp. Method of decreasing the UV light degradation of polymers
JP2008501749A (ja) * 2004-06-08 2008-01-24 ニューロサーチ スウェーデン アクチボラゲット ドーパミン及びセロトニン神経伝達のモジュレーターとしての新規なジ置換フェニルピペリジン
DE602005021641D1 (de) 2004-06-08 2010-07-15 Nsab, Filial Af Neurosearch Sweden Ab Neue disubstituierte phenylpiperidine und piperazine als modulatoren der dopamin-neurotransmission
US7851629B2 (en) 2004-06-08 2010-12-14 Nsab, Filial Af Neurosearch Sweden Ab, Sverige Disubstituted phenylpiperidines as modulators of dopamine and serotonin neurotransmission
WO2005123663A1 (en) * 2004-06-14 2005-12-29 Wyeth Processes for the preparation of 2-cyano-3-naphthalene-1-yl-3-phenyl-propionic acid alkyl or benzyl esters
EP2248524A3 (en) 2004-08-25 2011-03-09 Takeda Pharmaceutical Company Limited Preventives/remedies for stress urinary incontinence and method of screening the same
CA2584831C (en) 2004-10-13 2013-09-17 Neurosearch Sweden Ab Process for the synthesis of 4-(3-methanesulfonylphenyl)-1-n-propyl-piperidine
CN100562514C (zh) * 2005-07-22 2009-11-25 中国科学院上海药物研究所 一类取代丙酰胺衍生物、其制备方法和用途
SE529246C2 (sv) 2005-10-13 2007-06-12 Neurosearch Sweden Ab Nya disubstituerade fenyl-piperidiner som modulatorer för dopaminneurotransmission
RU2303597C1 (ru) * 2006-05-12 2007-07-27 Иващенко Андрей Александрович Фармацевтическая композиция, способы ее получения и применения
EP2742936A1 (en) 2006-05-16 2014-06-18 Takeda Pharmaceutical Company Limited Fused heterocyclic compound and use thereof
EP2089355A2 (en) * 2006-11-01 2009-08-19 Brystol-Myers Squibb Company Modulators of glucocorticoid receptor, ap-1, and/or nf- kappa b activity and use thereof
EP2789338A3 (en) 2007-11-15 2015-01-14 Takeda Pharmaceutical Company Limited Condensed pyridine derivate and use thereof
JPWO2011071136A1 (ja) 2009-12-11 2013-04-22 アステラス製薬株式会社 線維筋痛症治療剤
WO2011094426A1 (en) 2010-01-29 2011-08-04 The United State Of America, As Represented By The Secretary, Department Of Health & Human Services Caspase inhibitors
ES2703176T3 (es) * 2010-03-11 2019-03-07 Univ New York Compuestos amido como moduladores de RORgammat y usos de los mismos
BR112014005268A2 (pt) * 2011-09-09 2017-03-28 Univ New York compostos de amido como moduladores de ror t e usos dos mesmos
MX347209B (es) 2011-12-08 2017-04-19 Teva Pharmaceuticals Int Gmbh La sal de bromhidrato de pridopidina.
HK1206297A1 (en) 2012-04-04 2016-01-08 Teva Pharmaceuticals International Gmbh Pharmaceutical compositions for combination therapy
IN2014DN09937A (https=) 2012-05-30 2015-08-14 Clariant Int Ltd
ES2599504T3 (es) 2012-05-30 2017-02-02 Clariant International Ltd Utilización de N-metil-N-acil-glucaminas como agentes solubilizantes
DE102012021647A1 (de) 2012-11-03 2014-05-08 Clariant International Ltd. Wässrige Adjuvant-Zusammensetzungen
TWI653235B (zh) 2013-05-28 2019-03-11 阿斯特捷利康公司 作為抗癌劑之吲哚衍生物
DE202014008418U1 (de) 2014-02-19 2014-11-14 Clariant International Ltd. Schaumarme agrochemische Zusammensetzungen
DE102014005771A1 (de) 2014-04-23 2015-10-29 Clariant International Ltd. Verwendung von wässrigen driftreduzierenden Zusammensetzungen
DE102015219651A1 (de) 2015-10-09 2017-04-13 Clariant International Ltd. Zusammensetzungen enthaltend Zuckeramin und Fettsäure
DE102015219608B4 (de) 2015-10-09 2018-05-03 Clariant International Ltd Universelle Pigmentdispersionen auf Basis von N-Alkylglukaminen
DE102016207877A1 (de) 2016-05-09 2017-11-09 Clariant International Ltd Stabilisatoren für Silikatfarben
KR101828240B1 (ko) 2016-10-17 2018-02-13 (주)네오팜 항염용 조성물
KR101828241B1 (ko) * 2016-10-17 2018-02-13 (주)네오팜 항염용 조성물

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6451817B1 (en) * 1995-03-10 2002-09-17 Eli Lilly And Company Alpha-substituted-1-benzyl-napthyls
RU2188819C2 (ru) * 1996-08-12 2002-09-10 Селджин Корпорейшн НОВЫЕ ИММУНОТЕРАПЕВТИЧЕСКИЕ СОЕДИНЕНИЯ, СОДЕРЖАЩАЯ ИХ ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ И СПОСОБ СНИЖЕНИЯ УРОВНЕЙ ФДЭ, TNFα И NFκB
US6271199B2 (en) * 1997-02-15 2001-08-07 Millennium Pharmaceuticals, Inc. Treatment of infarcts
JP2001513501A (ja) * 1997-08-07 2001-09-04 イーライ・リリー・アンド・カンパニー エストロゲン阻害活性を有する1−[4−(置換アルコキシ)ベンジル]ナフタレン化合物
JPH11295383A (ja) * 1998-04-15 1999-10-29 Mitsubishi Electric Corp マイクロ波帯域用半導体トランジスタのバーンイン方法、バーンイン装置及びバーンインした半導体装置
HUP0102782A3 (en) * 1998-06-19 2002-12-28 Smithkline Beecham Corp Salycilanilide as inhibitors of transcription factor nf-kb
SI1194425T1 (sl) * 1999-06-23 2005-12-31 Sanofi Aventis Deutschland Substituirani benzimidazoli
DE19951360A1 (de) * 1999-10-26 2001-05-03 Aventis Pharma Gmbh Substituierte Indole
WO2005039581A1 (en) * 2003-09-24 2005-05-06 Wyeth Use of estrogen receptor ligands for the treatment of inflammatory bowel disease
WO2005039582A1 (en) * 2003-09-24 2005-05-06 Wyeth METHODS OF TREATING ATHEROSCLEROSIS USING NF-kB INHIBITORS
AU2003278955A1 (en) * 2003-09-24 2005-05-11 Wyeth METHOD OF TREATING RHEUMATOID ARTHRITIS USING NF-kB INHIBITORS

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CR8041A (es) 2006-05-30
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US20070299105A1 (en) 2007-12-27
ATE418335T1 (de) 2009-01-15
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EP1620102B1 (en) 2008-12-24
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