RU2003101393A - Фармацевтические композиции для лечения воспаления слизистой оболочки, стоматита и синдрома бехчета - Google Patents
Фармацевтические композиции для лечения воспаления слизистой оболочки, стоматита и синдрома бехчетаInfo
- Publication number
- RU2003101393A RU2003101393A RU2003101393/15A RU2003101393A RU2003101393A RU 2003101393 A RU2003101393 A RU 2003101393A RU 2003101393/15 A RU2003101393/15 A RU 2003101393/15A RU 2003101393 A RU2003101393 A RU 2003101393A RU 2003101393 A RU2003101393 A RU 2003101393A
- Authority
- RU
- Russia
- Prior art keywords
- agents
- mucous membrane
- composition according
- stomatitis
- inflammation
- Prior art date
Links
- 210000004400 Mucous Membrane Anatomy 0.000 title claims 3
- 206010061218 Inflammation Diseases 0.000 title claims 2
- 208000003265 Stomatitis Diseases 0.000 title claims 2
- 230000004054 inflammatory process Effects 0.000 title claims 2
- 239000008194 pharmaceutical composition Substances 0.000 title claims 2
- 206010002556 Ankylosing spondylitis Diseases 0.000 title 1
- 239000000203 mixture Substances 0.000 claims 5
- MPDGHEJMBKOTSU-YKLVYJNSSA-N 18β-glycyrrhetic acid Chemical compound C([C@H]1C2=CC(=O)[C@H]34)[C@@](C)(C(O)=O)CC[C@]1(C)CC[C@@]2(C)[C@]4(C)CC[C@@H]1[C@]3(C)CC[C@H](O)C1(C)C MPDGHEJMBKOTSU-YKLVYJNSSA-N 0.000 claims 4
- 229940073144 Glycyrrhetinic acid Drugs 0.000 claims 2
- 239000004480 active ingredient Substances 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- KCXVZYZYPLLWCC-UHFFFAOYSA-N edta Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims 2
- 229960003720 enoxolone Drugs 0.000 claims 2
- 239000000796 flavoring agent Substances 0.000 claims 2
- 235000013355 food flavoring agent Nutrition 0.000 claims 2
- 229920002674 hyaluronan Polymers 0.000 claims 2
- 229960003160 hyaluronic acid Drugs 0.000 claims 2
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 2
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 2
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 2
- MAKUBRYLFHZREJ-JWBQXVCJSA-M sodium;(2S,3S,4R,5R,6R)-3-[(2S,3R,5S,6R)-3-acetamido-5-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4,5,6-trihydroxyoxane-2-carboxylate Chemical compound [Na+].CC(=O)N[C@@H]1C[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](C([O-])=O)O[C@@H](O)[C@H](O)[C@H]1O MAKUBRYLFHZREJ-JWBQXVCJSA-M 0.000 claims 2
- 229940116904 ANTIINFLAMMATORY THERAPEUTIC RADIOPHARMACEUTICALS Drugs 0.000 claims 1
- IAOZJIPTCAWIRG-QWRGUYRKSA-N Aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 claims 1
- 229960003438 Aspartame Drugs 0.000 claims 1
- 108010011485 Aspartame Proteins 0.000 claims 1
- 208000009137 Behcet Syndrome Diseases 0.000 claims 1
- 201000008335 Behcet's disease Diseases 0.000 claims 1
- 239000004375 Dextrin Substances 0.000 claims 1
- 229920001353 Dextrin Polymers 0.000 claims 1
- 210000003238 Esophagus Anatomy 0.000 claims 1
- 210000002200 Mouth Mucosa Anatomy 0.000 claims 1
- 229940074726 OPHTHALMOLOGIC ANTIINFLAMMATORY AGENTS Drugs 0.000 claims 1
- 210000003300 Oropharynx Anatomy 0.000 claims 1
- 229940069338 Potassium Sorbate Drugs 0.000 claims 1
- CHHHXKFHOYLYRE-STWYSWDKSA-M Potassium sorbate Chemical compound [K+].C\C=C\C=C\C([O-])=O CHHHXKFHOYLYRE-STWYSWDKSA-M 0.000 claims 1
- 210000000664 Rectum Anatomy 0.000 claims 1
- CVHZOJJKTDOEJC-UHFFFAOYSA-N Saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 claims 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M Sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 claims 1
- 239000004283 Sodium sorbate Substances 0.000 claims 1
- 210000001215 Vagina Anatomy 0.000 claims 1
- 206010056651 Vestibulitis Diseases 0.000 claims 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 230000000240 adjuvant Effects 0.000 claims 1
- 239000003242 anti bacterial agent Substances 0.000 claims 1
- 239000002260 anti-inflammatory agent Substances 0.000 claims 1
- 239000003429 antifungal agent Substances 0.000 claims 1
- 239000000605 aspartame Substances 0.000 claims 1
- 235000010357 aspartame Nutrition 0.000 claims 1
- 239000000227 bioadhesive Substances 0.000 claims 1
- 239000004359 castor oil Substances 0.000 claims 1
- 235000019438 castor oil Nutrition 0.000 claims 1
- 239000001913 cellulose Substances 0.000 claims 1
- 229920002678 cellulose Polymers 0.000 claims 1
- 229920001577 copolymer Polymers 0.000 claims 1
- 239000006184 cosolvent Substances 0.000 claims 1
- 239000000645 desinfectant Substances 0.000 claims 1
- 230000000249 desinfective Effects 0.000 claims 1
- 235000019425 dextrin Nutrition 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drugs Drugs 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 239000003974 emollient agent Substances 0.000 claims 1
- 235000003599 food sweetener Nutrition 0.000 claims 1
- LYCAIKOWRPUZTN-UHFFFAOYSA-N glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 1
- 230000004968 inflammatory condition Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000005395 methacrylic acid group Chemical class 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 235000010241 potassium sorbate Nutrition 0.000 claims 1
- 239000004302 potassium sorbate Substances 0.000 claims 1
- 230000002335 preservative Effects 0.000 claims 1
- 239000003755 preservative agent Substances 0.000 claims 1
- DNIAPMSPPWPWGF-UHFFFAOYSA-N propylene glycol Chemical class CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims 1
- 235000013772 propylene glycol Nutrition 0.000 claims 1
- 235000010234 sodium benzoate Nutrition 0.000 claims 1
- 239000004299 sodium benzoate Substances 0.000 claims 1
- 235000019250 sodium sorbate Nutrition 0.000 claims 1
- 239000003381 stabilizer Substances 0.000 claims 1
- 239000004094 surface-active agent Substances 0.000 claims 1
- 239000003765 sweetening agent Substances 0.000 claims 1
- 230000000699 topical Effects 0.000 claims 1
Claims (6)
1. Фармацевтические композиции, содержащие в качестве активных ингредиентов эффективные дозы гиалуроновой кислоты, глицирретиновой кислоты и поливинилпирролидона в смеси с эксципиентами и адъювантами, подходящими для местного введения.
2. Композиции по п.1, дополнительно содержащие агенты, увеличивающие вязкость, поверхностно-активные вещества, стабилизирующие агенты - консерванты, корригенты, ароматизирующие вещества, подсластители, биоадгезивные агенты, сорастворители.
3. Композиции по п.2, дополнительно содержащие производные целлюлозы, полимеры или сополимеры акриловой или метакриловой кислот, этилен- или пропиленгликоли, полиэтоксилированное гидрогенизированное касторовое масло, этилендиаминтетрауксусную кислоту (ЭДТА), бензоат натрия, сорбат натрия или калия, декстрины, сахарин натрия, аспартам.
4. Композиции по любому из пп.1-3, дополнительно содержащие другие активные ингредиенты, обладающие дополнительной или любой другой полезной активностью.
5. Композиции по п.4, содержащие антибактериальные агенты/дезинфицирующие средства, противогрибковые агенты, обезболивающие средства, противовоспалительные агенты, смягчающие вещества, местные обезболивающие средства.
6. Применение гиалуроновой кислоты, глицирретиновой кислоты и поливинилпирролидона для изготовления лекарств для местного лечения воспалительных состояний слизистой оболочки полости рта и выстилки ротоглотки и пищевода, в частности, воспаления слизистой оболочки и стоматита, а также слизистой оболочки влагалища и прямой кишки (включающих в себя, но не ограничиваясь ими, вестибулит и синдром Бехчета).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2000MI001732A IT1318649B1 (it) | 2000-07-28 | 2000-07-28 | Composizioni farmaceutiche per il trattamento di mucositi e stomatiti. |
| ITMI2000A001732 | 2000-07-28 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2003101393A true RU2003101393A (ru) | 2004-06-27 |
| RU2272636C2 RU2272636C2 (ru) | 2006-03-27 |
Family
ID=11445589
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2003101393/15A RU2272636C2 (ru) | 2000-07-28 | 2001-07-18 | Фармацевтическая композиция для местного лечения воспаления и способ ее изготовления |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US20020173485A1 (ru) |
| EP (1) | EP1313489B1 (ru) |
| JP (1) | JP2004505028A (ru) |
| KR (1) | KR100761051B1 (ru) |
| CN (1) | CN1198625C (ru) |
| AR (1) | AR030068A1 (ru) |
| AT (1) | ATE289512T1 (ru) |
| AU (2) | AU2002212113B2 (ru) |
| BR (1) | BRPI0112962B8 (ru) |
| CA (1) | CA2424346C (ru) |
| CZ (1) | CZ301461B6 (ru) |
| DE (1) | DE60109044T2 (ru) |
| ES (1) | ES2236324T3 (ru) |
| HK (1) | HK1059215A1 (ru) |
| HR (1) | HRP20030046B1 (ru) |
| IT (1) | IT1318649B1 (ru) |
| MX (1) | MXPA03000712A (ru) |
| MY (1) | MY130477A (ru) |
| NO (1) | NO329574B1 (ru) |
| NZ (1) | NZ523832A (ru) |
| PL (1) | PL204397B1 (ru) |
| PT (1) | PT1313489E (ru) |
| RU (1) | RU2272636C2 (ru) |
| UA (1) | UA79075C2 (ru) |
| WO (1) | WO2002009637A2 (ru) |
| ZA (1) | ZA200300712B (ru) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7544348B2 (en) | 2001-02-15 | 2009-06-09 | Access Pharmaceuticals, Inc. | Liquid formulations for the prevention and treatment of mucosal diseases and disorders |
| NZ549469A (en) | 2001-02-15 | 2009-02-28 | Access Pharma Inc | Liquid formulations for the prevention and treatment of mucosal diseases and disorders |
| US6585997B2 (en) | 2001-08-16 | 2003-07-01 | Access Pharmaceuticals, Inc. | Mucoadhesive erodible drug delivery device for controlled administration of pharmaceuticals and other active compounds |
| RU2308954C2 (ru) | 2002-05-09 | 2007-10-27 | Медиджинез | Фармацевтическая композиция для лечения ран, содержащая плазму или сыворотку крови |
| US20060234977A1 (en) * | 2003-01-23 | 2006-10-19 | Gina Wenham | Antiviral compostion comprising a sulphated glucose polymer and a bacteriostatic agent |
| GB0312485D0 (en) * | 2003-05-30 | 2003-07-09 | Dodson & Horrell | Horse food composition |
| ITMI20031291A1 (it) | 2003-06-25 | 2004-12-26 | Ricerfarma Srl | Uso di acido ialuronico per la preparazione di composizioni per il trattamento di afte del cavo orale. |
| AU2003265624B2 (en) * | 2003-08-21 | 2011-03-31 | Abeona Therapeutics Inc. | Liquid formulations for the prevention and treatment of mucosal diseases and disorders |
| US8497258B2 (en) | 2005-11-12 | 2013-07-30 | The Regents Of The University Of California | Viscous budesonide for the treatment of inflammatory diseases of the gastrointestinal tract |
| EP2489338B1 (en) * | 2006-08-28 | 2014-05-14 | Rexaderm, INC. | Dry wound dressing and drug delivery system |
| KR100758636B1 (ko) * | 2006-12-19 | 2007-09-13 | 고려대학교 산학협력단 | 생체 점막 점착성 고분자 접합체 및 이의 제조방법 |
| US20090143343A1 (en) | 2007-11-13 | 2009-06-04 | Meritage Pharma, Inc. | Compositions for the treatment of inflammation of the gastrointestinal tract |
| SI3354276T1 (sl) | 2007-11-13 | 2020-09-30 | Meritage Pharma, Inc. | Sestavki za zdravljenje gastrointestinalnega vnetja |
| US20090264392A1 (en) * | 2008-04-21 | 2009-10-22 | Meritage Pharma, Inc. | Treating eosinophilic esophagitis |
| GB0813589D0 (en) * | 2008-07-24 | 2008-09-03 | Sinclair Pharmaceuticals Ltd | Composition |
| PT2435021E (pt) * | 2009-05-25 | 2013-09-30 | Sofar Swiss Sa | Utilização de uma combinação fixa de glicosaminoglicano e composição mastigável compreendendo a referida combinação fixa |
| JP6306349B2 (ja) | 2010-04-14 | 2018-04-04 | アルトリア クライアント サービシーズ リミテッド ライアビリティ カンパニー | 予成形無煙タバコ製品 |
| CA2815639C (en) * | 2010-11-12 | 2016-11-08 | Colgate-Palmolive Company | Dual phase mouthwase |
| ES2388281B1 (es) | 2010-12-27 | 2013-10-01 | Laboratorios Viñas S.A. | Composición farmacéutica que comprende ácido hialurónico y un compuesto de zinc y pastilla con palito y procedimiento para preparación correspondientes |
| ITMI20110954A1 (it) * | 2011-05-26 | 2012-11-27 | Professional Dietetics Srl | Combinazioni per il trattamento delle mucositi vaginali o rettali |
| US10799548B2 (en) * | 2013-03-15 | 2020-10-13 | Altria Client Services Llc | Modifying taste and sensory irritation of smokeless tobacco and non-tobacco products |
| CA2964064C (en) | 2013-10-16 | 2022-07-05 | Orahealth Corporation | Treating mucosal lesions with hyaluronan delivered from an adhering troche |
| CN105342987A (zh) * | 2015-12-04 | 2016-02-24 | 亚飞（上海）生物医药科技有限公司 | 一种凝胶及其制备方法和应用 |
| ITUA20161822A1 (it) * | 2016-03-18 | 2017-09-18 | Indena Spa | Composizioni utili nella prevenzione e/o nel trattamento di patologie del cavo orale, delle prime vie aeree e dell’esofago |
| US10842741B2 (en) * | 2016-07-27 | 2020-11-24 | Ritapharma, Co., Ltd. | Oral mucosa application material and method for producing same therefor |
| IT201600079773A1 (it) * | 2016-07-29 | 2018-01-29 | Matteo Bevilacqua | Composizioni contenenti oligosaccaridi di acido ialuronico (HA4), condroitin solfato (CS2-4) ed eparan solfato (HS2-4), triterpeni pentaciclici e derivati per uso medico curativo e metodo per la preparazione di tali composizioni. |
| CN106176863A (zh) * | 2016-08-04 | 2016-12-07 | 陈广圣 | 一种医用抗菌剂 |
| CN107802641A (zh) * | 2016-09-09 | 2018-03-16 | 李明典 | 口腔软组织(牙龈、粘膜)抗发炎酸痛剂 |
| EP3459368A1 (en) * | 2017-09-20 | 2019-03-27 | Geophyt S.r.L. | Food integrator for antineoplastic therapies |
| CN109331023A (zh) * | 2018-11-12 | 2019-02-15 | 沈阳药科大学 | 甘草次酸的医药用途 |
| KR102475125B1 (ko) | 2019-08-07 | 2022-12-07 | 고려대학교 산학협력단 | 일산화질소 복합체를 포함하는 구강 점막염 치료용 조성물 및 구강 점막염 치료제 |
| AU2020372237A1 (en) * | 2019-10-25 | 2022-05-19 | Mucocort Ab | Treatment of inflammatory condition in mucous membrane or skin |
| IT202100011879A1 (it) * | 2021-05-10 | 2022-11-10 | Aurora Biofarma S R L | Composizione orale per il trattamento delle esofagiti |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2092442B (en) * | 1981-02-06 | 1984-02-08 | Biorex Laboratories Ltd | Pharmaceutical composition for treating diseases of the oral cavity containing glycyrrhetinic acid or a derivative thereof |
| ZA82361B (en) * | 1981-02-06 | 1982-12-29 | Biorex Laboratories Ltd | Pharmaceutical composition for treating diseases of the oral cavity |
| JPS6117510A (ja) * | 1984-07-03 | 1986-01-25 | Toyobo Co Ltd | 口腔粘膜適用徐放性ニフエジピン製剤 |
| JPS6440423A (en) * | 1987-08-05 | 1989-02-10 | Kyukyu Yakuhin Kogyo Kk | Patch for mucosa in oral cavity |
| US4965253A (en) * | 1987-10-14 | 1990-10-23 | University Of Florida | Viscoelastic material for ophthalmic surgery |
| IT1240316B (it) * | 1990-02-21 | 1993-12-07 | Ricerca Di Schiena Del Dr. Michele G. Di Schiema & C. | Composizioni a base di acido ialuronico ad alto peso molecolare somministrabili per via topica per il trattamento di infiammazioni del cavo orale ,per la cosmetica e l'igiene del cavo orale |
| JPH09169652A (ja) * | 1995-12-18 | 1997-06-30 | Lion Corp | 水性液状組成物 |
| JPH10182390A (ja) * | 1996-12-25 | 1998-07-07 | Lion Corp | 口腔用組成物 |
| JP2000178185A (ja) * | 1998-12-18 | 2000-06-27 | Lion Corp | 口腔粘膜付着型徐放性錠剤 |
-
2000
- 2000-07-28 IT IT2000MI001732A patent/IT1318649B1/it active
-
2001
- 2001-07-18 AT AT01980213T patent/ATE289512T1/de active
- 2001-07-18 BR BRPI0112962A patent/BRPI0112962B8/pt not_active IP Right Cessation
- 2001-07-18 DE DE60109044T patent/DE60109044T2/de not_active Expired - Lifetime
- 2001-07-18 JP JP2002515192A patent/JP2004505028A/ja active Pending
- 2001-07-18 PL PL362921A patent/PL204397B1/pl unknown
- 2001-07-18 WO PCT/EP2001/008303 patent/WO2002009637A2/en active IP Right Grant
- 2001-07-18 ES ES01980213T patent/ES2236324T3/es not_active Expired - Lifetime
- 2001-07-18 AU AU2002212113A patent/AU2002212113B2/en not_active Expired
- 2001-07-18 PT PT01980213T patent/PT1313489E/pt unknown
- 2001-07-18 AU AU1211302A patent/AU1211302A/xx active Pending
- 2001-07-18 CZ CZ20030262A patent/CZ301461B6/cs not_active IP Right Cessation
- 2001-07-18 EP EP01980213A patent/EP1313489B1/en not_active Expired - Lifetime
- 2001-07-18 CN CNB018134386A patent/CN1198625C/zh not_active Expired - Lifetime
- 2001-07-18 UA UA2003010420A patent/UA79075C2/ru unknown
- 2001-07-18 MX MXPA03000712A patent/MXPA03000712A/es active IP Right Grant
- 2001-07-18 CA CA002424346A patent/CA2424346C/en not_active Expired - Lifetime
- 2001-07-18 KR KR1020037001222A patent/KR100761051B1/ko active IP Right Grant
- 2001-07-18 RU RU2003101393/15A patent/RU2272636C2/ru active
- 2001-07-18 NZ NZ523832A patent/NZ523832A/en not_active IP Right Cessation
- 2001-07-27 AR ARP010103606A patent/AR030068A1/es not_active Application Discontinuation
- 2001-10-13 MY MYPI20014770A patent/MY130477A/en unknown
-
2002
- 2002-02-21 US US10/080,624 patent/US20020173485A1/en not_active Abandoned
-
2003
- 2003-01-24 HR HR20030046A patent/HRP20030046B1/xx not_active IP Right Cessation
- 2003-01-27 ZA ZA200300712A patent/ZA200300712B/xx unknown
- 2003-01-27 NO NO20030411A patent/NO329574B1/no not_active IP Right Cessation
-
2004
- 2004-03-16 HK HK04101910A patent/HK1059215A1/xx not_active IP Right Cessation
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