RU2005106356A - Новое соединение - Google Patents
Новое соединение Download PDFInfo
- Publication number
- RU2005106356A RU2005106356A RU2005106356/04A RU2005106356A RU2005106356A RU 2005106356 A RU2005106356 A RU 2005106356A RU 2005106356/04 A RU2005106356/04 A RU 2005106356/04A RU 2005106356 A RU2005106356 A RU 2005106356A RU 2005106356 A RU2005106356 A RU 2005106356A
- Authority
- RU
- Russia
- Prior art keywords
- compound
- pharmaceutically acceptable
- formula
- acceptable salt
- solvate
- Prior art date
Links
- JRTCCNKNXFGGJT-UHFFFAOYSA-N CC(CO)(CO)Nc(nc(nc1N2)SCc(cccc3F)c3F)c1SC2=O Chemical compound CC(CO)(CO)Nc(nc(nc1N2)SCc(cccc3F)c3F)c1SC2=O JRTCCNKNXFGGJT-UHFFFAOYSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/16—Central respiratory analeptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Physical Education & Sports Medicine (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Dermatology (AREA)
- Biomedical Technology (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Claims (16)
1. Соединение формулы (I) и его фармацевтически приемлемые соли или их сольваты
2. Соединение формулы (I), или его фармацевтически приемлемая соль, или их сольват по п.1 для применения в терапии.
3. Соединение, его фармацевтически приемлемая соль, сольват или гидролизуемый in vivo сложный эфир по п.1 для применения в качестве лекарства для лечения астмы, аллергического ринита, ХОЗЛ (хроническое обструктивное заболевание легких), воспалительной болезни кишечника, остеоартрита, остеопороза, ревматоидного артрита или псориаза.
4. Соединение, его фармацевтически приемлемая соль, сольват или гидролизуемый in vivo сложный эфир по п.1 для применения в качестве лекарства для лечения рака.
5. Применение соединения формулы (I), или его фармацевтически приемлемой соли, или их сольвата по п.1 в производстве лекарства для применения в терапии.
6. Способ лечения хемокин-опосредованного заболевания, где хемокин связывается с одним или более чем одним хемокиновым рецептором, включающий введение пациенту терапевтически эффективного количества соединения формулы (I), или его фармацевтически приемлемой соли, или их сольвата по п.1.
7. Способ лечения воспалительного заболевания у пациента, страдающего от указанного заболевания или с риском его развития, включающий введение пациенту терапевтически эффективного количества соединения формулы (I), или его фармацевтически приемлемой соли, или их сольвата по п.1.
8. Способ лечения заболевания, при котором ангиогенез связан с повышенными хемокиновыми уровнями CXCR2, или есть риск такого повышения, включающий введение пациенту терапевтически эффективного количества соединения формулы (I), или его фармацевтически приемлемой соли, или их сольвата по п.1.
9. Способ получения соединения формулы (I), который включает взаимодействие соединения формулы (II)
где R представляет собой C1-6алкил,
с кислотой и возможное после этого образование фармацевтически приемлемой соли.
10. Комбинированная терапия, включающая введение соединения формулы (I), или его фармацевтически приемлемой соли, сольвата или гидролизуемого in vivo сложного эфира, или фармацевтической композиции или препарата, содержащих соединение формулы (I), одновременно или последовательно с другой терапией и/или другим фармацевтическим агентом.
11. Комбинированная терапия по п.10 для лечения астмы, аллергического ринита, ХОЗЛ, воспалительной болезни кишечника, синдрома раздраженной кишки, остеоартрита, остеопороза, ревматоидного артрита или псориаза.
12. Комбинированная терапия по п.10 для лечения рака.
13. Фармацевтическая композиция, содержащая соединение формулы (I), или его фармацевтически приемлемую соль, или их сольват по п.1, в ассоциации с фармацевтически приемлемым адъювантом, разбавителем или носителем.
14. Фармацевтическая композиция по п.13 для лечения астмы, аллергического ринита, ХОЗЛ, воспалительной болезни кишечника, синдрома раздраженной кишки, остеоартрита, остеопороза, ревматоидного артрита или псориаза.
15. Фармацевтическая композиция по п.13 для лечения рака.
16. Способ приготовления фармацевтической композиции по п.13, который включает смешивание соединения формулы (I), или его фармацевтически приемлемой соли, или их сольвата по п.1 с фармацевтически приемлемым адъювантом, разбавителем или носителем.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0221828.7A GB0221828D0 (en) | 2002-09-20 | 2002-09-20 | Novel compound |
| GB0221828.7 | 2002-09-20 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2005106356A true RU2005106356A (ru) | 2005-11-20 |
| RU2342389C2 RU2342389C2 (ru) | 2008-12-27 |
Family
ID=9944428
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2005106356/04A RU2342389C2 (ru) | 2002-09-20 | 2003-09-16 | МОНОНАТРИЕВАЯ СОЛЬ 5-[[(2,3-ДИФТОРФЕНИЛ)МЕТИЛ]ТИО]-7-[[2-ГИДРОКСИ-1-(ГИДРОКСИМЕТИЛ)-1-МЕТИЛЭТИЛ]-АМИНО]-ТИАЗОЛО[4,5-d]ПИРИМИДИН-2(3Н)-ОНА В КАЧЕСТВЕ МОДУЛЯТОРА АКТИВНОСТИ ХЕМОКИНОВЫХ РЕЦЕПТОРОВ, ЕЕ ПРИМЕНЕНИЕ И ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ |
Country Status (27)
| Country | Link |
|---|---|
| US (2) | US7585867B2 (ru) |
| EP (1) | EP1543013B1 (ru) |
| JP (1) | JP4619787B2 (ru) |
| KR (1) | KR20050057427A (ru) |
| CN (1) | CN1315848C (ru) |
| AR (1) | AR041340A1 (ru) |
| AT (1) | ATE419254T1 (ru) |
| AU (1) | AU2003267571B2 (ru) |
| BR (1) | BR0314844A (ru) |
| CA (1) | CA2498762A1 (ru) |
| DE (1) | DE60325614D1 (ru) |
| DK (1) | DK1543013T3 (ru) |
| ES (1) | ES2318152T3 (ru) |
| GB (1) | GB0221828D0 (ru) |
| HK (1) | HK1077060A1 (ru) |
| IS (1) | IS7793A (ru) |
| MX (1) | MXPA05002935A (ru) |
| NO (1) | NO20051892L (ru) |
| NZ (1) | NZ538826A (ru) |
| PL (1) | PL375952A1 (ru) |
| PT (1) | PT1543013E (ru) |
| RU (1) | RU2342389C2 (ru) |
| SI (1) | SI1543013T1 (ru) |
| TW (1) | TW200413395A (ru) |
| UA (1) | UA81257C2 (ru) |
| WO (1) | WO2004026880A1 (ru) |
| ZA (1) | ZA200502272B (ru) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9903544D0 (sv) * | 1999-10-01 | 1999-10-01 | Astra Pharma Prod | Novel compounds |
| GB2359551A (en) * | 2000-02-23 | 2001-08-29 | Astrazeneca Uk Ltd | Pharmaceutically active pyrimidine derivatives |
| SE0003828D0 (sv) | 2000-10-20 | 2000-10-20 | Astrazeneca Ab | Novel compounds |
| SE0102716D0 (sv) * | 2001-08-14 | 2001-08-14 | Astrazeneca Ab | Novel compounds |
| GB0221828D0 (en) | 2002-09-20 | 2002-10-30 | Astrazeneca Ab | Novel compound |
| GB0221829D0 (en) * | 2002-09-20 | 2002-10-30 | Astrazeneca Ab | Novel compound |
| GB0328243D0 (en) * | 2003-12-05 | 2004-01-07 | Astrazeneca Ab | Methods |
| AR053347A1 (es) * | 2005-04-06 | 2007-05-02 | Astrazeneca Ab | Derivados de [1,3]tiazolo[4,5-d]pirimidin-2(3h)-ona 5,7-sustituidos |
| UA90707C2 (en) | 2005-04-06 | 2010-05-25 | Астразенека Аб | Novel 5-substituted 7-amino-[1,3]thiazolo[4,5-d]pyrimidine derivatives |
| US7605154B2 (en) * | 2005-08-08 | 2009-10-20 | Janssen Pharmaceutica N.V. | Substituted Thiazolo [4,5-d]pyrimidines as protein kinase inhibitors |
| PE20080145A1 (es) | 2006-03-21 | 2008-02-11 | Janssen Pharmaceutica Nv | Tetrahidro-pirimidoazepinas como moduladores de trpv1 |
| TW200820973A (en) | 2006-09-29 | 2008-05-16 | Astrazeneca Ab | Novel compounds 480 |
| WO2009078999A1 (en) | 2007-12-17 | 2009-06-25 | Janssen Pharmaceutica N.V. | Imidazolo-, oxazolo-, and thiazolopyrimidine modulators of trpv1 |
| AR071036A1 (es) * | 2008-03-26 | 2010-05-19 | Astrazeneca Ab | Derivados 5, 7-disustituidos de [1, 3]tiazolo[4, 5-d]pirimidin-2 (3h)-ona, una composicion farmaceutica que los comprende y su uso en el tratamiento de enfermedades mediadas por el receptor cx3cr1. |
| WO2009151910A2 (en) * | 2008-05-25 | 2009-12-17 | Wyeth | Combination product of receptor tyrosine kinase inhibitor and fatty acid synthase inhibitor for treating cancer |
| AR079492A1 (es) | 2009-12-23 | 2012-02-01 | Ironwood Pharmaceuticals Inc | Moduladores de crth2 |
| WO2012009137A1 (en) | 2010-07-12 | 2012-01-19 | Ironwood Pharmaceuticals, Inc. | Crth2 modulators |
| WO2012009134A1 (en) | 2010-07-12 | 2012-01-19 | Ironwood Pharmaceuticals, Inc. | Crth2 modulators |
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2002
- 2002-09-20 GB GBGB0221828.7A patent/GB0221828D0/en not_active Ceased
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- 2003-09-16 NZ NZ538826A patent/NZ538826A/en unknown
- 2003-09-16 EP EP03748263A patent/EP1543013B1/en not_active Expired - Lifetime
- 2003-09-16 UA UAA200501951A patent/UA81257C2/uk unknown
- 2003-09-16 AT AT03748263T patent/ATE419254T1/de not_active IP Right Cessation
- 2003-09-16 JP JP2004537276A patent/JP4619787B2/ja not_active Expired - Fee Related
- 2003-09-16 KR KR1020057004643A patent/KR20050057427A/ko active IP Right Grant
- 2003-09-16 DK DK03748263T patent/DK1543013T3/da active
- 2003-09-16 PT PT03748263T patent/PT1543013E/pt unknown
- 2003-09-16 RU RU2005106356/04A patent/RU2342389C2/ru not_active IP Right Cessation
- 2003-09-16 AU AU2003267571A patent/AU2003267571B2/en not_active Ceased
- 2003-09-16 US US10/528,316 patent/US7585867B2/en not_active Expired - Fee Related
- 2003-09-16 PL PL03375952A patent/PL375952A1/xx not_active Application Discontinuation
- 2003-09-16 BR BR0314844-0A patent/BR0314844A/pt not_active IP Right Cessation
- 2003-09-16 MX MXPA05002935A patent/MXPA05002935A/es unknown
- 2003-09-16 CA CA002498762A patent/CA2498762A1/en not_active Abandoned
- 2003-09-16 CN CNB03822335XA patent/CN1315848C/zh not_active Expired - Fee Related
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- 2003-09-16 SI SI200331519T patent/SI1543013T1/sl unknown
- 2003-09-16 WO PCT/GB2003/003998 patent/WO2004026880A1/en active Application Filing
- 2003-09-16 DE DE60325614T patent/DE60325614D1/de not_active Expired - Lifetime
- 2003-09-19 AR ARP030103432A patent/AR041340A1/es unknown
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- 2005-10-13 HK HK05109051.2A patent/HK1077060A1/xx not_active IP Right Cessation
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Also Published As
| Publication number | Publication date |
|---|---|
| PT1543013E (pt) | 2009-02-27 |
| DK1543013T3 (da) | 2009-03-09 |
| JP4619787B2 (ja) | 2011-01-26 |
| US20080306262A1 (en) | 2008-12-11 |
| US7585867B2 (en) | 2009-09-08 |
| EP1543013A1 (en) | 2005-06-22 |
| ATE419254T1 (de) | 2009-01-15 |
| ZA200502272B (en) | 2005-09-19 |
| MXPA05002935A (es) | 2005-05-27 |
| TW200413395A (en) | 2004-08-01 |
| GB0221828D0 (en) | 2002-10-30 |
| UA81257C2 (en) | 2007-12-25 |
| AR041340A1 (es) | 2005-05-11 |
| US20060100221A1 (en) | 2006-05-11 |
| DE60325614D1 (de) | 2009-02-12 |
| AU2003267571A1 (en) | 2004-04-08 |
| CN1315848C (zh) | 2007-05-16 |
| EP1543013B1 (en) | 2008-12-31 |
| BR0314844A (pt) | 2005-08-09 |
| SI1543013T1 (sl) | 2009-04-30 |
| CA2498762A1 (en) | 2004-04-01 |
| HK1077060A1 (en) | 2006-02-03 |
| AU2003267571B2 (en) | 2007-08-16 |
| ES2318152T3 (es) | 2009-05-01 |
| IS7793A (is) | 2005-04-11 |
| RU2342389C2 (ru) | 2008-12-27 |
| WO2004026880A1 (en) | 2004-04-01 |
| NZ538826A (en) | 2006-12-22 |
| NO20051892L (no) | 2005-06-17 |
| CN1681826A (zh) | 2005-10-12 |
| JP2006503835A (ja) | 2006-02-02 |
| KR20050057427A (ko) | 2005-06-16 |
| PL375952A1 (en) | 2005-12-12 |
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| MM4A | The patent is invalid due to non-payment of fees |
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