NZ518263A - Methods of producing a target molecule in a transgenic animal and purification of the target molecule - Google Patents

Methods of producing a target molecule in a transgenic animal and purification of the target molecule

Info

Publication number
NZ518263A
NZ518263A NZ518263A NZ51826300A NZ518263A NZ 518263 A NZ518263 A NZ 518263A NZ 518263 A NZ518263 A NZ 518263A NZ 51826300 A NZ51826300 A NZ 51826300A NZ 518263 A NZ518263 A NZ 518263A
Authority
NZ
New Zealand
Prior art keywords
polypeptide
matrix
transgenic
target polypeptide
target
Prior art date
Application number
NZ518263A
Other languages
English (en)
Inventor
Scott P Fulton
Yann Echelard
Harry M Meade
Original Assignee
Gtc Biotherapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gtc Biotherapeutics Inc filed Critical Gtc Biotherapeutics Inc
Publication of NZ518263A publication Critical patent/NZ518263A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14Extraction; Separation; Purification
    • C07K1/16Extraction; Separation; Purification by chromatography
    • C07K1/22Affinity chromatography or related techniques based upon selective absorption processes
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00Modified animals
    • A01K2207/15Humanized animals
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00Genetically modified animals
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00Genetically modified animals
    • A01K2217/05Animals comprising random inserted nucleic acids (transgenic)
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00Animals characterised by species
    • A01K2227/10Mammal
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00Animals characterised by purpose
    • A01K2267/01Animal expressing industrially exogenous proteins
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00Vector systems having a special element relevant for transcription
    • C12N2830/008Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Environmental Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Animal Husbandry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Plant Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
NZ518263A 1999-10-14 2000-10-16 Methods of producing a target molecule in a transgenic animal and purification of the target molecule NZ518263A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US15974899P 1999-10-14 1999-10-14
US20466200P 2000-05-17 2000-05-17
PCT/US2000/028589 WO2001026455A1 (en) 1999-10-14 2000-10-16 Methods of producing a target molecule in a transgenic animal and purification of the target molecule

Publications (1)

Publication Number Publication Date
NZ518263A true NZ518263A (en) 2004-03-26

Family

ID=26856252

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ518263A NZ518263A (en) 1999-10-14 2000-10-16 Methods of producing a target molecule in a transgenic animal and purification of the target molecule

Country Status (14)

Country Link
EP (1) EP1220606A4 (pt)
JP (1) JP2003511048A (pt)
KR (1) KR100772465B1 (pt)
CN (1) CN1322003C (pt)
AU (1) AU781944B2 (pt)
BR (1) BR0014860A (pt)
CA (1) CA2382741A1 (pt)
HU (1) HUP0203537A2 (pt)
IL (1) IL149003A0 (pt)
MX (1) MXPA02003702A (pt)
NO (1) NO20021686L (pt)
NZ (1) NZ518263A (pt)
RU (1) RU2002112460A (pt)
WO (1) WO2001026455A1 (pt)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030049694A1 (en) * 2001-09-10 2003-03-13 Chung-Hsiun Wu Production of fusion proteins and use for identifying binding molecules
US6800462B2 (en) * 2001-09-10 2004-10-05 Abgenomics Corporation Production of recombinant proteins in vivo and use for generating antibodies
CN1283785C (zh) * 2002-05-20 2006-11-08 上海杰隆生物工程股份有限公司 利用转基因动物乳腺生产人促红细胞生成素的方法
WO2007052096A2 (en) * 2005-06-29 2007-05-10 Cameron Malcolm Lang Clokie Production of bone morphogenic proteins (bmps) in transgenic mammals
RU2010100911A (ru) * 2007-06-13 2011-07-20 Стэрнбэлт Байэутекнолэджай Нос Эмерикэ, Инк. (US) Плазмида, содержащая нуклеотидную последовательность, кодирующую модифицированный предшественник инсулина, и способ ее трансфекции в клетки млекопитающего, трансгенное млекопитающее, продуцирующее указанный предшественник, и способ его получения
WO2010036976A2 (en) 2008-09-25 2010-04-01 Transgenrx, Inc. Novel vectors for production of antibodies
WO2010036978A2 (en) 2008-09-25 2010-04-01 Transgenrx, Inc. Novel vectors for production of growth hormone
US9150881B2 (en) 2009-04-09 2015-10-06 Proteovec Holding, L.L.C. Production of proteins using transposon-based vectors
CA2858825A1 (en) * 2011-12-19 2013-06-27 Lfb Usa, Inc. Recombinant human alpha-1-antitrypsin for the treatment of inflammatory disorders
CN105263319A (zh) 2013-02-13 2016-01-20 法国化学与生物科技实验室 具有经修饰的糖基化的蛋白及其生产方法
JP2016508515A (ja) 2013-02-13 2016-03-22 ラボラトワール フランセ デュ フラクショヌマン エ デ ビオテクノロジーLaboratoire Francais du Fractionnement et des Biotechnologies 高ガラクトシル化抗TNF−α抗体およびその使用
AU2014285971A1 (en) 2013-07-05 2016-02-04 Laboratoire Francais Du Fractionnement Et Des Biotechnologies Affinity chromatography matrix
FR3025515B1 (fr) 2014-09-05 2016-09-09 Lab Francais Du Fractionnement Procede de purification d'un anticorps monoclonal
FR3034420A1 (fr) 2015-03-31 2016-10-07 Lab Francais Du Fractionnement Anticorps monoclonaux anti-cd303
JP6712125B2 (ja) * 2015-09-04 2020-06-17 株式会社フジクラ 酸化物超電導線材の接続構造体およびその製造方法
FR3060394B1 (fr) 2016-12-16 2019-05-24 Laboratoire Francais Du Fractionnement Et Des Biotechnologies Combinaison d'anticorps anti-cd303 et anti-amhrii
FR3060395B1 (fr) 2016-12-16 2019-05-24 Laboratoire Francais Du Fractionnement Et Des Biotechnologies Combinaison d'anticorps anti-cd303 et anti-her2
FR3076294B1 (fr) 2017-12-29 2022-01-28 Lab Francais Du Fractionnement Procede de purification d'anticorps a partir de lait brut
CA3223956A1 (en) 2021-12-20 2023-06-29 Vetoquinol Sa Anti-canine interleukine-31-receptor a (il-31ra) antibodies and the uses thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK580789D0 (da) * 1989-11-20 1989-11-20 Novo Nordisk As Fremgangsmaade til oprensning af polypeptider
US5639940A (en) * 1994-03-03 1997-06-17 Pharmaceutical Proteins Ltd. Production of fibrinogen in transgenic animals
CN1114357A (zh) * 1994-07-01 1996-01-03 唐勇炜 利用转基因动物生产重组多肽

Also Published As

Publication number Publication date
AU8025400A (en) 2001-04-23
EP1220606A1 (en) 2002-07-10
CN1387399A (zh) 2002-12-25
KR100772465B1 (ko) 2007-11-02
AU781944B2 (en) 2005-06-23
MXPA02003702A (es) 2002-09-18
HUP0203537A2 (hu) 2003-02-28
CN1322003C (zh) 2007-06-20
WO2001026455A1 (en) 2001-04-19
IL149003A0 (en) 2002-11-10
CA2382741A1 (en) 2001-04-19
KR20030022759A (ko) 2003-03-17
NO20021686D0 (no) 2002-04-10
JP2003511048A (ja) 2003-03-25
BR0014860A (pt) 2003-07-08
EP1220606A4 (en) 2004-04-14
RU2002112460A (ru) 2004-02-27
NO20021686L (no) 2002-06-12

Similar Documents

Publication Publication Date Title
AU781944B2 (en) Methods of producing a target molecule in a transgenic animal and purification of the target molecule
US20040226053A1 (en) Methods of producing a target molecule in a transgenic animal and purification of the target molecule
NZ278744A (en) Transgenic production of immunoglobulin in milk and transgenic animals selectively expressing the gene for the antibody
US20060179500A1 (en) Methods and vectors for improving nucleic acid expression
CA2506629A1 (en) Modified antibodies stably produced in milk and methods of producing same
US20040092719A1 (en) Isolation of immunoglobulin molecules that lack inter-heavy chain disulfide bonds
WO2000026357A2 (en) Transgenic and cloned mammals
US20030177513A1 (en) Transgenic and cloned mammals
AU8025400B2 (pt)
AU781915B2 (en) Method of purifying heterologous proteins
US20030046716A1 (en) Transgenically produced platelet derived growth factor
US20050193431A1 (en) Somatic cell line
EP1375654A2 (en) Transgenic and cloned mammals
AU783143B2 (en) Methods of producing cloned and transgenic mammals
AU5008300A (en) Transgenically produced antithrombin iii and mutants thereof
AU2003204830B2 (en) Transgenic and cloned mammals
AU2004210607A1 (en) Transgenic and cloned mammals
AU2008202456A1 (en) Transgenic and cloned mammals

Legal Events

Date Code Title Description
PSEA Patent sealed
RENW Renewal (renewal fees accepted)
RENW Renewal (renewal fees accepted)