RS57901B1 - Soli inhibitora kinaze receptora epidermalnog faktora rasta - Google Patents

Soli inhibitora kinaze receptora epidermalnog faktora rasta

Info

Publication number
RS57901B1
RS57901B1 RS20181300A RSP20181300A RS57901B1 RS 57901 B1 RS57901 B1 RS 57901B1 RS 20181300 A RS20181300 A RS 20181300A RS P20181300 A RSP20181300 A RS P20181300A RS 57901 B1 RS57901 B1 RS 57901B1
Authority
RS
Serbia
Prior art keywords
salts
lever
growth factor
kinase inhibitor
factor receptor
Prior art date
Application number
RS20181300A
Other languages
English (en)
Inventor
Mei Lai
Steven Richard Witowski
Richland Wayne Tester
Kwangho Lee
Original Assignee
Celgene Car Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Celgene Car Llc filed Critical Celgene Car Llc
Publication of RS57901B1 publication Critical patent/RS57901B1/sr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
    • C07C309/03—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C309/04—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing only one sulfo group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
    • C07C309/03—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C309/05—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing at least two sulfo groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/25—Sulfonic acids having sulfo groups bound to carbon atoms of rings other than six-membered aromatic rings of a carbon skeleton
    • C07C309/27—Sulfonic acids having sulfo groups bound to carbon atoms of rings other than six-membered aromatic rings of a carbon skeleton containing carboxyl groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/29—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/29—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings
    • C07C309/30—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings of six-membered aromatic rings substituted by alkyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/33—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of six-membered aromatic rings being part of condensed ring systems
    • C07C309/34—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of six-membered aromatic rings being part of condensed ring systems formed by two rings
    • C07C309/35—Naphthalene sulfonic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C55/00—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms
    • C07C55/02—Dicarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C55/00—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms
    • C07C55/02—Dicarboxylic acids
    • C07C55/06—Oxalic acid
    • C07C55/07—Salts thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C62/02—Saturated compounds containing hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Air-Conditioning For Vehicles (AREA)
  • Electric Connection Of Electric Components To Printed Circuits (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Description

1. Oblast tehnike na koju se pronalazak odnosi
Predmetni pronalazak pripada oblasti elektrotehnike t.j. osnovnim električnim elementima a konkretno se odnosina električne prekidače koji se pokreću ugaonim pomeranjem aktivirajućeg dela čija je oznaka prema međunarodnoj klasifikaciji patenata (MRP) ^MS=H9Ž(Sr.
2. Tehnički problem
Tehnički problem koji se rešava predmetnim pronalaskom je kako konstrukciono resiti prekidač koji će ugaonim pomeranjem aičice omogućiti regulisanje grejanja ili hlađenja u vozačkom prostoru.
3. Stanje tehnike
Prekidač za floridu sa ugaonim pomeranjem ručice je od štancovanih t.j presovanih limenih bakarnih provodnika koje je vrlo teško tačno pozicionirati kako bi prekidač imao zadovoljvajuću funkciju
Takođe konektovanje se ne obavlja na prekidaču, već svaki od limenih provodnika je zavaren t j zalemljen za kablove koji su ustopljeni u spojnicu t.j. konektor.
4. Suština pronalaska
Pronalazak je nova konstrukcija sa štampanim kolima. Štampana kola su zamenile postojeće pločaste bakarne provodnike koji su se pokazali nepouzdani
Pronalazak, se sastoji od štampanih kola po kojima klizi pokretni kontakt, koji se nalazi na ručici Ručica se fiksira na svakih 15°, sa okretanjem za 15° aičica zauzima novi položaj a sa tim se dobija druga brzina za ubrizgavanje vazduha. j
Ovo je predstavljeno u nacrtu na slici 1, slici 2
5. Kratak opis slika nacrta
Slika 1- prikazuje presek A-A sa slike 2
Slika 2 - prikazuje prekidač ventilatora grejača, pogled odozgo
6. Detaljni opis pronalaska
Ručica 1 pronalaska kreće se levo i desno za ukupni ugao od 60 stepeni Pomoću ručice 1 pomeranjem desno menjaju se brzine ubrizgavanja vazduha u vozačkom prostoru. Ručica 1 preko pokretnog kontakta 3 sa oprugom 7 klizi po štampanim kolima 4 t.j. štampanoj ploči'i uspostavlja se električno kolo za odgovarajuću brzinu.
Na određenoj brzini ručica 1 je ubravljena u posebno gnezdo 8, opruga 6 naleže na bravicu 5 koja upada u odgovarajuća gnezda što omogućava ručical da zauzme odgovarajući položaj koji omogućava određenu brzinu ubrizgavanje vazduha. Svakim okretanjem ručice 1 za 15° uspostavljamo sledeću brzinu za ubrizgavanje vazduha tako što pokretni kontakt 3 spaja masu sa napajanjem preko odgovarajućeg štampanog kola na ploči 4 Opruga 7 naleže na pokretni kontakt3 i uspostavlja bolji kontakt sa štampanim kolima 4 kada se ručica pomeri za 15°
Najveća brzina ubrizgavanja vazduha je u zadnjem položaju ručice 1 gde pokretni kontakt 4 premosti štampana kola preko elektro instalacije direktno za motor ventilatora grejača. Konektovanje sa električnom instalacijomjvrši se bravljenjem na ispustu 9 od kućišta 2 preko standardnih konektora, a povezano sa štampanim kolima 4. Štampana kola je dvostruko kasirana sa metaliziranim rupama za povezivanje gornjih štampanih kola sa donjim da bi se zadovoljila strujna opterećenja.

Claims (1)

  1. Prekidač ventilatora grejača naznačen time da štampana kola na ploči(4) omogućavaju odgovarajuća električna kola na relaciji motor ventilatora grejača i prekidača ventilatora grejača pomoću ručice (1) koja pomeranjem za oko 15 stepeni povećava brzinu ubrizgavania vazduha, ručica (1) se pomoću opruge (6) i bravice (5) ubravljuje u odgovarajuću lokaciju gnezda (8) i tako uspostavlja odgovarajuće brzine, na ovaj način i pokretni kontakt (3) preko opruge(7jnaleže na štampana kola;'4)i uspostavlja električno kolo za odgovarajuće brzine, pokretni kontakt (3) je konstruisan da može da poveže masu sa napajanjem u vozilu preko konektora iz instalacije koji je zabravljen na ispustu (9) od kućišta (2).
RS20181300A 2012-03-15 2013-03-13 Soli inhibitora kinaze receptora epidermalnog faktora rasta RS57901B1 (sr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261611400P 2012-03-15 2012-03-15
EP13761487.1A EP2825042B1 (en) 2012-03-15 2013-03-13 Salts of an epidermal growth factor receptor kinase inhibitor
PCT/US2013/030996 WO2013138502A1 (en) 2012-03-15 2013-03-13 Salts of an epidermal growth factor receptor kinase inhibitor

Publications (1)

Publication Number Publication Date
RS57901B1 true RS57901B1 (sr) 2019-01-31

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US (5) US9108927B2 (sr)
EP (1) EP2825042B1 (sr)
JP (2) JP6317320B2 (sr)
KR (1) KR102090453B1 (sr)
CN (2) CN104284584B (sr)
AR (1) AR090357A1 (sr)
AU (3) AU2013201519C1 (sr)
BR (1) BR112014022790B1 (sr)
CA (1) CA2866857C (sr)
CY (1) CY1122176T1 (sr)
DK (1) DK2825042T3 (sr)
ES (1) ES2698298T3 (sr)
HR (1) HRP20181784T1 (sr)
IL (1) IL234426B (sr)
LT (1) LT2825042T (sr)
MX (1) MX356179B (sr)
MY (1) MY185243A (sr)
PH (1) PH12014502037B1 (sr)
PL (1) PL2825042T3 (sr)
PT (1) PT2825042T (sr)
RS (1) RS57901B1 (sr)
RU (1) RU2711077C9 (sr)
SG (2) SG11201405692UA (sr)
SI (1) SI2825042T1 (sr)
SM (1) SMT201800571T1 (sr)
TR (1) TR201816244T4 (sr)
TW (1) TWI591060B (sr)
WO (1) WO2013138502A1 (sr)

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