RU2005102102A - Полисахарид echinacea angustifolia - Google Patents
Полисахарид echinacea angustifolia Download PDFInfo
- Publication number
- RU2005102102A RU2005102102A RU2005102102/04A RU2005102102A RU2005102102A RU 2005102102 A RU2005102102 A RU 2005102102A RU 2005102102/04 A RU2005102102/04 A RU 2005102102/04A RU 2005102102 A RU2005102102 A RU 2005102102A RU 2005102102 A RU2005102102 A RU 2005102102A
- Authority
- RU
- Russia
- Prior art keywords
- polysaccharide
- solvent
- water
- roots
- fraction
- Prior art date
Links
- 150000004676 glycans Chemical class 0.000 title claims abstract 17
- 229920001282 polysaccharide Polymers 0.000 title claims abstract 17
- 239000005017 polysaccharide Substances 0.000 title claims abstract 17
- 244000133098 Echinacea angustifolia Species 0.000 title claims abstract 5
- 235000014134 echinacea Nutrition 0.000 title claims abstract 5
- 238000000034 method Methods 0.000 claims abstract 21
- 239000002904 solvent Substances 0.000 claims abstract 9
- AEMOLEFTQBMNLQ-YMDCURPLSA-N D-galactopyranuronic acid Chemical compound OC1O[C@H](C(O)=O)[C@H](O)[C@H](O)[C@H]1O AEMOLEFTQBMNLQ-YMDCURPLSA-N 0.000 claims abstract 4
- 238000004587 chromatography analysis Methods 0.000 claims abstract 4
- 239000000203 mixture Substances 0.000 claims abstract 4
- IAJILQKETJEXLJ-UHFFFAOYSA-N Galacturonsaeure Natural products O=CC(O)C(O)C(O)C(O)C(O)=O IAJILQKETJEXLJ-UHFFFAOYSA-N 0.000 claims abstract 3
- WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 claims abstract 3
- PYMYPHUHKUWMLA-WDCZJNDASA-N arabinose Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)C=O PYMYPHUHKUWMLA-WDCZJNDASA-N 0.000 claims abstract 3
- PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 claims abstract 3
- SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 claims abstract 3
- 238000000605 extraction Methods 0.000 claims abstract 3
- 229930182830 galactose Natural products 0.000 claims abstract 3
- SHZGCJCMOBCMKK-UHFFFAOYSA-N D-mannomethylose Natural products CC1OC(O)C(O)C(O)C1O SHZGCJCMOBCMKK-UHFFFAOYSA-N 0.000 claims abstract 2
- SHZGCJCMOBCMKK-JFNONXLTSA-N L-rhamnopyranose Chemical compound C[C@@H]1OC(O)[C@H](O)[C@H](O)[C@H]1O SHZGCJCMOBCMKK-JFNONXLTSA-N 0.000 claims abstract 2
- PNNNRSAQSRJVSB-UHFFFAOYSA-N L-rhamnose Natural products CC(O)C(O)C(O)C(O)C=O PNNNRSAQSRJVSB-UHFFFAOYSA-N 0.000 claims abstract 2
- 235000015872 dietary supplement Nutrition 0.000 claims abstract 2
- 239000003814 drug Substances 0.000 claims abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 8
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 7
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims 6
- 238000004140 cleaning Methods 0.000 claims 4
- 125000004432 carbon atom Chemical group C* 0.000 claims 3
- 238000002203 pretreatment Methods 0.000 claims 3
- 238000009835 boiling Methods 0.000 claims 2
- 238000000638 solvent extraction Methods 0.000 claims 2
- 108010090785 inulinase Proteins 0.000 claims 1
- 238000004255 ion exchange chromatography Methods 0.000 claims 1
- 238000002955 isolation Methods 0.000 claims 1
- 235000016709 nutrition Nutrition 0.000 claims 1
- 238000001556 precipitation Methods 0.000 claims 1
- 238000000926 separation method Methods 0.000 claims 1
- 238000001542 size-exclusion chromatography Methods 0.000 claims 1
- 239000011877 solvent mixture Substances 0.000 claims 1
- 238000000108 ultra-filtration Methods 0.000 claims 1
- 239000000470 constituent Substances 0.000 abstract 1
- 230000007123 defense Effects 0.000 abstract 1
- 210000000987 immune system Anatomy 0.000 abstract 1
- 239000002417 nutraceutical Substances 0.000 abstract 1
- 235000021436 nutraceutical agent Nutrition 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 230000002269 spontaneous effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/20—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents
- A23L29/206—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents of vegetable origin
- A23L29/244—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents of vegetable origin from corms, tubers or roots, e.g. glucomannan
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/18—Reserve carbohydrates, e.g. glycogen, inulin, laminarin; Derivatives thereof
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Polymers & Plastics (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Materials Engineering (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Virology (AREA)
- Botany (AREA)
- Nutrition Science (AREA)
- Biotechnology (AREA)
- Oncology (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Communicable Diseases (AREA)
- Dispersion Chemistry (AREA)
- Alternative & Traditional Medicine (AREA)
- Food Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Medicines Containing Plant Substances (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Claims (21)
1. Полисахарид из корней Echinacea angustifolia, имеющий молекулярную массу 1,3·105 Да и состоящий из рамнозы, арабинозы, галактозы и галактуроновой кислоты в соотношении 0,5:2,5:1,75:10,25.
2. Полисахарид по п.1, отличающийся тем, что имеет остов с чередующимися прямыми и разветвленными участками, причем прямые участки состоят из частично ацетилированных и метилированных остатков галактуроновой кислоты, связанных α-(1-4) связями, и разветвленные участки состоят из чередующихся остатков галактуроновой кислоты и рамнозы, к которым присоединены боковые цепи, состоящие из арабинозы и галактозы в соотношении 2,5:1,75.
3. Способ получения полисахарида по п.1, включающий следующие стадии:
a) удаление неполисахаридных компонентов из корней экстракцией растворителем;
b) экстракция растворителем полисахаридной фракции из корней, непосредственно получаемой в предыдущей стадии;
с) выделение полисахарида хроматографией полисахаридной фракции.
4. Способ по п.3, в котором растворитель, используемый на стадии а), представляет собой ацетон или спирт, имеющий от одного до трех атомов углерода.
5. Способ по п.4, в котором растворитель находится в смеси с водой.
6. Способ по п.5, в котором водная составляющая растворителя составляет не более 40%.
7. Способ по любому из пп.4-6, в котором растворитель представляет собой этанол в концентрации от 80 до 95%.
8. Способ по любому из пп.4-6, в котором температура экстракции составляет от 20°С до температуры кипения растворителя.
9. Способ по п.3, в котором растворитель, используемый на стадии b), представляет собой воду или смесь воды и ацетона или воды и спирта, имеющего от одного до трех атомов углерода.
10. Способ по п.9, в котором содержание воды в смеси растворителей составляет 60% или более.
11. Способ по п.9, в котором растворитель представляет собой 15% этанол.
12. Способ по п.9, в котором экстракцию проводят при температуре в диапазоне от 20°С до температуры кипения растворителя.
13. Способ по п.3, в котором хроматография стадии с) представляет собой исключающую по размеру хроматографию или ионообменную хроматографию.
14. Способ по п.3, в котором перед хроматографией стадии с) полисахаридную фракцию из стадии b) подвергают одной или нескольким процедурам предварительной очистки.
15. Способ по п.14, в котором процедуры предварительной очистки выбирают из
с1) осаждения и выделения фракции, обогащенной полисахаридами, растворением в смеси воды и 50-70% ацетона или воды и 50-70% спирта, содержащего от одного до трех атомов углерода;
с2) удаления нерастворимой полисахаридной фракции обработкой водой;
с3) обработки инулиназой;
с4) ультрафильтрации с отсечкой при 10000 Да или выше.
16. Способ по п.15, в котором проводят процедуры предварительной очистки с1) и с2).
17. Способ по п.15, в котором проводят процедуру предварительной очистки с3), необязательно предваряемую одной или обеими процедурами очистки с1) и с2).
18. Способ по п.15, в котором проводят процедуру предварительной очистки с4), необязательно предваряемую одной или обеими процедурами очистки с1) и с2).
19. Полисахарид Echinacea angustifolia, получаемый способом по любому из пп. 3-18.
20. Полисахарид по любому из пп.1 и 2 для применения в качестве лекарственного средства.
21. Фармацевтические или питательные композиции и пищевые добавки, содержащие полисахарид по любому из пп.1, 2 и 19.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI2002A001692 | 2002-07-30 | ||
| IT001692A ITMI20021692A1 (it) | 2002-07-30 | 2002-07-30 | Polisaccaride di echinacea angustifolia. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2005102102A true RU2005102102A (ru) | 2005-07-10 |
| RU2308460C2 RU2308460C2 (ru) | 2007-10-20 |
Family
ID=30776596
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2005102102/04A RU2308460C2 (ru) | 2002-07-30 | 2003-06-26 | Полисахарид из корней echinacea angustifolia, способ его получения, фармацевтическая композиция |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US6818761B2 (ru) |
| EP (1) | EP1560855B1 (ru) |
| JP (1) | JP2005536588A (ru) |
| KR (2) | KR101124047B1 (ru) |
| CN (1) | CN1290867C (ru) |
| AT (1) | ATE335768T1 (ru) |
| AU (1) | AU2003246588B2 (ru) |
| CA (1) | CA2494089C (ru) |
| DE (1) | DE60307500T2 (ru) |
| DK (1) | DK1560855T3 (ru) |
| ES (1) | ES2270141T3 (ru) |
| HK (1) | HK1079224A1 (ru) |
| IL (1) | IL166554A0 (ru) |
| IT (1) | ITMI20021692A1 (ru) |
| NO (1) | NO333509B1 (ru) |
| PL (1) | PL209967B1 (ru) |
| PT (1) | PT1560855E (ru) |
| RU (1) | RU2308460C2 (ru) |
| SI (1) | SI1560855T1 (ru) |
| WO (1) | WO2004014958A1 (ru) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0524782D0 (en) * | 2005-12-05 | 2006-01-11 | Chiron Srl | Analysis of samples |
| US7642062B2 (en) | 2006-12-29 | 2010-01-05 | Avon Products Inc. | Compositions and methods of their use for improving the condition and appearance of skin |
| US20090253650A1 (en) * | 2008-04-03 | 2009-10-08 | Pongsamart S | Teat antiseptic prepared from polysaccharide gel with bactericidal and immuno-stimulating activity isolated from durian fruit-rind |
| US20090252848A1 (en) * | 2008-04-03 | 2009-10-08 | Sunanta Pongsamart | Immunomodulating polysaccharide gel from durian fruit-rind as additive in animal feed |
| WO2012005876A2 (en) | 2010-06-30 | 2012-01-12 | Avon Products, Inc. | Compositions and methods for stimulating magp-1 to improve the appearance of skin |
| EP2588062B1 (en) | 2010-06-30 | 2019-05-29 | Avon Products, Inc. | Use of tiliacora triandra in cosmetics and compositions thereof |
| RU2493171C1 (ru) * | 2012-03-12 | 2013-09-20 | Государственное научное учреждение Краснодарский научно-исследовательский институт хранения и переработки сельскохозяйственной продукции Российской академии сельскохозяйственных наук (ГНУ КНИИХП Россельхозакадемии) | Способ получения инулинсодержащего раствора из топинамбура |
| US9777076B2 (en) | 2012-07-16 | 2017-10-03 | Pfizer Inc. | Saccharides and uses thereof |
| US8920855B1 (en) | 2012-10-30 | 2014-12-30 | Setem Hemth, Inc | Methods of topically treating tinnitus and related disorders |
| JP6788882B2 (ja) * | 2016-08-09 | 2020-11-25 | イマジン・グローバル・ケア株式会社 | 自然免疫活性化作用を有する多糖類及び該多糖類を含有する自然免疫活性化剤又は飲食品 |
| CN114805621B (zh) * | 2020-04-28 | 2022-12-06 | 华南农业大学 | 具有抗肿瘤活性的多糖及其应用和制备方法 |
| CN112656807A (zh) * | 2021-01-22 | 2021-04-16 | 山东德信生物科技有限公司 | 桔梗多糖在制备降解socs1/2的药物中的应用 |
| KR102478769B1 (ko) * | 2022-05-31 | 2022-12-20 | 한국콜마주식회사 | 에키네시아 추출물을 포함하는 피부 개선용 조성물 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE950674C (de) * | 1955-01-15 | 1956-10-11 | Gruenenthal Chemie | Verfahren zur Gewinnung von Wirkstoffen aus waessrigen Extrakten von Echinaceen-Arten |
| US4010650A (en) * | 1974-12-26 | 1977-03-08 | Ford Motor Company | Apparatus for generating an electrical signal indicative of liquid level |
| DE3217214A1 (de) * | 1982-05-07 | 1983-11-10 | Wagner, Hildebert, Prof. Dr., 8211 Breitbrunn | Polysaccharide aus pflanzen der compositen-familie, verfahren zu ihrer gewinnung und sie enthaltende pharmazeutische zubereitungen |
| US4859375A (en) * | 1986-12-29 | 1989-08-22 | Air Products And Chemicals, Inc. | Chemical refill system |
| DE3541945A1 (de) * | 1985-11-27 | 1987-06-04 | Lomapharm Rudolf Lohman Gmbh K | Immunstimulierend wirkende polysaccharide aus zellkulturen von echinacea purpurea (l.) moench und echinacea angustifolia, d.c. verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zubereitungen |
| US5031068A (en) * | 1987-11-06 | 1991-07-09 | Hansen Technologies Corporation | Liquid level control system for refrigeration apparatus |
| DE19817177A1 (de) * | 1998-04-17 | 1999-10-21 | Lohmann Rudolf Lomapharm | Pflanzliche Polysaccharide mit immunstimulierender Wirkung, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel |
| IL133102A0 (en) * | 1998-11-30 | 2001-03-19 | Air Prod & Chem | Ultrasonic level sense in a chemical refill system |
| JP2001078717A (ja) * | 1999-09-17 | 2001-03-27 | Fancl Corp | 食品組成物 |
| WO2001022977A2 (en) * | 1999-09-30 | 2001-04-05 | Factors R & D Technologies Ltd. | Echinacea supplement and method of manufacture |
| JP2002012546A (ja) * | 2000-06-29 | 2002-01-15 | Noevir Co Ltd | 皮膚外用剤 |
-
2002
- 2002-07-30 IT IT001692A patent/ITMI20021692A1/it unknown
- 2002-11-25 US US10/302,843 patent/US6818761B2/en not_active Expired - Fee Related
-
2003
- 2003-06-26 PL PL373112A patent/PL209967B1/pl not_active IP Right Cessation
- 2003-06-26 AU AU2003246588A patent/AU2003246588B2/en not_active Ceased
- 2003-06-26 WO PCT/EP2003/006717 patent/WO2004014958A1/en active IP Right Grant
- 2003-06-26 CN CNB038181797A patent/CN1290867C/zh not_active Expired - Fee Related
- 2003-06-26 DE DE60307500T patent/DE60307500T2/de not_active Expired - Lifetime
- 2003-06-26 EP EP03783988A patent/EP1560855B1/en not_active Expired - Lifetime
- 2003-06-26 KR KR1020117003013A patent/KR101124047B1/ko not_active IP Right Cessation
- 2003-06-26 SI SI200330421T patent/SI1560855T1/sl unknown
- 2003-06-26 AT AT03783988T patent/ATE335768T1/de active
- 2003-06-26 PT PT03783988T patent/PT1560855E/pt unknown
- 2003-06-26 JP JP2004526704A patent/JP2005536588A/ja active Pending
- 2003-06-26 KR KR1020057000634A patent/KR101124105B1/ko not_active IP Right Cessation
- 2003-06-26 RU RU2005102102/04A patent/RU2308460C2/ru not_active IP Right Cessation
- 2003-06-26 CA CA2494089A patent/CA2494089C/en not_active Expired - Fee Related
- 2003-06-26 ES ES03783988T patent/ES2270141T3/es not_active Expired - Lifetime
- 2003-06-26 DK DK03783988T patent/DK1560855T3/da active
-
2005
- 2005-01-28 NO NO20050508A patent/NO333509B1/no not_active IP Right Cessation
- 2005-01-31 IL IL16655405A patent/IL166554A0/xx not_active IP Right Cessation
- 2005-12-06 HK HK05111117A patent/HK1079224A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| PL209967B1 (pl) | 2011-11-30 |
| ITMI20021692A1 (it) | 2002-10-29 |
| US6818761B2 (en) | 2004-11-16 |
| EP1560855B1 (en) | 2006-08-09 |
| NO333509B1 (no) | 2013-06-24 |
| ES2270141T3 (es) | 2007-04-01 |
| US20040024199A1 (en) | 2004-02-05 |
| HK1079224A1 (en) | 2006-03-31 |
| WO2004014958A1 (en) | 2004-02-19 |
| DE60307500D1 (de) | 2006-09-21 |
| AU2003246588B2 (en) | 2008-10-16 |
| CA2494089C (en) | 2012-07-31 |
| PT1560855E (pt) | 2006-12-29 |
| CN1671745A (zh) | 2005-09-21 |
| KR101124105B1 (ko) | 2012-03-22 |
| SI1560855T1 (sl) | 2006-10-31 |
| KR20050025967A (ko) | 2005-03-14 |
| KR101124047B1 (ko) | 2012-03-27 |
| IL166554A0 (en) | 2006-01-15 |
| KR20110018468A (ko) | 2011-02-23 |
| PL373112A1 (en) | 2005-08-08 |
| EP1560855A1 (en) | 2005-08-10 |
| RU2308460C2 (ru) | 2007-10-20 |
| NO20050508L (no) | 2005-01-28 |
| CA2494089A1 (en) | 2004-02-19 |
| ATE335768T1 (de) | 2006-09-15 |
| DK1560855T3 (da) | 2006-12-18 |
| JP2005536588A (ja) | 2005-12-02 |
| AU2003246588A1 (en) | 2004-02-25 |
| DE60307500T2 (de) | 2007-03-29 |
| CN1290867C (zh) | 2006-12-20 |
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