AU781944B2 - Methods of producing a target molecule in a transgenic animal and purification of the target molecule - Google Patents
Methods of producing a target molecule in a transgenic animal and purification of the target moleculeInfo
- Publication number
- AU781944B2 AU781944B2 AU80254/00A AU8025400A AU781944B2 AU 781944 B2 AU781944 B2 AU 781944B2 AU 80254/00 A AU80254/00 A AU 80254/00A AU 8025400 A AU8025400 A AU 8025400A AU 781944 B2 AU781944 B2 AU 781944B2
- Authority
- AU
- Australia
- Prior art keywords
- polypeptide
- matrix
- multivalent
- target
- transgenic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
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- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/15—Humanized animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/01—Animal expressing industrially exogenous proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
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- Biodiversity & Conservation Biology (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
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| US15974899P | 1999-10-14 | 1999-10-14 | |
| US60/159748 | 1999-10-14 | ||
| US20466200P | 2000-05-17 | 2000-05-17 | |
| US60/204662 | 2000-05-17 | ||
| PCT/US2000/028589 WO2001026455A1 (fr) | 1999-10-14 | 2000-10-16 | Methodes de production d'une molecule cible chez un animal transgenique et de purification de la molecule cible |
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| AU8025400A AU8025400A (en) | 2001-04-23 |
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| AU80254/00A Ceased AU781944B2 (en) | 1999-10-14 | 2000-10-16 | Methods of producing a target molecule in a transgenic animal and purification of the target molecule |
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| EP (1) | EP1220606A4 (fr) |
| JP (1) | JP2003511048A (fr) |
| KR (1) | KR100772465B1 (fr) |
| CN (1) | CN1322003C (fr) |
| AU (1) | AU781944B2 (fr) |
| BR (1) | BR0014860A (fr) |
| CA (1) | CA2382741A1 (fr) |
| HU (1) | HUP0203537A2 (fr) |
| IL (1) | IL149003A0 (fr) |
| MX (1) | MXPA02003702A (fr) |
| NO (1) | NO20021686L (fr) |
| NZ (1) | NZ518263A (fr) |
| RU (1) | RU2002112460A (fr) |
| WO (1) | WO2001026455A1 (fr) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US20030049694A1 (en) * | 2001-09-10 | 2003-03-13 | Chung-Hsiun Wu | Production of fusion proteins and use for identifying binding molecules |
| US6800462B2 (en) * | 2001-09-10 | 2004-10-05 | Abgenomics Corporation | Production of recombinant proteins in vivo and use for generating antibodies |
| CN1283785C (zh) * | 2002-05-20 | 2006-11-08 | 上海杰隆生物工程股份有限公司 | 利用转基因动物乳腺生产人促红细胞生成素的方法 |
| WO2007052096A2 (fr) * | 2005-06-29 | 2007-05-10 | Cameron Malcolm Lang Clokie | Production de proteines morphogeniques osseuses dans des mammiferes transgeniques |
| JP2010528677A (ja) * | 2007-06-13 | 2010-08-26 | スターンベルド バイオテクノロジー ノース アメリカ， インコーポレイテッド | 乳中に外因性タンパク質を産生するトランスジェニック哺乳動物 |
| US9157097B2 (en) | 2008-09-25 | 2015-10-13 | Proteovec Holding, L.L.C. | Vectors for production of growth hormone |
| US9150880B2 (en) | 2008-09-25 | 2015-10-06 | Proteovec Holding, L.L.C. | Vectors for production of antibodies |
| WO2010118360A1 (fr) | 2009-04-09 | 2010-10-14 | The Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Production de protéines au moyen de vecteurs à base de transposon |
| WO2013096458A1 (fr) * | 2011-12-19 | 2013-06-27 | Gtc Biotherapeutics, Inc. | Alpha-1-antitrypsine humaine recombinante pour le traitement de troubles inflammatoires |
| EP2956003A2 (fr) | 2013-02-13 | 2015-12-23 | Laboratoire Français du Fractionnement et des Biotechnologies | Protéines à glycosylation modifiée et leurs procédés de production |
| JP2016508515A (ja) | 2013-02-13 | 2016-03-22 | ラボラトワール フランセ デュ フラクショヌマン エ デ ビオテクノロジーＬａｂｏｒａｔｏｉｒｅ Ｆｒａｎｃａｉｓ ｄｕ Ｆｒａｃｔｉｏｎｎｅｍｅｎｔ ｅｔ ｄｅｓ Ｂｉｏｔｅｃｈｎｏｌｏｇｉｅｓ | 高ガラクトシル化抗ＴＮＦ−α抗体およびその使用 |
| JP2016532100A (ja) | 2013-07-05 | 2016-10-13 | ラボラトワール・フランセ・デュ・フラクシオンマン・エ・デ・ビョテクノロジーＬａｂｏｒａｔｏｉｒｅ Ｆｒａｎｃａｉｓ Ｄｕ Ｆｒａｃｔｉｏｎｎｅｍｅｎｔ Ｅｔ Ｄｅｓ Ｂｉｏｔｅｃｈｎｏｌｏｇｉｅｓ | アフィニティークロマトグラフィーマトリックス |
| FR3025515B1 (fr) | 2014-09-05 | 2016-09-09 | Lab Francais Du Fractionnement | Procede de purification d'un anticorps monoclonal |
| FR3034420A1 (fr) | 2015-03-31 | 2016-10-07 | Lab Francais Du Fractionnement | Anticorps monoclonaux anti-cd303 |
| JP6712125B2 (ja) * | 2015-09-04 | 2020-06-17 | 株式会社フジクラ | 酸化物超電導線材の接続構造体およびその製造方法 |
| FR3060394B1 (fr) | 2016-12-16 | 2019-05-24 | Laboratoire Francais Du Fractionnement Et Des Biotechnologies | Combinaison d'anticorps anti-cd303 et anti-amhrii |
| FR3060395B1 (fr) | 2016-12-16 | 2019-05-24 | Laboratoire Francais Du Fractionnement Et Des Biotechnologies | Combinaison d'anticorps anti-cd303 et anti-her2 |
| FR3076294B1 (fr) | 2017-12-29 | 2022-01-28 | Lab Francais Du Fractionnement | Procede de purification d'anticorps a partir de lait brut |
| CA3223956A1 (fr) | 2021-12-20 | 2023-06-29 | Vetoquinol Sa | Anticorps anti-recepteur a de l'interleukine-31 canin (il-31ra) et leurs utilisations |
| WO2024165823A2 (fr) | 2023-02-09 | 2024-08-15 | Commissariat A L'energie Atomique Et Aux Energies Alternatives | Fragment fab mutant pour l'obtention de conjugués mono- ou bi-fonctionnalisés site-spécifiques |
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| DK580789D0 (da) * | 1989-11-20 | 1989-11-20 | Novo Nordisk As | Fremgangsmaade til oprensning af polypeptider |
| US5639940A (en) * | 1994-03-03 | 1997-06-17 | Pharmaceutical Proteins Ltd. | Production of fibrinogen in transgenic animals |
| CN1114357A (zh) * | 1994-07-01 | 1996-01-03 | 唐勇炜 | 利用转基因动物生产重组多肽 |
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2000
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- 2000-10-16 BR BR0014860-1A patent/BR0014860A/pt not_active Application Discontinuation
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- 2000-10-16 WO PCT/US2000/028589 patent/WO2001026455A1/fr active IP Right Grant
- 2000-10-16 EP EP00970945A patent/EP1220606A4/fr not_active Withdrawn
- 2000-10-16 CA CA002382741A patent/CA2382741A1/fr not_active Abandoned
- 2000-10-16 RU RU2002112460/13A patent/RU2002112460A/ru unknown
- 2000-10-16 KR KR1020027004804A patent/KR100772465B1/ko not_active IP Right Cessation
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- 2000-10-16 AU AU80254/00A patent/AU781944B2/en not_active Ceased
- 2000-10-16 HU HU0203537A patent/HUP0203537A2/hu unknown
- 2000-10-16 CN CNB008152802A patent/CN1322003C/zh not_active Expired - Fee Related
- 2000-10-16 MX MXPA02003702A patent/MXPA02003702A/es not_active Application Discontinuation
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2002
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Also Published As
| Publication number | Publication date |
|---|---|
| JP2003511048A (ja) | 2003-03-25 |
| AU8025400A (en) | 2001-04-23 |
| IL149003A0 (en) | 2002-11-10 |
| EP1220606A4 (fr) | 2004-04-14 |
| KR100772465B1 (ko) | 2007-11-02 |
| RU2002112460A (ru) | 2004-02-27 |
| CN1387399A (zh) | 2002-12-25 |
| HUP0203537A2 (hu) | 2003-02-28 |
| EP1220606A1 (fr) | 2002-07-10 |
| KR20030022759A (ko) | 2003-03-17 |
| BR0014860A (pt) | 2003-07-08 |
| NO20021686D0 (no) | 2002-04-10 |
| CN1322003C (zh) | 2007-06-20 |
| WO2001026455A1 (fr) | 2001-04-19 |
| NO20021686L (no) | 2002-06-12 |
| MXPA02003702A (es) | 2002-09-18 |
| CA2382741A1 (fr) | 2001-04-19 |
| NZ518263A (en) | 2004-03-26 |
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