FI103668B1 - Menetelmä farmakologisesti aktiivisten pyrrolo[3,2-e]indol-4(5H)-onidimeerien valmistamiseksi - Google Patents

Menetelmä farmakologisesti aktiivisten pyrrolo[3,2-e]indol-4(5H)-onidimeerien valmistamiseksi

Info

Publication number
FI103668B1
FI103668B1 FI911193A FI911193A FI103668B1 FI 103668 B1 FI103668 B1 FI 103668B1 FI 911193 A FI911193 A FI 911193A FI 911193 A FI911193 A FI 911193A FI 103668 B1 FI103668 B1 FI 103668B1
Authority
FI
Finland
Prior art keywords
pct
unidimers
indole
preparation
pharmacologically active
Prior art date
Application number
FI911193A
Other languages
English (en)
Swedish (sv)
Other versions
FI103668B (fi
FI911193A0 (fi
Inventor
Robert C Kelly
Paul A Aristoff
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of FI911193A0 publication Critical patent/FI911193A0/fi
Application granted granted Critical
Publication of FI103668B publication Critical patent/FI103668B/fi
Publication of FI103668B1 publication Critical patent/FI103668B1/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Error Detection And Correction (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
  • Semiconductor Integrated Circuits (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Solid State Image Pick-Up Elements (AREA)
  • Amplifiers (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Television Systems (AREA)
  • Television Receiver Circuits (AREA)
  • Stereophonic System (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
FI911193A 1988-09-12 1991-03-11 Menetelmä farmakologisesti aktiivisten pyrrolo[3,2-e]indol-4(5H)-onidimeerien valmistamiseksi FI103668B1 (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US24335088A 1988-09-12 1988-09-12
US24335088 1988-09-12
US8903329 1989-08-07
PCT/US1989/003329 WO1990002746A1 (en) 1988-09-12 1989-08-07 Novel cc-1065 analogs having two cpi subunits

Publications (3)

Publication Number Publication Date
FI911193A0 FI911193A0 (fi) 1991-03-11
FI103668B FI103668B (fi) 1999-08-13
FI103668B1 true FI103668B1 (fi) 1999-08-13

Family

ID=22918400

Family Applications (1)

Application Number Title Priority Date Filing Date
FI911193A FI103668B1 (fi) 1988-09-12 1991-03-11 Menetelmä farmakologisesti aktiivisten pyrrolo[3,2-e]indol-4(5H)-onidimeerien valmistamiseksi

Country Status (14)

Country Link
US (1) US5541339A (fi)
JP (1) JP3380237B2 (fi)
KR (1) KR0137959B1 (fi)
AT (1) ATE198335T1 (fi)
AU (1) AU632288B2 (fi)
CA (1) CA1340215C (fi)
DE (1) DE68929275T2 (fi)
DK (1) DK175458B1 (fi)
FI (1) FI103668B1 (fi)
GR (1) GR3035589T3 (fi)
LV (1) LV12806B (fi)
NO (1) NO303498B1 (fi)
TW (1) TW217383B (fi)
WO (1) WO1990002746A1 (fi)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0563475B1 (en) * 1992-03-25 2000-05-31 Immunogen Inc Cell binding agent conjugates of derivatives of CC-1065
US5502068A (en) * 1995-01-31 1996-03-26 Synphar Laboratories, Inc. Cyclopropylpyrroloindole-oligopeptide anticancer agents
US20100056762A1 (en) 2001-05-11 2010-03-04 Old Lloyd J Specific binding proteins and uses thereof
US7589180B2 (en) 2001-05-11 2009-09-15 Abbott Laboratories Inc. Specific binding proteins and uses thereof
WO2003041708A1 (en) 2001-11-09 2003-05-22 Boehringer Ingelheim Pharmaceuticals, Inc. Benzimidazoles useful as protein kinase inhibitors
WO2004014905A1 (en) * 2002-08-08 2004-02-19 Boehringer Ingelheim Pharmaceuticals, Inc. Substituted benzimidazole compounds
JP2006505571A (ja) * 2002-10-15 2006-02-16 リゲル ファーマシューテイカルズ、インコーポレイテッド 置換されたインドール及びｈｃｖ阻害剤としてのその使用
CA2531485C (en) * 2003-07-07 2013-03-26 Merck Patent Gmbh Malonamide derivatives
WO2005079791A1 (en) * 2004-02-12 2005-09-01 Boehringer Ingelheim Pharmaceuticals, Inc. Thiophene -2- carboxylic acid - (1h - benzimidazol - 2 yl) - amide derivatives and related compounds as inhibitors of the tec kinase itk (interleukin -2- inducible t cell kinase) for the treatment of inflammation, immunological and allergic disorders
MX2008002364A (es) * 2005-08-17 2008-03-18 Schering Corp Ligandos novedosos de cinasa basados en tiofeno y en furano de alta afinidad.
US9090693B2 (en) 2007-01-25 2015-07-28 Dana-Farber Cancer Institute Use of anti-EGFR antibodies in treatment of EGFR mutant mediated disease
JP5618549B2 (ja) 2007-03-15 2014-11-05 ルードヴィッヒ インスティテュート フォー キャンサーリサーチ リミテッド Ｅｇｆｒ抗体及びｓｒｃ阻害剤を用いる治療方法及び関連製剤
US9901567B2 (en) 2007-08-01 2018-02-27 Syntarga B.V. Substituted CC-1065 analogs and their conjugates
JP5532486B2 (ja) 2007-08-14 2014-06-25 ルードヴィッヒ インスティテュート フォー キャンサー リサーチ Ｅｇｆ受容体を標的とするモノクローナル抗体１７５ならびにその誘導体および用途
HUE035798T2 (en) 2008-11-03 2018-05-28 Syntarga Bv CC-1065 analogues and conjugates
HUE030846T2 (en) 2010-04-21 2017-06-28 Syntarga Bv Conjugates of CC-1065 analogues and bifunctional linkers
EP2908809A2 (en) 2012-10-22 2015-08-26 Arnold Glazier Methods for the effective treatment of metastatic cancer
DE102013012622A1 (de) * 2013-07-30 2015-02-05 Clariant lnternational Ltd Neue sterisch gehinderte cyclische Amine
AU2015205574B2 (en) 2014-01-10 2019-08-15 Byondis B.V. Method for purifying Cys-linked antibody-drug conjugates
PT3099692T (pt) * 2014-01-27 2019-05-24 Pfizer Agentes citotóxicos bifuncionais
WO2016001485A1 (en) 2014-06-30 2016-01-07 Glykos Finland Oy Saccharide derivative of a toxic payload and antibody conjugates thereof
DE102015000124A1 (de) * 2015-01-07 2016-07-07 Clariant International Ltd. Verfahren zur Stabilisierung von Polyamiden
MX2017012102A (es) * 2015-03-20 2018-01-12 Pfizer Agentes citotoxicos bifuncionales que contienen el farmacoforo de cti.

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4169888A (en) * 1977-10-17 1979-10-02 The Upjohn Company Composition of matter and process
US4301248A (en) * 1979-12-21 1981-11-17 Bristol-Myers Company Fermentation process for making rachelmycin
US4413132A (en) * 1980-11-18 1983-11-01 The Upjohn Company Antibiotic CC-1065 indoline intermediates
CA1238907A (en) * 1984-02-21 1988-07-05 Robert C. Kelly 1,2,8,8a-tetrahydrocyclopropa¬c|pyrrolo(3,2-e)- indol-4(5h)-ones and related compounds
US4912227A (en) * 1984-02-21 1990-03-27 The Upjohn Company 1,2,8,8A-tetrahydrocyclopropa(c)pyrrolo(3,2-e)-indol-4-(5H)-ones and related compounds
GB8528848D0 (en) * 1985-11-22 1985-12-24 Davy Mckee Poole Rolling mills
WO1988004659A2 (en) * 1986-12-19 1988-06-30 The Upjohn Company Novel cc-1065 analogs

Also Published As

Publication number Publication date
CA1340215C (en) 1998-12-15
FI103668B (fi) 1999-08-13
KR0137959B1 (ko) 1998-05-15
DK175458B1 (da) 2004-11-01
JP3380237B2 (ja) 2003-02-24
NO303498B1 (no) 1998-07-20
LV12806B (lv) 2002-05-20
AU632288B2 (en) 1992-12-24
NO910958L (no) 1991-05-10
FI911193A0 (fi) 1991-03-11
GR3035589T3 (en) 2001-06-29
AU4192289A (en) 1990-04-02
JPH04500664A (ja) 1992-02-06
WO1990002746A1 (en) 1990-03-22
DE68929275D1 (de) 2001-02-01
ATE198335T1 (de) 2001-01-15
DE68929275T2 (de) 2001-05-23
NO910958D0 (no) 1991-03-11
DK41791A (da) 1991-03-08
KR900701801A (ko) 1990-12-04
US5541339A (en) 1996-07-30
LV12806A (en) 2002-03-20
TW217383B (fi) 1993-12-11
DK41791D0 (da) 1991-03-08

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Legal Events

Date Code Title Description
HC Name/ company changed in application

Owner name: PHARMACIA & UPJOHN COMPANY

MA Patent expired