BR0014860A - Métodos para a produção de uma molécula alvo em um animal transgênico e purificação da molécula alvo - Google Patents

Métodos para a produção de uma molécula alvo em um animal transgênico e purificação da molécula alvo

Info

Publication number
BR0014860A
BR0014860A BR0014860-1A BR0014860A BR0014860A BR 0014860 A BR0014860 A BR 0014860A BR 0014860 A BR0014860 A BR 0014860A BR 0014860 A BR0014860 A BR 0014860A
Authority
BR
Brazil
Prior art keywords
target molecule
methods
producing
target
purifying
Prior art date
Application number
BR0014860-1A
Other languages
English (en)
Inventor
Harry M Meade
Scott P Fulton
Yann Echelard
Original Assignee
Genzyme Transgenics Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genzyme Transgenics Corp filed Critical Genzyme Transgenics Corp
Publication of BR0014860A publication Critical patent/BR0014860A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/01—Animal expressing industrially exogenous proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination

Abstract

"MéTODOS PARA A PRODUçãO DE UMA MOLéCULA ALVO EM UM ANIMAL TRANSGêNICO E PURIFICAçãO DA MOLéCULA ALVO". A invenção proporciona sistemas e métodos para a produção e purificação de polipeptídios alvo presentes em sistemas biológicos. Os sistemas e métodos de acordo com a invenção utilizam a expressão transgênica de polipeptídios de ligação multivalente coo meios de afinidade, para a purificação de tais moléculas alvo. Os polipeptídios de ligação multivalente transgênicos se ligam tanto as moléculas alvo, como por exemplo um epitopo ligável de uma molécula alvo, como a uma matriz.
BR0014860-1A 1999-10-14 2000-10-16 Métodos para a produção de uma molécula alvo em um animal transgênico e purificação da molécula alvo BR0014860A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US15974899P 1999-10-14 1999-10-14
US20466200P 2000-05-17 2000-05-17
PCT/US2000/028589 WO2001026455A1 (en) 1999-10-14 2000-10-16 Methods of producing a target molecule in a transgenic animal and purification of the target molecule

Publications (1)

Publication Number Publication Date
BR0014860A true BR0014860A (pt) 2003-07-08

Family

ID=26856252

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0014860-1A BR0014860A (pt) 1999-10-14 2000-10-16 Métodos para a produção de uma molécula alvo em um animal transgênico e purificação da molécula alvo

Country Status (14)

Country Link
EP (1) EP1220606A4 (pt)
JP (1) JP2003511048A (pt)
KR (1) KR100772465B1 (pt)
CN (1) CN1322003C (pt)
AU (1) AU781944B2 (pt)
BR (1) BR0014860A (pt)
CA (1) CA2382741A1 (pt)
HU (1) HUP0203537A2 (pt)
IL (1) IL149003A0 (pt)
MX (1) MXPA02003702A (pt)
NO (1) NO20021686L (pt)
NZ (1) NZ518263A (pt)
RU (1) RU2002112460A (pt)
WO (1) WO2001026455A1 (pt)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030049694A1 (en) * 2001-09-10 2003-03-13 Chung-Hsiun Wu Production of fusion proteins and use for identifying binding molecules
US6800462B2 (en) * 2001-09-10 2004-10-05 Abgenomics Corporation Production of recombinant proteins in vivo and use for generating antibodies
CN1283785C (zh) * 2002-05-20 2006-11-08 上海杰隆生物工程股份有限公司 利用转基因动物乳腺生产人促红细胞生成素的方法
CA2612479A1 (en) * 2005-06-29 2007-05-10 Cameron Malcolm Lang Clokie Production of bone morphogenic proteins (bmps) in transgenic mammals
WO2008156668A1 (en) * 2007-06-13 2008-12-24 Sterrenbeld Biotechnologie North America, Inc. Transgenic mammals that produce exogenous proteins in milk
WO2010036976A2 (en) 2008-09-25 2010-04-01 Transgenrx, Inc. Novel vectors for production of antibodies
US9157097B2 (en) 2008-09-25 2015-10-13 Proteovec Holding, L.L.C. Vectors for production of growth hormone
WO2010118360A1 (en) 2009-04-09 2010-10-14 The Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Production of proteins using transposon-based vectors
EP2793936A4 (en) * 2011-12-19 2015-05-27 Lfb Usa Inc RECOMBINANT HUMAN ALPHA-1-ANTITRYPINE FOR THE TREATMENT OF INFLAMMATORY DISEASES
EP2956480B1 (en) 2013-02-13 2019-09-04 Laboratoire Français du Fractionnement et des Biotechnologies Highly galactosylated anti-tnf-alpha antibodies and uses thereof
BR112015019348A2 (pt) 2013-02-13 2017-08-22 Lab Francais Du Fractionnement Métodos para produção de proteína com glicosilação modificada e com sialilação aumentada, para aumentar a atividade de sialil transferase na glândula mamária e para produzir sialil transferase, proteína com glicosilação modificada ou proteína com sialilação aumentada, composição, sialil transferase, mamífero transgênico, e, célula epitelial mamária
TW201509432A (zh) 2013-07-05 2015-03-16 Lab Francais Du Fractionnement 親和層析基質
FR3025515B1 (fr) 2014-09-05 2016-09-09 Lab Francais Du Fractionnement Procede de purification d'un anticorps monoclonal
FR3034420A1 (fr) 2015-03-31 2016-10-07 Lab Francais Du Fractionnement Anticorps monoclonaux anti-cd303
JP6712125B2 (ja) * 2015-09-04 2020-06-17 株式会社フジクラ 酸化物超電導線材の接続構造体およびその製造方法
FR3060395B1 (fr) 2016-12-16 2019-05-24 Laboratoire Francais Du Fractionnement Et Des Biotechnologies Combinaison d'anticorps anti-cd303 et anti-her2
FR3060394B1 (fr) 2016-12-16 2019-05-24 Laboratoire Francais Du Fractionnement Et Des Biotechnologies Combinaison d'anticorps anti-cd303 et anti-amhrii
FR3076294B1 (fr) 2017-12-29 2022-01-28 Lab Francais Du Fractionnement Procede de purification d'anticorps a partir de lait brut
WO2023118241A1 (en) 2021-12-20 2023-06-29 Vetoquinol Sa Anti-canine interleukine-31-receptor a (il-31ra) antibodies and the uses thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK580789D0 (da) * 1989-11-20 1989-11-20 Novo Nordisk As Fremgangsmaade til oprensning af polypeptider
US5639940A (en) * 1994-03-03 1997-06-17 Pharmaceutical Proteins Ltd. Production of fibrinogen in transgenic animals
CN1114357A (zh) * 1994-07-01 1996-01-03 唐勇炜 利用转基因动物生产重组多肽

Also Published As

Publication number Publication date
KR20030022759A (ko) 2003-03-17
NZ518263A (en) 2004-03-26
JP2003511048A (ja) 2003-03-25
AU8025400A (en) 2001-04-23
CN1322003C (zh) 2007-06-20
NO20021686D0 (no) 2002-04-10
CN1387399A (zh) 2002-12-25
CA2382741A1 (en) 2001-04-19
MXPA02003702A (es) 2002-09-18
AU781944B2 (en) 2005-06-23
NO20021686L (no) 2002-06-12
KR100772465B1 (ko) 2007-11-02
EP1220606A4 (en) 2004-04-14
RU2002112460A (ru) 2004-02-27
IL149003A0 (en) 2002-11-10
EP1220606A1 (en) 2002-07-10
WO2001026455A1 (en) 2001-04-19
HUP0203537A2 (hu) 2003-02-28

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Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]