WO2001026455A1 - Methodes de production d'une molecule cible chez un animal transgenique et de purification de la molecule cible - Google Patents

Methodes de production d'une molecule cible chez un animal transgenique et de purification de la molecule cible Download PDF

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Publication number
WO2001026455A1
WO2001026455A1 PCT/US2000/028589 US0028589W WO0126455A1 WO 2001026455 A1 WO2001026455 A1 WO 2001026455A1 US 0028589 W US0028589 W US 0028589W WO 0126455 A1 WO0126455 A1 WO 0126455A1
Authority
WO
WIPO (PCT)
Prior art keywords
polypeptide
matrix
target
multivalent
transgenic
Prior art date
Application number
PCT/US2000/028589
Other languages
English (en)
Inventor
Harry Meade
Scott P. Fulton
Yann Echelard
Original Assignee
Genzyme Transgenics Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to AU80254/00A priority Critical patent/AU781944B2/en
Priority to EP00970945A priority patent/EP1220606A4/fr
Priority to MXPA02003702A priority patent/MXPA02003702A/es
Priority to BR0014860-1A priority patent/BR0014860A/pt
Priority to CA002382741A priority patent/CA2382741A1/fr
Priority to HU0203537A priority patent/HUP0203537A2/hu
Application filed by Genzyme Transgenics Corporation filed Critical Genzyme Transgenics Corporation
Priority to IL14900300A priority patent/IL149003A0/xx
Priority to NZ518263A priority patent/NZ518263A/en
Priority to KR1020027004804A priority patent/KR100772465B1/ko
Priority to JP2001529255A priority patent/JP2003511048A/ja
Publication of WO2001026455A1 publication Critical patent/WO2001026455A1/fr
Priority to NO20021686A priority patent/NO20021686L/no

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/01—Animal expressing industrially exogenous proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Environmental Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Plant Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

L'invention concerne des systèmes et des méthodes de production et de purification de molécules cibles présentes dans des systèmes biologiques. Les systèmes et les méthodes de l'invention utilisent l'expression transgénique de polypeptides de fixation multivalents, en tant que supports d'affinité, pour purifier lesdites molécules cibles. Les polypeptides de fixation multivalents transgéniques fixent à la fois les molécules cibles, par exemple, un épitope fixable d'une molécule cible, et une matrice.
PCT/US2000/028589 1999-10-14 2000-10-16 Methodes de production d'une molecule cible chez un animal transgenique et de purification de la molecule cible WO2001026455A1 (fr)

Priority Applications (11)

Application Number Priority Date Filing Date Title
EP00970945A EP1220606A4 (fr) 1999-10-14 2000-10-16 Methodes de production d'une molecule cible chez un animal transgenique et de purification de la molecule cible
MXPA02003702A MXPA02003702A (es) 1999-10-14 2000-10-16 Metodos de producir una molecula objetivo en un animal transgenico y purificacion de la molecula.
BR0014860-1A BR0014860A (pt) 1999-10-14 2000-10-16 Métodos para a produção de uma molécula alvo em um animal transgênico e purificação da molécula alvo
CA002382741A CA2382741A1 (fr) 1999-10-14 2000-10-16 Methodes de production d'une molecule cible chez un animal transgenique et de purification de la molecule cible
HU0203537A HUP0203537A2 (hu) 1999-10-14 2000-10-16 Célmolekula transzgénikus állatban történő előállítására és tisztítására szolgáló eljárások
AU80254/00A AU781944B2 (en) 1999-10-14 2000-10-16 Methods of producing a target molecule in a transgenic animal and purification of the target molecule
IL14900300A IL149003A0 (en) 1999-10-14 2000-10-16 Methods of producing a target molecule in a transgenic animal and purification of the target molecule
NZ518263A NZ518263A (en) 1999-10-14 2000-10-16 Methods of producing a target molecule in a transgenic animal and purification of the target molecule
KR1020027004804A KR100772465B1 (ko) 1999-10-14 2000-10-16 트랜스제닉 동물 내에서 표적 분자를 생성시키는 방법, 및그 표적 분자를 정제하는 방법
JP2001529255A JP2003511048A (ja) 1999-10-14 2000-10-16 遺伝子導入された動物中において標的分子を産生する方法および該標的分子を精製する方法
NO20021686A NO20021686L (no) 1999-10-14 2002-04-10 Fremgangsmåter for fremstilling av målemolekyler i et transgent dyr og rensing av målmolekylet

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US15974899P 1999-10-14 1999-10-14
US60/159,748 1999-10-14
US20466200P 2000-05-17 2000-05-17
US60/204,662 2000-05-17

Publications (1)

Publication Number Publication Date
WO2001026455A1 true WO2001026455A1 (fr) 2001-04-19

Family

ID=26856252

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/028589 WO2001026455A1 (fr) 1999-10-14 2000-10-16 Methodes de production d'une molecule cible chez un animal transgenique et de purification de la molecule cible

Country Status (14)

Country Link
EP (1) EP1220606A4 (fr)
JP (1) JP2003511048A (fr)
KR (1) KR100772465B1 (fr)
CN (1) CN1322003C (fr)
AU (1) AU781944B2 (fr)
BR (1) BR0014860A (fr)
CA (1) CA2382741A1 (fr)
HU (1) HUP0203537A2 (fr)
IL (1) IL149003A0 (fr)
MX (1) MXPA02003702A (fr)
NO (1) NO20021686L (fr)
NZ (1) NZ518263A (fr)
RU (1) RU2002112460A (fr)
WO (1) WO2001026455A1 (fr)

Cited By (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003097818A1 (fr) * 2002-05-20 2003-11-27 Shanghai Genon Bioengineering Co., Ltd. Procede de production de glandes mammaires d'animal transgenique secretant de l'erythropoietine humaine (epo)
EP1432810A2 (fr) * 2001-09-10 2004-06-30 Abgenomics Corporation Production de proteines recombinantes in vivo et utilisation associee permettant de produire des anticorps
EP1432451A2 (fr) * 2001-09-10 2004-06-30 Abgenomics Co. Obtention de proteines de fusion et leur utilisation dans l'identification de molecules de liaison
WO2007052096A2 (fr) * 2005-06-29 2007-05-10 Cameron Malcolm Lang Clokie Production de proteines morphogeniques osseuses dans des mammiferes transgeniques
WO2013096458A1 (fr) * 2011-12-19 2013-06-27 Gtc Biotherapeutics, Inc. Alpha-1-antitrypsine humaine recombinante pour le traitement de troubles inflammatoires
US9150881B2 (en) 2009-04-09 2015-10-06 Proteovec Holding, L.L.C. Production of proteins using transposon-based vectors
US9150880B2 (en) 2008-09-25 2015-10-06 Proteovec Holding, L.L.C. Vectors for production of antibodies
US9157097B2 (en) 2008-09-25 2015-10-13 Proteovec Holding, L.L.C. Vectors for production of growth hormone
WO2018109210A1 (fr) 2016-12-16 2018-06-21 Laboratoire Français Du Fractionnement Et Des Biotechnologies Combinaison d'anticorps anti-cd303 et anti-her2
WO2018109209A1 (fr) 2016-12-16 2018-06-21 Laboratoire Français Du Fractionnement Et Des Biotechnologies Combinaison d'anticorps anti-cd303 et anti-amhrii
US10034921B2 (en) 2013-02-13 2018-07-31 Laboratoire Français Du Fractionnement Et Des Biotechnologies Proteins with modified glycosylation and methods of production thereof
US10174110B2 (en) 2013-02-13 2019-01-08 Laboratoire Français Du Fractionnement Et Des Biotechnologies Highly galactosylated anti-TNF-α antibodies and uses thereof
WO2019129848A1 (fr) 2017-12-29 2019-07-04 Laboratoire Francais Du Fractionnement Et Des Biotechnologies Procédé de purification d'anticorps à partir de lait brut
US10363496B2 (en) 2014-09-05 2019-07-30 Laboratoire Francais Du Fractionnement Et Des Biotechnologies Method for purification of monoclonal antibodies
US10611826B2 (en) 2013-07-05 2020-04-07 Laboratoire Français Du Fractionnement Et Des Biotechnologies Affinity chromatography matrix
US10611843B2 (en) 2015-03-31 2020-04-07 Laboratoire Francais Du Fractionnement Et Des Biotechnologies Anti-CD303 monoclonal antibodies
WO2023118241A1 (fr) 2021-12-20 2023-06-29 Vetoquinol Sa Anticorps anti-récepteur a de l'interleukine-31 canin (il-31ra) et leurs utilisations

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2690565A1 (fr) * 2007-06-13 2008-12-24 Sterrenbeld Biotechnologie North America, Inc. Procede de production d'une proteine exogene dans le lait de mammiferes transgeniques
JP6712125B2 (ja) * 2015-09-04 2020-06-17 株式会社フジクラ 酸化物超電導線材の接続構造体およびその製造方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK580789D0 (da) * 1989-11-20 1989-11-20 Novo Nordisk As Fremgangsmaade til oprensning af polypeptider
US5639940A (en) * 1994-03-03 1997-06-17 Pharmaceutical Proteins Ltd. Production of fibrinogen in transgenic animals
CN1114357A (zh) * 1994-07-01 1996-01-03 唐勇炜 利用转基因动物生产重组多肽

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
CASTILLA J. ET AL.: "Engineering passive immunity in transgenic mice secreting virus-neutralizing antibodies in milk", NATURE BIOTECHNOLOGY, vol. 16, April 1998 (1998-04-01), pages 349 - 354, XP002937184 *
GAVIN W.G. ET AL.: "Expression of the antibody hBR96-2 in the milk of transgenic mice and production of hBR96-2 in transgenic goats", THERIOGENOLOGY, vol. 47, no. 1, 1997, pages 214, XP002937181 *
NUIJENS J.H. ET AL.: "Characterization of recombinant human lactoferrin secreted in milk of transgenic mice", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 272, no. 13, 28 March 1997 (1997-03-28), pages 8802 - 8807, XP002937182 *
See also references of EP1220606A4 *
SOLA I. ET AL.: "Transgenic mice secreting coronavirus neutralizing antibodies into the milk", JOURNAL OF VIROLOGY, vol. 72, no. 5, May 1998 (1998-05-01), pages 3762 - 3772, XP002937185 *
WOLF E. ET AL.: "Human insulin-like growth factor I (IGF-I) produced in the mammary glands of transgenic rabbits: Yield, receptor binding, mitogenic activity and effects on IGF-binding proteins", ENDOCRINOLOGY, vol. 138, no. 1, 1997, pages 307 - 313, XP002937183 *

Cited By (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1432810A2 (fr) * 2001-09-10 2004-06-30 Abgenomics Corporation Production de proteines recombinantes in vivo et utilisation associee permettant de produire des anticorps
EP1432451A2 (fr) * 2001-09-10 2004-06-30 Abgenomics Co. Obtention de proteines de fusion et leur utilisation dans l'identification de molecules de liaison
EP1432451A4 (fr) * 2001-09-10 2005-02-02 Abgenomics Co Obtention de proteines de fusion et leur utilisation dans l'identification de molecules de liaison
EP1432810A4 (fr) * 2001-09-10 2005-02-02 Abgenomics Corp Production de proteines recombinantes in vivo et utilisation associee permettant de produire des anticorps
WO2003097818A1 (fr) * 2002-05-20 2003-11-27 Shanghai Genon Bioengineering Co., Ltd. Procede de production de glandes mammaires d'animal transgenique secretant de l'erythropoietine humaine (epo)
WO2007052096A2 (fr) * 2005-06-29 2007-05-10 Cameron Malcolm Lang Clokie Production de proteines morphogeniques osseuses dans des mammiferes transgeniques
WO2007052096A3 (fr) * 2005-06-29 2008-02-14 Cameron Malcolm Lang Clokie Production de proteines morphogeniques osseuses dans des mammiferes transgeniques
US9150880B2 (en) 2008-09-25 2015-10-06 Proteovec Holding, L.L.C. Vectors for production of antibodies
US9157097B2 (en) 2008-09-25 2015-10-13 Proteovec Holding, L.L.C. Vectors for production of growth hormone
US9150881B2 (en) 2009-04-09 2015-10-06 Proteovec Holding, L.L.C. Production of proteins using transposon-based vectors
US20140228301A1 (en) * 2011-12-19 2014-08-14 Revo Biologics, Inc. Recombinant human alpha-1-antitrypsin for the treatment of inflammatory disorders
WO2013096458A1 (fr) * 2011-12-19 2013-06-27 Gtc Biotherapeutics, Inc. Alpha-1-antitrypsine humaine recombinante pour le traitement de troubles inflammatoires
US10034921B2 (en) 2013-02-13 2018-07-31 Laboratoire Français Du Fractionnement Et Des Biotechnologies Proteins with modified glycosylation and methods of production thereof
US10174110B2 (en) 2013-02-13 2019-01-08 Laboratoire Français Du Fractionnement Et Des Biotechnologies Highly galactosylated anti-TNF-α antibodies and uses thereof
US10611826B2 (en) 2013-07-05 2020-04-07 Laboratoire Français Du Fractionnement Et Des Biotechnologies Affinity chromatography matrix
US10363496B2 (en) 2014-09-05 2019-07-30 Laboratoire Francais Du Fractionnement Et Des Biotechnologies Method for purification of monoclonal antibodies
US10611843B2 (en) 2015-03-31 2020-04-07 Laboratoire Francais Du Fractionnement Et Des Biotechnologies Anti-CD303 monoclonal antibodies
WO2018109209A1 (fr) 2016-12-16 2018-06-21 Laboratoire Français Du Fractionnement Et Des Biotechnologies Combinaison d'anticorps anti-cd303 et anti-amhrii
WO2018109210A1 (fr) 2016-12-16 2018-06-21 Laboratoire Français Du Fractionnement Et Des Biotechnologies Combinaison d'anticorps anti-cd303 et anti-her2
WO2019129848A1 (fr) 2017-12-29 2019-07-04 Laboratoire Francais Du Fractionnement Et Des Biotechnologies Procédé de purification d'anticorps à partir de lait brut
WO2023118241A1 (fr) 2021-12-20 2023-06-29 Vetoquinol Sa Anticorps anti-récepteur a de l'interleukine-31 canin (il-31ra) et leurs utilisations

Also Published As

Publication number Publication date
EP1220606A4 (fr) 2004-04-14
MXPA02003702A (es) 2002-09-18
NO20021686D0 (no) 2002-04-10
CN1387399A (zh) 2002-12-25
AU8025400A (en) 2001-04-23
IL149003A0 (en) 2002-11-10
CN1322003C (zh) 2007-06-20
BR0014860A (pt) 2003-07-08
EP1220606A1 (fr) 2002-07-10
RU2002112460A (ru) 2004-02-27
AU781944B2 (en) 2005-06-23
NZ518263A (en) 2004-03-26
CA2382741A1 (fr) 2001-04-19
JP2003511048A (ja) 2003-03-25
KR100772465B1 (ko) 2007-11-02
KR20030022759A (ko) 2003-03-17
NO20021686L (no) 2002-06-12
HUP0203537A2 (hu) 2003-02-28

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