RU2003131970A - Производные 4-(фенил-пиперидин-4-илиден-метил)-бензамида и их применение для лечения боли, тревоги или желудочно-кишечных расстройств - Google Patents
Производные 4-(фенил-пиперидин-4-илиден-метил)-бензамида и их применение для лечения боли, тревоги или желудочно-кишечных расстройств Download PDFInfo
- Publication number
- RU2003131970A RU2003131970A RU2003131970/04A RU2003131970A RU2003131970A RU 2003131970 A RU2003131970 A RU 2003131970A RU 2003131970/04 A RU2003131970/04 A RU 2003131970/04A RU 2003131970 A RU2003131970 A RU 2003131970A RU 2003131970 A RU2003131970 A RU 2003131970A
- Authority
- RU
- Russia
- Prior art keywords
- phenyl
- compound
- methyl
- ylidene
- diethylbenzamide
- Prior art date
Links
- 208000019901 Anxiety disease Diseases 0.000 title claims 4
- 208000018522 Gastrointestinal disease Diseases 0.000 title claims 4
- 230000036506 anxiety Effects 0.000 title claims 4
- 230000036407 pain Effects 0.000 title claims 4
- 208000027520 Somatoform disease Diseases 0.000 title claims 2
- 208000027753 pain disease Diseases 0.000 title claims 2
- TZKLMPPHEAGFJR-UHFFFAOYSA-N 4-[phenyl(piperidin-4-ylidene)methyl]benzamide Chemical class C1=CC(C(=O)N)=CC=C1C(C=1C=CC=CC=1)=C1CCNCC1 TZKLMPPHEAGFJR-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 20
- -1 phenyl (2) pyridinyl Chemical group 0.000 claims 8
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 6
- 238000000034 method Methods 0.000 claims 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 4
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 claims 3
- 125000001072 heteroaryl group Chemical group 0.000 claims 3
- JOYRKODLDBILNP-UHFFFAOYSA-N urethane group Chemical group NC(=O)OCC JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 claims 3
- 125000001246 bromo group Chemical group Br* 0.000 claims 2
- 125000001309 chloro group Chemical group Cl* 0.000 claims 2
- 125000001153 fluoro group Chemical group F* 0.000 claims 2
- 125000002346 iodo group Chemical group I* 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 125000000168 pyrrolyl group Chemical group 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 125000001424 substituent group Chemical group 0.000 claims 2
- 125000001544 thienyl group Chemical group 0.000 claims 2
- GOTUDRDNYGCEFR-UHFFFAOYSA-N 4-[(3-aminophenyl)-(1-benzylpiperidin-4-ylidene)methyl]-n,n-diethylbenzamide Chemical compound C1=CC(C(=O)N(CC)CC)=CC=C1C(C=1C=C(N)C=CC=1)=C1CCN(CC=2C=CC=CC=2)CC1 GOTUDRDNYGCEFR-UHFFFAOYSA-N 0.000 claims 1
- IDBQGJLBDNWHHT-UHFFFAOYSA-N 4-[(3-aminophenyl)-[1-(1h-pyrrol-2-ylmethyl)piperidin-4-ylidene]methyl]-n,n-diethylbenzamide Chemical compound C1=CC(C(=O)N(CC)CC)=CC=C1C(C=1C=C(N)C=CC=1)=C1CCN(CC=2NC=CC=2)CC1 IDBQGJLBDNWHHT-UHFFFAOYSA-N 0.000 claims 1
- KDZZJVBMONDHCG-UHFFFAOYSA-N 4-[(3-aminophenyl)-[1-(furan-2-ylmethyl)piperidin-4-ylidene]methyl]-n,n-diethylbenzamide Chemical compound C1=CC(C(=O)N(CC)CC)=CC=C1C(C=1C=C(N)C=CC=1)=C1CCN(CC=2OC=CC=2)CC1 KDZZJVBMONDHCG-UHFFFAOYSA-N 0.000 claims 1
- LUDBTSUCODMUMG-UHFFFAOYSA-N 4-[(3-aminophenyl)-[1-(furan-3-ylmethyl)piperidin-4-ylidene]methyl]-n,n-diethylbenzamide Chemical compound C1=CC(C(=O)N(CC)CC)=CC=C1C(C=1C=C(N)C=CC=1)=C1CCN(CC2=COC=C2)CC1 LUDBTSUCODMUMG-UHFFFAOYSA-N 0.000 claims 1
- DPPKMLGQONNXEX-UHFFFAOYSA-N 4-[(3-aminophenyl)-[1-(pyridin-2-ylmethyl)piperidin-4-ylidene]methyl]-n,n-diethylbenzamide Chemical compound C1=CC(C(=O)N(CC)CC)=CC=C1C(C=1C=C(N)C=CC=1)=C1CCN(CC=2N=CC=CC=2)CC1 DPPKMLGQONNXEX-UHFFFAOYSA-N 0.000 claims 1
- PWEDDQYLWLLKBR-UHFFFAOYSA-N 4-[(3-aminophenyl)-[1-(pyridin-4-ylmethyl)piperidin-4-ylidene]methyl]-n,n-diethylbenzamide Chemical compound C1=CC(C(=O)N(CC)CC)=CC=C1C(C=1C=C(N)C=CC=1)=C1CCN(CC=2C=CN=CC=2)CC1 PWEDDQYLWLLKBR-UHFFFAOYSA-N 0.000 claims 1
- LCLKADFRDCULRB-UHFFFAOYSA-N 4-[(3-aminophenyl)-[1-(thiophen-2-ylmethyl)piperidin-4-ylidene]methyl]-n,n-diethylbenzamide Chemical compound C1=CC(C(=O)N(CC)CC)=CC=C1C(C=1C=C(N)C=CC=1)=C1CCN(CC=2SC=CC=2)CC1 LCLKADFRDCULRB-UHFFFAOYSA-N 0.000 claims 1
- ZAXWRRQOARHXLK-UHFFFAOYSA-N 4-[(3-aminophenyl)-[1-(thiophen-3-ylmethyl)piperidin-4-ylidene]methyl]-n,n-diethylbenzamide Chemical compound C1=CC(C(=O)N(CC)CC)=CC=C1C(C=1C=C(N)C=CC=1)=C1CCN(CC2=CSC=C2)CC1 ZAXWRRQOARHXLK-UHFFFAOYSA-N 0.000 claims 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical class OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims 1
- 208000014540 Functional gastrointestinal disease Diseases 0.000 claims 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical class Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical class [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 239000003054 catalyst Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000002541 furyl group Chemical group 0.000 claims 1
- JMZFEHDNIAQMNB-UHFFFAOYSA-N m-aminophenylboronic acid Chemical compound NC1=CC=CC(B(O)O)=C1 JMZFEHDNIAQMNB-UHFFFAOYSA-N 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 229910052763 palladium Inorganic materials 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 229940095064 tartrate Drugs 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 125000000335 thiazolyl group Chemical group 0.000 claims 1
- 125000001425 triazolyl group Chemical group 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0101765-6 | 2001-05-18 | ||
| SE0101765A SE0101765D0 (sv) | 2001-05-18 | 2001-05-18 | Novel compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2003131970A true RU2003131970A (ru) | 2005-05-10 |
Family
ID=20284168
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2003131970/04A RU2003131970A (ru) | 2001-05-18 | 2002-05-16 | Производные 4-(фенил-пиперидин-4-илиден-метил)-бензамида и их применение для лечения боли, тревоги или желудочно-кишечных расстройств |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US7074808B2 (enExample) |
| EP (1) | EP1395576B1 (enExample) |
| JP (1) | JP2005510457A (enExample) |
| KR (1) | KR20040000467A (enExample) |
| CN (1) | CN1509282A (enExample) |
| AR (1) | AR035973A1 (enExample) |
| AT (1) | ATE303379T1 (enExample) |
| BG (1) | BG108326A (enExample) |
| BR (1) | BR0209676A (enExample) |
| CA (1) | CA2446332A1 (enExample) |
| CO (1) | CO5611136A2 (enExample) |
| CZ (1) | CZ20033085A3 (enExample) |
| DE (1) | DE60205894T2 (enExample) |
| EE (1) | EE200300540A (enExample) |
| HU (1) | HUP0401096A2 (enExample) |
| IL (1) | IL158704A0 (enExample) |
| IS (1) | IS7026A (enExample) |
| MX (1) | MXPA03010439A (enExample) |
| NO (1) | NO20035116D0 (enExample) |
| PL (1) | PL366640A1 (enExample) |
| RU (1) | RU2003131970A (enExample) |
| SE (1) | SE0101765D0 (enExample) |
| SK (1) | SK13952003A3 (enExample) |
| WO (1) | WO2002094812A1 (enExample) |
| ZA (1) | ZA200308633B (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2319876T3 (es) | 2001-05-18 | 2009-05-14 | Astrazeneca Ab | Derivados de 4 (fenil-piperazinil-metil) benzamida y su uso para el tratamiento de la ansiedad o trastornos gastrointestinales. |
| SE0203303D0 (sv) | 2002-11-07 | 2002-11-07 | Astrazeneca Ab | Novel Compounds |
| SE0203300D0 (sv) | 2002-11-07 | 2002-11-07 | Astrazeneca Ab | Novel Compounds |
| SE0300103D0 (sv) * | 2003-01-16 | 2003-01-16 | Astrazeneca Ab | Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof |
| SE0300104D0 (sv) * | 2003-01-16 | 2003-01-16 | Astrazeneca Ab | Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof |
| US20070099957A1 (en) * | 2003-05-16 | 2007-05-03 | Astra Zeneca Ab | Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof |
| SE0301442D0 (sv) * | 2003-05-16 | 2003-05-16 | Astrazeneca Ab | Diarylmethylidene piperidine derivatives, preparations therof and uses thereof |
| EP1644373A1 (en) * | 2003-06-27 | 2006-04-12 | Janssen Pharmaceutica N.V. | Tricyclic delta opioid modulators |
| US7338962B2 (en) | 2003-10-01 | 2008-03-04 | Adolor Corporation | Spirocyclic heterocyclic derivatives and methods of their use |
| SE0400027D0 (sv) * | 2004-01-09 | 2004-01-09 | Astrazeneca Ab | Diarylmethyl piperazine derivatives, preparations thereof and uses thereof |
| SE0400026D0 (sv) * | 2004-01-09 | 2004-01-09 | Astrazeneca Ab | Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof |
| SE0400025D0 (sv) * | 2004-01-09 | 2004-01-09 | Astrazeneca Ab | Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof |
| DK1781631T3 (da) | 2004-08-02 | 2012-05-14 | Astrazeneca Ab | Diarylmethylpiperazinderivater, præparater dermed og anvendelser deraf |
| US7598261B2 (en) | 2005-03-31 | 2009-10-06 | Adolor Corporation | Spirocyclic heterocyclic derivatives and methods of their use |
| CN101389623A (zh) * | 2006-02-28 | 2009-03-18 | 阿斯利康(瑞典)有限公司 | 吲哚衍生物的新的盐及其在医药中的用途 |
| US7576207B2 (en) | 2006-04-06 | 2009-08-18 | Adolor Corporation | Spirocyclic heterocyclic derivatives and methods of their use |
| JP2010503669A (ja) | 2006-09-12 | 2010-02-04 | アドラー コーポレーション | 認知機能の強化のためのｎ含有スピロ化合物の使用 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2898339A (en) | 1957-07-29 | 1959-08-04 | Wm S Merrell Co | N-substituted benzhydrol, benzhydryl, and benzhydrylidene piperidine |
| US4581171A (en) | 1983-07-27 | 1986-04-08 | Janssen Pharmaceutica, N.V. | [[Bis(aryl)methylene]-1-piperidinyl]alkyl-pyrimidinones useful for treating psychotropic disorders |
| US4816586A (en) | 1987-07-29 | 1989-03-28 | Regents Of The University Of Minnesota | Delta opioid receptor antagonists |
| US5140029A (en) | 1989-01-09 | 1992-08-18 | Janssen Pharmaceutica N.V. | 2-aminopyrimidinone derivatives |
| US4939137A (en) | 1989-06-28 | 1990-07-03 | Ortho Pharmaceutical Corporation | Ring-fused thienopyrimidinedione derivatives |
| US5683998A (en) | 1991-04-23 | 1997-11-04 | Toray Industries, Inc. | Tricyclic triazolo derivatives, processes for producing the same and the uses of the same |
| GB9202238D0 (en) | 1992-02-03 | 1992-03-18 | Wellcome Found | Compounds |
| US5574159A (en) | 1992-02-03 | 1996-11-12 | Delta Pharmaceuticals, Inc. | Opioid compounds and methods for making therefor |
| SE9504661D0 (sv) | 1995-12-22 | 1995-12-22 | Astra Pharma Inc | New compounds |
| TW548271B (en) | 1996-12-20 | 2003-08-21 | Astra Pharma Inc | Novel piperidine derivatives having an exocyclic double bond with analgesic effects |
| JP4754068B2 (ja) | 1997-12-24 | 2011-08-24 | オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド | δ−オピオイドレセプターに結合する４−［アリール（ピペリジン−４−イル）］アミノベンズアミド類 |
| AU2001241676A1 (en) * | 2000-03-03 | 2001-09-17 | Ortho-Mcneil Pharmaceutical, Inc. | 3-(diarylmethylene)-8-azabicyclo(3.2.1)octane derivatives |
| US6556387B1 (en) * | 2000-03-31 | 2003-04-29 | Seagate Technology Llc | Controlling mechanical response characteristics of a disc drive actuator by adjusting a fastener engaging the actuator shaft to vary axial force on the bearing assembly |
| SE0001208D0 (sv) | 2000-04-04 | 2000-04-04 | Astrazeneca Canada Inc | Novel compounds |
| SE0001207D0 (sv) | 2000-04-04 | 2000-04-04 | Astrazeneca Canada Inc | Novel compounds |
-
2001
- 2001-05-18 SE SE0101765A patent/SE0101765D0/xx unknown
-
2002
- 2002-05-16 SK SK1395-2003A patent/SK13952003A3/sk unknown
- 2002-05-16 MX MXPA03010439A patent/MXPA03010439A/es unknown
- 2002-05-16 AT AT02733710T patent/ATE303379T1/de not_active IP Right Cessation
- 2002-05-16 RU RU2003131970/04A patent/RU2003131970A/ru not_active Application Discontinuation
- 2002-05-16 BR BR0209676-5A patent/BR0209676A/pt not_active Application Discontinuation
- 2002-05-16 AR ARP020101810A patent/AR035973A1/es unknown
- 2002-05-16 EE EEP200300540A patent/EE200300540A/xx unknown
- 2002-05-16 IL IL15870402A patent/IL158704A0/xx unknown
- 2002-05-16 WO PCT/SE2002/000953 patent/WO2002094812A1/en not_active Ceased
- 2002-05-16 JP JP2002591485A patent/JP2005510457A/ja active Pending
- 2002-05-16 CA CA002446332A patent/CA2446332A1/en not_active Abandoned
- 2002-05-16 CN CNA028101952A patent/CN1509282A/zh active Pending
- 2002-05-16 CZ CZ20033085A patent/CZ20033085A3/cs unknown
- 2002-05-16 DE DE60205894T patent/DE60205894T2/de not_active Expired - Fee Related
- 2002-05-16 US US10/477,821 patent/US7074808B2/en not_active Expired - Fee Related
- 2002-05-16 KR KR10-2003-7014941A patent/KR20040000467A/ko not_active Withdrawn
- 2002-05-16 EP EP02733710A patent/EP1395576B1/en not_active Expired - Lifetime
- 2002-05-16 PL PL02366640A patent/PL366640A1/xx not_active Application Discontinuation
- 2002-05-16 HU HU0401096A patent/HUP0401096A2/hu unknown
-
2003
- 2003-11-05 ZA ZA200308633A patent/ZA200308633B/en unknown
- 2003-11-07 BG BG108326A patent/BG108326A/bg unknown
- 2003-11-11 IS IS7026A patent/IS7026A/is unknown
- 2003-11-12 CO CO03100156A patent/CO5611136A2/es not_active Application Discontinuation
- 2003-11-17 NO NO20035116A patent/NO20035116D0/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| SK13952003A3 (sk) | 2004-04-06 |
| CN1509282A (zh) | 2004-06-30 |
| US7074808B2 (en) | 2006-07-11 |
| MXPA03010439A (es) | 2004-03-09 |
| US20040142967A1 (en) | 2004-07-22 |
| EP1395576B1 (en) | 2005-08-31 |
| KR20040000467A (ko) | 2004-01-03 |
| BG108326A (bg) | 2004-12-30 |
| BR0209676A (pt) | 2004-07-27 |
| AR035973A1 (es) | 2004-07-28 |
| SE0101765D0 (sv) | 2001-05-18 |
| ATE303379T1 (de) | 2005-09-15 |
| IS7026A (is) | 2003-11-11 |
| IL158704A0 (en) | 2004-05-12 |
| EE200300540A (et) | 2004-02-16 |
| CO5611136A2 (es) | 2006-02-28 |
| HUP0401096A2 (hu) | 2004-09-28 |
| DE60205894T2 (de) | 2006-06-08 |
| EP1395576A1 (en) | 2004-03-10 |
| CA2446332A1 (en) | 2002-11-28 |
| CZ20033085A3 (cs) | 2004-05-12 |
| PL366640A1 (en) | 2005-02-07 |
| DE60205894D1 (de) | 2005-10-06 |
| NO20035116D0 (no) | 2003-11-17 |
| ZA200308633B (en) | 2005-02-07 |
| JP2005510457A (ja) | 2005-04-21 |
| WO2002094812A1 (en) | 2002-11-28 |
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