RU2002109595A - Амфифильные пролекарства - Google Patents
Амфифильные пролекарства Download PDFInfo
- Publication number
- RU2002109595A RU2002109595A RU2002109595/14A RU2002109595A RU2002109595A RU 2002109595 A RU2002109595 A RU 2002109595A RU 2002109595/14 A RU2002109595/14 A RU 2002109595/14A RU 2002109595 A RU2002109595 A RU 2002109595A RU 2002109595 A RU2002109595 A RU 2002109595A
- Authority
- RU
- Russia
- Prior art keywords
- prodrug
- therapeutic compound
- etoposide
- oligomers
- peg
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15364999P | 1999-09-13 | 1999-09-13 | |
| US60/153,649 | 1999-09-13 | ||
| US09/474,915 US6713454B1 (en) | 1999-09-13 | 1999-12-31 | Prodrugs of etoposide and etoposide analogs |
| US09/474,915 | 1999-12-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2002109595A true RU2002109595A (ru) | 2003-11-27 |
Family
ID=26850733
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2002109595/14A RU2002109595A (ru) | 1999-09-13 | 2000-09-07 | Амфифильные пролекарства |
Country Status (17)
Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6703381B1 (en) * | 1998-08-14 | 2004-03-09 | Nobex Corporation | Methods for delivery therapeutic compounds across the blood-brain barrier |
| US6541508B2 (en) | 1999-09-13 | 2003-04-01 | Nobex Corporation | Taxane prodrugs |
| US6380405B1 (en) | 1999-09-13 | 2002-04-30 | Nobex Corporation | Taxane prodrugs |
| US6713454B1 (en) * | 1999-09-13 | 2004-03-30 | Nobex Corporation | Prodrugs of etoposide and etoposide analogs |
| CA2385533C (en) | 1999-10-04 | 2008-03-25 | Shearwater Corporation | Polymer stabilized neuropeptides |
| EP1274460A4 (en) * | 2000-04-15 | 2005-06-29 | Kolon Inc | Aqueous PRODRUG COMPOUND WITH A PART OF PACLITAXEL OR ITS DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEREOF |
| WO2003082876A1 (en) * | 2002-03-28 | 2003-10-09 | Council Of Scientific And Industrial Research | 4-beta-1''-`(2''-(substituted benzoyl)anilino! podophyllotoxin analogues useful as anticancer agents |
| US7632866B2 (en) | 2002-10-21 | 2009-12-15 | Ramot At Tel Aviv University | Derivatives of N-phenylanthranilic acid and 2-benzimidazolone as potassium channel and/or neuron activity modulators |
| JP2006513154A (ja) * | 2002-10-21 | 2006-04-20 | ラモト アット テル アヴィヴ ユニヴァーシティ リミテッド | カリウムチャネルおよび／または皮質ニューロン活性モジュレーターとしての、ｎ−フェニルアントラニル酸および２−ベンズイミダゾロンの誘導体 |
| SG159387A1 (en) * | 2002-11-26 | 2010-03-30 | Biocon Ltd In | Modified natriuretic compounds, conjugates, and uses thereof |
| US7648962B2 (en) * | 2002-11-26 | 2010-01-19 | Biocon Limited | Natriuretic compounds, conjugates, and uses thereof |
| CN102775472A (zh) * | 2003-01-06 | 2012-11-14 | 安吉奥开米公司 | 作为穿过血脑屏障的载体的抑酶肽及类似物 |
| US7140522B2 (en) * | 2003-06-26 | 2006-11-28 | Spencer Forrest, Inc. | Applicator for hair building solids |
| US20060182692A1 (en) | 2003-12-16 | 2006-08-17 | Fishburn C S | Chemically modified small molecules |
| US7786133B2 (en) * | 2003-12-16 | 2010-08-31 | Nektar Therapeutics | Chemically modified small molecules |
| NZ548195A (en) * | 2004-01-14 | 2011-01-28 | Gilead Sciences Inc | Lipid-based dispersions useful for drug delivery |
| US8329958B2 (en) | 2004-07-02 | 2012-12-11 | Biocon Limited | Combinatorial synthesis of PEG oligomer libraries |
| EP1792927B1 (en) * | 2004-09-22 | 2013-03-06 | Nippon Kayaku Kabushiki Kaisha | Novel block copolymer, micelle preparation, and anticancer agent containing the same as active ingredient |
| WO2006076471A2 (en) * | 2005-01-12 | 2006-07-20 | Nobex Corporation | Bnp conjugates and methods of use |
| ES2383901T5 (es) * | 2005-02-18 | 2015-02-25 | Angiochem Inc. | Polipéptidos de aprotinina para transportar un compuesto a través de la barrera sangre-cerebro |
| US20090016959A1 (en) * | 2005-02-18 | 2009-01-15 | Richard Beliveau | Delivery of antibodies to the central nervous system |
| PL2233156T3 (pl) | 2005-07-15 | 2013-09-30 | Angiochem Inc | Zastosowanie polipeptydów aprotyninowych jako nośników w koniugatach farmaceutycznych |
| JP5173199B2 (ja) * | 2006-01-16 | 2013-03-27 | 株式会社アイ・ティー・オー | 創傷治癒用高分子組成物 |
| US8323669B2 (en) | 2006-03-28 | 2012-12-04 | Nippon Kayaku Kabushiki Kaisha | Polymer conjugate of taxane |
| WO2007135910A1 (ja) * | 2006-05-18 | 2007-11-29 | Nippon Kayaku Kabushiki Kaisha | ポドフィロトキシン類の高分子結合体 |
| US20090239782A1 (en) * | 2006-10-03 | 2009-09-24 | Masaharu Nakamura | High-molecular weight conjugate of resorcinol derivatives |
| JP5503872B2 (ja) | 2006-11-06 | 2014-05-28 | 日本化薬株式会社 | 核酸系代謝拮抗剤の高分子誘導体 |
| WO2008056654A1 (en) | 2006-11-08 | 2008-05-15 | Nippon Kayaku Kabushiki Kaisha | Polymeric derivative of nucleic acid metabolic antagonist |
| US9365634B2 (en) * | 2007-05-29 | 2016-06-14 | Angiochem Inc. | Aprotinin-like polypeptides for delivering agents conjugated thereto to tissues |
| WO2009037707A2 (en) | 2007-09-20 | 2009-03-26 | Ramot At Tel Aviv University Ltd. | N-phenyl anthranilic acid derivatives and uses thereof |
| US8703878B2 (en) * | 2007-09-28 | 2014-04-22 | Nippon Kayaku Kabushiki Kaisha | High-molecular weight conjugate of steroids |
| US8920788B2 (en) * | 2008-03-18 | 2014-12-30 | Nippon Kayaku Kabushiki Kaisha | High-molecular weight conjugate of physiologically active substances |
| ES2721148T3 (es) * | 2008-04-18 | 2019-07-29 | Angiochem Inc | Composiciones farmacéuticas de paclitaxel, análogos de paclitaxel o conjugados de paclitaxel y métodos relacionados de preparación y uso |
| US9149540B2 (en) | 2008-05-08 | 2015-10-06 | Nippon Kayaku Kabushiki Kaisha | Polymer conjugate of folic acid or folic acid derivative |
| EP2317994A4 (en) * | 2008-07-23 | 2012-09-12 | Massachusetts Inst Technology | ACTIVATION OF HISTONE DEACETYLASE 1 (HDAC1) PROTECTS DNA DAMAGE AND INCREASES NEURONAL SURVIVAL |
| EP2346906A4 (en) | 2008-10-15 | 2013-04-24 | Angiochem Inc | CONJUGATES FROM GLP-1 AGONISTS AND THEIR USE |
| EP2346896A4 (en) | 2008-10-15 | 2014-06-25 | Angiochem Inc | CONJUGATES OF ETOPOSIDE AND DOXORUBICIN FOR THE ADMINISTRATION OF MEDICAMENTS |
| BRPI0922689A2 (pt) * | 2008-12-05 | 2018-11-06 | Angiochem Inc. | conjugados de neurotensina ou análogos de neurotensina e usos dos mesmos |
| JP2012512185A (ja) | 2008-12-17 | 2012-05-31 | アンジオケム インコーポレーテッド | 膜１型マトリックス金属タンパク質阻害剤およびその使用 |
| JP2012524030A (ja) | 2009-04-20 | 2012-10-11 | アンジオケム インコーポレーテッド | Ａｎｇｉｏｐｅｐ−２アナログにコンジュゲート化した抗癌剤を用いた卵巣癌の治療 |
| US8808749B2 (en) | 2009-05-15 | 2014-08-19 | Nippon Kayaku Kabushiki Kaisha | Polymer conjugate of bioactive substance having hydroxy group |
| BRPI1015918A2 (pt) | 2009-07-02 | 2019-09-24 | Angiochem Inc | conjugados de peptídeo multiméricos e usos dos mesmos |
| CA2779497A1 (en) | 2009-10-30 | 2011-05-05 | Massachusetts Institute Of Technology | The use of ci-994 and dinaline for the treatment of memory/cognition and anxiety disorders |
| EP2525831B1 (en) * | 2010-01-22 | 2019-05-15 | Ascendis Pharma A/S | Carrier-linked carbamate prodrug linkers |
| SA111320200B1 (ar) | 2010-02-17 | 2014-02-16 | ديبيوفارم اس ايه | مركبات ثنائية الحلقة واستخداماتها كمثبطات c-src/jak مزدوجة |
| WO2011141891A1 (en) | 2010-05-12 | 2011-11-17 | Debio Recherche Pharmaceutique S.A. | Use of cycloundecadepsipeptide compounds |
| EP2624869A4 (en) * | 2010-10-08 | 2015-11-04 | Univ Virginia Commonwealth | PRODRUGS USING A CONTAINER CONTROLLED ABSORPTION MECHANISM |
| CN103221054A (zh) | 2010-11-17 | 2013-07-24 | 日本化药株式会社 | 新的胞苷类代谢拮抗剂的高分子衍生物 |
| CA2834548C (en) | 2011-04-28 | 2021-06-01 | The Broad Institute, Inc. | Inhibitors of histone deacetylase |
| EP2734510B8 (en) | 2011-07-22 | 2019-05-29 | Massachusetts Institute of Technology | Activators of class i histone deacetylases (hdacs) and uses thereof |
| PT2754682T (pt) | 2011-09-11 | 2017-08-29 | Nippon Kayaku Kk | Método para o fabrico de copolímero de bloco |
| US8993614B2 (en) | 2012-03-15 | 2015-03-31 | F. Hoffmann-La Roche Ag | Substituted pyrrolidine-2-carboxamides |
| CA2873984A1 (en) | 2012-05-23 | 2013-11-28 | Stemergie Biotechnology Sa | Inhibitors of the activity of complex (iii) of the mitochondrial electron transport chain and use thereof |
| US9914717B2 (en) | 2012-12-20 | 2018-03-13 | The Broad Institute, Inc. | Cycloalkenyl hydroxamic acid derivatives and their use as histone deacetylase inhibitors |
| US10980892B2 (en) | 2015-06-15 | 2021-04-20 | Angiochem Inc. | Methods for the treatment of leptomeningeal carcinomatosis |
| US20170007618A1 (en) | 2015-06-17 | 2017-01-12 | Massachusetts Institute Of Technology | Serotonin 2c receptor antagonists to prevent and treat stress-related trauma disorders |
| AU2018331278A1 (en) | 2017-09-18 | 2020-03-26 | Massachusetts Institute Of Technology | Cyclin-dependent kinase 5 (CDK5) inhibitory peptides |
| CN112266409B (zh) * | 2020-10-28 | 2022-05-13 | 南开大学 | 依托泊苷自组装纳米纤维多肽、制备方法及应用 |
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| US6380405B1 (en) * | 1999-09-13 | 2002-04-30 | Nobex Corporation | Taxane prodrugs |
| US6713454B1 (en) | 1999-09-13 | 2004-03-30 | Nobex Corporation | Prodrugs of etoposide and etoposide analogs |
-
1999
- 1999-12-31 US US09/474,915 patent/US6713454B1/en not_active Expired - Fee Related
-
2000
- 2000-09-07 CA CA002384645A patent/CA2384645A1/en not_active Abandoned
- 2000-09-07 KR KR1020027003276A patent/KR20020059398A/ko not_active Application Discontinuation
- 2000-09-07 RU RU2002109595/14A patent/RU2002109595A/ru not_active Application Discontinuation
- 2000-09-07 EP EP00964949A patent/EP1212099A2/en not_active Withdrawn
- 2000-09-07 BR BR0013948-3A patent/BR0013948A/pt not_active IP Right Cessation
- 2000-09-07 NZ NZ517681A patent/NZ517681A/en unknown
- 2000-09-07 MX MXPA02002712A patent/MXPA02002712A/es unknown
- 2000-09-07 CZ CZ2002928A patent/CZ2002928A3/cs unknown
- 2000-09-07 WO PCT/US2000/024520 patent/WO2001019406A2/en not_active Application Discontinuation
- 2000-09-07 CN CN00815508A patent/CN1390143A/zh active Pending
- 2000-09-07 IL IL14855800A patent/IL148558A0/xx unknown
- 2000-09-07 PL PL00354261A patent/PL354261A1/xx not_active Application Discontinuation
- 2000-09-07 AU AU75756/00A patent/AU7575600A/en not_active Abandoned
- 2000-09-07 JP JP2001523037A patent/JP2003509385A/ja active Pending
- 2000-09-07 HU HU0204110A patent/HUP0204110A3/hu unknown
-
2002
- 2002-03-12 NO NO20021213A patent/NO20021213L/no not_active Application Discontinuation
-
2004
- 2004-03-24 US US10/808,044 patent/US7119074B2/en not_active Expired - Fee Related
- 2004-03-29 US US10/811,760 patent/US20040253206A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| IL148558A0 (en) | 2002-09-12 |
| AU7575600A (en) | 2001-04-17 |
| US6713454B1 (en) | 2004-03-30 |
| US20040253206A1 (en) | 2004-12-16 |
| PL354261A1 (en) | 2003-12-29 |
| WO2001019406A3 (en) | 2002-01-17 |
| NO20021213L (no) | 2002-05-13 |
| CZ2002928A3 (cs) | 2002-09-11 |
| MXPA02002712A (es) | 2003-10-14 |
| US20040180840A1 (en) | 2004-09-16 |
| CN1390143A (zh) | 2003-01-08 |
| NO20021213D0 (no) | 2002-03-12 |
| BR0013948A (pt) | 2002-05-14 |
| EP1212099A2 (en) | 2002-06-12 |
| CA2384645A1 (en) | 2001-03-22 |
| HUP0204110A2 (hu) | 2003-04-28 |
| HUP0204110A3 (en) | 2003-08-28 |
| KR20020059398A (ko) | 2002-07-12 |
| NZ517681A (en) | 2004-01-30 |
| US7119074B2 (en) | 2006-10-10 |
| JP2003509385A (ja) | 2003-03-11 |
| WO2001019406A2 (en) | 2001-03-22 |
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