RS54030B1 - Derivati piperidinona kao inhibitori mdm2 za lečenje kancera - Google Patents

Derivati piperidinona kao inhibitori mdm2 za lečenje kancera

Info

Publication number
RS54030B1
RS54030B1 RS20150364A RSP20150364A RS54030B1 RS 54030 B1 RS54030 B1 RS 54030B1 RS 20150364 A RS20150364 A RS 20150364A RS P20150364 A RSP20150364 A RS P20150364A RS 54030 B1 RS54030 B1 RS 54030B1
Authority
RS
Serbia
Prior art keywords
chlorophenyl
mmol
solution
methyl
reference example
Prior art date
Application number
RS20150364A
Other languages
English (en)
Serbian (sr)
Inventor
Michael David Bartberger
Ana Gonzalez Buenrostro
Hilary Plake Beck
Xiaoqi Chen
Richard Victor Connors
Jeffrey Deignan
Jason Duquette
John Eksterowicz
Benjamin Fisher
Brian Matthew Fox
Jiasheng Fu
Zice Fu
Felix Gonzalez Lopez De Turiso
Michael William Gribble Jr.
Darin James Gustin
Julie Anne Heath
Xin Huang
Xianyun Jiao
Michael Johnson
Frank Kayser
David John Kopecky
Sujen Lai
Yihong Li
Zhihong Li
Jiwen Liu
Jonathan Dante Low
Brian Stuart Lucas
Zhihua Ma
Lawrence Mcgee
Joel Mcintosh
Dustin Mcminn
Julio Cesar Medina
Jeffrey Thomas Mihalic
Steven Howard Olson
Yosup Rew
Philip Marley Roveto
Daqing Sun
Xiaodong Wang
Yingcai Wang
Xuelei Yan
Ming Yu
Jiang Zhu
Original Assignee
Amgen Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44504412&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=RS54030(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Amgen Inc. filed Critical Amgen Inc.
Publication of RS54030B1 publication Critical patent/RS54030B1/sr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D211/74—Oxygen atoms
    • C07D211/76—Oxygen atoms attached in position 2 or 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/45—Non condensed piperidines, e.g. piperocaine having oxo groups directly attached to the heterocyclic ring, e.g. cycloheximide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
    • A—HUMAN NECESSITIES
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/20—Spiro-condensed ring systems
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SG186147A1 (en) 2013-01-30
CN105153014A (zh) 2015-12-16
IL223201A0 (en) 2013-02-03
RS65141B1 (sr) 2024-02-29
SMT201900099T1 (it) 2019-02-28
NZ604074A (en) 2014-11-28
TN2012000559A1 (en) 2014-04-01
CL2012003415A1 (es) 2013-08-09
ZA201400948B (en) 2015-06-24
ME03322B (me) 2019-10-20
PT2576510E (pt) 2015-07-01
MX343587B (es) 2016-11-10
PH12012502410A1 (en) 2013-02-18
PL2576510T3 (pl) 2015-10-30
MX337178B (es) 2016-02-15
JO2998B1 (ar) 2016-09-05
CO6710897A2 (es) 2013-07-15
DK2927213T3 (en) 2019-03-11
PE20130229A1 (es) 2013-03-22
HK1186462A1 (en) 2014-03-14
CN103180296A (zh) 2013-06-26
HRP20190273T1 (hr) 2019-04-05
HK1182711A1 (en) 2013-12-06
KR20210068144A (ko) 2021-06-08
ME02150B (me) 2015-10-20
UY39338A (es) 2021-08-31
PH12016501048A1 (en) 2017-05-29
US9296736B2 (en) 2016-03-29
AR082763A1 (es) 2013-01-09
SI2927213T1 (sl) 2019-04-30
KR20140032929A (ko) 2014-03-17
HUE041488T2 (hu) 2019-05-28
CY1121265T1 (el) 2020-05-29
CA3157177C (en) 2023-11-07
HRP20240055T1 (hr) 2024-03-29
DK2576510T3 (en) 2015-06-29
US8569341B2 (en) 2013-10-29
EA023004B1 (ru) 2016-04-29
EP2927213A1 (en) 2015-10-07
US20220169611A1 (en) 2022-06-02
KR20180059574A (ko) 2018-06-04
BR112012030923B1 (pt) 2021-12-28
SG10201604817QA (en) 2016-08-30
TW201211020A (en) 2012-03-16
MY202394A (en) 2024-04-25
AU2011261263A1 (en) 2012-12-13
TWI519519B (zh) 2016-02-01
KR20250044461A (ko) 2025-03-31
MA34342B1 (fr) 2013-06-01
IL295076A (en) 2022-09-01
JP6077695B2 (ja) 2017-02-08
UY33430A (es) 2011-12-30
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HK1215707A1 (en) 2016-09-09
WO2011153509A1 (en) 2011-12-08
US20190062276A1 (en) 2019-02-28
CL2016001733A1 (es) 2017-05-12
EP3483143A8 (en) 2020-04-15
CA3207676A1 (en) 2011-12-08
TWI433844B (zh) 2014-04-11
IL233411A0 (en) 2014-08-31
PT2927213T (pt) 2019-02-21
US20110319378A1 (en) 2011-12-29
PT3483143T (pt) 2024-01-23
TW201434816A (zh) 2014-09-16
IL233411A (en) 2017-08-31
BR112012030923B8 (pt) 2022-01-25
EP2576510A1 (en) 2013-04-10
IL277579A (en) 2020-11-30
KR20220083817A (ko) 2022-06-20
IL317703A (en) 2025-02-01
RS58366B1 (sr) 2019-03-29
UA110481C2 (en) 2016-01-12
JP2013530958A (ja) 2013-08-01
EP2927213B1 (en) 2018-11-14
SI2576510T1 (sl) 2015-06-30
AU2011261263B2 (en) 2013-11-21
CN105153014B (zh) 2021-06-01
IL277579B (en) 2022-09-01
SMT202400024T1 (it) 2024-03-13
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KR20190058694A (ko) 2019-05-29
BR122020013151B1 (pt) 2022-02-22
SG10202006923RA (en) 2020-08-28
DK3483143T3 (da) 2024-01-15
MX2012014044A (es) 2013-05-22
CN103180296B (zh) 2015-05-27
LT2927213T (lt) 2019-04-25
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KR101863407B1 (ko) 2018-06-29
CA2799972A1 (en) 2011-12-08
SI3483143T1 (sl) 2024-03-29
NZ627385A (en) 2016-02-26
TWI582076B (zh) 2017-05-11
EP4092012A1 (en) 2022-11-23
IL246296A0 (en) 2016-07-31
IL223201A (en) 2015-05-31
PL3483143T3 (pl) 2024-03-25
ES2540992T3 (es) 2015-07-15
US20160137667A1 (en) 2016-05-19
ES2717306T3 (es) 2019-06-20
US20210179560A1 (en) 2021-06-17
SG10202112488SA (en) 2021-12-30
US9593129B2 (en) 2017-03-14
IL265278A (en) 2019-05-30
JP2014062093A (ja) 2014-04-10
JP2016147891A (ja) 2016-08-18
EP3483143B1 (en) 2023-10-18
IL265278B (en) 2021-01-31
EA201291356A1 (ru) 2013-06-28
CA3060703C (en) 2022-08-02
US20140011796A1 (en) 2014-01-09
KR20140091009A (ko) 2014-07-18
JP5420797B2 (ja) 2014-02-19
CA2799972C (en) 2020-08-25
CA3157177A1 (en) 2011-12-08
KR101456801B1 (ko) 2014-10-31
KR20200063255A (ko) 2020-06-04
US20140315895A1 (en) 2014-10-23
BR112012030923A2 (pt) 2016-11-08
PL2927213T3 (pl) 2019-06-28
AU2011261263C1 (en) 2014-05-29
FI3483143T3 (fi) 2024-01-15
KR20230156431A (ko) 2023-11-14
IL295076B1 (en) 2025-01-01
CA3060703A1 (en) 2011-12-08
US20240300892A1 (en) 2024-09-12
HRP20150704T1 (hr) 2015-08-14
SMT201500168B (it) 2015-09-07
IL295076B2 (en) 2025-05-01
ES2971445T3 (es) 2024-06-05
LT3483143T (lt) 2024-02-12
US20170144971A1 (en) 2017-05-25
CR20120659A (es) 2013-03-11

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