RU2002112460A - Способы получения целевой молекулы в трансгенном животном и выделения целевой молекулы - Google Patents
Способы получения целевой молекулы в трансгенном животном и выделения целевой молекулыInfo
- Publication number
- RU2002112460A RU2002112460A RU2002112460/13A RU2002112460A RU2002112460A RU 2002112460 A RU2002112460 A RU 2002112460A RU 2002112460/13 A RU2002112460/13 A RU 2002112460/13A RU 2002112460 A RU2002112460 A RU 2002112460A RU 2002112460 A RU2002112460 A RU 2002112460A
- Authority
- RU
- Russia
- Prior art keywords
- binding
- polypeptide
- matrix
- transgenic
- specifically binds
- Prior art date
Links
- 230000009261 transgenic effect Effects 0.000 title claims 22
- 238000000034 method Methods 0.000 title claims 15
- 238000002955 isolation Methods 0.000 title 1
- 229920001184 polypeptide Polymers 0.000 claims 48
- 102000004196 processed proteins & peptides Human genes 0.000 claims 48
- 108090000765 processed proteins & peptides Proteins 0.000 claims 48
- 239000011159 matrix material Substances 0.000 claims 19
- 239000008267 milk Substances 0.000 claims 9
- 210000004080 milk Anatomy 0.000 claims 9
- 235000013336 milk Nutrition 0.000 claims 9
- 239000011541 reaction mixture Substances 0.000 claims 6
- 125000005647 linker group Chemical group 0.000 claims 5
- 102000039446 nucleic acids Human genes 0.000 claims 5
- 108020004707 nucleic acids Proteins 0.000 claims 5
- 150000007523 nucleic acids Chemical class 0.000 claims 5
- 210000000069 breast epithelial cell Anatomy 0.000 claims 3
- 230000003197 catalytic effect Effects 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 230000003993 interaction Effects 0.000 claims 2
- 101001065501 Escherichia phage MS2 Lysis protein Proteins 0.000 claims 1
- 210000000481 breast Anatomy 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 229920002678 cellulose Polymers 0.000 claims 1
- 239000001913 cellulose Substances 0.000 claims 1
- 210000002919 epithelial cell Anatomy 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/15—Humanized animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/01—Animal expressing industrially exogenous proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Environmental Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Plant Pathology (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Animal Behavior & Ethology (AREA)
- Animal Husbandry (AREA)
- Biodiversity & Conservation Biology (AREA)
- Medicinal Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15974899P | 1999-10-14 | 1999-10-14 | |
| US60/159,748 | 1999-10-14 | ||
| US20466200P | 2000-05-17 | 2000-05-17 | |
| US60/204,662 | 2000-05-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2002112460A true RU2002112460A (ru) | 2004-02-27 |
Family
ID=26856252
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2002112460/13A RU2002112460A (ru) | 1999-10-14 | 2000-10-16 | Способы получения целевой молекулы в трансгенном животном и выделения целевой молекулы |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP1220606A4 (fr) |
| JP (1) | JP2003511048A (fr) |
| KR (1) | KR100772465B1 (fr) |
| CN (1) | CN1322003C (fr) |
| AU (1) | AU781944B2 (fr) |
| BR (1) | BR0014860A (fr) |
| CA (1) | CA2382741A1 (fr) |
| HU (1) | HUP0203537A2 (fr) |
| IL (1) | IL149003A0 (fr) |
| MX (1) | MXPA02003702A (fr) |
| NO (1) | NO20021686L (fr) |
| NZ (1) | NZ518263A (fr) |
| RU (1) | RU2002112460A (fr) |
| WO (1) | WO2001026455A1 (fr) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030049694A1 (en) * | 2001-09-10 | 2003-03-13 | Chung-Hsiun Wu | Production of fusion proteins and use for identifying binding molecules |
| US6800462B2 (en) * | 2001-09-10 | 2004-10-05 | Abgenomics Corporation | Production of recombinant proteins in vivo and use for generating antibodies |
| CN1283785C (zh) * | 2002-05-20 | 2006-11-08 | 上海杰隆生物工程股份有限公司 | 利用转基因动物乳腺生产人促红细胞生成素的方法 |
| WO2007052096A2 (fr) * | 2005-06-29 | 2007-05-10 | Cameron Malcolm Lang Clokie | Production de proteines morphogeniques osseuses dans des mammiferes transgeniques |
| US20090187999A1 (en) * | 2007-06-13 | 2009-07-23 | Sterrenbeld Biotechnologie North America, Inc. | Process for Producing Exogenous Protein in the Milk of Transgenic Mammals and a Process For Purifying Proteins Therefrom |
| US9150880B2 (en) | 2008-09-25 | 2015-10-06 | Proteovec Holding, L.L.C. | Vectors for production of antibodies |
| US9157097B2 (en) | 2008-09-25 | 2015-10-13 | Proteovec Holding, L.L.C. | Vectors for production of growth hormone |
| WO2010118360A1 (fr) | 2009-04-09 | 2010-10-14 | The Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Production de protéines au moyen de vecteurs à base de transposon |
| WO2013096458A1 (fr) * | 2011-12-19 | 2013-06-27 | Gtc Biotherapeutics, Inc. | Alpha-1-antitrypsine humaine recombinante pour le traitement de troubles inflammatoires |
| EP3594231A1 (fr) | 2013-02-13 | 2020-01-15 | Laboratoire Français du Fractionnement et des Biotechnologies | Anticorps anti-tnf-alpha hautement galactosylatés et leurs utilisations |
| CN105263319A (zh) | 2013-02-13 | 2016-01-20 | 法国化学与生物科技实验室 | 具有经修饰的糖基化的蛋白及其生产方法 |
| US10611826B2 (en) | 2013-07-05 | 2020-04-07 | Laboratoire Français Du Fractionnement Et Des Biotechnologies | Affinity chromatography matrix |
| FR3025515B1 (fr) | 2014-09-05 | 2016-09-09 | Lab Francais Du Fractionnement | Procede de purification d'un anticorps monoclonal |
| FR3034420A1 (fr) | 2015-03-31 | 2016-10-07 | Lab Francais Du Fractionnement | Anticorps monoclonaux anti-cd303 |
| JP6712125B2 (ja) * | 2015-09-04 | 2020-06-17 | 株式会社フジクラ | 酸化物超電導線材の接続構造体およびその製造方法 |
| FR3060394B1 (fr) | 2016-12-16 | 2019-05-24 | Laboratoire Francais Du Fractionnement Et Des Biotechnologies | Combinaison d'anticorps anti-cd303 et anti-amhrii |
| FR3060395B1 (fr) | 2016-12-16 | 2019-05-24 | Laboratoire Francais Du Fractionnement Et Des Biotechnologies | Combinaison d'anticorps anti-cd303 et anti-her2 |
| FR3076294B1 (fr) | 2017-12-29 | 2022-01-28 | Lab Francais Du Fractionnement | Procede de purification d'anticorps a partir de lait brut |
| WO2023118241A1 (fr) | 2021-12-20 | 2023-06-29 | Vetoquinol Sa | Anticorps anti-récepteur a de l'interleukine-31 canin (il-31ra) et leurs utilisations |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK580789D0 (da) * | 1989-11-20 | 1989-11-20 | Novo Nordisk As | Fremgangsmaade til oprensning af polypeptider |
| US5639940A (en) * | 1994-03-03 | 1997-06-17 | Pharmaceutical Proteins Ltd. | Production of fibrinogen in transgenic animals |
| CN1114357A (zh) * | 1994-07-01 | 1996-01-03 | 唐勇炜 | 利用转基因动物生产重组多肽 |
-
2000
- 2000-10-16 IL IL14900300A patent/IL149003A0/xx unknown
- 2000-10-16 MX MXPA02003702A patent/MXPA02003702A/es not_active Application Discontinuation
- 2000-10-16 AU AU80254/00A patent/AU781944B2/en not_active Ceased
- 2000-10-16 WO PCT/US2000/028589 patent/WO2001026455A1/fr active IP Right Grant
- 2000-10-16 BR BR0014860-1A patent/BR0014860A/pt not_active Application Discontinuation
- 2000-10-16 JP JP2001529255A patent/JP2003511048A/ja active Pending
- 2000-10-16 EP EP00970945A patent/EP1220606A4/fr not_active Withdrawn
- 2000-10-16 CA CA002382741A patent/CA2382741A1/fr not_active Abandoned
- 2000-10-16 KR KR1020027004804A patent/KR100772465B1/ko not_active IP Right Cessation
- 2000-10-16 NZ NZ518263A patent/NZ518263A/en unknown
- 2000-10-16 RU RU2002112460/13A patent/RU2002112460A/ru unknown
- 2000-10-16 HU HU0203537A patent/HUP0203537A2/hu unknown
- 2000-10-16 CN CNB008152802A patent/CN1322003C/zh not_active Expired - Fee Related
-
2002
- 2002-04-10 NO NO20021686A patent/NO20021686L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| HUP0203537A2 (hu) | 2003-02-28 |
| EP1220606A1 (fr) | 2002-07-10 |
| AU781944B2 (en) | 2005-06-23 |
| AU8025400A (en) | 2001-04-23 |
| CN1387399A (zh) | 2002-12-25 |
| NO20021686L (no) | 2002-06-12 |
| WO2001026455A1 (fr) | 2001-04-19 |
| CN1322003C (zh) | 2007-06-20 |
| KR100772465B1 (ko) | 2007-11-02 |
| CA2382741A1 (fr) | 2001-04-19 |
| NO20021686D0 (no) | 2002-04-10 |
| MXPA02003702A (es) | 2002-09-18 |
| KR20030022759A (ko) | 2003-03-17 |
| BR0014860A (pt) | 2003-07-08 |
| NZ518263A (en) | 2004-03-26 |
| EP1220606A4 (fr) | 2004-04-14 |
| JP2003511048A (ja) | 2003-03-25 |
| IL149003A0 (en) | 2002-11-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2002112460A (ru) | Способы получения целевой молекулы в трансгенном животном и выделения целевой молекулы | |
| DE3484673D1 (de) | Digitalis-antikoerper, verfahren zu ihrer herstellung und ihre verwendung zur therapie von digitalis-intoxikationen. | |
| JP2003530543A5 (fr) | ||
| CA2258518A1 (fr) | Molecules de reconnaissance ayant une interaction specifique avec le site actif ou la fissure d'une molecule cible | |
| EP2105447A1 (fr) | Anticorps d'origine aviaire capable de se lier spécifiquement au hmgb1 humain, procédé de détermination immunologique pour le hmgb1 humain, et réactif de détermination immunologique pour le hmgb1 humain | |
| EP0105359A4 (fr) | Procede de purification par affinite utilisant des anticorps monoclonaux. | |
| JPH08233811A (ja) | Ｉ型コラーゲン検出用の抗原及び抗体 | |
| JP5271354B2 (ja) | 水性二相系中での組換えタンパク質の分離方法 | |
| Hansen et al. | Capture of human Fab fragments by expanded bed adsorption with a mixed mode adsorbent | |
| KR870010192A (ko) | 융합단백질 및 항체의 제조방법 | |
| Larsson et al. | Multiplexed PrEST immunization for high-throughput affinity proteomics | |
| WO2005023981A3 (fr) | Bibliotheques de proteines chimeriques de liaison a la cellulose et ses methodes d'utilisation | |
| Subramanian et al. | Simultaneous purification of biotin-binding proteins-I and-II from chicken egg yolk and their characterization | |
| JPH01500188A (ja) | ヘパトーム由来成長因子 | |
| JPH0383579A (ja) | イヌ×マウスヘテロハイブリドーマおよびイヌ免疫グロブリンλ鎖の定常領域をコードする遺伝子断片 | |
| WO2000055192A3 (fr) | Molecule d'acides nucleiques, comprenant une sequence d'acides nucleiques codant pour une hemocyanine | |
| JPS60130600A (ja) | 抗犬ジステンバ−モノクロ−ナル抗体及びそれを使用する測定方法 | |
| Gramzow et al. | Sponge aggregation factor: identification of the specific collagen-binding site by means of a monoclonal antibody. | |
| AU781486B2 (en) | Method for identifying substances which mimic mammal epitopes | |
| DE19919121B4 (de) | Multimeres CMV-Antigen | |
| US20060247424A1 (en) | Anti-idiotype antibody, method of constructing the anti-idiotype antibody, and method of preparing idiotype antibody using the anti-idiotype antibody | |
| Carter | Production of Anti‐Peptide Antisera | |
| WO2000045839A3 (fr) | Procede de selection et de fabrication de preparations de vaccination et diagnostiques | |
| US20030049694A1 (en) | Production of fusion proteins and use for identifying binding molecules | |
| US20060154302A1 (en) | Iterative, subtractive immunoaffinity method for proteome analyte enrichment |