RS14704A - Hyperbranched amylopectin for use in methods for surgical or therapeutic treatment of mammals or in diagnostic methods especially for use as a plasma volume expander - Google Patents
Hyperbranched amylopectin for use in methods for surgical or therapeutic treatment of mammals or in diagnostic methods especially for use as a plasma volume expanderInfo
- Publication number
- RS14704A RS14704A YUP-147/04A YUP14704A RS14704A RS 14704 A RS14704 A RS 14704A YU P14704 A YUP14704 A YU P14704A RS 14704 A RS14704 A RS 14704A
- Authority
- RS
- Serbia
- Prior art keywords
- amylopectin
- methods
- plasma volume
- surgical
- therapeutic treatment
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0026—Blood substitute; Oxygen transporting formulations; Plasma extender
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
- A01N1/0205—Chemical aspects
- A01N1/021—Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
- A01N1/0221—Freeze-process protecting agents, i.e. substances protecting cells from effects of the physical process, e.g. cryoprotectants, osmolarity regulators like oncotic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/718—Starch or degraded starch, e.g. amylose, amylopectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B30/00—Preparation of starch, degraded or non-chemically modified starch, amylose, or amylopectin
- C08B30/20—Amylose or amylopectin
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B35/00—Preparation of derivatives of amylopectin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Polymers & Plastics (AREA)
- Materials Engineering (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Dentistry (AREA)
- Inorganic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- External Artificial Organs (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Upotreba hiperrazgranatog amilopektina sa srednjim stepenom razgranatosti izmedju > 10 i 25mol% i molekularnom težinom od 40.000 do 800.000 Daltona i njegovih derivata u postupcima hirurškog ili terapeutskog lecenja ljudskog ili životinjskog tela ili u postupcima dijagnosticiranja, prvenstveno kao ekspander volumena plazme. Ekspanderi volumena plazme na bazi hidroksi-etiliranog amilopektina usled hidroksi-etilizacije, za sada, imaju nedostatak nepotpune mogucnosti metabolizacije a time i privremenog zadržavanja u tkivu, što je pvoezano sa propratnim dejstvima. Treba pronaći nove ekspandere plazme na bazi polisaharida koji nemaju taj nedostatak. Poboljšani ekspanderi, koji se mogu potpuno metabolisati, na bazi hiperrazgranatog amilopektina dobijaju se, na primer, tako što se nativni biljni amilopektini pomoću transglikozacije toliko promene da podešljivi, visoki stepen razgranatosti omogućava upravljanje razgradnje serum-a-α amilaze tako da uopšte nije potrebna ili je potrebna samo beznačajna hidroksi-etilizacija. Treba pronaći nove ekspandere plazme na bazi polisaharida koji nemaju taj nedostatak. Poboljšani ekspander plazme na bazi hiperrazgranatog amilopektina, koji se mogu potpuno metabolisati, dobijaju se, na primer, tako što se nativni biljni amilopektini pomoću transglikozacije toliko izmene da podešljivi, visoki stepen razgranatosti omogućava upravljanje razgradnje serum-α-amilaze tako da uopšte nije potrebna ili je potrebna samo beznacajna hidroksi-etilizacija.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10141099 | 2001-08-22 | ||
PCT/EP2002/008757 WO2003018639A1 (de) | 2001-08-22 | 2002-08-06 | Hyperverzweigtes amylopektin zum einsatz in verfahren zur chirurgischen oder therapeutischen behandlung von säugern oder in diagnostizierverfahren, insbesondere zur verwendung als plasmavolumenexpander |
Publications (2)
Publication Number | Publication Date |
---|---|
RS14704A true RS14704A (en) | 2007-02-05 |
RS51420B RS51420B (sr) | 2011-02-28 |
Family
ID=7696220
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
YUP-147/04A RS51420B (sr) | 2001-08-22 | 2002-08-06 | Hiperrazgranati amilopektin za upotrebu u postupcima hirurškog ili terapeutskog lečenja sisara ili u postupcima dijagnosticiranja, a naročito za upotrebu kao ekspander volumena plazme |
Country Status (20)
Country | Link |
---|---|
US (1) | US7393841B2 (sr) |
EP (1) | EP1421120B1 (sr) |
JP (1) | JP2005501930A (sr) |
KR (1) | KR100898528B1 (sr) |
CN (1) | CN100390203C (sr) |
AT (1) | ATE360651T1 (sr) |
AU (1) | AU2002325398B2 (sr) |
CA (1) | CA2456507C (sr) |
DE (2) | DE10235954A1 (sr) |
DK (1) | DK1421120T3 (sr) |
ES (1) | ES2283585T3 (sr) |
HK (1) | HK1068356A1 (sr) |
HU (1) | HUP0401188A3 (sr) |
MX (1) | MXPA04001606A (sr) |
PL (1) | PL209763B1 (sr) |
PT (1) | PT1421120E (sr) |
RO (1) | RO122279B1 (sr) |
RS (1) | RS51420B (sr) |
RU (1) | RU2303984C2 (sr) |
WO (1) | WO2003018639A1 (sr) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2840612B1 (fr) * | 2002-06-06 | 2005-05-06 | Roquette Freres | Polymeres solubles de glucose hautement branches et leur procede d'obtention |
DE10237442B4 (de) * | 2002-08-16 | 2004-08-19 | Fresenius Kabi Deutschland Gmbh | Hochverzweigte, niedrig substituierte Stärkeprodukte |
DE10256558A1 (de) * | 2002-12-04 | 2004-09-16 | Supramol Parenteral Colloids Gmbh | Ester von Polysaccharid Aldonsäuren, Verfahren zu ihrer Herstellung und Verwendung zur Kopplung an pharmazeutische Wirkstoffe |
CZ20033424A3 (cs) * | 2003-12-16 | 2005-08-17 | Parenteral, A. S. | Náhražka krevní plazmy, výchozí produkt a způsob výroby výchozího produktu pro náhražku lidské krevní plazmy |
FR2864088B1 (fr) * | 2003-12-19 | 2006-04-28 | Roquette Freres | Polymeres solubles de glucose hautement branches |
WO2006130978A1 (en) | 2005-06-06 | 2006-12-14 | The University Of British Columbia | Polymer-based serum albumin substitute |
EP1943908A1 (en) * | 2006-12-29 | 2008-07-16 | Nederlandse Organisatie voor toegepast-natuurwetenschappelijk Onderzoek TNO | Novel slowly digestible storage carbohydrate |
BR112012021991A2 (pt) | 2010-03-01 | 2020-09-01 | The University Of British Columbia | policlicerol hiperramificado uso de um poliglicerol hipermanificado, método de adiministração de uma força biologicamente ativa a um tecido biológico, composição farmacêutica e método de síntese de um poliglicerol hiperrramificado. |
KR20170001712A (ko) * | 2010-06-17 | 2017-01-04 | 가부시기가이샤하야시바라 | 풀루란 함유 분말과 그 제조방법 및 용도 |
AR095937A1 (es) * | 2013-04-05 | 2015-11-25 | Acraf | Potenciador de la solubilidad en agua a base de glucógeno |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA928215A (en) | 1969-08-08 | 1973-06-12 | M. Brake Jon | Process for the cryogenic preservation of blood and erythrocytes and products produced thereby |
US4125492A (en) * | 1974-05-31 | 1978-11-14 | Pedro Cuatrecasas | Affinity chromatography of vibrio cholerae enterotoxin-ganglioside polysaccharide and the biological effects of ganglioside-containing soluble polymers |
US4111199A (en) * | 1977-03-31 | 1978-09-05 | Isaac Djerassi | Method of collecting transfusable granulocytes by gravity leukopheresis |
DE3029307A1 (de) | 1980-08-01 | 1982-03-04 | Dr. Eduard Fresenius, Chemisch-pharmazeutische Industrie KG, 6380 Bad Homburg | Haemoglobin enthaltendes blutersatzmittel |
US4454161A (en) * | 1981-02-07 | 1984-06-12 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | Process for the production of branching enzyme, and a method for improving the qualities of food products therewith |
DE3313600A1 (de) | 1983-04-14 | 1984-10-18 | Laevosan-Gesellschaft mbH & Co. KG, Linz | Plasmastreckmittel auf staerkebasis und verfahren zu ihrer herstellung |
NL8902128A (nl) * | 1989-08-23 | 1991-03-18 | Avebe Coop Verkoop Prod | Vertakkingsenzym en gebruik daarvan. |
JP2896580B2 (ja) | 1989-08-25 | 1999-05-31 | チッソ株式会社 | アミロース―リゾチームハイブリッドと活性化糖およびその製造法 |
DE19628705A1 (de) | 1996-07-08 | 1998-01-15 | Fresenius Ag | Neue Sauerstoff-Transport-Mittel, diese enthaltende Hämoglobin-Hydroxyethylstärke-Konjugate, Verfahren zu deren Herstellung, sowie deren Verwendung als Blutersatzstoffe |
FR2783838B1 (fr) * | 1998-09-25 | 2000-12-01 | Roquette Freres | Procede de preparation d'un melange d'enzymes de branchement de l'amidon extraites d'algues |
AT409928B (de) * | 1999-08-10 | 2002-12-27 | Tulln Zuckerforschung Gmbh | Plasmaexpander, blutverdünnungsmittel und kryoprotektor, hergestellt unter verwendung von amylopektin-kartoffelstärke |
JP2001294601A (ja) | 2000-04-11 | 2001-10-23 | Akita Prefecture | 高度分岐澱粉と該高度分岐澱粉の製造方法 |
DE10112825A1 (de) | 2001-03-16 | 2002-10-02 | Fresenius Kabi De Gmbh | HESylierung von Wirkstoffen in wässriger Lösung |
-
2002
- 2002-08-06 WO PCT/EP2002/008757 patent/WO2003018639A1/de active IP Right Grant
- 2002-08-06 AU AU2002325398A patent/AU2002325398B2/en not_active Ceased
- 2002-08-06 JP JP2003523498A patent/JP2005501930A/ja active Pending
- 2002-08-06 AT AT02758435T patent/ATE360651T1/de active
- 2002-08-06 ES ES02758435T patent/ES2283585T3/es not_active Expired - Lifetime
- 2002-08-06 PT PT02758435T patent/PT1421120E/pt unknown
- 2002-08-06 KR KR10-2004-7002536A patent/KR100898528B1/ko not_active IP Right Cessation
- 2002-08-06 CA CA2456507A patent/CA2456507C/en not_active Expired - Fee Related
- 2002-08-06 US US10/486,943 patent/US7393841B2/en not_active Expired - Fee Related
- 2002-08-06 DE DE10235954A patent/DE10235954A1/de not_active Withdrawn
- 2002-08-06 DE DE50210039T patent/DE50210039D1/de not_active Expired - Lifetime
- 2002-08-06 HU HU0401188A patent/HUP0401188A3/hu unknown
- 2002-08-06 RU RU2004108122/15A patent/RU2303984C2/ru not_active IP Right Cessation
- 2002-08-06 PL PL369363A patent/PL209763B1/pl not_active IP Right Cessation
- 2002-08-06 RS YUP-147/04A patent/RS51420B/sr unknown
- 2002-08-06 RO ROA200400154A patent/RO122279B1/ro unknown
- 2002-08-06 MX MXPA04001606A patent/MXPA04001606A/es active IP Right Grant
- 2002-08-06 DK DK02758435T patent/DK1421120T3/da active
- 2002-08-06 EP EP02758435A patent/EP1421120B1/de not_active Expired - Lifetime
- 2002-08-06 CN CNB028163540A patent/CN100390203C/zh not_active Expired - Fee Related
-
2005
- 2005-01-17 HK HK05100431A patent/HK1068356A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
WO2003018639A1 (de) | 2003-03-06 |
EP1421120A1 (de) | 2004-05-26 |
PT1421120E (pt) | 2007-08-03 |
PL369363A1 (en) | 2005-04-18 |
KR100898528B1 (ko) | 2009-05-20 |
RU2303984C2 (ru) | 2007-08-10 |
DE50210039D1 (de) | 2007-06-06 |
ATE360651T1 (de) | 2007-05-15 |
DK1421120T3 (da) | 2007-09-17 |
HK1068356A1 (en) | 2005-04-29 |
EP1421120B1 (de) | 2007-04-25 |
RS51420B (sr) | 2011-02-28 |
RO122279B1 (ro) | 2009-03-30 |
RU2004108122A (ru) | 2005-03-27 |
AU2002325398B2 (en) | 2008-02-28 |
PL209763B1 (pl) | 2011-10-31 |
CN1545522A (zh) | 2004-11-10 |
HUP0401188A3 (en) | 2012-09-28 |
CN100390203C (zh) | 2008-05-28 |
US7393841B2 (en) | 2008-07-01 |
CA2456507C (en) | 2011-05-03 |
DE10235954A1 (de) | 2003-03-06 |
CA2456507A1 (en) | 2003-03-06 |
HUP0401188A2 (hu) | 2004-09-28 |
ES2283585T3 (es) | 2007-11-01 |
MXPA04001606A (es) | 2005-03-07 |
KR20040052215A (ko) | 2004-06-22 |
JP2005501930A (ja) | 2005-01-20 |
US20040157207A1 (en) | 2004-08-12 |
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