RS14704A - Hyperbranched amylopectin for use in methods for surgical or therapeutic treatment of mammals or in diagnostic methods especially for use as a plasma volume expander - Google Patents

Hyperbranched amylopectin for use in methods for surgical or therapeutic treatment of mammals or in diagnostic methods especially for use as a plasma volume expander

Info

Publication number
RS14704A
RS14704A YUP-147/04A YUP14704A RS14704A RS 14704 A RS14704 A RS 14704A YU P14704 A YUP14704 A YU P14704A RS 14704 A RS14704 A RS 14704A
Authority
RS
Serbia
Prior art keywords
amylopectin
methods
plasma volume
surgical
therapeutic treatment
Prior art date
Application number
YUP-147/04A
Other languages
English (en)
Inventor
Klaus Sommermeyer
Original Assignee
Supramol Parenteral Colloids Gmbh.,
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Supramol Parenteral Colloids Gmbh., filed Critical Supramol Parenteral Colloids Gmbh.,
Publication of RS14704A publication Critical patent/RS14704A/sr
Publication of RS51420B publication Critical patent/RS51420B/sr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0026—Blood substitute; Oxygen transporting formulations; Plasma extender
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A01N1/0205—Chemical aspects
    • A01N1/021—Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
    • A01N1/0221—Freeze-process protecting agents, i.e. substances protecting cells from effects of the physical process, e.g. cryoprotectants, osmolarity regulators like oncotic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/718—Starch or degraded starch, e.g. amylose, amylopectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B30/00—Preparation of starch, degraded or non-chemically modified starch, amylose, or amylopectin
    • C08B30/20—Amylose or amylopectin
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B35/00—Preparation of derivatives of amylopectin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Polymers & Plastics (AREA)
  • Materials Engineering (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dentistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Environmental Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • External Artificial Organs (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Upotreba hiperrazgranatog amilopektina sa srednjim stepenom razgranatosti izmedju > 10 i 25mol% i molekularnom težinom od 40.000 do 800.000 Daltona i njegovih derivata u postupcima hirurškog ili terapeutskog lecenja ljudskog ili životinjskog tela ili u postupcima dijagnosticiranja, prvenstveno kao ekspander volumena plazme. Ekspanderi volumena plazme na bazi hidroksi-etiliranog amilopektina usled hidroksi-etilizacije, za sada, imaju nedostatak nepotpune mogucnosti metabolizacije a time i privremenog zadržavanja u tkivu, što je pvoezano sa propratnim dejstvima. Treba pronaći nove ekspandere plazme na bazi polisaharida koji nemaju taj nedostatak. Poboljšani ekspanderi, koji se mogu potpuno metabolisati, na bazi hiperrazgranatog amilopektina dobijaju se, na primer, tako što se nativni biljni amilopektini pomoću transglikozacije toliko promene da podešljivi, visoki stepen razgranatosti omogućava upravljanje razgradnje serum-a-α amilaze tako da uopšte nije potrebna ili je potrebna samo beznačajna hidroksi-etilizacija. Treba pronaći nove ekspandere plazme na bazi polisaharida koji nemaju taj nedostatak. Poboljšani ekspander plazme na bazi hiperrazgranatog amilopektina, koji se mogu potpuno metabolisati, dobijaju se, na primer, tako što se nativni biljni amilopektini pomoću transglikozacije toliko izmene da podešljivi, visoki stepen razgranatosti omogućava upravljanje razgradnje serum-α-amilaze tako da uopšte nije potrebna ili je potrebna samo beznacajna hidroksi-etilizacija.
YUP-147/04A 2001-08-22 2002-08-06 Hiperrazgranati amilopektin za upotrebu u postupcima hirurškog ili terapeutskog lečenja sisara ili u postupcima dijagnosticiranja, a naročito za upotrebu kao ekspander volumena plazme RS51420B (sr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10141099 2001-08-22
PCT/EP2002/008757 WO2003018639A1 (de) 2001-08-22 2002-08-06 Hyperverzweigtes amylopektin zum einsatz in verfahren zur chirurgischen oder therapeutischen behandlung von säugern oder in diagnostizierverfahren, insbesondere zur verwendung als plasmavolumenexpander

Publications (2)

Publication Number Publication Date
RS14704A true RS14704A (en) 2007-02-05
RS51420B RS51420B (sr) 2011-02-28

Family

ID=7696220

Family Applications (1)

Application Number Title Priority Date Filing Date
YUP-147/04A RS51420B (sr) 2001-08-22 2002-08-06 Hiperrazgranati amilopektin za upotrebu u postupcima hirurškog ili terapeutskog lečenja sisara ili u postupcima dijagnosticiranja, a naročito za upotrebu kao ekspander volumena plazme

Country Status (20)

Country Link
US (1) US7393841B2 (sr)
EP (1) EP1421120B1 (sr)
JP (1) JP2005501930A (sr)
KR (1) KR100898528B1 (sr)
CN (1) CN100390203C (sr)
AT (1) ATE360651T1 (sr)
AU (1) AU2002325398B2 (sr)
CA (1) CA2456507C (sr)
DE (2) DE10235954A1 (sr)
DK (1) DK1421120T3 (sr)
ES (1) ES2283585T3 (sr)
HK (1) HK1068356A1 (sr)
HU (1) HUP0401188A3 (sr)
MX (1) MXPA04001606A (sr)
PL (1) PL209763B1 (sr)
PT (1) PT1421120E (sr)
RO (1) RO122279B1 (sr)
RS (1) RS51420B (sr)
RU (1) RU2303984C2 (sr)
WO (1) WO2003018639A1 (sr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2840612B1 (fr) * 2002-06-06 2005-05-06 Roquette Freres Polymeres solubles de glucose hautement branches et leur procede d'obtention
DE10237442B4 (de) * 2002-08-16 2004-08-19 Fresenius Kabi Deutschland Gmbh Hochverzweigte, niedrig substituierte Stärkeprodukte
DE10256558A1 (de) * 2002-12-04 2004-09-16 Supramol Parenteral Colloids Gmbh Ester von Polysaccharid Aldonsäuren, Verfahren zu ihrer Herstellung und Verwendung zur Kopplung an pharmazeutische Wirkstoffe
CZ20033424A3 (cs) * 2003-12-16 2005-08-17 Parenteral, A. S. Náhražka krevní plazmy, výchozí produkt a způsob výroby výchozího produktu pro náhražku lidské krevní plazmy
FR2864088B1 (fr) * 2003-12-19 2006-04-28 Roquette Freres Polymeres solubles de glucose hautement branches
US9346029B2 (en) 2005-06-06 2016-05-24 The University Of British Columbia Polymer-based serum albumin substitute
EP1943908A1 (en) * 2006-12-29 2008-07-16 Nederlandse Organisatie voor toegepast-natuurwetenschappelijk Onderzoek TNO Novel slowly digestible storage carbohydrate
BR112012021991A2 (pt) 2010-03-01 2020-09-01 The University Of British Columbia policlicerol hiperramificado uso de um poliglicerol hipermanificado, método de adiministração de uma força biologicamente ativa a um tecido biológico, composição farmacêutica e método de síntese de um poliglicerol hiperrramificado.
WO2011158936A1 (ja) * 2010-06-17 2011-12-22 株式会社林原生物化学研究所 プルラン含有粉末とその製造方法並びに用途
AR095937A1 (es) * 2013-04-05 2015-11-25 Acraf Potenciador de la solubilidad en agua a base de glucógeno

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA928215A (en) 1969-08-08 1973-06-12 M. Brake Jon Process for the cryogenic preservation of blood and erythrocytes and products produced thereby
US4125492A (en) * 1974-05-31 1978-11-14 Pedro Cuatrecasas Affinity chromatography of vibrio cholerae enterotoxin-ganglioside polysaccharide and the biological effects of ganglioside-containing soluble polymers
US4111199A (en) * 1977-03-31 1978-09-05 Isaac Djerassi Method of collecting transfusable granulocytes by gravity leukopheresis
DE3029307A1 (de) 1980-08-01 1982-03-04 Dr. Eduard Fresenius, Chemisch-pharmazeutische Industrie KG, 6380 Bad Homburg Haemoglobin enthaltendes blutersatzmittel
US4454161A (en) * 1981-02-07 1984-06-12 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Process for the production of branching enzyme, and a method for improving the qualities of food products therewith
DE3313600A1 (de) 1983-04-14 1984-10-18 Laevosan-Gesellschaft mbH & Co. KG, Linz Plasmastreckmittel auf staerkebasis und verfahren zu ihrer herstellung
NL8902128A (nl) * 1989-08-23 1991-03-18 Avebe Coop Verkoop Prod Vertakkingsenzym en gebruik daarvan.
JP2896580B2 (ja) 1989-08-25 1999-05-31 チッソ株式会社 アミロース―リゾチームハイブリッドと活性化糖およびその製造法
DE19628705A1 (de) 1996-07-08 1998-01-15 Fresenius Ag Neue Sauerstoff-Transport-Mittel, diese enthaltende Hämoglobin-Hydroxyethylstärke-Konjugate, Verfahren zu deren Herstellung, sowie deren Verwendung als Blutersatzstoffe
FR2783838B1 (fr) * 1998-09-25 2000-12-01 Roquette Freres Procede de preparation d'un melange d'enzymes de branchement de l'amidon extraites d'algues
AT409928B (de) 1999-08-10 2002-12-27 Tulln Zuckerforschung Gmbh Plasmaexpander, blutverdünnungsmittel und kryoprotektor, hergestellt unter verwendung von amylopektin-kartoffelstärke
JP2001294601A (ja) * 2000-04-11 2001-10-23 Akita Prefecture 高度分岐澱粉と該高度分岐澱粉の製造方法
DE10112825A1 (de) 2001-03-16 2002-10-02 Fresenius Kabi De Gmbh HESylierung von Wirkstoffen in wässriger Lösung

Also Published As

Publication number Publication date
RO122279B1 (ro) 2009-03-30
RU2004108122A (ru) 2005-03-27
CA2456507C (en) 2011-05-03
RS51420B (sr) 2011-02-28
PL209763B1 (pl) 2011-10-31
WO2003018639A1 (de) 2003-03-06
CN1545522A (zh) 2004-11-10
HUP0401188A3 (en) 2012-09-28
DK1421120T3 (da) 2007-09-17
MXPA04001606A (es) 2005-03-07
ATE360651T1 (de) 2007-05-15
EP1421120B1 (de) 2007-04-25
US20040157207A1 (en) 2004-08-12
RU2303984C2 (ru) 2007-08-10
DE10235954A1 (de) 2003-03-06
EP1421120A1 (de) 2004-05-26
ES2283585T3 (es) 2007-11-01
HK1068356A1 (en) 2005-04-29
KR100898528B1 (ko) 2009-05-20
PT1421120E (pt) 2007-08-03
HUP0401188A2 (hu) 2004-09-28
PL369363A1 (en) 2005-04-18
DE50210039D1 (de) 2007-06-06
CA2456507A1 (en) 2003-03-06
KR20040052215A (ko) 2004-06-22
JP2005501930A (ja) 2005-01-20
CN100390203C (zh) 2008-05-28
US7393841B2 (en) 2008-07-01
AU2002325398B2 (en) 2008-02-28

Similar Documents

Publication Publication Date Title
HK1068356A1 (en) Hyperbranched amylopectin for use in methods for surgical or therapeutic treatment of mammals or in diagnostic methods
WO1997029779A3 (en) EGF-Genistein conjugates for the treatment of cancer
UA66857C2 (uk) КОН'ЮГАТ ПОЛІОЛ-<font face="Symbol">b</font>-ІНТЕРФЕРОН, СПОСІБ ОДЕРЖАННЯ КОН'ЮГАТУ ПОЛІОЛ-<font face="Symbol">b</font>-ІНТЕРФЕРОН ТА СПОСІБ ЛІКУВАННЯ ІНФЕКЦІЙНИХ ХВОРОБ, ПУХЛИН І АУТОІМУННИХ І ЗАПАЛЬНИХ ЗАХВОРЮВАНЬ
WO2003022210A3 (en) Pharmaceutical compositions of drug-oligomer conjugates and methods of treating diseases therewith
DE69925830D1 (de) Peg-lhrh analog konjugate
EP2292649A3 (en) Therapeutic epitopes and uses thereof
WO2003002022A3 (en) Minimally invasive orthopaedic apparatus and methods
WO2000051662A9 (en) Bioabsorbable, biocompatible polymers for tissue engineering
WO2004039248A3 (en) Repairing or replacing tissues or organs
WO2001038303A3 (fr) Analogues de la vitamine d
EP2258702A3 (en) Purified compositions of 10-Propargyl-10-Deazaaminopterin and method of using same in the treatment of tumors
WO2003106384A3 (en) NOVEL BORIC CHALCONE DERIVATIVES AND USES THEREOF
HUP0002012A2 (hu) Dezferriexochelin alkalmazása ateroszklerózis és érfalkárosodás kezelésére szolgáló gyógyszerkészítmények előállítására
WO2001005408A8 (en) Fat-binding polymers, optionally combined with lipase inhibitors
ATE237349T1 (en) Fat-binding polymers
JPH1160499A (ja) 抗腫瘍剤
WO2003103614A3 (en) METHOD AND COMPOSITIONS FOR THE TREATMENT OF OEDEMATUS FIBROSCLEREUS PANNICULOPATHY
AU2002319223A1 (en) Medicament for treating tumours and their metastases using a binding molecule against bone-sialoprotein
MXPA02000052A (es) Metodos y composiciones para el soporte, regeneracion y reparacion de tejidos conectivos.
AU2001276437A1 (en) Use of polysulphated cyclodextrins for treating osteoarthritis
WO2004075977A3 (en) Methods using diffuse field ultrasound-induced hyperthermia
MD1270F1 (en) Method for treatment of the hand navicular bone pseudarthrosis
Dubey et al. Immediate placement of dental implants in non vascularised iliac graft after resection of anterior mandible: A case report
WO2004078761A8 (en) Enantiomerically pure cilazapril,process for preparation
UA32302A (uk) Спосіб усунення післяопераційних деформацій м'яких тканин