RO92853B1 - Procedeu pentru prepararea unor derivati de 6,16-dimetilcorticoide - Google Patents
Procedeu pentru prepararea unor derivati de 6,16-dimetilcorticoideInfo
- Publication number
- RO92853B1 RO92853B1 RO121055A RO12105583A RO92853B1 RO 92853 B1 RO92853 B1 RO 92853B1 RO 121055 A RO121055 A RO 121055A RO 12105583 A RO12105583 A RO 12105583A RO 92853 B1 RO92853 B1 RO 92853B1
- Authority
- RO
- Romania
- Prior art keywords
- dimethylcorticoid
- derivatives
- preparing
- formyl
- chlorine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
- C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
- C07J5/0061—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
- C07J5/0069—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group
- C07J5/0076—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group by an alkyl group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
- C07J7/008—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21
- C07J7/0085—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21 by an halogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/001—Oxiranes
- C07J71/0015—Oxiranes at position 9(11)
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Pain & Pain Management (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Saccharide Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Medicines Containing Plant Substances (AREA)
- Manufacture Of Tobacco Products (AREA)
- Cosmetics (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Detergent Compositions (AREA)
Abstract
Inventia de fata se refera la un procedeu pentru prepararea unor derivati de 6,16-dimetilcorticoide cu formula generala I : (vezi formula) în care .................. reprezinta o legatura simpla sau dubla, X reprezinta clor sau brom, Y reprezinta clor sau alcanoiloxi cu 2 sau 3 atomi de carbon, iar R1 este un radical alcoxialchil cu 2 sau 3 atomi de carbon sau alcanoil cu 2..4 atomi de carbon, prin tratarea unui compus cu formula generala II : (vezi formula) în care Y si R1 au semnificatiile de mai sus, cu N-bromusuccimida sau N-clorsucinimida în mediul de dioxan, la temperatura de 20 degreeC si în prezenta de acid percloric. Aceste substante utilizate în combinatie cu materiale de suport uzuale în combinatie cu materiale de suport uzuale în farmacia galenica pentru tratarea determatitelor de contact, eczemelor de diferite feluri, arsurilor si a altor boli de piele.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE3227312A DE3227312A1 (de) | 1982-07-19 | 1982-07-19 | Neue 6,16-dimethylkortikoide, ihre herstellung und verwendung |
Publications (2)
Publication Number | Publication Date |
---|---|
RO92853A2 RO92853A2 (ro) | 1987-11-30 |
RO92853B1 true RO92853B1 (ro) | 1987-12-01 |
Family
ID=6168986
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RO83121037A RO92855A (ro) | 1982-07-19 | 1983-07-18 | Procedeu pentru prepararea unor derivati de 6,16-dimetilcorticoide |
RO83121058A RO92856A (ro) | 1982-07-19 | 1983-07-18 | Procedeu pentru prepararea unor derivati de 6,16-dimetilcorticoide |
RO121055A RO92853B1 (ro) | 1982-07-19 | 1983-07-18 | Procedeu pentru prepararea unor derivati de 6,16-dimetilcorticoide |
RO83121056A RO92854A (ro) | 1982-07-19 | 1983-07-18 | Procedeu pentru prepararea unor derivati de 6,16-dimetilcorticoide |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RO83121037A RO92855A (ro) | 1982-07-19 | 1983-07-18 | Procedeu pentru prepararea unor derivati de 6,16-dimetilcorticoide |
RO83121058A RO92856A (ro) | 1982-07-19 | 1983-07-18 | Procedeu pentru prepararea unor derivati de 6,16-dimetilcorticoide |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RO83121056A RO92854A (ro) | 1982-07-19 | 1983-07-18 | Procedeu pentru prepararea unor derivati de 6,16-dimetilcorticoide |
Country Status (23)
Country | Link |
---|---|
US (2) | US4555507A (ro) |
EP (1) | EP0100874B1 (ro) |
JP (1) | JPS5967298A (ro) |
AT (1) | ATE50780T1 (ro) |
AU (1) | AU1694183A (ro) |
BG (2) | BG43693A3 (ro) |
CA (1) | CA1312856C (ro) |
DD (1) | DD214134A5 (ro) |
DE (2) | DE3227312A1 (ro) |
DK (1) | DK162232C (ro) |
ES (1) | ES524238A0 (ro) |
FI (1) | FI832575A (ro) |
GB (1) | GB2124230A (ro) |
GR (1) | GR78902B (ro) |
HU (1) | HU191539B (ro) |
IE (1) | IE55771B1 (ro) |
IL (1) | IL69230A (ro) |
NO (1) | NO157453C (ro) |
PH (1) | PH19976A (ro) |
PL (1) | PL141537B1 (ro) |
PT (1) | PT76995B (ro) |
RO (4) | RO92855A (ro) |
ZA (1) | ZA835249B (ro) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3227312A1 (de) * | 1982-07-19 | 1984-01-19 | Schering AG, 1000 Berlin und 4709 Bergkamen | Neue 6,16-dimethylkortikoide, ihre herstellung und verwendung |
DE3400188A1 (de) * | 1984-01-02 | 1985-07-11 | Schering AG, Berlin und Bergkamen, 1000 Berlin | Neue 6(alpha),16(alpha)-dimethylkortikoide |
DE3401680A1 (de) * | 1984-01-16 | 1985-07-18 | Schering AG, 1000 Berlin und 4709 Bergkamen | 6(alpha),16ss-dimethylkortikoide |
PT78973A (en) * | 1984-07-25 | 1984-08-01 | Joao Emerico Villax | New preparation process of the 9alpha-fluoro 17,21-acylates or hidroxilades in 17 and 21 chloro-corticosteroid |
US5319115A (en) * | 1987-08-25 | 1994-06-07 | Cocensys Inc. | Method for making 3α-hydroxy, 3β-substituted-pregnanes |
US4866050A (en) * | 1988-04-27 | 1989-09-12 | Ben Amoz Daniel | Ultrasonic transdermal application of steroid compositions |
DE3915951C1 (ro) * | 1989-05-12 | 1990-09-13 | Schering Ag, 1000 Berlin Und 4709 Bergkamen, De | |
AU7556291A (en) * | 1990-03-27 | 1991-10-21 | Schering Corporation | Process for 9alpha-hydroxy steroid dehydration |
FR2701262B1 (fr) * | 1993-02-05 | 1995-03-24 | Roussel Uclaf | Nouveau procédé de préparation de stéroïdes 6 alpa, 9 alpha-difluorés et nouveaus intermédiaires. |
DE4333920A1 (de) * | 1993-10-05 | 1995-04-13 | Hoechst Ag | Corticoid-17,21-dicarbonsäureester sowie Corticosteroid-17-carbonsäureester-21-kohlensäureester, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel |
US5502222A (en) * | 1994-06-01 | 1996-03-26 | Schering Corporation | Process for preparing delta 9,11 and 21-chloro corticosteroids |
JP5780521B2 (ja) | 2008-05-28 | 2015-09-16 | リベラジェン・バイオファーマ・インコーポレイテッドReveraGen BioPharma,Inc. | 疾患を治療するための、NF−κBの非ホルモン性ステロイド調節因子 |
EP2556083A4 (en) | 2010-04-05 | 2013-12-04 | Validus Biopharma Inc | NONHORMONAL STEROID MODULATORS OF NF-KAPPA-B FOR DISEASE TREATMENT |
US10799514B2 (en) | 2015-06-29 | 2020-10-13 | Reveragen Biopharma, Inc. | Non-hormonal steroid modulators of NF-kappa beta for treatment of disease |
US11382922B2 (en) | 2019-03-07 | 2022-07-12 | Reveragen Biopharma, Inc. | Aqueous oral pharmaceutical suspension compositions |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
LU75903A1 (ro) * | 1976-09-29 | 1978-05-16 | ||
GB931224A (en) * | 1958-10-01 | 1963-07-17 | Merck & Co Inc | Steroid compounds and their production |
GB898291A (en) * | 1959-03-18 | 1962-06-06 | Upjohn Co | Improvements in or relating to steroids and the manufacture thereof |
GB898292A (en) * | 1959-03-18 | 1962-06-06 | Upjohn Co | Improvements in or relating to steroids and the manufacture thereof |
CH429716A (de) * | 1961-06-24 | 1967-02-15 | Vismara Francesco Spa | Verfahren zur Herstellung von 17a-Acyloxy-21-hydroxy-Steroiden |
US3054811A (en) * | 1961-09-14 | 1962-09-18 | Merck & Co Inc | Ring a unsaturated 6, 16-dimethyl steroids of the pregnane series |
GB1047518A (en) * | 1963-06-11 | 1966-11-02 | Glaxo Lab Ltd | 17ª-monoesters of 11,17,21-trihydroxy steroid compounds |
GB1047519A (en) * | 1963-06-11 | 1966-11-02 | Glaxo Lab Ltd | 17ª‡,21-diesters of 11,17,21-trihydroxy steroid compounds |
GB1544642A (en) * | 1976-06-04 | 1979-04-25 | Bristol Myers Co | 9,11-epoxy steroids and synthesis of corticosteroids therefrom |
DE2645105C2 (de) * | 1976-10-04 | 1986-03-13 | Schering AG, 1000 Berlin und 4709 Bergkamen | Derivate des 9-Chlorprednisolons, Verfahren zu ihrer Herstellung und diese enthaltendes pharmazeutisches Präparat |
DE2715854A1 (de) * | 1977-04-06 | 1978-10-19 | Schering Ag | Verfahren zur herstellung von 11alpha,21-dihydroxy-1,4-pregnadien- 3,20-dion-derivaten |
US4086254A (en) * | 1977-04-13 | 1978-04-25 | The Upjohn Company | Photocleavable steroids |
DE2759135A1 (de) * | 1977-12-30 | 1979-07-19 | Lark Spa | Neue steroidverbindungen und deren herstellung und verwendung |
US4154748A (en) * | 1978-01-20 | 1979-05-15 | The Upjohn Company | Phosphate catalyzed acylation of steroidal tertiary alcohols |
DE2803661A1 (de) * | 1978-01-25 | 1979-07-26 | Schering Ag | Neue in 17-position substituierte 11beta-hydroxysteroide der pregnanreihe, ihre herstellung und verwendung |
DE2901561A1 (de) * | 1979-01-12 | 1980-07-31 | Schering Ag | Verfahren zur herstellung von 11 beta, 17 alpha, 21-trihydroxy-4-pregnen-3,20dion-derivaten |
ATE12237T1 (de) * | 1980-12-23 | 1985-04-15 | Schering Ag | Neue 6-alpha-methylhydrocortison-derivate, ihre herstellung und verwendung. |
DE3227312A1 (de) * | 1982-07-19 | 1984-01-19 | Schering AG, 1000 Berlin und 4709 Bergkamen | Neue 6,16-dimethylkortikoide, ihre herstellung und verwendung |
-
1982
- 1982-07-19 DE DE3227312A patent/DE3227312A1/de not_active Withdrawn
-
1983
- 1983-07-07 AT AT83106649T patent/ATE50780T1/de not_active IP Right Cessation
- 1983-07-07 PT PT76995A patent/PT76995B/pt unknown
- 1983-07-07 DE DE8383106649T patent/DE3381291D1/de not_active Expired - Lifetime
- 1983-07-07 EP EP83106649A patent/EP0100874B1/de not_active Expired - Lifetime
- 1983-07-14 IL IL69230A patent/IL69230A/xx unknown
- 1983-07-14 FI FI832575A patent/FI832575A/fi not_active Application Discontinuation
- 1983-07-15 DD DD83253117A patent/DD214134A5/de not_active IP Right Cessation
- 1983-07-18 RO RO83121037A patent/RO92855A/ro unknown
- 1983-07-18 GB GB08319363A patent/GB2124230A/en not_active Withdrawn
- 1983-07-18 RO RO83121058A patent/RO92856A/ro unknown
- 1983-07-18 RO RO121055A patent/RO92853B1/ro unknown
- 1983-07-18 IE IE1658/83A patent/IE55771B1/en not_active IP Right Cessation
- 1983-07-18 DK DK329183A patent/DK162232C/da not_active IP Right Cessation
- 1983-07-18 GR GR71957A patent/GR78902B/el unknown
- 1983-07-18 PL PL1983243082A patent/PL141537B1/pl unknown
- 1983-07-18 BG BG8361781A patent/BG43693A3/xx unknown
- 1983-07-18 HU HU832540A patent/HU191539B/hu not_active IP Right Cessation
- 1983-07-18 RO RO83121056A patent/RO92854A/ro unknown
- 1983-07-18 CA CA000432599A patent/CA1312856C/en not_active Expired - Fee Related
- 1983-07-18 BG BG8467461A patent/BG43692A3/xx not_active Expired
- 1983-07-18 PH PH29244A patent/PH19976A/en unknown
- 1983-07-18 NO NO832609A patent/NO157453C/no unknown
- 1983-07-18 AU AU16941/83A patent/AU1694183A/en not_active Abandoned
- 1983-07-19 US US06/515,243 patent/US4555507A/en not_active Expired - Lifetime
- 1983-07-19 JP JP58130373A patent/JPS5967298A/ja active Granted
- 1983-07-19 ES ES524238A patent/ES524238A0/es active Granted
- 1983-07-19 ZA ZA835249A patent/ZA835249B/xx unknown
-
1985
- 1985-10-29 US US06/777,144 patent/US4701451A/en not_active Expired - Fee Related
Also Published As
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