RS50165B - Primena rar selektivnih retinoid antagonista za proizvodnju leka za tretiranje emfizema - Google Patents

Primena rar selektivnih retinoid antagonista za proizvodnju leka za tretiranje emfizema

Info

Publication number
RS50165B
RS50165B YUP-290/02A YUP29002A RS50165B RS 50165 B RS50165 B RS 50165B YU P29002 A YUP29002 A YU P29002A RS 50165 B RS50165 B RS 50165B
Authority
RS
Serbia
Prior art keywords
alkyl
carbons
hydrogen
group
formula
Prior art date
Application number
YUP-290/02A
Other languages
English (en)
Serbian (sr)
Inventor
Paula Nanette Belloni
Michael Klaus
Original Assignee
F. Hoffmann-La Roche Ag.,
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F. Hoffmann-La Roche Ag., filed Critical F. Hoffmann-La Roche Ag.,
Publication of YU29002A publication Critical patent/YU29002A/sh
Publication of RS50165B publication Critical patent/RS50165B/sr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A61K31/355—Tocopherols, e.g. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Pulmonology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
YUP-290/02A 1999-10-19 2000-10-13 Primena rar selektivnih retinoid antagonista za proizvodnju leka za tretiranje emfizema RS50165B (sr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US16041599P 1999-10-19 1999-10-19

Publications (2)

Publication Number Publication Date
YU29002A YU29002A (sh) 2005-06-10
RS50165B true RS50165B (sr) 2009-05-06

Family

ID=22576814

Family Applications (1)

Application Number Title Priority Date Filing Date
YUP-290/02A RS50165B (sr) 1999-10-19 2000-10-13 Primena rar selektivnih retinoid antagonista za proizvodnju leka za tretiranje emfizema

Country Status (33)

Country Link
US (1) US6300350B1 (cg-RX-API-DMAC10.html)
EP (1) EP1225878B1 (cg-RX-API-DMAC10.html)
JP (2) JP4074458B2 (cg-RX-API-DMAC10.html)
KR (1) KR100485581B1 (cg-RX-API-DMAC10.html)
CN (1) CN1201730C (cg-RX-API-DMAC10.html)
AR (1) AR029648A1 (cg-RX-API-DMAC10.html)
AT (1) ATE344661T1 (cg-RX-API-DMAC10.html)
AU (1) AU777325B2 (cg-RX-API-DMAC10.html)
BR (1) BR0015225A (cg-RX-API-DMAC10.html)
CA (1) CA2387844C (cg-RX-API-DMAC10.html)
CY (1) CY1105941T1 (cg-RX-API-DMAC10.html)
CZ (1) CZ20021657A3 (cg-RX-API-DMAC10.html)
DE (1) DE60031790T2 (cg-RX-API-DMAC10.html)
DK (1) DK1225878T3 (cg-RX-API-DMAC10.html)
ES (1) ES2274810T3 (cg-RX-API-DMAC10.html)
HR (1) HRP20020329A2 (cg-RX-API-DMAC10.html)
HU (1) HUP0203295A3 (cg-RX-API-DMAC10.html)
IL (1) IL149151A0 (cg-RX-API-DMAC10.html)
JO (1) JO2178B1 (cg-RX-API-DMAC10.html)
MA (1) MA26835A1 (cg-RX-API-DMAC10.html)
MX (1) MXPA02003843A (cg-RX-API-DMAC10.html)
MY (1) MY129001A (cg-RX-API-DMAC10.html)
NO (1) NO328738B1 (cg-RX-API-DMAC10.html)
NZ (1) NZ518118A (cg-RX-API-DMAC10.html)
PE (1) PE20010678A1 (cg-RX-API-DMAC10.html)
PL (1) PL357499A1 (cg-RX-API-DMAC10.html)
PT (1) PT1225878E (cg-RX-API-DMAC10.html)
RS (1) RS50165B (cg-RX-API-DMAC10.html)
RU (1) RU2257383C2 (cg-RX-API-DMAC10.html)
TR (1) TR200201071T2 (cg-RX-API-DMAC10.html)
TW (1) TWI288639B (cg-RX-API-DMAC10.html)
WO (1) WO2001030326A1 (cg-RX-API-DMAC10.html)
ZA (1) ZA200202576B (cg-RX-API-DMAC10.html)

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Publication number Priority date Publication date Assignee Title
WO2000061233A2 (en) * 1999-04-14 2000-10-19 Allergan Sales, Inc. Methods and compositions for the treatment and prevention of lung disease involving a specific rar-gamma agonist
BR0212583A (pt) * 2001-09-18 2004-10-13 Hoffmann La Roche Agonistas i para retinóides de alquil uréia
AU2002340886B2 (en) 2001-09-18 2008-01-31 F. Hoffmann-La Roche Ag Substituted urea retinoid agonists II
US6858615B2 (en) 2002-02-19 2005-02-22 Parion Sciences, Inc. Phenyl guanidine sodium channel blockers
US7745442B2 (en) 2003-08-20 2010-06-29 Parion Sciences, Inc. Methods of reducing risk of infection from pathogens
JP4926707B2 (ja) 2003-08-22 2012-05-09 ダニスコ エイ／エス 封入化抗菌材料
GB2388581A (en) 2003-08-22 2003-11-19 Danisco Coated aqueous beads
WO2008057930A2 (en) * 2006-11-02 2008-05-15 Aestus Therapeutics, Inc. Methods of treating neuropathic pain with retinoic acid receptor agonists
CN111773213B (zh) 2010-09-01 2023-02-24 托马斯杰弗逊大学 用于肌肉修复和再生的组合物和方法
CN111298120A (zh) 2011-06-24 2020-06-19 格里生物公司 炎性病症的预防和治疗
AR086745A1 (es) 2011-06-27 2014-01-22 Parion Sciences Inc 3,5-diamino-6-cloro-n-(n-(4-(4-(2-(hexil(2,3,4,5,6-pentahidroxihexil)amino)etoxi)fenil)butil)carbamimidoil)pirazina-2-carboxamida
US20140155381A1 (en) * 2011-07-29 2014-06-05 Erkan Baloglu Compounds and methods
HUE032891T2 (hu) 2012-12-17 2017-11-28 Parion Sciences Inc Klórpirazin-karboxamid-származékok nem kielégítõ nyálkahártya-hidratáció által elõsegített megbetegedések kezelésére
RU2671976C2 (ru) 2012-12-17 2018-11-08 Пэрион Сайенсиз, Инк. Соединения 3,5-диамино-6-хлор-n-(n-(4-фенилбутил)карбамимидоил)пиразин-2-карбоксамида
EP3044216B1 (en) 2013-08-20 2022-02-23 University of Washington through its Center for Commercialization Novel and specific inhibitors of cytochrome p450 26 retinoic acid hydroxylase
US10500232B2 (en) 2013-08-26 2019-12-10 The J. David Gladstone Ins., a testamentary trust established under the Will of J. David Gladstone Small molecule cellular reprogramming to generate neuronal cells
US9102633B2 (en) 2013-12-13 2015-08-11 Parion Sciences, Inc. Arylalkyl- and aryloxyalkyl-substituted epithelial sodium channel blocking compounds

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AU618590B2 (en) * 1988-04-11 1992-01-02 Allergan, Inc. Tetralin esters of phenols or benzoic acids having retinoid like activity
ATE256130T1 (de) * 1993-08-19 2003-12-15 Janssen Pharmaceutica Nv Gefässverengende dihydrobenzopyranderivate
CA2129773C (en) * 1993-09-02 2007-05-01 Michael Klaus Aromatic carboxylic acid derivatives
US5498795A (en) * 1994-12-29 1996-03-12 Allergan, Inc. Acetylenes disubstituted with hydroxyaryl and aryl or heteroaryl groups having retinoid-like biological activity
ES2138765T3 (es) * 1995-02-24 2000-01-16 Hoffmann La Roche Nuevos retinoides.
US5807900A (en) * 1995-03-31 1998-09-15 Hoffmann-La Roche, Inc. Method for identifying compounds having increased activity for the repair of skin photodamage
TW418186B (en) * 1995-06-05 2001-01-11 Bristol Myers Squibb Co Retinoid-like compounds
US5624957A (en) * 1995-06-06 1997-04-29 Bristol-Myers Squibb Company Rary-specific retinobenzoic acid derivatives
FR2739557B1 (fr) * 1995-10-09 1997-11-14 Cird Galderma Utilisation d'un ligand agoniste specifique rar-gamma
US5726191A (en) * 1995-11-16 1998-03-10 Hoffmann-La Roche Inc. Aromatic carboxylic acid esters
FR2747041B1 (fr) 1996-04-05 1998-05-22 Cird Galderma Utilisation de derives benzonaphtaleniques pour la fabrication de medicaments destines au traitement des neuropathies
BR9814957A (pt) * 1997-11-12 2000-10-03 Hoffmann La Roche Tratamento de doenças imune mediadas por célula auxiliar "t" tipo 2 com antagonistas retinóides
US6083973A (en) * 1998-03-09 2000-07-04 Syntex (U.S.A.) Inc. Methods for inhibiting mucin secretion using RAR α selective antagonists
WO2000061182A2 (en) 1999-04-14 2000-10-19 Allergan Sales, Inc. Methods and compositions for the treatment and prevention of lung disease involving a selective rar-alpha agonist
WO2000061232A2 (en) * 1999-04-14 2000-10-19 Allergan Sales, Inc. Methods and compositions for the treatment and prevention of lung disease involving a specific rar-beta antagonist
WO2000061233A2 (en) * 1999-04-14 2000-10-19 Allergan Sales, Inc. Methods and compositions for the treatment and prevention of lung disease involving a specific rar-gamma agonist
PT1206436E (pt) * 1999-08-02 2004-12-31 Hoffmann La Roche Retinoides para o tratamento de enfisema
US6479670B1 (en) * 1999-08-25 2002-11-12 Hoffmann-La Roche Inc. Selective retinoid acid receptor agonists

Also Published As

Publication number Publication date
WO2001030326A1 (en) 2001-05-03
EP1225878B1 (en) 2006-11-08
IL149151A0 (en) 2002-11-10
CA2387844A1 (en) 2001-05-03
ATE344661T1 (de) 2006-11-15
CN1382042A (zh) 2002-11-27
MXPA02003843A (es) 2002-09-30
PE20010678A1 (es) 2001-07-04
YU29002A (sh) 2005-06-10
DE60031790T2 (de) 2007-09-20
RU2257383C2 (ru) 2005-07-27
MA26835A1 (fr) 2004-12-20
JP4850791B2 (ja) 2012-01-11
TR200201071T2 (tr) 2002-08-21
NO20021823L (no) 2002-04-18
HRP20020329A2 (en) 2004-04-30
JO2178B1 (en) 2003-04-23
NO20021823D0 (no) 2002-04-18
ES2274810T3 (es) 2007-06-01
JP2007302689A (ja) 2007-11-22
NZ518118A (en) 2004-02-27
EP1225878A1 (en) 2002-07-31
AR029648A1 (es) 2003-07-10
PL357499A1 (pl) 2004-07-26
CN1201730C (zh) 2005-05-18
TWI288639B (en) 2007-10-21
JP4074458B2 (ja) 2008-04-09
MY129001A (en) 2007-03-30
HUP0203295A3 (en) 2003-04-28
BR0015225A (pt) 2002-07-16
AU1137401A (en) 2001-05-08
CA2387844C (en) 2009-04-14
KR100485581B1 (ko) 2005-04-27
JP2003512418A (ja) 2003-04-02
NO328738B1 (no) 2010-05-03
CY1105941T1 (el) 2011-04-06
HK1051002A1 (en) 2003-07-18
AU777325B2 (en) 2004-10-14
KR20020043640A (ko) 2002-06-10
DE60031790D1 (de) 2006-12-21
DK1225878T3 (da) 2007-03-05
HUP0203295A2 (hu) 2003-01-28
US6300350B1 (en) 2001-10-09
PT1225878E (pt) 2007-01-31
CZ20021657A3 (cs) 2002-10-16
ZA200202576B (en) 2003-09-23

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