ATE211171T1 - Weitgehend reine rezeptorartige, tgf-beta-1- bindende moleküle und deren verwendungen - Google Patents
Weitgehend reine rezeptorartige, tgf-beta-1- bindende moleküle und deren verwendungenInfo
- Publication number
- ATE211171T1 ATE211171T1 AT92914515T AT92914515T ATE211171T1 AT E211171 T1 ATE211171 T1 AT E211171T1 AT 92914515 T AT92914515 T AT 92914515T AT 92914515 T AT92914515 T AT 92914515T AT E211171 T1 ATE211171 T1 AT E211171T1
- Authority
- AT
- Austria
- Prior art keywords
- beta
- tgf
- pct
- molecules
- type
- Prior art date
Links
- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 abstract 3
- 102000003886 Glycoproteins Human genes 0.000 abstract 1
- 108090000288 Glycoproteins Proteins 0.000 abstract 1
- 230000002900 effect on cell Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000000178 monomer Substances 0.000 abstract 1
- 150000007523 nucleic acids Chemical group 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/495—Transforming growth factor [TGF]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Cell Biology (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/717,316 US5229495A (en) | 1991-06-18 | 1991-06-18 | Substantially pure receptor like TGF-β 1 binding molecules and uses thereof |
| PCT/US1992/005199 WO1992022319A1 (en) | 1991-06-18 | 1992-06-18 | SUBSTANTIALLY PURE RECEPTOR LIKE TGF-β1 BINDING MOLECULES AND USES THEREOF |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE211171T1 true ATE211171T1 (de) | 2002-01-15 |
Family
ID=24881526
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT92914515T ATE211171T1 (de) | 1991-06-18 | 1992-06-18 | Weitgehend reine rezeptorartige, tgf-beta-1- bindende moleküle und deren verwendungen |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US5229495A (de) |
| EP (1) | EP0590071B1 (de) |
| JP (1) | JPH06508519A (de) |
| AT (1) | ATE211171T1 (de) |
| AU (1) | AU665561B2 (de) |
| CA (1) | CA2111853C (de) |
| DE (2) | DE69232309T4 (de) |
| DK (1) | DK0590071T3 (de) |
| ES (1) | ES2165843T3 (de) |
| WO (1) | WO1992022319A1 (de) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6150328A (en) * | 1986-07-01 | 2000-11-21 | Genetics Institute, Inc. | BMP products |
| US5705609A (en) * | 1988-06-28 | 1998-01-06 | La Jolla Cancer Research Foundation | Decorin fragments inhibiting cell regulatory factors |
| US5177197A (en) * | 1990-02-27 | 1993-01-05 | Ludwig Institute For Cancer Research | Isolated nucleotide sequence expressing human transforming growth factor-β1-binding protein |
| US5229495A (en) * | 1991-06-18 | 1993-07-20 | Ludwig Institute For Cancer Research | Substantially pure receptor like TGF-β 1 binding molecules and uses thereof |
| US6515009B1 (en) | 1991-09-27 | 2003-02-04 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
| US5811447A (en) | 1993-01-28 | 1998-09-22 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
| US6008011A (en) * | 1991-10-31 | 1999-12-28 | Whitehead Institute For Biomedical Research | TGF-β type II receptor cDNAs |
| US20080139474A1 (en) * | 1991-11-04 | 2008-06-12 | David Israel | Recombinant bone morphogenetic protein heterodimers, compositions and methods of use |
| ATE238417T1 (de) | 1991-11-04 | 2003-05-15 | Inst Genetics Llc | Rekombinante knochenmorphogenetische protein heterodimere, zusammensetzungen und verfahren zur verwendung |
| US6251920B1 (en) | 1993-05-13 | 2001-06-26 | Neorx Corporation | Prevention and treatment of cardiovascular pathologies |
| US6306421B1 (en) | 1992-09-25 | 2001-10-23 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
| US6395494B1 (en) * | 1993-05-13 | 2002-05-28 | Neorx Corporation | Method to determine TGF-β |
| US5770609A (en) * | 1993-01-28 | 1998-06-23 | Neorx Corporation | Prevention and treatment of cardiovascular pathologies |
| US6663881B2 (en) | 1993-01-28 | 2003-12-16 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
| US5981568A (en) | 1993-01-28 | 1999-11-09 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
| US5595722A (en) * | 1993-01-28 | 1997-01-21 | Neorx Corporation | Method for identifying an agent which increases TGF-beta levels |
| US6491938B2 (en) | 1993-05-13 | 2002-12-10 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
| US6197789B1 (en) | 1995-06-07 | 2001-03-06 | Neorx Corporation | Prevention and treatment of cardiovascular pathologies with tamoxifen analogues |
| JPH08510451A (ja) * | 1993-05-13 | 1996-11-05 | ネオルックス コーポレイション | 異常増殖性平滑筋細胞に関連した病因の予防及び治療 |
| US5453492A (en) * | 1993-07-28 | 1995-09-26 | La Jolla Cancer Research Foundation | 60 kDa transforming growth factor-β-binding protein and its use to detect or purify TGF-β |
| US6291206B1 (en) * | 1993-09-17 | 2001-09-18 | Genetics Institute, Inc. | BMP receptor proteins |
| DE69434651T2 (de) | 1993-12-07 | 2007-03-08 | Genetics Institute, Inc., Cambridge | Bmp-12, bmp-13 und diese enthaltende sehne-induzierende zusammensetzungen |
| US6074840A (en) | 1994-02-18 | 2000-06-13 | The Regents Of The University Of Michigan | Recombinant production of latent TGF-beta binding protein-3 (LTBP-3) |
| WO1998046588A2 (en) | 1997-04-11 | 1998-10-22 | Neorx Corporation | Compounds and therapies for the prevention of vascular and non-vascular pathologies |
| US6030831A (en) * | 1997-09-19 | 2000-02-29 | Genetech, Inc. | Tie ligand homologues |
| US6444657B1 (en) | 1998-12-31 | 2002-09-03 | Guilford Pharmaceuticals Inc. | Methods for treating certain diseases using naaladase inhibitors |
| US6727224B1 (en) * | 1999-02-01 | 2004-04-27 | Genetics Institute, Llc. | Methods and compositions for healing and repair of articular cartilage |
| DE60012557T2 (de) | 1999-10-15 | 2005-08-04 | Genetics Institute, LLC, Cambridge | Hyaluronsäure enthaltende zusammensetzungen zur abgabe osteogener proteine |
| US20030082233A1 (en) * | 2000-12-01 | 2003-05-01 | Lyons Karen M. | Method and composition for modulating bone growth |
| ATE393573T1 (de) * | 2001-06-01 | 2008-05-15 | Wyeth Corp | Zusammensetzungen für die systemische verabreichung von sequenzen, die für knochenmorphogenese-proteinen kodieren |
| TWI267378B (en) * | 2001-06-08 | 2006-12-01 | Wyeth Corp | Calcium phosphate delivery vehicles for osteoinductive proteins |
| JP3887588B2 (ja) * | 2002-08-30 | 2007-02-28 | 株式会社リガク | Ｘ線回折による応力測定法 |
| DE602004005477T2 (de) * | 2003-09-12 | 2007-12-13 | Wyeth | Injizierbare feste Calciumphosphat-Stäbe zur Abgabe von osteogenen Proteinen |
| MX2007011591A (es) * | 2005-03-30 | 2007-12-10 | Wyeth Corp | Metodo para estimular el crecimiento de cabello administrando bmps. |
| US10961305B2 (en) | 2016-12-21 | 2021-03-30 | Mereo Biopharma 3 Limited | Use of anti-sclerostin antibodies in the treatment of osteogenesis imperfecta |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0725798B2 (ja) * | 1986-12-15 | 1995-03-22 | 東燃料株式会社 | ＴＧＦ−β制御糖タンパク質 |
| CA2002011A1 (en) * | 1988-11-14 | 1990-05-14 | Anthony F. Purchio | Normal human growth regulatory receptor for tgf-beta |
| US5177197A (en) * | 1990-02-27 | 1993-01-05 | Ludwig Institute For Cancer Research | Isolated nucleotide sequence expressing human transforming growth factor-β1-binding protein |
| WO1992005199A1 (en) * | 1990-09-26 | 1992-04-02 | Genetics Institute, Inc. | Bmp-5 derivatives |
| US5229495A (en) * | 1991-06-18 | 1993-07-20 | Ludwig Institute For Cancer Research | Substantially pure receptor like TGF-β 1 binding molecules and uses thereof |
| US5280109A (en) * | 1992-01-27 | 1994-01-18 | Ludwig Institute For Cancer Research | Isolated, large latent complexes of TGF-β2 and TGF-β3, and new binding protein for latent form TGF-β1, TGF-β2 and TGF-β3 LTBP-2 |
-
1991
- 1991-06-18 US US07/717,316 patent/US5229495A/en not_active Expired - Fee Related
-
1992
- 1992-06-18 AT AT92914515T patent/ATE211171T1/de not_active IP Right Cessation
- 1992-06-18 US US08/167,939 patent/US5578703A/en not_active Expired - Fee Related
- 1992-06-18 ES ES92914515T patent/ES2165843T3/es not_active Expired - Lifetime
- 1992-06-18 DK DK92914515T patent/DK0590071T3/da active
- 1992-06-18 WO PCT/US1992/005199 patent/WO1992022319A1/en active IP Right Grant
- 1992-06-18 CA CA002111853A patent/CA2111853C/en not_active Expired - Fee Related
- 1992-06-18 EP EP92914515A patent/EP0590071B1/de not_active Expired - Lifetime
- 1992-06-18 JP JP5501129A patent/JPH06508519A/ja active Pending
- 1992-06-18 DE DE69232309T patent/DE69232309T4/de not_active Expired - Lifetime
- 1992-06-18 DE DE69232309A patent/DE69232309D1/de not_active Expired - Fee Related
- 1992-06-18 AU AU22618/92A patent/AU665561B2/en not_active Ceased
-
1995
- 1995-12-05 US US08/567,538 patent/US5731200A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| AU2261892A (en) | 1993-01-12 |
| US5731200A (en) | 1998-03-24 |
| EP0590071B1 (de) | 2001-12-19 |
| US5229495A (en) | 1993-07-20 |
| US5578703A (en) | 1996-11-26 |
| CA2111853C (en) | 2002-09-17 |
| EP0590071A1 (de) | 1994-04-06 |
| WO1992022319A1 (en) | 1992-12-23 |
| EP0590071A4 (en) | 1997-01-29 |
| CA2111853A1 (en) | 1992-12-23 |
| AU665561B2 (en) | 1996-01-11 |
| DE69232309T4 (de) | 2003-02-20 |
| DE69232309T2 (de) | 2002-08-14 |
| ES2165843T3 (es) | 2002-04-01 |
| DK0590071T3 (da) | 2002-04-15 |
| JPH06508519A (ja) | 1994-09-29 |
| DE69232309D1 (de) | 2002-01-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |