JP2005508293A5 - - Google Patents
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- Publication number
- JP2005508293A5 JP2005508293A5 JP2002591467A JP2002591467A JP2005508293A5 JP 2005508293 A5 JP2005508293 A5 JP 2005508293A5 JP 2002591467 A JP2002591467 A JP 2002591467A JP 2002591467 A JP2002591467 A JP 2002591467A JP 2005508293 A5 JP2005508293 A5 JP 2005508293A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- methyl
- phenyl
- benzamide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 19
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 claims 12
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims 9
- 229910052739 hydrogen Inorganic materials 0.000 claims 7
- 239000001257 hydrogen Substances 0.000 claims 7
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims 6
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 6
- -1 4-fluoro-3-hydroxy-phenyl Chemical group 0.000 claims 4
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 4
- 125000001153 fluoro group Chemical group F* 0.000 claims 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 4
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 claims 3
- 125000002541 furyl group Chemical group 0.000 claims 3
- 125000001072 heteroaryl group Chemical group 0.000 claims 3
- 125000002883 imidazolyl group Chemical group 0.000 claims 3
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 125000006239 protecting group Chemical group 0.000 claims 3
- 125000000168 pyrrolyl group Chemical group 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 125000001544 thienyl group Chemical group 0.000 claims 3
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 claims 2
- 125000001246 bromo group Chemical group Br* 0.000 claims 2
- 125000001309 chloro group Chemical group Cl* 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 125000002346 iodo group Chemical group I* 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 2
- CWXPZXBSDSIRCS-UHFFFAOYSA-N tert-butyl piperazine-1-carboxylate Chemical compound CC(C)(C)OC(=O)N1CCNCC1 CWXPZXBSDSIRCS-UHFFFAOYSA-N 0.000 claims 2
- HTLHMIALIFKABS-UHFFFAOYSA-N 4-[(3-aminophenyl)-(4-benzylpiperazin-1-yl)methyl]-n,n-di(propan-2-yl)benzamide Chemical compound C1=CC(C(=O)N(C(C)C)C(C)C)=CC=C1C(C=1C=C(N)C=CC=1)N1CCN(CC=2C=CC=CC=2)CC1 HTLHMIALIFKABS-UHFFFAOYSA-N 0.000 claims 1
- AQJCXKVOPRUSOL-UHFFFAOYSA-N 4-[(3-aminophenyl)-(4-benzylpiperazin-1-yl)methyl]-n,n-diethylbenzamide Chemical compound C1=CC(C(=O)N(CC)CC)=CC=C1C(C=1C=C(N)C=CC=1)N1CCN(CC=2C=CC=CC=2)CC1 AQJCXKVOPRUSOL-UHFFFAOYSA-N 0.000 claims 1
- QZZACLAJJQPESF-UHFFFAOYSA-N 4-[(3-aminophenyl)-[4-(1h-imidazol-2-ylmethyl)piperazin-1-yl]methyl]-n,n-di(propan-2-yl)benzamide Chemical compound C1=CC(C(=O)N(C(C)C)C(C)C)=CC=C1C(C=1C=C(N)C=CC=1)N1CCN(CC=2NC=CN=2)CC1 QZZACLAJJQPESF-UHFFFAOYSA-N 0.000 claims 1
- NZXYDHJFJFWXKL-UHFFFAOYSA-N 4-[(3-aminophenyl)-[4-(thiophen-3-ylmethyl)piperazin-1-yl]methyl]-n,n-di(propan-2-yl)benzamide Chemical compound C1=CC(C(=O)N(C(C)C)C(C)C)=CC=C1C(C=1C=C(N)C=CC=1)N1CCN(CC2=CSC=C2)CC1 NZXYDHJFJFWXKL-UHFFFAOYSA-N 0.000 claims 1
- BHPNFYBHNQPYEY-UHFFFAOYSA-N 4-[(3-aminophenyl)-[4-(thiophen-3-ylmethyl)piperazin-1-yl]methyl]-n,n-diethylbenzamide Chemical compound C1=CC(C(=O)N(CC)CC)=CC=C1C(C=1C=C(N)C=CC=1)N1CCN(CC2=CSC=C2)CC1 BHPNFYBHNQPYEY-UHFFFAOYSA-N 0.000 claims 1
- MNUZJZQILRFDRM-UHFFFAOYSA-N 4-[(4-benzylpiperazin-1-yl)-(4-fluoro-3-hydroxyphenyl)methyl]-n,n-di(propan-2-yl)benzamide Chemical compound C1=CC(C(=O)N(C(C)C)C(C)C)=CC=C1C(C=1C=C(O)C(F)=CC=1)N1CCN(CC=2C=CC=CC=2)CC1 MNUZJZQILRFDRM-UHFFFAOYSA-N 0.000 claims 1
- DCZPTCGNXVKMTI-UHFFFAOYSA-N 4-[(4-fluoro-3-hydroxyphenyl)-[4-(thiophen-3-ylmethyl)piperazin-1-yl]methyl]-n,n-di(propan-2-yl)benzamide Chemical compound C1=CC(C(=O)N(C(C)C)C(C)C)=CC=C1C(C=1C=C(O)C(F)=CC=1)N1CCN(CC2=CSC=C2)CC1 DCZPTCGNXVKMTI-UHFFFAOYSA-N 0.000 claims 1
- AKCMIUUHQWRJRW-UHFFFAOYSA-N 4-[[3-(methanesulfonamido)phenyl]-[4-(thiophen-3-ylmethyl)piperazin-1-yl]methyl]-n,n-di(propan-2-yl)benzamide Chemical compound C1=CC(C(=O)N(C(C)C)C(C)C)=CC=C1C(C=1C=C(NS(C)(=O)=O)C=CC=1)N1CCN(CC2=CSC=C2)CC1 AKCMIUUHQWRJRW-UHFFFAOYSA-N 0.000 claims 1
- 208000019901 Anxiety disease Diseases 0.000 claims 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims 1
- LCGLNKUTAGEVQW-UHFFFAOYSA-N Dimethyl ether Chemical compound COC LCGLNKUTAGEVQW-UHFFFAOYSA-N 0.000 claims 1
- 208000018522 Gastrointestinal disease Diseases 0.000 claims 1
- 208000027520 Somatoform disease Diseases 0.000 claims 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 230000036506 anxiety Effects 0.000 claims 1
- 239000003054 catalyst Substances 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 238000003776 cleavage reaction Methods 0.000 claims 1
- 150000003840 hydrochlorides Chemical class 0.000 claims 1
- 150000002431 hydrogen Chemical class 0.000 claims 1
- 238000007327 hydrogenolysis reaction Methods 0.000 claims 1
- 125000004170 methylsulfonyl group Chemical group [H]C([H])([H])S(*)(=O)=O 0.000 claims 1
- 208000027753 pain disease Diseases 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 230000007017 scission Effects 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 229940095064 tartrate Drugs 0.000 claims 1
- 125000000335 thiazolyl group Chemical group 0.000 claims 1
- 125000001425 triazolyl group Chemical group 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0101772A SE0101772D0 (sv) | 2001-05-18 | 2001-05-18 | Novel compounds |
| SE0103820A SE0103820D0 (sv) | 2001-11-15 | 2001-11-15 | Novel compounds |
| PCT/SE2002/000956 WO2002094794A1 (en) | 2001-05-18 | 2002-05-16 | 4 (phenyl-piperazinyl-methyl) benzamide derivatives and their use for the treatment of pain anxiety or gastrointestinal disorders |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010002450A Division JP5028500B2 (ja) | 2001-05-18 | 2010-01-08 | ４（フェニル−ピペラジニル−メチル）ベンズアミド誘導体及び疼痛、不安症又は胃腸障害の治療のためのその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005508293A JP2005508293A (ja) | 2005-03-31 |
| JP2005508293A5 true JP2005508293A5 (enExample) | 2005-12-22 |
| JP4549024B2 JP4549024B2 (ja) | 2010-09-22 |
Family
ID=26655470
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002591467A Expired - Fee Related JP4549024B2 (ja) | 2001-05-18 | 2002-05-16 | ４（フェニル−ピペラジニル−メチル）ベンズアミド誘導体及び疼痛、不安症又は胃腸障害の治療のためのその使用 |
| JP2010002450A Expired - Fee Related JP5028500B2 (ja) | 2001-05-18 | 2010-01-08 | ４（フェニル−ピペラジニル−メチル）ベンズアミド誘導体及び疼痛、不安症又は胃腸障害の治療のためのその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010002450A Expired - Fee Related JP5028500B2 (ja) | 2001-05-18 | 2010-01-08 | ４（フェニル−ピペラジニル−メチル）ベンズアミド誘導体及び疼痛、不安症又は胃腸障害の治療のためのその使用 |
Country Status (31)
| Country | Link |
|---|---|
| US (3) | US7229994B2 (enExample) |
| EP (2) | EP1395567B1 (enExample) |
| JP (2) | JP4549024B2 (enExample) |
| KR (2) | KR100885100B1 (enExample) |
| CN (1) | CN1269805C (enExample) |
| AR (1) | AR035974A1 (enExample) |
| AT (1) | ATE420866T1 (enExample) |
| AU (1) | AU2002305994B2 (enExample) |
| BG (1) | BG108333A (enExample) |
| BR (1) | BR0209678A (enExample) |
| CA (1) | CA2446326C (enExample) |
| CO (1) | CO5540309A2 (enExample) |
| CY (1) | CY1108913T1 (enExample) |
| CZ (1) | CZ20033092A3 (enExample) |
| DE (1) | DE60230869D1 (enExample) |
| DK (1) | DK1395567T3 (enExample) |
| EE (1) | EE05243B1 (enExample) |
| ES (1) | ES2319876T3 (enExample) |
| HU (1) | HUP0401086A3 (enExample) |
| IL (2) | IL158631A0 (enExample) |
| IS (1) | IS2625B (enExample) |
| MX (1) | MXPA03010445A (enExample) |
| MY (1) | MY140070A (enExample) |
| NO (1) | NO326632B1 (enExample) |
| NZ (2) | NZ539828A (enExample) |
| PL (1) | PL367142A1 (enExample) |
| PT (1) | PT1395567E (enExample) |
| RU (1) | RU2297412C2 (enExample) |
| SI (1) | SI1395567T1 (enExample) |
| SK (1) | SK287555B6 (enExample) |
| WO (1) | WO2002094794A1 (enExample) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ539828A (en) | 2001-05-18 | 2007-01-26 | Astrazeneca Ab | 4 (phenyl-piperazinyl-methyl) benzamide derivatives and their use for the treatment of pain, anxiety or gastrointestinal disorders |
| JP4892654B2 (ja) | 2001-10-29 | 2012-03-07 | マウント クック ファーマ，インコーポレーテッド | デルタレセプターアゴニスト化合物によるうつ病の治療方法 |
| SE0203300D0 (sv) | 2002-11-07 | 2002-11-07 | Astrazeneca Ab | Novel Compounds |
| SE0203302D0 (sv) * | 2002-11-07 | 2002-11-07 | Astrazeneca Ab | Novel Compounds |
| SE0203303D0 (sv) * | 2002-11-07 | 2002-11-07 | Astrazeneca Ab | Novel Compounds |
| KR20140015122A (ko) | 2003-10-01 | 2014-02-06 | 아돌로 코포레이션 | 스피로시클릭 헤테로시클릭 유도체 및 이의 사용 방법 |
| KR101234421B1 (ko) * | 2004-08-02 | 2013-02-18 | 아스트라제네카 아베 | 디아릴메틸 피페라진 유도체, 이의 제조 방법 및 용도 |
| SE0401968D0 (sv) * | 2004-08-02 | 2004-08-02 | Astrazeneca Ab | Diarylmethyl piperazine derivatives, preparations thereof and uses thereof |
| CN101128447A (zh) * | 2005-02-28 | 2008-02-20 | 阿斯利康(瑞典)有限公司 | 二芳基甲基哌嗪衍生物，其制备及其用途 |
| US7598261B2 (en) | 2005-03-31 | 2009-10-06 | Adolor Corporation | Spirocyclic heterocyclic derivatives and methods of their use |
| TWI410406B (zh) | 2005-05-13 | 2013-10-01 | Otsuka Pharma Co Ltd | 吡咯烷化合物 |
| WO2007018459A1 (en) * | 2005-08-08 | 2007-02-15 | Astrazeneca Ab | Therapeutic agents |
| US7576207B2 (en) | 2006-04-06 | 2009-08-18 | Adolor Corporation | Spirocyclic heterocyclic derivatives and methods of their use |
| US20100029681A1 (en) * | 2006-05-26 | 2010-02-04 | Hassan Pajouhesh | Heterocyclic compounds as calcium channel blockers |
| WO2008033299A2 (en) | 2006-09-12 | 2008-03-20 | Adolor Corporation | Use of n-containing spirocompounds for the enhancement of cognitive function |
| EA201001644A1 (ru) * | 2008-05-20 | 2011-06-30 | Астразенека Аб | Способ лечения тревожного большого депрессивного расстройства |
| CA2728675A1 (en) | 2008-06-20 | 2009-12-23 | Astrazeneca Ab | Dibenzothiazepine derivatives and use thereof |
| GB201111704D0 (en) | 2011-07-07 | 2011-08-24 | Takeda Pharmaceutical | Novel compounds |
| GB201111705D0 (en) | 2011-07-07 | 2011-08-24 | Takeda Pharmaceutical | Compounds and their use |
| JO3115B1 (ar) | 2011-08-22 | 2017-09-20 | Takeda Pharmaceuticals Co | مركبات بيريدازينون واستخدامها كمثبطات daao |
| GB201209587D0 (en) | 2012-05-30 | 2012-07-11 | Takeda Pharmaceutical | Therapeutic compounds |
| JP6401254B2 (ja) | 2013-06-21 | 2018-10-10 | 武田薬品工業株式会社 | プロキネシチン受容体のモジュレータとしての１−スルホニルピペリジン誘導体 |
| GB201314286D0 (en) | 2013-08-08 | 2013-09-25 | Takeda Pharmaceutical | Therapeutic Compounds |
| GB201318222D0 (en) | 2013-10-15 | 2013-11-27 | Takeda Pharmaceutical | Novel compounds |
| GB201320905D0 (en) | 2013-11-27 | 2014-01-08 | Takeda Pharmaceutical | Therapeutic compounds |
| TW201613864A (en) | 2014-02-20 | 2016-04-16 | Takeda Pharmaceutical | Novel compounds |
| CN104163788A (zh) * | 2014-07-07 | 2014-11-26 | 湖南华腾制药有限公司 | 一种吡啶衍生物的制备方法 |
| GB201616839D0 (en) | 2016-10-04 | 2016-11-16 | Takeda Pharmaceutical Company Limited | Therapeutic compounds |
| GB201619514D0 (en) | 2016-11-18 | 2017-01-04 | Takeda Pharmaceuticals Co | Novel compounds |
| JP2021138648A (ja) | 2020-03-04 | 2021-09-16 | 武田薬品工業株式会社 | 経口固形製剤 |
| CN113350348B (zh) * | 2020-11-05 | 2022-03-01 | 东南大学 | 一种1-二苯甲基-4-甲基哌嗪类化合物在制备保护肠道屏障完整性药物中的应用 |
| GB202414197D0 (en) | 2024-09-27 | 2024-11-13 | Addex Pharmaceuticals Sa | Novel compounds |
| GB202414193D0 (en) | 2024-09-27 | 2024-11-13 | Addex Pharmaceuticals Sa | Novel compounds |
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| IT1140978B (it) | 1980-05-23 | 1986-10-10 | Selvi & C Spa | 1-(4-clorobenzidril)-4-(2,3-diidros sipropil)-piperazina, metodi per la sua preparazione e relative composizione farmaceutiche |
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| FR2696744B1 (fr) | 1992-10-12 | 1994-12-30 | Logeais Labor Jacques | Dérivés de 2-pyrrolidone, leur procédé de préparation et leurs applications en thérapeutique. |
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| SE9904675D0 (sv) | 1999-12-20 | 1999-12-20 | Astra Pharma Inc | Novel compounds |
| SE9904673D0 (sv) | 1999-12-20 | 1999-12-20 | Astra Pharma Inc | Novel compounds |
| SE9904674D0 (sv) | 1999-12-20 | 1999-12-20 | Astra Pharma Inc | Novel compounds |
| SE0001209D0 (sv) * | 2000-04-04 | 2000-04-04 | Astrazeneca Canada Inc | Novel compounds |
| NZ539828A (en) | 2001-05-18 | 2007-01-26 | Astrazeneca Ab | 4 (phenyl-piperazinyl-methyl) benzamide derivatives and their use for the treatment of pain, anxiety or gastrointestinal disorders |
| SE0101765D0 (sv) | 2001-05-18 | 2001-05-18 | Astrazeneca Ab | Novel compounds |
| SE0101766D0 (sv) | 2001-05-18 | 2001-05-18 | Astrazeneca Ab | Novel compounds |
| SE0103313D0 (sv) | 2001-10-03 | 2001-10-03 | Astrazeneca Ab | Novel compounds |
| JP4892654B2 (ja) * | 2001-10-29 | 2012-03-07 | マウント クック ファーマ，インコーポレーテッド | デルタレセプターアゴニスト化合物によるうつ病の治療方法 |
| US8476280B2 (en) | 2002-05-09 | 2013-07-02 | Versi Group, Llc | Compositions and methods for combating lower urinary tract dysfunctions with delta opioid receptor agonists |
| SE0203302D0 (sv) | 2002-11-07 | 2002-11-07 | Astrazeneca Ab | Novel Compounds |
| SE0203303D0 (sv) | 2002-11-07 | 2002-11-07 | Astrazeneca Ab | Novel Compounds |
| SE0203300D0 (sv) | 2002-11-07 | 2002-11-07 | Astrazeneca Ab | Novel Compounds |
| SE0300105D0 (sv) | 2003-01-16 | 2003-01-16 | Astrazeneca Ab | Diarylmethylidene piperdine derivatives, preparations thereof and uses thereof |
| SE0400027D0 (sv) | 2004-01-09 | 2004-01-09 | Astrazeneca Ab | Diarylmethyl piperazine derivatives, preparations thereof and uses thereof |
| KR101234421B1 (ko) | 2004-08-02 | 2013-02-18 | 아스트라제네카 아베 | 디아릴메틸 피페라진 유도체, 이의 제조 방법 및 용도 |
| SE0401968D0 (sv) | 2004-08-02 | 2004-08-02 | Astrazeneca Ab | Diarylmethyl piperazine derivatives, preparations thereof and uses thereof |
| CN101128447A (zh) | 2005-02-28 | 2008-02-20 | 阿斯利康(瑞典)有限公司 | 二芳基甲基哌嗪衍生物，其制备及其用途 |
| EA201001644A1 (ru) | 2008-05-20 | 2011-06-30 | Астразенека Аб | Способ лечения тревожного большого депрессивного расстройства |
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